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Genetic dissection of glutathione S-transferase omega-1:identification of novel downstream targets and Alzheimer's disease pathways

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Neural Regeneration Research 2022年第11期17卷 2452-2458页

作者： Yue Jia Meng-Die Gao yun-fang liu Lu Lu Gang Chen Ying Chen Department of Histology and Embryology Medical CollegeNantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and the Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Genetics Genomics and InformaticsUniversity of Tennessee Health Science CenterMemphisTNUSA Department of Anesthesiology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Alzheimer's disease(AD)is affected by genetic factors.Polymorphisms in the glutathione S-transfe rase omega-1(Gsto1)gene have been shown by genetic correlation analyses performed in different ethnic populations to be genetic risk factors for AD.Gene expression profile data from BXD recombinant inbred mice were used in combination with genetic and bioinformatic analyses to chara cterize the mechanisms underlying regulation of Gstol variation regulation and to identify network membe rs that may contribute to AD risk or progression.Allele-specific assays confirmed that variation in Gstol expression is controlled by cis-expression quantitative trait loci.We found that Gstol mRNA levels were related to several central nervous system traits,such as glial acidic fibrillary protein levels in the caudate putamen,co rtical gray matter volume,and hippocampus mossy fiber pathway volume.We identified 2168 genes whose expression was highly correlated with that of Gsto1.Some genes were enriched for the most common neurodegenerative diseases.Some Gsto1-related genes identified in this study had previously been identified as susceptibility genes for AD,such as APP,Grin2 b,Ide,and Psenen.To evaluate the relationships between Gstol and candidate network members,we transfected astrocytes with Gstol siRNA and assessed the effect on putative downstream effecto rs.We confirmed that knockdown of Gstol had a significant influence on Pa2g4 expression,suggesting that Pa2g4 may be a downstream effector of Gstol,and that both genes intera ct with other genes in a network during AD pathogenesis.

关键词： Alzheimer's disease BXD recombinant inbred mice co-expression correlation analysis expression quantitative trait locus expression variation genetic dissection glutathione S-transferase omega-1 hippocampus proliferation-associated 2G4

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Research progress in artificial intelligence assisted diabetic retinopathy diagnosis

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1395-1405页

作者： yun-fang liu Yu-Ke Ji fang-Qin Fei Nai-Mei Chen Zhen-Tao Zhu Xing-Zhen Fei Department of Ophthalmology First People’s Hospital of HuzhouHuzhou UniversityHuzhou 313000Zhejiang ProvinceChina Eye Hospital Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Endocrinology First People’s Hospital of HuzhouHuzhou UniversityHuzhou 313000Zhejiang ProvinceChina Department of Ophthalmology Huai’an Hospital of Huai’an CityHuai’an 223000Jiangsu ProvinceChina

Diabetic retinopathy(DR)is one of the most common retinal vascular diseases and one of the main causes of blindness worldwide.Early detection and treatment can effectively delay vision decline and even blindness in patients with DR.In recent years,artificial intelligence(AI)models constructed by machine learning and deep learning(DL)algorithms have been widely used in ophthalmology research,especially in diagnosing and treating ophthalmic diseases,particularly DR.Regarding DR,AI has mainly been used in its diagnosis,grading,and lesion recognition and segmentation,and good research and application results have been achieved.This study summarizes the research progress in AI models based on machine learning and DL algorithms for DR diagnosis and discusses some limitations and challenges in AI research.

关键词： diabetic retinopathy artificial intelligence machine learning deep learning diagnosis grading lesions segmentation

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Prevalence and Influencing Factors on Fatigue of First-line Nurses Combating with COVID-19 in China:A Descriptive Cross-Sectional Study

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Current Medical Science 2020年第4期40卷 625-635页

作者： Yu-xin ZHAN Shi-yu ZHAO Jiao YUAN Huan liu yun-fang liu Ling-li GUI Hong ZHENG Ya-min ZHOU Li-hua QIU Jiao-hong CHEN Jiao-hua YU Su-yun LI Deparment of Nursing Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Deparment of Operating Room Union HospialTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department ofAcademic Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Deparment of Nursing Yijishan Hospital Affiliated to Wannan Medical CollegeWuhu 241001China Department of Radiation and Medical Oncology Zhongnan HospitalWuhan UniversityWuhan 430071China Department of Urology Renmin Hospital of Wuhan UniversityWuhan 430060China Depariment of Operating Room Affiliated Hospital of Jianghan UniversityWuhan 430015China Department of Nursing Union Jiangbei HospitalWuhan 430100China Department of Neurosurgery Hubei Provincial Hospital of Integrated Chinese&Western MedicineWuhan 430015China

Summary:Nurses'work-related fatigue has been recognized as a threat to nurse health and patient safety.The aim of this study was to assess the prevalence of fatigue among first-line nurses combating with COVID-19 in Wuhan,China,and to analyze its influencing factors on fatigue.A multi-center,descriptive,cross-sectional design with a convenience sample was used.The statistical population consisted of the first-line nurses in 7 tertiary general hospitals from March 3,2020 to March 10,2020 in Wuhan of China.A total of 2667 samples from 2768 contacted participants completed the investgation,with a response rate of 96.35%.Social-demographic questionnaire,work-related questionnaire,Fatigue Scale-14,Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Chinese Perceived Stress Scale were used to conduct online survey.The descriptive statistic of nurses'social-demographic characteristics was conducted,and the related variables of work,anxiety,depression,perceived stress and fatigue were analyzed by Z-tests,nonparametric test and Pearson's correlation analysis.The significant factors which resulted in nurses'fatigue were further analyzed by multiple linear regression analysis.The median score for the first-line nurses'fatigue in Wuhan was 4(2,8).The median score of physical and mental fatigue of them was 3(1,6)and 1(0,3)respectively.According to the scoring criteria,35.06%nurses(w=935)of all participants were in the fatigue status,their median score of fatigue was 10(8,11),and the median score of physical and mental fatigue of them was 7(5,8)and 3(2,4)respectively.Multiple linear regression analysis revealed the participants in the risk groups of anxiety,depression and perceived stress had higher scores on physical and mental fatigue and the statistically significant positive correlation was observed between the variables and nurses'fatigue,the frequency of exercise and nurses'fatigue had a statistically significant negative correlation,and average daily working hours had a significantly positive correlation w

关键词： COVID-19 pandemic Chinese nurses fatigue anxiety depression perceived stress cross-sectional study

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Coral-shaped and Core-Shell Structure Copolyethylene Nanocomposites Particles Prepared by in situ Coordination Polymerization

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Chinese Journal of Polymer Science 2015年第12期33卷 1650-1660页

作者： Jing Wang Hong-ming Li Jiang-ping Guo 黄启谷 Jian-jun Yi yun-fang liu Ke-jing Gao Wan-tai Yang State Key Laboratory of Chemical Resource Engineering Key Laboratory of Carbon Fiber and Functional PolymersMinistry of Education Beijing University of Chemical Technology Lab for Synthetic Resin Research Institution of Petrochemical Technology China National Petroleum Corporation

The example of the preparation ofnano- and micro-scaled, coral-shaped and core-shell topological morphology of copolyethylene particles promoted by the novel heterogeneous non-metallocene catalyst （m-CH3PhO）TiC13/carbon nanotubes （CNTs） was reported. Mass fraction of titanium component of the catalyst was 4.0 wt% determined by ICP analysis. The catalyst system can effectively catalyze polymerization of ethylene and eopolymerization of ethylene with 1-hexene. Morphological examination of the obtained polymer particles was carried out by scanning electron microscope （SEM） and high resolution transmission electron microscope （HR-TEM） technique. The results revealed that the morphology of the nascent copolyethylene particles looked like coral shape with size in micro-scaled and featured the core-shell structure consisting of CNTs as the core and copolyethylene as the shell.

关键词： Catalysts Composites Copolymers.

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Quantifying peripapillary vessel density and retinal nerve fibre layer in type 1 diabetic children without clinically detectable retinopathy using OCTA

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 278-281页

作者： Ling Chen yun Feng Sha-Sha Zhang Yan-fang liu Ping Lin Xi’an Children’s Hospital Affiliated to Xi’an Jiaotong University Xi’an 710002Shaanxi ProvinceChina

AIM:To quantify changes in radial peripapillary capillary vessel density(ppVD)and the peripapillary retinal nerve fiber layer(pRNFL)in children with type 1 diabetes without clinical diabetic retinopathy by optical coherence tomography angiography(OCTA),providing a basis for early retinopathy in children with type 1 diabetes.METHODS:This was a retrospective study.A total of 30 patients(3–14y)with type 1 diabetes without clinical diabetic retinopathy(NDR group)were included.A total of 30 age-matched healthy subjects were included as the normal control group(CON group).The HbA1c level in the last 3mo was measured once in the NDR group.The pRNFL thickness and ppVD were automatically measured,and the mean pRNFL and ppVD were calculated in the nasal,inferior,temporal,and superior quadrants.The changes in ppVD and pRNFL in the two groups were analyzed.RESULTS:Compared with CON group,the nasal and superior ppVDs decreased in the NDR group(all P0.05).Person and Spearman correlation analysis of ppVD and pRNFL thickness in each quadrant of the NDR group showed a positive correlation between nasal and superior(all P0.05).There was no significant correlation between the HbA1c level and ppVD and pRNFL in any quadrant(all P>0.05).There was no significant correlation between the course of diabetes mellitus and ppVD and pRNFL in any quadrant(all P>0.05).CONCLUSION:ppVD and pRNFL decrease in eyes of children with type 1 diabetes before clinically detectable retinopathy and OCTA is helpful for early monitoring.

关键词： diabetic retinopathy children peripapillary vessel density peripapillary retinal nerve fiber layer optical coherence tomography angiography

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A Novel Fracturing Fluid with High-Temperature Resistance for Ultra-Deep Reservoirs

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Fluid Dynamics & Materials Processing 2024年第5期20卷 975-987页

作者： Lian liu Liang Li Kebo Jiao Junwei fang yun Luo Northwest Oilfield Branch China Petroleum&Chemical CorporationUrumqi830011China Sinopec Key Laboratory for Enhanced Recovery in Fractured and Cavernous Reservoir Urumqi830011China

Ultra-deep reservoirs play an important role at present in fossil energy exploitation.Due to the related high temperature,high pressure,and high formation fracture pressure,however,methods for oil well stimulation do not produce satisfactory results when conventional fracturing fluids with a low pumping rate are used.In response to the above problem,a fracturing fluid with a density of 1.2~1.4 g/cm^(3)was developed by using Potassium formatted,hydroxypropyl guanidine gum and zirconium crosslinking agents.The fracturing fluid was tested and its ability to maintain a viscosity of 100 mPa.s over more than 60 min was verified under a shear rate of 1701/s and at a temperature of 175℃.This fluid has good sand-carrying performances,a low viscosity after breaking the rubber,and the residue content is less than 200 mg/L.Compared with ordinary reconstruction fluid,it can increase the density by 30%~40%and reduce the wellhead pressure of 8000 m level reconstruction wells.Moreover,the new fracturing fluid can significantly mitigate safety risks.

关键词： Ultra-deep reservoir high-temperature resistance weighted fracturing fluid guanidine gum potassium formatted

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Removal of Cr(Ⅵ)by glutaraldehyde-crosslinked chitosan encapsulating microscale zero-valent iron:Synthesis,mechanism,and longevity

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Journal of Environmental Sciences 2024年第8期142卷 115-128页

作者： Yijun Duan fang liu Xiang liu Miao Li School of Environment Tsinghua UniversityBeijing 100084China Transportation Institute of Inner Mongolia University Hohhot 010070China

Microscale zero-valent iron(mZVI)has shown great potential for groundwater Cr(Ⅵ)remediation.However,low Cr(Ⅵ)removal capacity caused by passivation restricted the wide use of mZVI.We prepared mZVI/GCS by encapsulating mZVI in a porous glutaraldehydecrosslinked chitosan matrix,and the formation of the passivation layer was alleviated by reducing the contact between zero-valent iron particles.The average pore diameter of mZVI/GCS was 8.775 nm,which confirmed the mesoporous characteristic of this material.Results of batch experiments demonstrated that mZVI/GCS exhibited high Cr(Ⅵ)removal efficiency in a wide range of pH(2-10)and temperature(5-35℃).Common groundwater coexisting ions slightly affected m ZVI/GCS.The material showed great reusability,and the average Cr(Ⅵ)removal efficiency was 90.41%during eight cycles.In this study,we also conducted kinetics and isotherms analysis.Pseudo-second-order model was the most matched kinetics model.The Cr(Ⅵ)adsorption process was fitted by both Langmuir and Freundlich isotherms models,and the maximum Langmuir adsorption capacity of m ZVI/GCS reached243.63 mg/g,which is higher than the adsorption capacities of materials reported in most of the previous studies.Notably,the column capacity for Cr(Ⅵ)removal of a mZVI/GCS-packed column was 6.4 times higher than that of a mZVI-packed column in a 50-day experiment.Therefore,mZVI/GCS with a porous structure effectively relieved passivation problems of mZVI and showed practical application prospects as groundwater Cr(Ⅵ)remediation material with practical application prospects.

关键词： Chitosan Glutaraldehyde mZVI Cr(Ⅵ) Groundwater

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Nuclear volume effects in kinetic isotope fractionation:A case study of mercury oxidation by chlorine species

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Acta Geochimica 2024年第3期43卷 411-423页

作者： Chenlu Yang Yining Zhang yun liu Research Center for Planetary Science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

It is well-known that the equilibrium isotope fractionation of mercury(Hg)includes classical massdependent fractionations(MDFs)and nuclear volume effect(NVE)induced mass-independent fractionations(MIFs).However,the effect of the NVE on these kinetic processes is not known.The total fractionations(MDFs+NVEinduced MIFs)of several representative Hg-incorporated substances were selected and calculated with ab initio calculations in this work for both equilibrium and kinetic processes.NVE-induced MIFs were calculated with scaled contact electron densities at the nucleus through systematic evaluations of their accuracy and errors using the Gaussian09 and DIRAC19 packages(named the electron density scaling method).Additionally,the NVE-induced kinetic isotope effect(KIE)of Hg isotopes are also calculated with this method for several representative Hg oxidation reactions by chlorine species.Total KIEs for 202 Hg/^(198)Hg ranging from−2.27‰to 0.96‰are obtained.Three anomalous^(202)Hg-enriched KIEs(δ^(202)Hg/^(198)Hg=0.83‰,0.94‰,and 0.96‰,)caused by the NVE are observed,which are quite different from the classical view(i.e.,light isotopes react faster than the heavy ones).The electron density scaling method we developed in this study can provide an easier way to calculate the NVE-induced KIEs for heavy isotopes and serve to better understand the fractionation mechanisms of mercury isotope systems.

关键词： Nuclear volume effect Kinetic fractionation Hg isotopes Ab initio calculations

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MRm-DLDet:a memory-resident malware detection framework based on memory forensics and deep neural network

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Cybersecurity 2024年第1期7卷 88-109页

作者： Jiaxi liu yun Feng Xinyu liu Jianjun Zhao Qixu liu Institute of Information Engineering Chinese Academy of SciencesBeijing 100085China School of Cyber Security University of Chinese Academy of SciencesBeijing 100049China

Cyber attackers have constantly updated their attack techniques to evade antivirus software detection in recent years.One popular evasion method is to execute malicious code and perform malicious actions only in memory.Mali-cious programs that use this attack method are called memory-resident malware,with excellent evasion capability,and have posed huge threats to cyber security.Traditional static and dynamic methods are not effective in detect-ing memory-resident malware.In addition,existing memory forensics detection solutions perform unsatisfactorily in detection rate and depend on massive expert knowledge in memory analysis.This paper proposes MRm-DLDet,a state-of-the-art memory-resident malware detection framework,to overcome these drawbacks.MRm-DLDet first builds a virtual machine environment and captures memory dumps,then creatively processes the memory dumps into RGB images using a pre-processing technique that combines deduplication and ultra-high resolution image cropping,followed by our neural network MRmNet in MRm-DLDet to fully extract high-dimensional features from memory dump files and detect *** receives the labeled sub-images of the cropped high-resolution RGB images as input of ResNet-18,which extracts the features of the sub-images.Then trains a network of gated recurrent units with an attention mechanism.Finally,it determines whether a program is memory-resident malware based on the detection results of each sub-image through a specially designed voting layer.We created a high-quality dataset consisting of 2,060 benign and memory-resident programs.In other words,the dataset contains 1,287,500 labeled sub-images cut from the MRm-DLDet transformed ultra-high resolution RGB images.We implement MRm-DLDet for Windows 10,and it performs better than the latest methods,with a detection accuracy of up to 98.34%.Moreover,we measured the effects of mimicry and adversarial attacks on MRm-DLDet,and the experimental results demonstrated the robustness of MRm-DLDet.

关键词： Memory-resident malware Memory forensics Malware detection Deep learning Ultra-high resolution image

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Chronic administration of triclosan leads to liver fibrosis through hepcidin-ferroportin axis-mediated iron overload

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Journal of Environmental Sciences 2024年第3期137卷 144-154页

作者： Jing liu Lecong Zhang fang Xu Ping Zhang Yang Song College of Eco-Environmental Engineering Guizhou Minzu UniversityGuiyang 550025China The Institute of Karst Wetland Ecology Guizhou Minzu UniversityGuiyang 550025China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Triclosan(TCS)has been manufactured as an antibacterial compound for half a century.Currently,it is widely used in various personal care products;however,its potential adverse effects raise a lot of attention.Here,we create a long-term oral administration mouse model and identify the corresponding hepatotoxicity of TCS.We discover that daily intragastric administration of 10 mg/kg TCS to mice for 12 weeks results in severe hepatic fibrosis.Further study displays that hepatic iron increased 18%,23%and 29%upon oral TCS treatment for4,8 and 12 weeks,respectively.Accompanied by hepatic iron variation,splenic and duodenal iron are increased,which indicates systemic iron disorder.Not only excessive iron accumulated in the liver,abnormal hepatic malondialdehyde,prostaglandin synthase 2 and glutathione peroxidase 4 are pointed to ferroptosis.Additional study uncovers that hepcidin expression increases 7%,10%,4%in serum and 2.4-,4.8-,and 2.3-fold on transcriptional levels upon TCS exposure for 4,8 and 12 weeks,individually.Taken together,the mice in the TCS-treated group show disordered systemic iron homeostasis via the upregulated hepatic hepcidin-ferroportin axis.Meanwhile,both hepatic iron overload(systemic level)and hepatocyte ferroptosis(cellular level)are accused of TCS-induced liver fibrosis.Ferriprox■,an iron scavenger,significantly ameliorates TCS-induced liver fibrosis.In summary,this study confirms the impact of TCS on liver fibrosis;a critical signal pathway is also displayed.The significance of the current study is to prompt us to reevaluate the“pros and cons”of TCS applications.

关键词： Triclosan Iron metabolism Hepcidin Hepatotoxicity Liver fibrosis

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