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Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsy

Neural Regeneration Research 2023年第6期18卷 1277-1285页

作者： Xiao-Xue Xu Rui-Xue Shi Yu Fu Jia-Lu wang Xin Tong Shi-Qi Zhang Na wang Mei-Xuan Li Yu Tong Wei wang Miao He bing-Yang Liu Gui-Lan Chen Feng Guo Department of Pharmaceutical Toxicology School of Pharmaceutical ScienceChina Medical UniversityShenyangLiaoning ProvinceChina Department of Neurology the First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Key Laboratory of Medical Electrophysiology Ministry of Education&Medical Electrophysiological Key Laboratory of Sichuan ProvinceInstitute of Cardiovascular ResearchSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Endocrinology and Metabolism the Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Endocrinology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Dysfunction of neuronal nitric oxide synthase contributes to neurotoxicity,which triggers cell death in various neuropathological diseases,including *** have shown that inhibition of neuronal nitric oxide synthase activity increases the epilepsy threshold,that is,has an anticonvulsant ***,the exact role and potential mechanism of neuronal nitric oxide synthase in seizures are still *** this study,we performed RNA sequencing,functional enrichment analysis,and weighted gene coexpression network analysis of the hippocampus of tremor rats,a rat model of genetic *** found damaged hippocampal mitochondria and abnormal succinate dehydrogenase level and Na+-K+-ATPase *** addition,we used a pilocarpine-induced N2a cell model to mimic epileptic *** application of neuronal nitric oxide synthase inhibitor 7-nitroindazole,changes in malondialdehyde,lactate dehydrogenase and superoxide dismutase,which are associated with oxidative stress,were reversed,and the increase in reactive oxygen species level was reversed by 7-nitroindazole or reactive oxygen species inhibitor *** of 7-nitroindazole or N-acetylcysteine downregulated the expression of caspase-3 and cytochrome c and reversed the apoptosis of epileptic ***,7-nitroindazole or N-acetylcysteine downregulated the abnormally high expression of NLRP3,gasdermin-D,interleukin-1βand *** indicated that 7-nitroindazole and N-acetylcysteine each reversed epileptic cell *** together,our findings suggest that the neuronal nitric oxide synthase/reactive oxygen species pathway is involved in pyroptosis of epileptic cells,and inhibiting neuronal nitric oxide synthase activity or its induced oxidative stress may play a neuroprotective role in epilepsy.

关键词： apoptosis bioinformatics analysis cell death epilepsy nitric oxide synthase oxidative stress pyroptosis RNA sequencing Tremor rat weighted gene co-expression network analysis

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点目标下基于变形镜本征模式的无波前传感器自适应光学系统

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中国激光 2016年第2期43卷 215-222页

作者：王瑞董冰北京理工大学光电学院北京100081

针对点目标提出了基于变形镜(DM)本征模式的无波前传感器自适应光学校正方法并进行了仿真和实验研究。由DM的影响函数矩阵推导出一组符合导数正交关系的DM本征模式代替传统的Lukosz模式。基于远场光斑的均方半径建立评价函数,利用DM本... 详细信息

针对点目标提出了基于变形镜(DM)本征模式的无波前传感器自适应光学校正方法并进行了仿真和实验研究。由DM的影响函数矩阵推导出一组符合导数正交关系的DM本征模式代替传统的Lukosz模式。基于远场光斑的均方半径建立评价函数,利用DM本征模式系数与评价函数之间的关系求解出各阶模式所需的校正量。通过仿真比较了上述两种模式的校正精度,分析了模式偏置系数对校正精度的影响,给出了算法对不同大小像差的闭环校正结果。基于37单元DM搭建了实验系统,实验结果表明算法可以有效校正低阶像差,且采用DM本征模式的校正精度优于Lukosz模式。

关键词：自适应光学无波前传感器自适应光学变形镜本征模式 Lukosz模式

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Chemical–biological approaches for the direct regulation of cell–cell aggregation

Aggregate

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Aggregate 2022年第2期3卷 33-49页

作者： Jia-Yi Ma Ya-Xin wang Yan Huang Yi Zhang yun-Xi Cui De-Ming Kong State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjinP.R.China School of Pharmacy Binzhou Medical UniversityYantaiShandongP.R.China College of Life Sciences Nankai UniversityTianjinP.R.China Tianjin Key Laboratory of Biosensing and Molecular Recognition Research Centre for Analytical SciencesCollege of ChemistryNankai UniversityTianjinP.R.China

Cell–cell aggregation is one of the most well-known modes of intercellular *** aggregation also plays a vital role in the formation of multicellularity,thus manipulating the growth and development of *** the past decades,cell–cell aggregation-related bioprocesses and molecular mechanisms have attracted enormous interest from scientists in biology,and *** have developed a series of strategies to artificially regulate cell–cell aggregation through chemical–biological *** date,not only the chemical reagents such as coordination compounds and polymers but also the biomacromolecules such as proteins and nucleic acids,are employed as the“cell glue”to achieve the control of the cell *** it is meaningful to review the recent advances of the chemical–biological approaches in cell–cell aggregation *** this review,we discuss the mechanisms and features of recently developed strategies to control cell–cell *** introduce molecules and designs relying on chemical reactions and biological conjugations respectively,and talk about their advantages and suitable applications.A perspective on the challenges in future applications in cell manipulation and cell-based therapy is also *** expect this review could inspire innovative work on manipulating cell–cell aggregation and further modulate cell–cell interactions in the research of bio/chemical fields.

关键词： cell-cell aggregation molecular glue precise regulation

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基于预防维护的单机调度问题

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控制与决策 2021年第2期36卷 395-402页

作者：吴慧王冰上海大学机电工程与自动化学院上海200444 青岛农业大学理学与信息科学学院山东青岛266109

在两种维护约束下,研究完工时间之和最小化的单机调度问题.第1种维护约束是,固定周期预防维护;第2种维护约束是,机器工作期间可连续加工的最大工件个数受限.对于这种带有约束的调度问题,根据问题的规模,采用4种方法进行求解.针对小规模... 详细信息

在两种维护约束下,研究完工时间之和最小化的单机调度问题.第1种维护约束是,固定周期预防维护;第2种维护约束是,机器工作期间可连续加工的最大工件个数受限.对于这种带有约束的调度问题,根据问题的规模,采用4种方法进行求解.针对小规模问题,建立一个二值整数规划模型,并根据最优解的特性制定剪枝规则,进而给出分支定界算法.针对中、大规模问题,采用遗传算法进行求解,为缓解遗传算法中常见的早熟问题,对变异算子进行改进,采用动态变异方法,提出动态遗传算法.最后通过仿真实验对各种算法进行性能评估.

关键词：单机调度预防维护二值整数规划分支定界算法遗传算法动态遗传算法

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Influence of deep defects on electrical properties of Ni/4H-SiC Schottky diode

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Chinese Physics B 2019年第2期28卷 400-405页

作者： Jin-Lan Li yun Li Ling wang Yue Xu Feng Yan Ping Han Xiao-Li Ji College of Electronic Science and Engineering Nanjing University Science and Technology on Monolithic Integrated Circuits and Modules Laboratory Electronic Devices Institute College of Electronic and Optical Engineering Nanjing University of Posts and Telecommunications

In this paper, we investigate the influence of deep level defects on the electrical properties of Ni/4H-SiC Schottky diodes by analyzing device current-voltage(I-V) characteristics and deep-level transient spectra(DLTS). Two Schottky barrier heights(SBHs) with different temperature dependences are found in Ni/4 H-SiC Schottky diode above room temperature. DLTS measurements further reveal that two kinds of defects Z_(1/2) and Ti(c)~a are located near the interface between Ni and SiC with the energy levels of E_C-0.67 eV and E_C-0.16 eV respectively. The latter one as the ionized titanium acceptor residing at cubic Si lattice site is thought to be responsible for the low SBH in the localized region of the diode, and therefore inducing the high reverse leakage current of the diode. The experimental results indicate that the Ti(c)~a defect has a strong influence on the electrical and thermal properties of the 4 H-SiC Schottky diode.

关键词： 4H–SiC Schottky diodes Schottky barrier heights deep defects DLTS

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Structures and Spectroscopy Properties of One Novel Keggin Type Polyoxomolybdate Compound

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光谱学与光谱分析 2016年第S1期36卷 208-209页

作者： GUO bing-cui ZHOU Meng-xi HUANG Mei-qing LIN Hui-yun SHI Lin HUANG Meng-meng CHEN Yi-ping College of Chemistry Fuzhou UniversityFuzhou 350108 China Fuzhou No.1High Middle School Fuzhou 350108 China

In this paper,One novel Keggin type polyoxomolybdate compounds have been hydrothermal synthesized:{[(CH3)2NH2]4(SiMo12O40)}[(CH3)2NH]·(DMF)0.5(1).The compound 1have been characterized by infrared spectrum,and the two... 详细信息

关键词： Polyoxomolybdate Keggin type structure 2DIR COS

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Risk pre-assessment method for regional drilling engineering based on deep learning and multi-source data

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Petroleum Science 2023年第6期20卷 3654-3672页

作者： Yu-Qiang Xu Kuan Liu Bao-Lun He Tatiana Pinyaeva bing-Shuo Li Yu-Cong wang Jia-Jun Nie Lei Yang Fu-Xiang Li National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina Shandong Ultra-Deep Drilling Process Control Tech RD Center Qingdao266580ShandongChina

Accurately predicting downhole risk before drilling in new exploration areas is one of the *** intelligent algorithms to explore the complex relationship between multi-source data and downhole risk is a hot research topic and frontier in this ***,due to the small number and uneven distribution of drilled wells in new exploration areas and the lack of sample data related to risk,the training model has insufficient generalization ability,and thus the prediction is not *** this paper,a drilling risk profile(depth domain)rich in geological and engineering information is constructed by introducing a quantitative evaluation method for drilling risk of drilled wells,which can provide sufficient risk sample data for model training and thus solve the small sample *** the problem of uneven distribution of drilling wells in new exploration areas,the concept of virtual wells and their deployment methods were ***,two methods for calculating rock mechanical parameters of virtual wells were proposed,and the accuracy and applicability of the two methods are *** LSTM deep learning model was optimized to tap the quantitative relationship between drilling risk profiles and multi-source data(e.g.,seismic,logging,and rock mechanical parameters).The model was validated to have an average relative error of 9.19%.The quantitative prediction of the drilling risk profile of the virtual well was achieved using the trained LSTM model and the calculation of the relevant parameters of the virtual ***,based on the sequential Gaussian simulation method and the risk distribution of drilled and virtual wells,a regional 3D drilling risk model was *** analysis of real cases shows that the addition of virtual wells can significantly improve the identification of regional drilling risks and the prediction accuracy of pre-drill drilling risks in unexplored areas can be improved by up to 21%compared with the 3D risk model

关键词： Pre-drill risk assessment Risk samples Deep learning LSTM neural network 3D model

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Association of Bone Turnover Levels with MTHFR Gene Polymorphisms among Pregnant Women in Wuhan, China

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Current Medical Science 2018年第4期38卷 602-609页

作者： Shu-yun LIU Qin HUANG Xue GU Bin ZHANG Wei SHEN Ping TIAN yun ZENG Ling-zhi QIN Lin-xiang YE Ze-min NI Qi wang Department of Epidemiology and Biostatistics MOE Key Lab of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Rehabilitation Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Wuhan Women and Children Medical Care Center Wuhan 430016 China Women and Children Medical Center of Jiang-an District Wuhan 430017 China

Pregnancy is a critical stimulator of bone mineral resorption. We used to find the MTHFR gene polymorphisms are related with blood lead levels among pregnant women. Pregnancy-stimulated bone turnover may be associated with MTHFR gene polymorphisms too. In this article, we aimed to determine the relationship between MTHFR gene polymorphisms and bone turnover rates among the pregnant women. The participants including pregnant and non-pregnant women were selected and recruited during their routine prenatal or physical examination from July to October in 2012. A total of 1000 participants, including 250 pregnant women in the first, second, and third trimesters and 250 non-pregnant women, were enrolled in the study. Finally, after excluding 27 participants unable to provide blood samples, 973 eligible participants （i.e., 234, 249, and 248 pregnant women in the first, second, and third trimesters, respectively, and 242 non-pregnant women） were included in the research. The MTHFR gene 1298CC homozygote carriers were more susceptible to yield higher plasma homocysteine levels than the 1298AA/AC carriers, with standardized coefficients of 0.086 （P〈0.05） and 0.104 （P〈0.01） of all the participants and the pregnant women, respectively. The MTHFR gene 1793AA homozygote carriers more likely showed higher plasma osteocalcin levels （standardized β=0.091, P〈0.01） than the 1793GG/GA carriers among all the subjects. Plasma homocysteine levels were positively correlated with blood lead levels among the participants and the pregnant women with standardized coefficients of 0.320 （P〈0.01） and 0.179 （P〈0.01）, respectively. Plasma osteocalcin levels were positively associated with blood lead levels among pregnant and non-pregnant women with standardized coefficients of 0.084 （P〈0.05） and 0.125 （P〈0.01）, respectively. In conclusion, homocysteine and osteocalcin contents in plasma are associated with the MTHFR gene A1298C polymorphism and blood lead levels among pregnant women. The MTHFR gene

关键词： pregnant women bone turnover levels blood lead levels MTHFR gene polymorphism

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Experimental Quantum Advantage with Quantum Coupon Collector

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Research 2022年第3期2022卷 309-319页

作者： Min-Gang Zhou Xiao-Yu Cao Yu-Shuo Lu Yang wang Yu Bao Zhao-Ying Jia Yao Fu Hua-Lei Yin Zeng-bing Chen National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China MatricTime Digital Technology Co.Ltd. Nanjing 211899China

An increasing number of communication and computational schemes with quantum advantages have recently been proposed,which implies that quantum technology has fertile application ***,demonstrating these schemes experimentally continues to be a central challenge because of the difficulty in preparing high-dimensional states or highly entangled *** this study,we introduce and analyze a quantum coupon collector protocol by employing coherent states and simple linear optical elements,which was successfully demonstrated using realistic experimental *** showed that our protocol can significantly reduce the number of samples needed to learn a specific set compared with the classical limit of the coupon collector *** also discuss the potential values and expansions of the quantum coupon collector by constructing a quantum blind box *** information transmitted by the proposed game also broke the classical *** results strongly prove the advantages of quantum mechanics in machine learning and communication complexity.

关键词： complexity. quantum implies

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Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2290-2293页

作者： Lei Fang Tu-Shuai Li Jing-Zi Zhang Zhi-Honq Liu Jie Yang bing-Hao wang Yu-Meng wang Jie Zhou Ling-Dong Kong The State Key Laboratory of Pharmaceutical Biotechnology Medical SchoolSchool of Life SciencesNanjing UniversityNanjingChina Chemistry and Biomedicine Innovation Center of Nanjing University NanjingChina

Dear Editor,The increasing consumption of dietary fructose has been proposed as a major contributor to metabolic syndrome,which promotes glomerular podocyte injury and proteinuria.1 Mitochondria are the key organelles for cellular bioenergetics to maintain energy homeostasis and gluconeogenesis.2 Mitochondrial damage may be linked to kidney diseases,in particular glomerular nephropathy.

关键词： homeostasis glomerular dietary

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