检索结果-南通市图书馆

Neuroimaging studies in major depressive disorder with suicidal ideation or behaviour among Chinese patients:implications for neural mechanisms and imaging signatures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2024年第5期37卷 511-521页

作者： yun-ai su Chong Ye Qin Xin Tianmei Si Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)BeijingChina Xi'an Janssen Pharmaceutical Ltd BeijingChina

Major depressive disorder(MDD)with suicidal ideation or behaviour(MDSI)is associated with an increased risk of future *** timely identification of suicide risk in patients with MDD and the subsequent implementation of interventions are crucially important to reduce their suffering and save ***,the early diagnosis of MDSI remains challenging across the world,as no objective diagnostic method is currently *** China,the challenge is greater due to the social stigma associated with mental health problems,leading many patients to avoid reporting their suicidal ***,the neural mechanisms underlying MDSl are stll unclear,which may hamper the development of effective *** thus conducted this narrative review to summarise the existing neuroimaging studies of MDSI in Chinese patients,including those involving structural magnetic resonance imaging(MRI),functional MRl,neuronal electrophysiological source imaging of the brain dynamics with electroencephalography and *** synthesising the current research efforts in neuroimaging studies of Chinese patients with MDSl,we identified potential objective neuroimaging biomarkers,which may aid in the early identification of patients with MDSI who are at high suicide-related *** findings also offer insights into the complex neural mechanisms underlying MDSI and suggest promising therapeutic ***,we propose future directions to discover novel imaging signatures,improve patient care,as well as help psychiatrists and clinical investigators plan their future research.

关键词： patients neural signature

Advances in functional MRI research in bipolar disorder:from the perspective of mood states

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2024年第1期37卷 33-43页

作者： Yankun Wu yun-ai su Linlin Zhu Jitao Li Tianmei Si Department of Clinical Psychopharmacology Peking University Sixth HospitalPeking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)BeijingChina Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratoryof Mental Health(Peking University)National Clinical Research Centerfor Mental Disorders(Peking University Sixth Hospital)BeijingChina

Bipolar disorder is characterised by recurrent and alternating episodes of mania/hypomania and *** breakthroughs in functional MRI techniques have uncovered the functional neuroanatomy of bipolar ***,the pathophysiology underlying mood instability,mood switching and the development of extreme mood states is less well *** reviewpresents a comprehensive overviewof current evidence from functional MRI studies from the perspective of mood *** first summarise the disrupted brain activation patterns and functional connectivity that have been reported in bipolar disorder,irrespective of the mood *** next focus on research that solely included patients in a single mood state for a better understanding of the pathophysiology of bipolar disorder and research comparing patients with different mood states to dissect mood state-related ***,we briefly summarise current theoretical models and conclude this review by proposing potential avenues for future research.A comprehensive understanding of the pathophysiology with consideration of mood states could not only deepen our understanding of how acute mood episodes develop at a neurophysiological level but could also facilitate the identification of biological targets for personalised treatment and the development of new interventions for bipolar disorder.

关键词： anatomy bipolar functional

Prefrontal Nectin3 Reduction Mediates Adolescent Stress-Induced Deficits of Social Memory,Spatial Working Memory,and Dendritic Structure in Mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第8期36卷 860-874页

作者： Hong-Li Wang Ji-Tao Li Han Wang Ya-Xin sun Rui Liu Xiao-Dong Wang yun-ai su Tian-Mei Si National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital/Institute of Mental Health)and the Key Laboratory of Mental Health Ministry of Health(Peking University Sixth Hospital)Beijing 100191China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding HospitalCapital Medical University&the Advanced Innovation Center for Human Brain ProtectionCapital Medical UniversityBeijing 100088China Department of Neurobiology Key Laboratory of Medical Neurobiology of The Ministry of Health of ChinaZhejiang Province Key Laboratory of NeurobiologyZhejiang University School of MedicineHangzhou 310003China

Chronic stress may disrupt the normal neurodevelopmental trajectory of the adolescent brain(especially the prefrontal cortex) and contribute to the pathophysiology of stress-related mental illnesses,but the underlying molecular mechanisms remain ***,we investigated how synaptic cell adhesion molecules(e.g.,nectin3)are involved in the effects of adolescent chronic stress on mouse medial prefrontal cortex(mPFC).Male C57BL/6N mice were subjected to chronic social instability stress from postnatal days 29 to *** week later,the mice exposed to chronic stress exhibited impaired social recognition and spatial working memory,simplified dendritic structure,and reduced spine density in the *** localization of nectin3 was also altered,and was significantly correlated with behavioral ***,knocking down mPFC nectin3 expression by adeno-associated virus in adolescent mice reproduced the stress-induced changes in behavior and mPFC *** results support the hypothesis that nectin3 is a potential mediator of the effects of adolescent chronic stress on prefrontal structural and functional abnormalities.

关键词： Adolescence Chronic stress Cell adhesion molecule Prefrontal cortex Social memory

Systemic low-grade inflammation associated with specific depressive symptoms:insights from network analyses of five independent NHANES samples

在线全文

学校读者我要写书评

暂无评论

General Psychiatry 2024年第2期37卷 284-288页

作者： Jingyu Lin Haiming Huang Tianmei Si Lin Chen Jingxu Chen yun-ai su Beijing Huilongguan Hospital BeijingChina Department of Clinical Laboratory Peking University First HospitalBeijingChina Neuropsychopharmacology Peking University Institute of Mental HealthBeijingChina National Clinical Research Center for Mental Disorders BeijingChina

To the editor:Major depressive disorder(MDD)is a heterogeneous disorder with varying symptom presentations and underlying biological mechanisms.1 The mainstream neurobiological hypotheses of depression involve monoami... 详细信息

关键词： inflammation depress pituitary

Antidepressant treatment strategy with an early onset of action improves the clinical outcome in patients with major depressive disorder and high anxiety: a multicenter and 6-week follow-up study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2020年第6期133卷 726-728页

作者： Xue-Mei Liao yun-ai su Ying Wang Xin Yu Tian-Mei Si Peking University Sixth Hospital Peking University Institute of Mental Health Beijing 100191China National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Key Laboratory of Mental Health(Peking University) Beijing 100191China The 984th Hospital of Chinese People's Liberation Army Beijing 110108China

Major depressive disorder(MDD)is a prevalent,often chronic,and highly disabling multidimensional psychiatric illness.[1] Moreover,co-occurring anxiety symptoms are extremely common among patients with MDD;up to 90%of patients present with anxiety symptoms.[2]Notably,high levels of anxiety symptoms may predict worse clinical outcomes because of poor response to pharmacotherapy for MDD.[3]So use of augmentation or combination strategies during early course of treatment could be necessary,but ensuring the accurate and timely change is difficult because of the lack of consensus to assess the early improvement of initial *** date,replicated evidence indicates that the lack of early improvement(eg,aimed to evaluate the early onset of antidepressant action and clinical outcomes in patients with MDD and high anxiety,and to explore the potential influencing factors of early onset improvement.

关键词： patients clinical treatment

The Nucleus Accumbens CRH–CRHR1 System Mediates Early-Life Stress-Induced Sleep Disturbance and Dendritic Atrophy in the Adult Mouse

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2023年第1期39卷 41-56页

作者： Ting Wang Yu-Nu Ma Chen-Chen Zhang Xiao Liu Ya-Xin sun Hong-Li Wang Han Wang Yu-Heng Zhong yun-ai su Ji-Tao Li Tian-Mei Si Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing100191China Department of Pharmacology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceFudan UniversityShanghai200032China

Adverse experiences in early life have long-lasting negative impacts on behavior and the brain in adulthood,one of which is sleep *** the corticotropin-releasing hormone(CRH)–corticotropin-releasing hormone receptor 1(CRHR1)system and nucleus accumbens(NAc)play important roles in both stress responses and sleep-wake regulation,in this study we investigated whether the NAc CRH–CRHR1 system mediates early-life stress-induced abnormalities in sleep-wake behavior in adult *** the limited nesting and bedding material paradigm from postnatal days 2 to 9,we found that early-life stress disrupted sleep-wake behaviors during adulthood,including increased wakefulness and decreased non-rapid eye movement(NREM)sleep time during the dark period and increased rapid eye movement(REM)sleep time during the light *** stress-induced sleep disturbances were accompanied by dendritic atrophy in the NAc and both were largely reversed by daily systemic administration of the CRHR1 antagonist antalarmin during stress ***,Crh overexpression in the NAc reproduced the effects of early-life stress on sleep-wake behavior and NAc morphology,whereas NAc Crhr1 knockdown reversed these effects(including increased wakefulness and reduced NREM sleep in the dark period and NAc dendritic atrophy).Together,our findings demonstrate the negative influence of early-life stress on sleep architecture and the structural plasticity of the NAc,and highlight the critical role of the NAc CRH–CRHR1 system in modulating these negative outcomes evoked by early-life stress.

关键词： Early-life stress Sleep CRH-CRHR1 Nucleus accumbens Morphology

TNF-α,IL-6 and hs CRP in patients with melancholic,atypical and anxious depression:an antibodyyarrayanalysis related to somatic symptoms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

General Psychiatry 2022年第5期35卷 354-365页

作者： Hongmei Liu Xiaohui Wu yun Wang Xiaohua Liu Daihui Peng Yan Wu Jun Chen yun-ai su Jia Xu Xiancang Ma Yi Li Jianfei Shi Xiaodong Yang Han Rong Marta Di Forti Yiru Fang Clinical Research Center Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders ShanghaiChina Peking University Sixth Hospital BeijingChina Harbin First Specific Hospital HarbinChina Department of Psychiatry The First Affiliated Hospital of Xi'an Jiaotong UniversityXianChina Wuhan Mental Health Center WuhanChina Hangzhou Seventh People's Hospital HangzhouChina Shandong Mental Health Center JinanChina Shenzhen Mental Health Center ShenzhenChina Department of Social Genetics and Developmental Psychiatry Institute of Psychiatry Psychology and Neuroscience King's College LondonLondonUK Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence GuangzhouChina State Key Laboratory of Neuroscience Shangha nstitute for Biological SciencesCASShanghaiChina

Background The association between inflammation and major depressive disorder(MDD)remains poorly understood,given the heterogeneity of patients with *** We investigated inflammatory markers,such as interleukin(IL)-6,high-sensitivity C reactive protein(hsCRP)and tumour necrosis factor-α.(TNF-α)in melancholic,atypical and anxious depression and explored whether baseline inflammatory protein levels could indicate *** The sample consisted of participants(aged 18-55 years)from a previously reported multicentre randomised controlled trial with a parallel-group design registered with ***,including melancholic(n=44),atypical(n=37)and anxious(n=44)patients with depression and healthy controls(HCs)(n=33).subtypes of MDD were classified according to the 30-item Inventory of Depressive Symptomatology,Self-Rated Version and the.17-item Hamilton Depression Rating *** *** TNF-α,IL-6 and hsCRP were assessed using antibody array *** Patients with MDD,classified according to melancholic,atypical and anxious depression subtypes,and HCs did not differ significantly in baseline TNF-α,IL-6 and hsCRP levels after *** patients with anxious depression,hsCRP levels increased significantly if they experienced no pain(adjusted(adj.)p=0.010)or mild to moderate pain(adj.p=0.038)compared with those with severe ***,the patients with anxious depression and severe pain showed a lower trend in hsCRP levels than patients with atypical depression who experienced severe pain(p=0.022;adj.p=0.155).Baseline TNF-α(adj.p=0.038)and IL-6(adj.p=0.006)levels in patients in remission were significantly lower than those in patients with no remission among the participants with the atypical depression subtype at the eighth-week *** This study provides evidence of differences in inflammatory proteins in patients with varied symptoms among melancholic,atypical and anxious depression *** studies on the immuno

关键词： patients atypical Blood

Association between Perceived Stressfulness of Stressful Life Events and the suicidal Risk in Chinese Patients with Major Depressive Disorder

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第8期131卷 912-919页

作者： Jing-Yu Lin Yu Huang yun-ai su Xin Yu Xiao-Zhen Lyu Qi Liu Tian-Mei Si Clinical Psychopharmacology Division Peking University Sixth Hospital National Clinical Research Center for Mental Disorders and Key Laboratory of Mental Health Ministry of Health (Peking University) Beijing 100191 China National Engineering Research Center for Software Engineering Peking University Beijing 100871 China

Background： Patients with major depressive disorder （MDD） usually have high risk of suicidality. Few studies have investigated the effects of stressful life events （SLEs） on the risk of suicide in Chinese patients who have developed MDD. This study aimed to investigate the impact of SLEs on suicidal risk in Chinese patients with MDD. Methods： In total, 1029 patients with MDD were included from nine psychiatric hospitals to evaluate the impact of SLEs on suicidal risk. Patients fulfilling the Mini-International Neuropsychiatric Interview （MINI） criteria for MDD were included in the study. Patients were excluded if they had lifetime or current diagnoses of psychotic disorder, bipolar disorder, and alcohol or substance dependence. Depressive symptoms were assessed by the 17-item Harnilton Depression Scale （HAMD-17）. The suicidal risk of MDD patients was determined by the suicide risk module of MINI. SLEs were assessed by the Life Events Scale. Results： No gender difference was found for suicidal risk in MDD patients. Patients with suicidal risk had younger ages, lower education levels, more drinking behavior, and lower marriage rate, and fewer people had child and more severe depressive symptoms than nonsuicidal risk group. High-level perceived stressfulness （HPS） and number of SLEs that patients were exposed to were significantly greater in patients with suicidal risk than patients without. In multivariate logistic analysis, HPS of SLEs （odds ratio [OR] = 1.54, 95% confidence interval [C1]： 1.16-2.05, P = 0.003） and depressive symptoms （OR = 1.08.95% CI： 1.05-1.11, P 〈 0.001 ） were associated with suicidal risk even after adjustment of gender, age, marriage, drinking behavior, and childless. Conclusions： HPS of SLEs is associated with suicide risk in Chinese patients with MDD. Further suicide prevention programs targeting this risk factor are needed. Trial Registration： ***： NCT02023567; https：//***/ct2/show/NCTO2023567？term=NCTO2023567＆r

关键词： Life Stresses: Major Depressive Disorder: suicide

Adolescent stress increases depression-like behaviors and alters the excitatory-inhibitory balance in aged mice

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2019年第14期132卷 1689-1699页

作者： Hong-Li Wang Ya-Xin sun Xiao Liu Han Wang Yu-Nu Ma yun-ai su Ji-Tao Li Tian-Mei Si National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital/Institute of Mental Health)and the Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100191China The Sixth People's Hospital of Hebei Province BaodingHebei 071000China

Background:Depression affects approximately 5% of elderly people and its etiology might be related to chronic stress exposure during neurodevelopmental *** this study,we examined the effects of adolescent chronic social stress in aged mice on depressive behaviors and the excitatory-inhibitory (E/I) balance in stress-sensitive regions of the ***:Sixty-four adolescent,male C57BL/6 mice were randomly assigned to either the 7-week (from post-natal days 29 to 77) social instability stress (stress group,n =32) or normal housing conditions (control group,n =32).At 15 months of age,16 mice were randomly selected from each group for a series of behavioral tests,including two depression-related tasks (the sucrose preference test and the tail suspension test).Three days following the last behavioral test,eight mice were randomly selected from each group for immunohistochemical analyses to measure the cell density of parvalbumin (PV+)-and calretinin (CR+)-positive gamma-aminobutyric-acid (GABA)ergic inhibitory inter-neurons,and the expression levels of vesicular transporters of glutamate-1 (VGIuT1) and vesicular GABA transporter (VGAT) in three stress-sensitive regions of the brain (the medial pre-frontal cortex [mPFC],hippocampus,and amygdala).Results:Behaviorally,compared with the control group,adolescent chronic stress increased depression-like behaviors as shown in decreased sucrose preference (54.96 ± 1.97% vs.43.11 ± 2.85%,t(22)=3.417,P =0.003) and reduced latency to immobility in the tail suspension test (92.77 ± 25.08 s vs.33.14 ± 5.95 s,t(25)=2.394,P =0.025),but did not affect anxiety-like behaviors and pre-pulse *** the neurobiologic level,adolescent stress down-regulated PV+,not CR+,inter-neuron density in the mPFC (F(1,39)=19.30,P 10.09

关键词： Adolescence Aging Depression Inter-neuron Stress Vesicular glutamate transporter-1