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Crowdsourcing intelligent design

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Frontiers of Information Technology & Electronic Engineering 2018年第1期19卷 126-138页

作者： Wei XIANG ling-yun SUN Wei-tao YOU Chang-yuan YANG State Key Lab of CAD & CG Zhejiang University Hangzhou 310058 China Modern Industrial Design Institute Zhejiang University Hangzhou 310027 China International User Experience Business Unit Alibaba Group Hangzhou 310000 China

Design intelligence,namely,artificial intelligence to solve creative problems and produce creative ideas,has improved rapidly with the new generation artificial ***,existing methods are more skillful in learning from data and have limitations in creating original ideas different from the training *** offers a promising method to produce creative designs by combining human inspiration and machines' computational *** propose a crowdsourcing intelligent design method called ‘flexible crowdsourcing design'.Design ideas produced through crowdsourcing design can be unreliable and inconsistent because they rely solely on selection among participants' submissions of *** contrast,the flexible crowdsourcing design method employs a cultivation procedure that integrates the ideas from crowd participants and cultivates these ideas to improve design quality at the same *** introduce a series of studies to show how flexible crowdsourcing design can produce original design ideas ***,we will describe the typical procedure of flexible crowdsourcing design,the refined crowdsourcing tasks,the factors that affect the idea development process,the method for calculating idea development potential,and two applications of the flexible crowdsourcing design ***,it summarizes the design capabilities enabled by crowdsourcing intelligent *** method enhances the performance of crowdsourcing design and supports the development of design intelligence.

关键词： Crowdsourcing Flexible crowdsourcing design Design intelligence

Mechanism of Fuzheng Kang'ai Formula Regulating Tumor Microenvironment in Non-Small Cell Lung Cancer

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Chinese Journal of Integrative Medicine 2022年第5期28卷 425-433页

作者： TIAN yun-ling FU Song-bo LI Bo YUAN ling-yan BING Zhi-tong Department of Endocrinology and Metabolism the First Hospital of Lanzhou UniversityLanzhou(730000)China Evidence Based Medicine Center School of Basic Medical Science of Lanzhou UniversityLanzhou(730000)China Department of Computational Physics Institute of Modern PhysicsChinese Academy of SciencesLanzhou(730000)China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing(100049)China

Objective:To study the mechanism of Chinese herbal medicine Fuzheng Kang’ai Formula(FZKA)on tumor microenvironment(TME).Methods:CIBERSORTx was used for analysis of *** Chinese Medicine Systems Pharmacology and Analysis Platform was applied to identify compounds-targets network and the Cancer Genome Atlas(TCGA)was employed to identify the differential expression genes(DEGs)between tumor and paracancerous tissues in lung adenocarcinoma(LUAD)from ***,DEGs with prognosis in LUAD was calculated by univariable and multivariate Cox *** core targets of FZKA were analyzed in lung adenocarcinoma ***-protein interaction database was employed to predict down-stream of *** reverse transcription polymerase chain reaction was employed for biological experiment in A549,H1299 and PC9 cell ***:The active and resting mast cells were significantly associated with prognosis of LUAD(P<0.05).Of the targets,CCNA2 as an important target of FZKA(hazard ratio=1.41,95%confidential interval:1.01-2.01,P<0.05)was a prognostic target and significantly associated with mast ***2 was positively correlated with mast cell activation and negatively correlated with mast cell resting ***1 L2,ACTL6 A and ITGAV were down-stream of CCNA2,which were validated by q RT-PCR in A549 ***:FZKA could directly bind to CCNA2 and inhibit tumor growth by regulating CCNA2 downstream genes and TME of NSCLC closely related to CCNA2.

关键词： network pharmacology prognosis tumor microenvironment Fuzheng Kang’ai Formula Chinese medicine lung adenocarcinoma

Enriched environment boosts the post-stroke recovery of neurological function by promoting autophagy

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Neural Regeneration Research 2021年第5期16卷 813-819页

作者： Yi-Hao Deng ling-ling Dong Yong-Jie Zhang Xiao-Ming Zhao Hong-yun He Department of Basic Medicine Medical SchoolKunming University of Science and TechnologyKunmingYunnan ProvinceChina

Autophagy is crucial for maintaining cellular homeostasis,and can be activated after ischemic *** also participates in nerve injury and *** purpose of this study was to investigate whether an enriched environment has neuroprotective effects through affecting autophagy.A Sprague-Dawley rat model of transient ischemic stroke was prepared by occlusion of the middle cerebral artery followed by *** week after surgery,these rats were raised in either a standard environment or an enriched environment for 4 successive *** enriched environment increased Beclin-1 expression and the LC3-II/LC3-I ratio in the autophagy/lysosomal pathway in the penumbra of middle cerebral artery-occluded *** environment-induced elevations in autophagic activity were mainly observed in *** environment treatment also promoted the fusion of autophagosomes with lysosomes,enhanced the lysosomal activities of lysosomal-associated membrane protein 1,cathepsin B,and cathepsin D,and reduced the expression of ubiquitin and *** 4 weeks of enriched environment treatment,neurological deficits and neuronal death caused by middle cerebral artery occlusion/reperfusion were significantly alleviated,and infarct volume was significantly *** findings suggest that neuronal autophagy is likely the neuroprotective mechanism by which an enriched environment promotes recovery from ischemic *** study was approved by the Animal Ethics Committee of the Kunming University of Science and Technology,China(approval No.5301002013855)on March 1,2019.

关键词： autophagy brain central nervous system factor injury pathways protection regeneration repair stroke

Hybrid superconducting photonic-phononic chip for quantum information processing

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Chip 2022年第3期1卷 1-7页

作者： Xin-biao Xu Wei-Ting Wang Lu-Yan Sun Chang-ling Zou Key Laboratory of Quantum Information University of Science and Technology of ChinaCASHefeiAnhui 230026China Center for Quantum Information Institute for Interdisciplinary Information SciencesTsinghua UniversityBeijing 100084China CAS Center For Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefeiAnhui 230026China

The integration of qubits with long coherence times and functional quantum devices on a single chip,and thus the realization of an allsolidstate quantum computing chip,is an important goal in current experimental research on quantum information *** various quantum platforms,a series of significant progresses have been made in photonic quantum chips and superconducting quantum chips,while both the number of qubits and the complexity of quantum circuits have been *** these two chip platforms have respective unique advantages and potentials,their shortcomings have been gradually revealed and need to be *** introducing phonon-integrated devices,it is possible to combine all unsuspended phononic,photonic,and superconducting quantum devices organi-cally on the same chip to achieve coherent coupling among ***,we provide a prospect and a short review on the integrated photonic,superconducting,and hybrid quantum chips for quantum information processing.

关键词： Photonic integ rated circuits Quantum infor mation processing Hybrid quantum chip Phononic circuits Superconducting quantum circuits

Effects of long-term organic fertilization on soil microbiologic characteristics,yield and sustainable production of winter wheat

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Journal of Integrative Agriculture 2018年第1期17卷 210-219页

作者： LI Chun-xi MA Shou-chen SHAO yun MA Shou-tian ZHANG ling-ling College of Life Science Henan Normal University Field Scientific Observation and Research Base of Land Use Ministry of Land and Resources/Henan Polytechnic University

We investigated the soil microbiologic characteristics, and the yield and sustainable production of winter wheat, by conducting a long-term fertilization experiment. A single application of N, P and K （NPK） fertilizer was taken as the control （CK） and three organic fertilization treatments were used： NPK fertilizer＋pig manure （T1）, NPK fertilizer＋straw return （T2）, NPK fertilizer＋pig manure＋straw return （T3）. The results showed that all three organic fertilization treatments （T1, T2 and T3） significantly increased both soil total N （STN） and soil organic carbon （SOC） from 2008 onwards. In 2016, the SOC content and soil C/N ratios for T1, T2 and T3 were significantly higher than those for CK. The three organic fertilization treatments increased soil microbial activity. In 2016, the activity of urease （sucrase） and the soil respiration rate （SRS） for T1, T2 and T3 were significantly higher than those under CK. The organic fertilization treatments also increased the content of soil microbial biomass carbon （SMBC） and microbial biomass nitrogen （SMBN）, the SMBC/SMBN ratio and the microbial quotient （qMB）. The yield for T1, T2 and T3 was significantly higher than that of CK, respectively. Over the nine years of the investigation, the average yield increased by 9.9, 13.2 and 17.4% for T1, T2 and T3, respectively, compared to the initial yield for each treatment, whereas the average yield of CK over the same period was reduced by 6.5%. T1, T2, and T3 lowered the coefficient of variation （CV） of wheat yield and increased the sustainable yield index （SYI）. Wheat grain yield was significantly positively correlated with each of the soil microbial properties （P〈0.01）. These results showed that the long-term application of combined organic and chemical fertilizers can stabilize crop yield and make it more sustainable by improving the properties of the soil.

关键词： winter wheat long-term organic fertilization soil microbial features yield stability yield sustainability

Thermal Conductivity at the Interface of CHB_(r3)/NaCl Under Shock Compression

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Chinese Physics Letters 2001年第7期18卷 955-956页

作者： HU Jin-biao YANG Jia-ling LIU Ji-Ping TAN Hua Institute of Solid Mechanics Beijing University of Aeronautics and AstronauticsBeijing 100083 Laboratory for Shock Wave and Detonation Physics Southwest Institute of Fluid PhysicsMianyang 621900 School of Chemical Industry and Material Science Beijing Institute of TechnologyBeijing 100081

A special experiment system has been proposed for studying the thermal physical property under shock *** optical radiation was recorded by a high time-resolution *** ratio α of sample and window materials under shock compression was studied by using this experiment *** thermal conductivity of CHB_(r3) calculated from α under shock compression is about 10^(3) times larger than that under normal condition.

关键词： technique. Conductivity thermal

Spatial variation of the relationship between transport accessibility and the level of economic development in Qinghai-Tibet Plateau, China

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Journal of Mountain Science 2019年第8期16卷 1883-1900页

作者： YANG Xue-ting QIU Xiao-ping FANG Yi-ping XU yun ZHU Fu-biao Research Center of Sichuan County Economy Development Mianyang Teachers’CollegeMianyang 621000China The faculty Geography Resource Sciences Sichuan Normal UniversityChengdu 610101China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China School of Economics Hefei University of TechnologyHefei 230009China

As an important component of China’ transportation systems, for a long time, the insufficient performance of transport in QinghaiTibet Plateau(QTP) was a bottleneck restricting the economic growth and social development in this area. Nevertheless, the implementation of the western development strategy has accelerated the preliminary construction of comprehensive transport network since 2000. Due to the large area and significant geographical heterogeneity, there is a growing need to understand the relationship between transportation and economic development based on the perspective of spatial difference. By using GIS-based raster analysis and Geographically Weighted Regression(GWR) model, we investigated the spatial-temporal distribution of highway, railway and airport accessibility, respectively, and estimated the correlation and heterogeneity between transport accessibility and the level of economic development. Results revealed that:(1) Transport accessibility in the QTP improved by 53.38% in the past 15 years, which is specifically embodied in the improvement of both highway and railway.(2) Accessibility presented prominent differentiation in the space, increasing from west to east and reducing with the rise of elevation, specifically, the best accessibility area of the highway is below 4000 m above sea level, while the area with an altitude of over 4000 m has the lowest aviation time cost.(3) In general, the long weighted average time cost to critical transport facilities posed significantly negative effect on county economic growth in QTP, more positively, the adverse effect gradually weakened over time.(4) Obvious heterogeneity exists at the influence of different transport accessibility factors on the level of economic development, reflecting both in the horizontal space and altitudinal belt. Therefore, region-specific policies should be addressed for the sustainable development of transport facilities as well as economy in the west mountain areas.

关键词： Accessibility Raster cost weighted Geographically weighted regression Economic effect Spatial variations

Effect of liquid surface depression size on discharge characteristics and chemical distribution in the plasma-liquid anode system

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Plasma Science and Technology 2024年第9期26卷 17-31页

作者： yun ling Dong DAI Jiaxin CHANG Buang WANG School of Electric Power South China University of TechnologyGuangzhou 510641People’s Republic of China University of Richmond Richmond 23173United States of America

Atmospheric pressure plasma-liquid interactions exist in a variety of applications,including wastewater treatment,wound sterilization,and *** practice,the phenomenon of liquid surface depression will inevitably *** applied gas will cause a depression on the liquid surface,which will undoubtedly affect the plasma generation and further affect the application ***,the effect of liquid surface deformation on the plasma is still *** this work,numerical models are developed to reveal the mechanism of liquid surface depressions affecting plasma discharge characteristics and the consequential distribution of plasma species,and further study the influence of liquid surface depressions of different sizes generated by different helium flow rates on the *** show that the liquid surface deformation changes the initial spatial electric field,resulting in the rearrangement of electrons on the liquid *** charges deposited on the liquid surface further increase the degree of distortion of the electric ***,the electric field and electron distribution affected by the liquid surface depression significantly influence the generation and distribution of active species,which determines the practical effectiveness of the relevant *** work explores the phenomenon of liquid surface depression,which has been neglected in previous related work,and contributes to further understanding of plasma-liquid interactions,providing better theoretical guidance for related applications and technologies.

关键词： plasma-liquid interaction deformation of the liquid surface liquid anode species fluxes

Intra-abdominal pressure monitoring in predicting outcome of patients with severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2007年第4期6卷 420-423页

作者： Zhang, Wei-Fang Ni, yun-Lan Cai, ling Li, Tong Fang, Xue-ling Zhang, yun-Tao Zhejiang Univ Sch Med Affiliated Hosp 1 Intens Care Unit Hangzhou 310003 Peoples R China Hangzhou Hosp Tradit Chinese Med Dept Resp Syst Hangzhou 310003 Peoples R China

BACKGROUND: Severe acute pancreatitis (SAP) is a serious disease with many complications, high mortality and poor prognosis. It is characterized by rapid deterioration and poses one of the most difficult challenges in clinical practice. Previous investigations suggest that SAP is one of the main causes of intra-abdominal pressure (IAP) increase. The aim of this study was to evaluate the utility of IAP-monitoring in predicting the severity and prognosis of SAP. METHODS: Eighty-nine patients with SAP who had been treated from February 2001 to December 2005 were studied. Since bladder pressure accurately reflects IAP, we measured it instead of IAP. Bladder pressure was measured at the time of admission and every 12 hours in the course of the disease, 9 consecutive times in all. The APACHE II scores of all patients were obtained within 24 hours after admission. According to a maximum bladder pressure <10 cmH(2)O, all patients were divided into two groups, mildly-elevated and severely-elevated. Mortality and mean APACHE II scores in the two groups were calculated. In addition, the mean bladder pressure and APACHE II scores in survivors were compared with those in deaths. RESULTS: Sixty-eight of the 89 patients were in the severely-elevated group. Mortality and mean APACHE II scores in this group were much higher than those in the mildly-elevated group (mortality, 39.71% vs. 9.52%; mean APACHE II score, 23.15 +/- 7.42 vs. 15.95 +/- 5.35, P<0.01). The mean bladder pressures and APACHE II scores in deaths were significantly greater than those in survivors (mean bladder pressure, 14.1 +/- 3.8 vs. 9.2 +/- 2.3 cmH(2)O, P<0.01; mean APACHE II score, 27.83 +/- 4.87 vs. 18.37 +/- 6.74, P<0.01). CONCLUSION: It is suggested that IAP may be used as a marker of the severity and prognosis of SAP.

关键词： severe acute pancreatitis intra-abdominal pressure APACHE II score mortality