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Homocysteine is associated with the progression of non-culprit coronary lesions in elderly acute coronary syndrome patients after percutaneous coronary intervention

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Journal of Geriatric Cardiology 2016年第4期13卷 299-305页

作者： Tian-Wen han Shan-Shan ZHOU Jian-Tao LI feng TIAN Yang MU Jing JING yun-feng han yun-Dai CHEN Department of Cardiology Chinese PLA General Hospital Beijing China

Background The influence of homocysteine （Hcy） on the migration and proliferation of vascular smooth muscle cells has been well established. However, the impact of Hcy levels on the progression of non-culprit coronary lesions （NCCLs） is controversial. This study aims to evaluate whether the plasma level of Hcy is related to the progression of NCCLs after percutaneous coronary stent implantation in elderly patients with acute coronary syndrome （ACS）. Methods A total of 223 elderly patients （〉 65 years old） with ACS undergoing stent im- plantation and follow-up coronary angiography were enrolled. Laboratory determination comprised of blood sample evaluation for Hcy was carried out before baseline coronary intervention. The patients were classified into two groups according to the blood Hcy tertiles （〉 15 mmol/L or 〈 15 mmol/L）. Patients were followed up for 12.2 months. NCCL progression was assessed by three-dimensional quantitative coronary angiography. Results A significantly higher ratio of NCCL progression was observed in the group with baseline Hcy concentrations above 15 mmol/L compared to the group with concentrations below 15 mmol/L （41/127, 32.3% vs. 14/96, 14.6%, P = 0.002）. Multivariate Cox regression analysis showed that Hcy and diabetes mellitus were independent risk factors for NCCL progression. The crude haz- ard ratio （HR） of NCCL progression for Hcy level was 1.056 （95% CI： 1.01-1.104, P = 0.015）. The adjusted HR of NCCL progression for Hcy level was 1.024 （95% CI： 1.007-1.042, P = 0.007）. The adjusted HR of NCCL progression for diabetes mellitus was 1.992 （95% CI： 1.15-3.44, P = 0.013）. Conclusions Hcy is an independent risk factor for NCCL progression after 12 months of follow-up in elderly patients with ACS who has undergone percutaneous coronary stenting.

关键词： Coronary angiography Elderly patients Homocysteine Non-culprit coronary lesion Percutaneous coronary intervention

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Chinese Medical Journal 2021年第17期134卷 2054-2065页

作者： Bin Chen Bin Liu Tao Yu yun-feng han Chao Wu Zhen-Yu Wang Department of Neurosurgery Peking University Third HospitalBeijing 100191China

Background:The Nuclear Dbf2-related(NDR1)kinase is a member of the NDR/LATS family,which was a supplementary of Hippo ***,whether NDR1 could inhibit glioblastoma(GBM)growth by phosphorylating Yes-associated protein(YAP)remains ***,the role of NDR1 in GBM was not *** study aimed to investigate the role of NDR1-YAP pathway in ***:Bioinformation analysis and immunohistochemistry(IHC)were performed to identify the expression of NDR1 in *** effect of NDR1 on cell proliferation and cell cycle was analyzed utilizing CCK-8,clone formation,immunofluorescence and flow cytometry,*** addition,the xenograft tumor model was established as *** interaction was examined by Coimmunoprecipitation and immunofluorescence to observe ***:Bioinformation analysis and IHC of our patients’tumor tissues showed that expression of NDR1 in tumor tissue was relatively lower than that in normal tissues and was positively related to a lower survival ***1 could markedly reduce the proliferation and colony formation of U87 and ***,the results of flow cytometry showed that NDR1 led to cell cycle arrest at the G1 *** growth was also inhibited in xenograft nude mouse models in NDR1-overexpression *** blotting and immunofluorescence showed that NDR1 could integrate with and phosphorylate YAP at S127 ***,NDR1 could mediate apoptosis ***:In summary,our findings point out that NDR1 functions as a tumor suppressor in ***1 is identified as a novel regulator of YAP,which gives us an in-depth comprehension of the Hippo signaling pathway.

关键词： Glioblastoma Hippo signaling pathway Nuclear Dbf2-related Yes-associated protein

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Quantum Computation on a Silicon Chip

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量子光学学报 2006年第B8期12卷 11-12页

作者： XIAO yun-feng han Zheng-fu GUO Guang-can Key Laboratory of Quantum Information University of Science and Technology of China Hefei 230026 China

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Understanding the Thermal Impedance of Silicone Rubber/Hexagonal Boron Nitride Composites as Thermal Interface Materials

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Chinese Journal of Polymer Science 2024年第3期42卷 352-363,I0008页

作者： Yuan Ji Shi-Da han Hong Wu Shao-yun Guo feng-Shun Zhang Jian-Hui Qiu The State Key Laboratory of Polymer Materials Engineering Sichuan Provincial Engineering Laboratory of Plastic/Rubber Complex Processing TechnologyPolymer Research InstituteSichuan UniversityChengdu 610065China Institute of Chemical Materials China Academy of Engineering PhysicsMianyang 621900China Department of Mechanical Engineering Faculty of Systems Science and TechnologyAkita Prefectural UniversityAkita 015-0055Japan

Silicone rubber(SR) composites are most widely used as thermal interface materials(TIMs) for electronics heat dissipation. Thermal impedance as the main bottleneck limiting the performance of TIMs is usually neglected. Herein, the thermal impedance of SR composites loaded with different levels of hexagonal boron nitride(h-BN) as TIMs was elaborated for the first time by the ASTM D 5470 standard test and finite element analysis. It was found that elastic modulus and surface roughness of SR composites increased with the increase of h-BN content, indicating that the conformity was reduced. When the assembly pressure was 0.69 MPa, there existed an optimal h-BN content at which the contact resistance was minimum(0.39 K·cm^(2)·W^(-1)). Although the decreased bond line thickness(BLT) by increasing the assembly pressure was beneficial to reduce the thermal impedance, the proper assembly pressure should be selected to prevent the warpage of the contact surfaces and the increase in contact resistance, according to the compression properties of the SR composites. This study provides valuable insights into fabrication of high-performance TIMs for modern electronic device applications.

关键词： Thermal interface materials Hexagonal boron nitride Thermal impedance Surfaces

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Enrichment of Chemical Element ^(7)Li in the Rotating Red Clump Star

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Chinese Physics Letters 2024年第8期41卷 121-125页

作者： Fang-Wen Wu han-feng Song Qing-Li Li yun He Xin-Yue Qu Zhuo han College of Physics Guizhou UniversityGuiyang 550025China Geneva Observatory University of GenevaCH-1290 SauvernySwitzerland

About 2 percent of red clump stars are found to be the lithium-rich and thus the surface lithium increases obviously in some red clump *** physical mechanism of the lithium enrichment in these stars has not yet been explained satisfactorily by the evolutionary models of single *** flash induced internal gravity wave mixing(i.e.,IGW)could play a primary role in explaining the red clump star with lithium enrichment and it has a very significant impact on the internal structure and surface compositions of a *** can significantly increase the mixing efficiency of the internal gravity wave because the timescale for the enrichment event has been *** mixing can explain the observed behavior of lithium on red giant stars that are more luminosity than the RGB ***,it has a very small effect on the diffusion of elements because its diffusion coefficient is much smaller than the one of IGW induced mixing after the core helium flash.

关键词： flash stars lithium

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Application of pulse index continuous cardiac output system in elderly patients with acute myocardial infarction complicated by cardiogenic shock: A prospective randomized study

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World Journal of Clinical Cases 2019年第11期7卷 1291-1301页

作者： Yuan-Bo Zhang Zhi-Zhong Zhang Jun-Xia Li Yu-Hong Wang Wei-Lin Zhang Xin-Li Tian yun-feng han Meng Yang Yu Liu Department of Cardiovascular Medicine The Seventh Medical Center General Hospital of the Chinese PLA Beijing 100700 China Department of Emergency Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Emergency Medicine The Seventh Medical Center General Hospital of Chinese PLA Beijing 100700 China Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Department of Emergency Medicine Dongzhimen Hospital The First Affiliated Hospital of Beijing University of Chinese Medicine Beijing 100700 China

BACKGROUND Cardiogenic shock (CS) secondary to acute myocardial infarction (AMI) complicates management of the condition, and often leads to poor prognosis. Prompt and accurate monitoring of cardiovascular and accompanying hemodynamic changes is crucial in achieving adequate management of the condition. Advances in technology has availed procedures such as pulse index continuous cardiac output (PiCCO), which can offer precise monitoring of cardiovascular functions and hemodynamic parameters. In this study, PiCCO is evaluated for its potential utility in improving management and clinical outcomes among elderly patients with AMI complicated by CS. AIM To assess whether use of the PiCCO system can improve clinical outcomes in elderly patients with AMI complicated by *** Patients from emergency intensive care units (EICU) or coronary care units (CCU) were randomized to receive PiCCO monitoring or not. The APACHE II score, SOFA score, hs-TnI, NT-proBNP, PaO2/FiO2 ratio and lactate levels on day 1, 3 and 7 after treatment were compared. The infusion and urine volume at 0-24 h, 24-48 h and 48-72 h were recorded, as were the cardiac index (CI), extravascular lung water index (EVLWI), intrathoracic blood volume index (ITBVI) and global end diastolic volume index (GEDVI) at similar time intervals. RESULTS Sixty patients with AMI complicated by CS were included in the study. The PiCCO group had a significantly lower APACHE II score, SOFA score, hs-TnI and NT-proBNP levels on day 1, 3 and 7 after treatment. The infusion and urine volume during 0-24 h in the PiCCO group were significantly greater, and this group also showed significantly higher ADL scores. Furthermore, the PiCCO group spent lesser days on vasoactive agents, mechanical ventilation, and had a reduced length of stay in EICU/CCU. Additionally, the CI was significantly higher at 48 h and 72 h in the PiCCO group compared with that at 24 h, and the EVLWI, ITBVI and GEDVI were significantly decreased at 48 h and

关键词： Pulse index continuous cardiac output Elderly patients Cardiogenic shock Acute myocardial infarction

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Construction of flower-like MoS_(2)decorated on Cu doped CoZn-ZIF derived N-doped carbon as superior microwave absorber

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Nano Research 2024年第9期17卷 8250-8260页

作者： yun han Di Lan Mengjun han Zihao Xia Jiaxiao Zou Zirui Jia College of Chemistry and Chemical Engineering Qingdao UniversityQingdao 266071China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China

The rational design of composition nanostructures and morphologies of the carbon-based composites materials has a significant potential for tuning electromagnetic parameters and thereby improving their performance as electromagnetic wave(EMW)*** this work,the flower-like Cu/Co-NC/MoS_(2)(NC=N-doped carbon skeleton)composites were successfully prepared by employing CuCoZn-ZIF(ZIF=zeolitic imidazolate framework)as precursor with subsequent annealing and hydrothermal *** unique flower-like morphology and electromagnetic synergy strategy between components enable the as-obtained Cu/Co-NC/MoS_(2)composites to exhibit outstanding microwave absorption ***,the minimum reflection loss of Cu/Co-NC/MoS_(2)reaches-54.36 dB at 2.7 *** the thickness reduces to 2.2 mm,the maximum effective absorption bandwidth can be achieved as large as 6.72 *** research develops useful ideas for optimizing multicomponent microwave absorbing materials.

关键词： ternary metal-organic frameworks(MOFs) MoS_(2) flower-like morphology microwave absorption

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Unstructured Road Extraction in UAV Images based on Lightweight Model

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 372-384页

作者： Di Zhang Qichao An Xiaoxue feng Ronghua Liu Jun han feng Pan School of Automation Beijing Institute of TechnologyBeijing 100081China Tianjin Institute of Maritime Navigation Instruments Tianjin 300130China The 716th Research Institute of China Shipbuilding Group Co. LtdJiangsu 222061China

There is no unified planning standard for unstructured roads,and the morphological structures of these roads are complex and *** is important to maintain a balance between accuracy and speed for unstructured road extraction *** road extraction algorithms based on deep learning have problems such as high model complexity,high computational cost,and the inability to adapt to current edge computing ***,it is best to use lightweight network *** the need for lightweight models and the characteristics of unstructured roads with different pattern shapes,such as blocks and strips,a TMB(Triple Multi-Block)feature extraction module is proposed,and the overall structure of the TMBNet network is *** TMB module was compared with SS-nbt,Non-bottleneck-1D,and other modules via *** feasibility and effectiveness of the TMB module design were proven through experiments and *** comparison experiment,using multiple convolution kernel categories,proved that the TMB module can improve the segmentation accuracy of the *** comparison with different semantic segmentation networks demonstrates that the TMBNet network has advantages in terms of unstructured road extraction.

关键词： Unstructured road Lightweight model Triple Multi-Block(TMB) Semantic segmentation net

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Study on Haploid Inducing and Its Meiotic Abnormality in Maize

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Agricultural Sciences in China 2009年第10期8卷 1159-1165页

作者： TANG Qi-lin, feng yun-chao, han Xue-li, ZHENG Ming-min and RONG Ting-zhao Maize Research Institute, Sichuan Agricultural University, Ya’an 625014, P.R.China Maize Research Institute Sichuan Agricultural University Ya'an 625014 P.R. China

The haploid-inducing line Stock 6 was used to produce haploid maize and expected to obtain maize haploid plants successfully. The detailed meiotic studies on selected haploid maize （n = x = 10） were conducted. Cytogenetic analysis revealed a high frequency of meiotic abnormality occurred in both meiosis Ⅰ and meiosis Ⅱ. During the prophase Ⅰ, univalents were common configurations, and there were bivalents or trivalents in some pollen mother cells, however, a few cells containing five bivalents were also observed. After prophase Ⅰ, chromosomes did not congregate in a single metaphase plate but they were scattered in the cytoplasm. At anaphase Ⅰ, the chromosome distribution was highly irregular with almost all possible combinations. In some cells, chromosomes were grouped into the three or four masses and several spindles appeared. At the tetrad stage of meiosis Ⅱ, eytokinesis splitting abnormality occurred, and a variety of diad, triad, tetrad, pentad, hexad, as well as decury microspores were easily observed. As a consequence of abnormalities of the two meiotic stages, various microspores and the pollen were almost completely sterile. grains with different size were formed, and its pollen grains

关键词： Zea mays L haploid maize meiosis chromosome Stock 6

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Mechanistic insights into stepwise activation of malachite for enhancing surface reactivity and flotation performance

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2159-2172页

作者： Qicheng feng Wanming Lu han Wang Qian Zhang State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Faculty of Land Resource EngineeringKunming University of Science and TechnologyKunming 650093China yunnan Key Laboratory of Green Separation and Enrichment of Strategic Mineral Resources Kunming University of Science and TechnologyKunming 650093China

Malachite is a common copper oxide mineral that is often enriched using the sulfidization-xanthate flotation ***,the direct sulfidization method cannot yield copper concentrate ***,a new sulfidization flotation process was developed to promote the efficient recovery of *** this study,Cu^(2+) was used as an activator to interact with the sample surface and increase its reaction sites,thereby strengthening the mineral sulfidization process and *** to single copper ion activation,the flota-tion effect of malachite significantly increased after stepwise Cu^(2+) *** potential,X-ray photoelectron spectroscopy(XPS),time-of-flight secondary ion mass spectroscopy(ToF-SIMS),scanning electron microscopy and energy dispersive spectrometry(SEM-EDS),and atomic force microscopy(AFM)analysis results indicated that the adsorption of S species was significantly enhanced on the mineral surface due to the increase in active Cu sites after Cu^(2+) stepwise ***,the proportion of active Cu-S spe-cies also increased,further improving the reaction between the sample surface and subsequent ***-transform infrared spec-troscopy(FT-IR)and contact angle tests implied that the xanthate species were easily and stably adsorbed onto the mineral surface after Cu^(2+) stepwise activation,thereby improving the hydrophobicity of the mineral ***,the copper sites on the malachite sur-face after Cu^(2+) stepwise activation promote the reactivity of the mineral surface and enhance sulfidization flotation of malachite.

关键词： malachite copper ions stepwise activation flotation mechanism enhanced sulfidization

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