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Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan(Liver)Depression and Qi Stagnation Syndrome:A Randomized,Double-Blind,Multicenter,Phase-ⅡClinical Trial

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Chinese Journal of Integrative Medicine 2024年第9期30卷 771-779页

作者： TENG Xiu-xiang XU Lian-wei LIN Jie ZHANG Jin-feng ZHANG Qin SUN yun YANG De-feng LI Hong-mei ZHAO Pei LIU Jun Department of Gynecology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100700China Department of Gynecology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China Department of Gynecology The First Hospital of Hunan University of Chinese MedicineChangsha410021China Department of Gynecology Shanxi Traditional Chinese Medicine HospitalTaiyuan030024China Department of Gynecology Hangzhou Hospital of Traditional Chinese MedicineHangzhou310005China Department of Gynecology Wenzhou Hospital Affiliated to Zhejiang University of Traditional Chinese MedicineWenzhouZhejiang Province325000China Department of Gynecology Luoyang First People’s HospitalLuoyangHenan Province471000China Department of Gynecology The Second Affiliated Hospital of Heilongjiang University of Chinese MedicineHarbin150001China

Objective:To confirm the efficacy and safety of Ganyushu Granule(GYSG)in treating premenstrual syndrome(PMS)in patients with Gan(Liver)depression and qi stagnation syndrome(GDQSS)and determine its effective ***:From June 2018 to March 2021,a total of 240 PMS women with GDQSS were included and randomly divided into 3 groups in a 1:1:1 ratio using central block randomization:high-dose GYSG group(n=78,GYSG 2 packs/time),low-dose GYSG group(n=82,GYSG and its simulant 1 pack/time),and placebo group(n=80,GYSG simulant 2 packs/time).Treatment with GYSG or placebo was given thrice daily and for up to 3 menstrual *** outcomes were PMS diary(PMSD)score and premenstrual tension syndrome self-rating scale(PMTS).Secondary outcomes were Chinese medicine(CM)syndrome ***,PMTS,and efficacy of CM were evaluated with menstrual cycles during the treatment *** indicators were analyzed after each menstrual *** analyses were performed using an intention-to-treat method,and clinical safety was ***:Of the 216 patients included in the effectiveness analysis,70,75,and 71 patients were in the high-,low-dose GYSG,and placebo groups,*** the 2nd treatment cycle,the change in PMSD scores in the high-and low-dose groups was lower than that in the placebo group(P<0.05).PMTS scores in the high-dose GYSG group after the 1st treatment cycle was lower than that in the placebo group(P<0.05),while after the 3rd treatment cycle,that in the low-dose group was lower than that in the placebo group(P<0.05).After the 2nd treatment cycle,the high-dose GYSG group had the best CM syndrome efficacy(P<0.05).No serious adverse reactions were ***:GYSG was safe and well-tolerated at both doses for treating PMS patients with ***-dose GYSG might be the optimal dose for a phaseⅢtrial.

关键词： premenstrual syndrome Chinese medicine Ganyushu Granule randomized controlled trial

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The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1

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Genes & Diseases 2024年第3期11卷 452-467页

作者： Min Wang Yixue gu Qiubo Li Bangzhe feng Xinke Lv Hao Zhang Qingxia Kong Zhifang Dong Xin Tian Yanke Zhang Department of Neurology Affiliated Hospital of Jining Medical UniversityJiningShandong 272000China Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqing 400016China Department of Pediatrics Affiliated Hospital of Jining Medical UniversityJiningShandong 272000China Department of Neurosurgery Affliated Hospital of Jining Medical UniversityJiningShandong 272000China Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Epilepsy,one of the most common neurological disorders,is characterized by spon-taneous recurrent *** lobe epilepsy(TLE)is one of the most common medically intractable seizure ***2-and NcK-interacting kinase(TNIK)has recently attracted attention as a critical modulation target of many neurological and psychiatric disorders,but its role in epilepsy remains *** this study,we hypothesized the involvement of TNIK in epilepsy and investigated TNIK expression in patients with intractable TLE and in a pilocarpineinduced rat model of epilepsy by western blotting,immunofluorescence,and immunohistochemistry.A pentylenetetrazole(PTZ)-induced epilepsy rat model was used to determine the effect of the TNIK inhibitor NCB-0846 on behavioral manifestations of ***(Co-IP)/mass spectrometry(MS)was used to identify the potential *** Co-IP,we detected and confirmed the main potential TNIK *** fractionation was used to establish the effect of NCB-0846 on the expression of the main interactors in postsynaptic density(PSD)*** found that TNIK was primarily located in neurons and decreased significantly in epilepsy model rats and TLE patients compared with ***-0846 delayed kindling progression and decreased seizure ***-IP/MS identified 63 candidate TNIK interactors in rat hippocampi,notably ***-IP showed that TNIK might correlate with endogenous GRIA1,SYN2,PSD-95,CaMKIV,GABRG1,and *** addition,the significant decrease in GRIA1 in hippocampal total lysate and PSDs after NCB-0846 treatment might help modify the progression of PTZ *** results suggest that TNIK contributes to epileptic pathology and is a potential antiepileptic drug target.

关键词： Epilepsy NCB-0846 Rat TLE TNIK Traf2-and NcK-interacting kinase

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Pars plana vitrectomy with internal limiting membrane plugging assisted by autologous blood for optic disc pit associated with vitreomacular traction

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1957-1959页

作者： Bin Chen Yan-Ting Li Tian-Hong Wu Ya-Ping Yuan yun-feng Lu Department of Ophthalmology Suzhou EENT HospitalSuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

Dear Editor,We report a case of optic disc pit(ODP)associated with vitreomacular traction which has been successfully treated by a combined *** have obtained the written informed consent from the patient,and this case... 详细信息

关键词： technique. traction macular

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Wettability-driven synergistic resistance of scale and oil on robust superamphiphobic coating

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Chinese Chemical Letters 2024年第7期35卷 433-438页

作者： Yixuan Wang Jiexin Li Zhihao Shang Chengcheng feng Jianmin gu Maosheng Ye Ran Zhao Danna Liu Jingxin Meng Shutao Wang CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences(UCAS) Beijing 100049China State Key Laboratory of Metastable Materials Science and Technology(MMST) Yanshan UniversityQinhuangdao 066004China

Disgusting deposits(e.g.,scale and crude oil)in daily life and industrial production are always serious problems,posing great threats to the safety and economic ***,most of developed coatings can only conquer one part of these deposits such as superhydrophobic coatings possess antiscaling capacity but would adhere crude *** integrate scale resistance with oil repellence,we herein report a robust superamphiphobic(SAB)coating simultaneously reducing pollution of scale and oil for extended period of time(two weeks with over 98%reduction).Compared with single role of superhydrophobic and amphiphilic surfaces,the SAB coating can not only inhibit interfacial nucleation of scale but also reduce the adhesion of formed scale and polluted *** durability of the SAB coating is evaluated via mechanical tests(sandpaper abrasion,tape stripping and sand falling)and chemical corrosion(corrosive liquid immersing),revealed by sustainable high contact angles and low contact angle hysteresis of water and *** universality of this strategy can be further confirmed by adding different particles like kaolin,Al_(2)O_(3),and SiO_(2),resisting multiple types of scale(i.e.,CaSO_(4),BaSO_(4)and MgCO_(3))and oil(i.e.,glycerol,glycol,and mineral oil).Therefore,this study provides an ideal avenue for resisting scale and oil,which may be used for conquering the complexity of application environments(e.g.,oil production and transportation).

关键词： Superamphiphobic Durability Wettability Anti-scaling Oil repellence

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Recombinant adeno-associated virus 8 vector in gene therapy:Opportunities and challenges

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Genes & Diseases 2024年第1期11卷 283-293页

作者： Liyuan Zhao Zixuan Yang Minhui Zheng Lei Shi Mengyun gu Gang Liu feng Miao Yan Chang Fanghua Huang Naping Tang Anhui University of Traditional Chinese Medicine HefeiAnhui 230000China Yangtze Delta Drug Advanced Research Institute Yangtze Delta Pharmaceutical CollegeNantongJiangsu226133China Shanghai Innostar Bio-Technology Co. LtdChina State Institute of Pharmaceutical IndustryShanghai 201203China Innostar Bio-tech Nantong Co. Ltd.NantongJiangsu 226133China Center for Drug Evaluation National Medical Products AdministrationBeijing 100022China

In recent years,significant breakthroughs have been made in the field of gene ***-associated virus(AAV)is one of the most promising gene therapy vectors and a powerful tool for delivering the gene of *** the AAV vectors,AAV serotype 8(AAv8)has attracted much attention for its efficient and stable gene transfection into specific ***,recombinant AAv8 has been widely used in gene therapy research on a va-riety of diseases,including genetic diseases,cancers,autoimmune diseases,and viral diseases.

关键词： AAV8 Adeno-associated virus Gene therapy Primates

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A_(2)B_(7)-type La-Mg-Ni alloys prepared by Mg thermal diffusion for improved hydrogen storage performance

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Rare Metals 2024年第7期43卷 3260-3272页

作者： Yong-Xi Zhang guan-Jiu Wu Jing gu Hong-Xing Kang Yuan Li Di Zhou Wen-feng Wang Lu Zhang Shu-Min Han Hebei Key Laboratory of Applied Chemistry School of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066004China Department of Chemistry and Biochemistry San Diego State UniversitySan DiegoCA92182-1030USA State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

A novel approach based on thermal diffusion was used to achieve controllable Mg content in A_(2)B_(7)-type La-Mg-Ni-based *** formation mechanism of the A_(2)B_(7)-type phase as a result of the thermal diffusion process and the effect of Mg content on hydrogen storage performance were investigated.X-ray diffraction(XRD)patterns and Rietveld refinement results showed that increased Mg transformed the LaNi_(5)phase in the La_(0.74)Sm_(0.03)Y_(0.23)Ni_(4.32)Al_(0.04)precursor alloy into a superlattice *** electron microscopy(SEM)images showed that Mg was evenly distributed in the alloy *** in the superlattice significantly inhibited the phase decomposition of the superlattice structure during the hydrogen absorption/desorption *** A_(2)B_(7)-type La_(0.57)Sm_(0.02)Y_(0.18)Mg_(0.23)Ni_(3.38)Al_(0.03)alloy composed of Gd_(2)Co_(7)and Ce_(2)Ni_(7)phases was successfully *** pressure-composition isotherm profiles showed that the alloy had a hydrogen storage capacity as high as 1.73 wt%,with good cycling *** 50 cycles of hydrogen absorption/desorption,the alloy retained a hydrogen storage capacity of 1.45 wt%,with a capacity retention rate of up to 84.28%.The Mg thermal diffusion process thus provides a new approach for the controlled preparation of La-Mg-Ni-based alloys.

关键词： La-Mg-Ni-based hydrogen storage alloy A_(2)B_(7)-type superlattice alloy Mg thermal diffusion process Phase transformation Hydrogen storage property

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Effects of Ta content on microstructure and oxidation behavior of AlCoCrFeNiYTax high entropy alloy

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Rare Metals 2024年第9期43卷 4462-4475页

作者： Cang gu Jun-Hao Hu Jian-Bo Song Cheng Xu Ming-Yu Hu Yu-Xuan Zhang Jiang Tian Chao Li Jing feng Faculty of Materials Science and Engineering Kunming University of Science and Technology Department of Physics Hong Kong Baptist University

The oxidation behavior of the Al Co Cr Fe Ni YTaxhigh entropy alloy（HEA） doped with different Ta contents at 1100 °C is investigated. In this study, different reasons for the spallation of the oxide scales of HEAs without/with excessive Ta addition after 1000 h of oxidation are discussed, and the most suitable Ta doping content for this HEA is explored, in which the HEA exhibits both an exceptionally low oxidation rate, and the formation of oxide scales composed of intact a-Al2O3. Meanwhile, it is found that the addition of Ta can effectively inhibit the phase transition of β phase, which makes the surface of the oxide scale smoother. By combining our experimental results with Wagner–Hauffe theory, the influence of Ta drag effect on oxide scale growth is explained, which provides some theoretical guidance for the subsequent design of Al Co Cr Fe Ni HEAs, and can lead to the development of thermal barrier coatings at higher service temperature.

关键词： Al2O3 scales Elements diffusion High-entropy alloy Oxidation

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Simultaneous determination of typical toxic aldehydes formed during food frying and digestion using isotope dilution UHPLC-QqQ-MS/MS

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Grain & Oil Science and Technology 2024年第1期7卷 42-49页

作者： feng Wang yun Cui Dongjie Liu Charles Brennan Soottawat Benjakul Weiwei Cheng Gengsheng Xiao Lukai Ma Key Laboratory of Green Processing and Intelligent Manufacturing of Lingnan Specialty Food of Ministry and Rural Affairs College of Light Industry and FoodZhongkai University of Agriculture and EngineeringGuangzhou 510225China School of Science Royal Melbourne Institute of Technology UniversityMelbourneAustralia International Center of Excellence in Seafood Science and Innovation Faculty of Agro-IndustryPrince of Songkla UniversitySongkhla 90110Thailand College of Food Science and Technology Zhejiang University of TechnologyHangzhou 310014China

An isotope dilution ultra-performance liquid chromatography-triple quadrupole mass spectrometry method was developed to simultaneously detect two typical kinds ofα,β-unsaturated aldehydes,namely 4-hydroxy-2-hexenal(4-HHE)and 4-hydroxy-2-nonenal(4-HNE),in *** proposed method exhibited a linear range of 10-1000 ng/mL with a limit of detection of 0.1-2.0 ng/g and a limit of quantification of 0.3-5.0 ng/*** recovery rates of these typical toxic aldehydes(i.e.,4-HHE,4-HNE)and their d3-labeled analogues were 91.54%-105.12%with a low matrix ***,this proposed method was successfully applied to a real frying system and a simulated digestion system,wherein the contents of 4-HHE and 4-HNE were determined for ***,the obtained results provide strong support for further research into the production of 4-HHE and 4-HNE resulting from foods during oil digestion and frying.

关键词： UHPLC-QqQ-MS/MS 4-Hydroxy-2-hexenal 4-Hydroxy-2-nonenal Frying Simulated digestion

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Alzheimer's disease with depressive symptoms: Clinical effect of intermittent theta burst stimulation repetitive transcranial magnetic stimulation

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World Journal of Psychiatry 2024年第8期14卷 1216-1223页

作者： Xin Jin Chun-yun Xu Jin-feng Fei Yu Fang Cong-Hao Sun Department of Psychiatry Huzhou Third Municipal HospitalThe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Alzheimer's disease(AD),characterized by the ongoing deterioration of neural function,often presents alongside depressive features and greatly affects the quality of life of individuals living with the *** several treatment methods exist,their efficacy is *** recent years,repetitive transcranial magnetic stimulation(rTMS)utilizing the theta burst stimulation(TBS)mode,specifically the intermittent TBS(iTBS),has demonstrated promising therapeutic potential in the management of neuropsychiatric *** To examine the therapeutic efficacy of iTBS mode of rTMS for treating depressive symptoms in patients with *** This retrospective study enrolled 105 individuals diagnosed with AD with depressive symptoms at Huzhou Third Municipal Hospital,affiliated with Huzhou University,between January 2020 and December *** received standard pharmacological interventions and were categorized into control(n=53)and observation(n=52)groups based on treatment *** observation group received iTBS mode of rTMS,while the control group received pseudo-stimulation.A comparative analysis evaluated psychological well-being,adverse events,and therapeutic at initiation of hospitalization(T0)and 15 days post-treatment(T1).RESULTS At T1,both groups exhibited a marked reduction in self-rating depression scale and Hamilton depression scale scores compared to ***,the observa-tion group showed a more pronounced decrease than the control *** T1,the Mini-mental state examination scores for both groups had increased markedly from their initial T0 ***,the increase was particularly more substantial in the observation group than in the control *** patients in the control group had ineffective treatment effects,while five patients in the observation group experienced the ***,the observation group experienced a substantially reduced incidence of ineffective treatment as compared to th

关键词： Alzheimer's disease Non-persistentθshort array fast pulse mode Depression Clinical efficacy Dementia Repetitive transcranial magnetic stimulation

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Electron-distribution control via Pt/NC and MoC/NC dual junction:Boosted hydrogen electro-oxidation and theoretical study

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Journal of Energy Chemistry 2024年第1期88卷 513-520,I0011页

作者： feng Zhou Xiaofeng Ke Yihuang Chen Mei Zhao yun Yang Youqing Dong Chao Zou Xi’an Chen Huile Jin Lijie Zhang Shun Wang Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000ZhejiangChina Zhejiang Engineering Research Center for Electrochemical Energy Materials and Devices Institute of New Materials&Industry TechnologyWenzhou UniversityWenzhou 325000ZhejiangChina

The scarcity,high cost and susceptibility to CO of Platinum severely restrict its application in alkaline hydrogen oxidation reaction(HOR).Hybridizing Pt with other transition metals provides an effective strategy to modulate its catalytic HOR performance,but at the cost of mass activity due to the coverage of modifiers on Pt ***,we constructed dual junctions'Pt/nitrogen-doped carbon(Pt/NC)andδ-MoC/NC to modify electronic structure of Pt via interfacial electron transfer to acquire Pt-MoC@NC catalyst with electron-deficient Pt nanoparticles,simultaneously endowing it with high mass activity and durability of alkaline ***,the unique structure of Pt-MoC@NC endows Pt with a high COtolerance at 1,000 ppm CO/H_(2),a quality that commercial Pt-C catalyst *** theoretical calculations not only confirm the diffusion of electrons from Pt/NC to Mo C/NC could occur,but also demonstrate the negative shift of Pt d-band center for the optimized binding energies of*H,*OH and CO.

关键词： Hydrogen oxidation reaction Dual junctions CO-tolerance Platinum

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