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Remote ischemic preconditioning protects liver ischemia-reperfusion injury by regulating eNOS-NO pathway and liver microRNA expressions in fatty liver rats

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Hepatobiliary & Pancreatic Diseases International 2017年第4期16卷 387-394页

作者： yun-fei duan Yong An Feng Zhu Yong Jiang Department of Hepatobiliary Surgery The Third Affiliated Hospital of Soochow UniversityChangzhou 213003China

BACKGROUND: Ischemic preconditioning (IPC) is a strategy to reduce ischemia-reperfusion (I/R) injury. The protective effect of remote ischemic preconditioning (RIPC) on liver I/R injury is not clear. This study aimed to investigate the roles of RIPC in liver I/R in fatty liver rats and the involvement of endothelial nitric oxide synthase-nitric oxide (eNOS-NO) pathway and microRNA expressions in this process. METHODS: A total of 32 fatty rats were randomly divided into the sham group, I/R group, RIPC group and RIPC+I/R group. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and nitric oxide (NO) were measured. Hematoxylin-eosin staining was used to observe histological changes of liver tissues, TUNEL to detect hepatocyte apoptosis, and immunohistochemistry assay to detect heat shock protein 70 (HSP70) expression. Western blotting was used to detect liver inducible NOS (iNOS) and eNOS protein levels and realtime quantitative polymerase chain reaction to detect miR-34a, miR-122 and miR-27b expressions. RESULTS: Compared with the sham and RIPC groups, serum ALT, AST and iNOS in liver tissue were significantly higher in other two groups, while serum NO and eNOS in liver tissue were lower, and varying degrees of edema, degeneration and inflammatory cell infiltration were found. Cell apoptosis number was slightly lower in the RIPC+I/R group than that in I/R group. Compared with the sham group, HSP70 expressions were significantly increased in other three groups (all P<0.05). Compared with the sham and RIPC groups, elevated miR-34a expressions were found in I/R and RIPC+I/R groups (P<0.05). MiR-122 and miR-27b were found significantly decreased in I/R and RIPC+I/R groups compared with the sham and RIPC groups (all P<0.05). CONCLUSION: RIPC can reduce fatty liver I/R injury by affecting the eNOS-NO pathway and liver microRNA expressions.

关键词： fatty liver ischemia-reperfusion remote ischemic preconditioning nitric oxide heat shock protein 70 endothelial nitric oxide synthase inducible nitric oxide synthase liver microRNA

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Traumatic rupture of a type Ⅳ a choledochal cyst in an adult male

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World Journal of Gastroenterology 2013年第24期19卷 3911-3914页

作者： yun-fei duan Bo Yang Feng Zhu Department of Hepatobiliary Surgery the Third Affiliated Hospital of Soochow University

Choledochal cyst (CC) is a rare, congenital anomaly of the bile ducts. We describe a 26-year-old male patient who was transferred to our hospital with a reported traumatic rupture of cystic liver lesions following a fall. At the time of injury, the patient experienced severe abdominal pain. He was found to have peritonitis and abdominal hemorrhage, which is quite rare. Laparot-omy revealed 3000 mL fluid consisting of a mixture of blood, bile and inflammatory effusion in the peritoneal cavity. The liver, gallbladder, spleen, stomach, duo-denum, small intestine, and colon appeared normal. A large cystic mass was discovered near the porta hepatis. This mass, which connected to the hepatic bifurcation and gallbladder had a 5 cm rupture in the right wall with active arterial bleeding. Abdominal com-puted tomography (CT) and emergency laparotomy revealed rupture of a huge type Ⅳa CC. The patient was successfully managed by primary cyst excision, cholecystectomy, and Roux-en-Y end-to-side hepatico-jejunostomy reconstruction. The postoperative course was uneventful and the patient was discharged on the 12 th day of hospitalization. Four weeks after surgery,abdominal CT scan showed pneumatosis in the intra-hepatic bile duct, and intrahepatic dilatation which decreased following adequate biliary drainage. The patient has remained well in the close follow-up period for 9 mo.

关键词： Biliary tract Choledochal cyst Trauma Rupture Peritonitis Hemorrhage

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Acute pancreatitis connected with hypercalcemia crisis in hyperparathyroidism: A case report

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World Journal of Clinical Cases 2019年第16期7卷 2367-2373页

作者： Yi-Bo Ma Jun Hu yun-fei duan Department of B-mode Ultrasound The First People’s Hospital of ChangzhouChangzhou 213003Jiangsu ProvinceChina Department of Hepatobiliary Surgery The First People’s Hospital of ChangzhouChangzhou 213003Jiangsu ProvinceChina

BACKGROUND The association between primary hyperparathyroidism (PHPT) and acute pancreatitis is rarely *** we describe the process of acute pancreatitismediated PHPT induced by hypercalcemia in a male *** induced by undiagnosed PHPT may be the causative factor in recurrent acute *** SUMMARY We report a case of hypercalcemia-induced acute pancreatitis caused by a functioning parathyroid adenoma in a 57-year-old *** patient initially experienced a series of continuous gastrointestinal symptoms including abdominal distension,abdominal pain,nausea,vomiting,electrolyte disturbance,renal dysfunction,and acute *** to prolonged hypercalcemia,the patient subsequently underwent surgical resection of the parathyroid *** weeks after surgery,his serum calcium,amylase,and lipase concentrations were *** patient had a good recovery after a series of other relevant *** Acute pancreatitis as the first presentation is a rare clinical symptom caused by PHPT-induced hypercalcemia.

关键词： Acute pancreatitis Hypercalcemia Hyperparathyroidism Case report

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An extended cellular automata model with modified floor field for evacuation

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Chinese Physics B 2020年第9期29卷 622-631页

作者： Da-Hui Qin yun-fei duan Dong Cheng Ming-Zhu Su Yong-Bo Shao School of Civil Engineering and Geomatics Southwest Petroleum UniversityChengdu 610500China

The floor field model has been widely used in evacuation simulation research based on cellular automata model. However, conventional methods of setting floor field will lead to highly insufficient utilization of the exit area when people gather on one side of the exit. In this study, an extended cellular automata model with modified floor field is proposed to solve this problem. Additionally, a congestion judgment mechanism is integrated in our model, whereby people can synthetically judge the degree of congestion and distance in front of them to determine whether they need to change another exit to evacuate or not. We contrasted the simulation results of the conventional floor field model, the extended model proposed in this paper, and Pathfinder software in a same scenario. It is demonstrated that this extended model can ameliorate the problem of insufficient utilization of the exit area and the trajectory of pedestrian movement and the crowd shape of pedestrians in front of exit in this new model are more realistic than those of the other two models. The findings have implications for modeling pedestrian evacuation.

关键词： evacuation simulation cellular automata model floor field model congestion

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Rare case of omentum-wrapped abscess caused by a fish bone penetrating the terminal ileum

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World Journal of Gastroenterology 2014年第32期20卷 11456-11459页

作者： Chuan-Xing Wu Bao-Qiang Wu yun-fei duan Dong-Lin Sun Yong Jiang Department of Hepatobiliary Surgery The Third Affiliated Hospital of Soochow University The First People Hospital of Changzhou

Accidentally ingested foreign bodies, for the most part, pass through the gastrointestinal tract, but can cause several complications. Perforation is rare, but can occur in any segment of the gastrointestinal tract. Intestinal perforations due to foreign bodies are rarely diagnosed preoperatively as clinical symptoms are non-specific and they can mimic other abdominal conditions. We describe a case of a 48-year-old patient who was admitted to the emergency room because of severe abdominal pain of 5 d duration. A computed tomography scan showed an undefined liquid collection involving a linear image 35 mm in size, suggestive of a foreign body. On laparotomy, an abscess containing a fish bone was resected. As fish bone ingestion is usually not remembered by the patient, the diagnosis can be delayed. The preoperative diagnosis is frequently acute abdomen of unknown cause. A low threshold of suspicion along with a good clinical history and radiologicalstudies are extremely important in order to make a correct diagnosis.

关键词： Foreign body Fish bone Terminal ileum perforation

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei duan fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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CBRDI:一种基于范例推理的数据集成方法

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计算机工程与应用 2003年第16期39卷 52-55页

作者：李宝林王秀峰兰芸段菲南开大学信息技术科学学院天津300071 北京航空航天大学高等教育研究所北京100083

设计并实现了基于范例推理的数据集成系统CBRDI,能够通过积累的领域知识即范例进行有效的数据集成操作。CBRDI采用框架网络表示范例,并通过聚类方法对源范例进行组织和索引,提高了范例搜索的效率。CBRDI系统实现简单,并具有较强的自学... 详细信息

设计并实现了基于范例推理的数据集成系统CBRDI,能够通过积累的领域知识即范例进行有效的数据集成操作。CBRDI采用框架网络表示范例,并通过聚类方法对源范例进行组织和索引,提高了范例搜索的效率。CBRDI系统实现简单,并具有较强的自学习的能力,推理效率高。

关键词：知识发现数据集成范例框架网络聚类

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用数据挖掘技术进行中文地址解构的新方法

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计算机工程与应用 2003年第13期39卷 72-74,87页

作者：李宝林王秀峰兰芸段菲南开大学信息技术科学学院天津300071 北京航空航天大学高等教育研究所北京100083

从数据挖掘的角度对中文地址解构规则的获取与应用进行研究。该文提出了一种高效自动获取地址解构规则的方法:首先利用文本挖掘技术从训练数据集中挖掘出候选规则,然后生成最终的强规则,同时构建地址元素特征词典。最后,根据获取的知识... 详细信息

从数据挖掘的角度对中文地址解构规则的获取与应用进行研究。该文提出了一种高效自动获取地址解构规则的方法:首先利用文本挖掘技术从训练数据集中挖掘出候选规则,然后生成最终的强规则,同时构建地址元素特征词典。最后,根据获取的知识进行地址解析,提取文本地址组成元素。试验结果证实了该方法的可行性。

关键词：文本地址地址解构数据挖掘序贯规则数字查找树

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Dramatic impact of metric choice on biogeographical regionalization

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Plant Diversity 2020年第2期42卷 67-73页

作者： Jian-fei Ye yun Liu Zhi-duan Chen State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China Beijing Botanical Garden.Institute of Botany Chinese Academy of SciencesBeijing W0093China

For a quantitative biogeographical regionalization,the choice of an appropriate dissimilarity index to measure pairwise distances is *** different metrics have been used,but there is no specific study to test the impact of metric choice on biogeographical *** herein applied a hierarchical cluster analysis on the mean nearest taxon distance(MNTD)and the phylogenetic turnover component of the SФrensen dissimilarity index(pβsim)pairwise distances to generate two schemes of phylogenetic regio nalization of the Chinese flora,and then evaluated the effect of metric *** regionalization based on MNTD was influenced by richness differences,but regionalization based on pβsim can clearly reflect the evolutionary history of the Chinese *** provided a brief description of the five regions identified by pβsim,and the regionalization can help develop strategies to effectively conserve the taxa and floristic regions with different origins and evolutionary histories.

关键词： Angiosperms Chinese flora Dissimilarity index Distance metrics Spatial turnover

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基于耦合界面键合效应的石墨烯磨损研究

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原子与分子物理学报 2025年第6期42卷 66-75页

作者：郑云飞卢艳武汉科技大学冶金装备及其控制教育部重点实验室武汉430081 武汉科技大学机械传动与制造工程湖北省重点实验室武汉430081 武汉科技大学精密制造研究院武汉430081

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖... 详细信息

石墨烯作为二维固体润滑材料,其超滑特性不仅是物理作用结果,其化学键结构机制下的摩擦化学现象,是深入理解石墨烯摩擦性能的关键.本文采用分子动力学(MD)方法构建了多重层数石墨烯增强不同粗糙形貌的金属基底模型,实现了其与金刚石尖端滑动过程的动态分析,揭示了考虑尖端与石墨烯之间存在界面键时石墨烯层的理化耦合作用下的磨损机理.研究结果表明:当考虑金刚石尖端与石墨烯之间化学键合时,石墨烯发生磨损破裂的临界载荷相对于不考虑界面化学键时的值减小,这是由于界面键的形成会剥离石墨烯导致石墨烯断裂所致;金属基底的粗糙度也是决定石墨烯发生磨损破裂时临界载荷的重要因素之一,当粗糙度增大,临界载荷减小,同时通过增加石墨烯层的层数(增韧)来提高石墨烯发生磨损破裂失效的临界载荷.

关键词：石墨烯层界面键分子动力学磨损破裂

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