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Attenuated FOLFIRINOX in the salvage treatment of gemcitabine-refractory advanced pancreatic cancer: a phase II study

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Cancer Communications 2018年第1期38卷 344-351页

作者： Jung Hoon Kim Sang-Cheol Lee Sung Yong Oh Seo-Young Song Namsu Lee Eun Mi Nam Soonil Lee In Gyu Hwang Hyo Rak Lee Kyu Taek Lee Sang-Byung Bae Han Jo Kim Joung Soon Jang Do Hyoung lim Hyun Woo Lee Seok yun Kang Jung Hun Kang Department of Internal Medicine Institute of Health SciencesGyeongsang National University15 Jinju-daero 816beon-gilJinju 52727Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital CheonanCheonan 31151Republic of Korea Department of Internal Medicine Dong-A University HospitalBusan 49201Republic of Korea Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Republic of Korea Divsion of Hematology and Oncology Department of Internal MedicineSoonchunhyang University Hospital SeoulSeoul 04401Republic of Korea Department of Internal Medicine Ewha Womans UniversityCollege of MedicineSeoul 07985Republic of Korea Department of Internal Medicine Dankook University HospitalCheonan 31116Republic of Korea Department of Internal Medicine Chung-Ang UniversityCollege of MedicineSeoul 06973Republic of Korea Division of Hematology and Medical Oncology Department of Internal MedicineKorea Cancer HospitalSeoul 01812Republic of Korea Department of Hematology-Oncology Ajou University HospitalSuwon 16499Republic of Korea

Background:Combination therapy with oxaliplatin,irinotecan,fluorouracil,and leucovorin(FOLFIRINOX)chemotherapy drastically improves survival of advanced pancreatic cancer ***,the efficacy of FOLFIRINOX as a second-line treatment after gemcitabine failure has not been tested *** investigated the feasibility and safety of attenuated FOLFIRINOX in patients with gemcitabine-refractory advanced pancreatic ***:A multicenter phase II prospective open-label,single-arm study was conducted at 14 *** with histologically proven invasive ductal pancreatic adenocarcinoma,a measurable or evaluable lesion,Eastern Cooperative Oncology Group performance status 0 or 1,adequate organ function,and aged 19 years or older were *** FOLFIRINOX consisted of oxaliplatin 65 mg/m2,irinotecan 135 mg/m2,and leucovorin 400 mg/m2 injected intravenously on day 1 and 5-fluorouracil 2000 mg/m2 continuously infused intravenously over 46 h on days 1-2,repeated every 2 *** primary endpoint was progression-free survival from the initiation of *** endpoints were the objective response rate,disease control rate,overall survival,safety,and *** estimated overall survival and progression-free survival using the Kaplan-Meier ***:We enrolled 39 patients from 14 *** objective response rate was 10.3%,while the disease control rate was 64.1%.The 6-month and 1-year overall survival rates were 59.0%and 15.4%,*** progression-free survival and overall survival were 3.8 months(95%confidence interval[CI]1.5-6.0 months)and 8.5 months(95%CI 5.6-11.4 months),*** 3 or 4 adverse events were neutropenia(41.0%),nausea(10.3%),anorexia(10.3%),anemia(7.7%),mucositis(7.7%),pneumonia/pleural effusion(5.1%),and fatigue(5.1%).One treatment-related death attributable to septic shock ***:Attenuated FOLFIRINOX may be promising as a second-line therapy for gemcitabin

关键词： Attenuated FOLFIRINOX Second-line Pancreatic cancer Gemcitabine

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马来西亚草药与中国相应传统药物的比较研究

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中草药 2021年第8期52卷 2480-2492页

作者：兰太进孔鹏云郭宏伟运晨霞侯小涛郝二伟杜正彩冯秋瑜张艺 lim Yang Mooi 邓家刚广西中医药大学基础医学院广西南宁530200 广西中医药大学广西中药药效筛选研究重点实验室广西南宁530200 广西医科大学药学院广西南宁530021 广西中医药大学瑶医药学院广西南宁530200 成都中医药大学民族医药学术传承创新研究中心四川成都611137 马来西亚拉曼大学医学与保健科学学院马来西亚吉隆坡43000

从马来西亚当地草药专著中共收集到马来西亚草药568味,对其草药名称、拉丁学名、科属来源、功效、主治、药用部位及在中国的地域分布情况进行汇总分析,并将其与中国相应传统药物进行比较研究。统计发现,马来西亚草药来源于147个科和445... 详细信息

从马来西亚当地草药专著中共收集到马来西亚草药568味,对其草药名称、拉丁学名、科属来源、功效、主治、药用部位及在中国的地域分布情况进行汇总分析,并将其与中国相应传统药物进行比较研究。统计发现,马来西亚草药来源于147个科和445个属,功效以"清热解毒(55.11%)、活血疗伤(23.42%)"等为主,用法多为"内服或外用"(75.18%),药用部位多为"全草"(45.25%),在我国各省份均有分布,但主要集中在广东(91.02%)、云南(88.38%)和广西(85.56%)。对比发现,有509味马来西亚草药在中国传统药物中有记载,其中95.48%与中国相应传统药物的药用部位与功效相同或相似,但有4.52%与中国相应传统药物的药用部位与功效完全不同。研究结果提示,我国传统医学对马来西亚传统医学产生了重要的影响,两国草药有着很大的相似性,但同时可能由于两国因地域和自然环境不同导致的疾病谱及药物有效成分差异,两国间部分草药亦存在显著差异。中、马两国草药的异同将为传统药物研究提供新的突破口,同时也为增进两国在传统医药领域的交流合作提供契机。

关键词：马来西亚草药中国传统药物清热解毒活血疗伤

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SiO2-Promoted Ni Bulk Catalyst for Single-Stage Water Gas Shift Reaction

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华东理工大学学报（自然科学版） 2010年第5期36卷 661-661页

作者： KIM Sung-Ho KIM yun-tae UM Ji-hyun NAM Suk-woo lim Tae-hoon LEE Ho-in School of Chemical and Biological Engineering and Research Center for Energy Conversion and Storage Seoul National University Seoul 151-744 Korea Center for Fuel Cell Research Korea Institute of Science and Technology Seoul 136-791 Korea

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Magnetic resonance evaluation of human mesenchymal stem cells in corpus cavernosa of rats and rabbits

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Asian Journal of Andrology 2007年第3期9卷 361-367页

作者： yun-Seob Song Ja-Hyeon Ku Eun-Seop Song Jung-Hoon Kim Jin-Suck Jeon Kong-Hee Lee Sook-Ja Kim Hee-Jeong Cheong Ik-Sung lim Dongho Choi Jong-Ho Won Department of Urology Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Urology Seoul National University Hospital Seoul 110-744 Korea Department of Obstetrics and Gynecology Inha University School of Medicine Incheon 400-103 Korea Department of Radiology Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Internal Medicine Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Urology Soonchunhyang School of Medicine Seoul 140-743 Korea Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Industrial Management ＆ Engineering Namseoul University College of Engineering Cheonan 330-707 Korea Department of Surgery Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea Department of Internal Medicine Stem Cell therapy Center Soonchunhyang School of Medicine Seoul 140-743 Korea

Aim： To investigate whether the biological process of superparamagnetic iron oxide （SPIO）-labeled human mesenchymal stem cells （hMSCs） may be monitored non-invasively by using in vivo magnetic resonance （MR） imaging with conventional 1.5-T system examinations in corpus cavernosa of rats and rabbits. Methods： The labeling efficiency and viability of SP10-labeled hMSCs were examined with Prussian blue and Tripan blue, respectively. After SPIO-labeled hMSCs were transplanted to the corpus cavernosa of rats and rabbits, serial T2-weighted MR images were taken and histological examinations were carried out over a 4-week period. Results： hMSCs loaded with SPIO compared to unlabeled cells had a similar viability. For SPIO-labeled hMSCs more than lx 105 concentration in vitro, MR images showed a decrease in signal intensity. MR signal intensity at the areas of SPIO-labeled hMSCs in the rat and rabbit corpus cavernosa decreased and was confined locally. After injection of SPIO-labeled hMSCs into the corpus cavernosum, MR imaging demonstrated that hMSCs could be seen for at least 12 weeks after injection. The presence of iron was confirmed with Prussian blue staining in histological sections. Conclusion： SP10-labeled hMSCs in corpus cavernosa of rats and rabbits can be evaluated non-invasively by molecular MR imaging. Our findings suggest that MR imaging has the ability to test the long-term therapeutic potential of hMSCs in animals in the setting of erectile dysfunction.

关键词： human mesenchymal stem cells magnetic resonance stem cells penis cell labeling corpus cavemosa

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Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype

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World Journal of Gastroenterology 2013年第41期19卷 7078-7088页

作者： Jae yun lim Sun Och Yoon So-Young Seol Soon Won Hong Jong Won Kim Seung Ho Choi Ju-Seog Lee Jae Yong Cho Department of Medical Oncology Gangnam Severance Cancer HospitalYonsei University College of MedicineSeoul 135-720South Korea Department of Systems Biology Division of Cancer MedicineUniversity of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Pathology Gangnam Severance Cancer HospitalYonsei University College of Medicine 135-720SeoulSouth Korea Department of Surgery Gangnam Severance Cancer HospitalYonsei University College of MedicineSeoul 135-720South Korea

AIM:To identify molecular biologic differences between two gastric adenocarcinoma subgroups presenting different prognoses through the analysis of microRNA and protein ***:Array technologies were used to generate1146 microRNAs and 124 proteins expression profiles of samples from 60 patients with gastric *** the integrative analysis,we used established mRNA expression data published in our previous *** mRNA expression levels were acquired from microarray data for 60 identical gastric cancer *** gastric adenocarcinoma subgroups with distinct mRNA expression profiles presented distinctly different *** and protein expression patterns were compared between gastric cancer tissue and normal gastric tissue and between two different prognostic *** expressed microRNA,associated mRNA,and protein in patients with poor-prognosis gastric cancer were validated by quantitative reverse transcription polymerase chain reaction and immunochemistry in independent ***:We obtained the expression data of 1146microRNAs and 124 cancer-related *** microRNAs were aberrantly expressed in the two prognostic groups and in cancer vs non-cancer tissues(P<0.05).In the poor-prognosis group,miR-196b,miR-135b,and miR-93 were up-regulated and miR-29c*was ***-196b expression positively correlated with Homeobox A10(HOXA10)expression(r=0.726,P<0.001),which was significantly increased in poor-prognosis patients(P<0.001).Comparing gastric cancer with non-cancer tissues,46/124 proteins showed differential expression(P<0.05);COX2(P<0.001)and cyclin B1(P=0.017)were clearly overexpressed in the poor-prognosis ***:Co-activation of miR-196b and HOXA10characterized a poor-prognosis subgroup of patients with gastric *** of the biologic function of miR-196b and HOXA10 is warranted.

关键词： Gastric cancer Gene expression Microarray MicroRNA miR-196b Homeobox A10

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操作系统的理论模型

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暨南理医学报 1982年第1期 1-11页

作者：苏运霖暨南大学数学系

本文作者曾于去年发表了有关操作系统理论模型的文章,该文仅仅是作者在操作系统理论研究方面的一个尝试。现在,想在本文中对该文作进一步的推进。该文谈到,可以把进程(任务)看作是一个具有k个值的函数。现在我们更仔细地探讨它。进程的... 详细信息

本文作者曾于去年发表了有关操作系统理论模型的文章,该文仅仅是作者在操作系统理论研究方面的一个尝试。现在,想在本文中对该文作进一步的推进。该文谈到,可以把进程(任务)看作是一个具有k个值的函数。现在我们更仔细地探讨它。进程的静态存在无非是程序。我们假设这一程序本身不包含错误,也假设硬件或整个系统本身不包含错误。于是,进程在系统中所经历的状态(值)的变化,便仅仅受其资源的影响,或者说仅仅是资源的函数。注意:这里我们所说的进程状态,指的是其宏观的状态,而不是它内部的特性。

关键词：进程队列理论模型资源分配资源管理变量集合定义操作系统计算机系统

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短暂的园亭

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风景园林 2012年第2期19卷 118-123页

作者：泰勒.森凡特马克.塔尔博特 Hon yun lim st事务所

2011年6月,一个奇怪的帐篷状结构出现在湖边。在周末度假者抵达之前,它只用了几天时间就完成了搭建工作。有人猜测它是一种预防毛毛虫入侵的控制措施,也有人猜想它是为人而建,可其目的是什么,谁也不知道。园亭围着原有的火坑和小路形成... 详细信息

2011年6月,一个奇怪的帐篷状结构出现在湖边。在周末度假者抵达之前,它只用了几天时间就完成了搭建工作。有人猜测它是一种预防毛毛虫入侵的控制措施,也有人猜想它是为人而建,可其目的是什么,谁也不知道。园亭围着原有的火坑和小路形成了拱顶空间．其外观酷似带拱顶的传统舞台．作为连接水陆的门道，为游客提供遮阴，同时也强化了远方的录观。

关键词：城市规划园林设计城市绿化自然景观园亭

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Impact of high-resolution HLA matching on outcomes of unrelated donor hematopoietic stem cell transplantation

Impact of high-resolution HLA matching on outcomes of unrela...

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第十届亚太国际骨髓移植会议

作者： Seok yun Kang Hyun Woo Lee Jun Ho Jang Joon Seong Park Jin Hyuk Choi Ho Young lim Hugh Chul Kim Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea

＜正＞Objective: We assessed the impact of high-resolution genotypic results of human leukocyte antigen （HLA） for all major class Ⅰand Ⅱloci between donors and recipients in the outcome of unrelated hematopoietic stem cell transplantation （HSCT）. Method: Between 1999 and 2005, high-resolution genotyping for HLA-A, -B, -C and -DRB1 was performed for 23 unrelated HSCT. All the patients were typed as HLA identical by serologic technique and then they were also typed HLA identical by high resolution technique. Unrelated bone marrow

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Is 1, 25-dihydroxyvitamin D_3 an ideal substitute for dexamethasone for inducing osteogenic differentiation of human adipose tissue-derived stromal cells in vitro?

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Chinese Medical Journal 2006年第15期119卷 1278-1286页

作者： ZHOU Yong-sheng LIU yun-song TAN Jian-guo Department of Prosthodontics School and Hospital of Stomatology Peking University Beijing 100081 China

Background Human adipose tissue-derived stromal cells （hADSCs） can be induced to differentiate along an osteoblastic lineage under stimulation of dexamethasone （DEX）. Recent studies, however, have questioned the efficacy of glucocorticoids such as DEX in mediating the osteogenesis process of skeletal progenitor cells and processed lipoaspirate cells. Is it possible to find a substitute for DEX？ Therefore, this study was designed to investigate osteogenic capacity and regulating mechanisms for osteoblastic differentiation of hADSCs by comparing osteogenic media （OM） containing either 1, 25-dihydroxyvitamin D3 （VD） or DEX and determine if VD was an ideal substitute for DEX as an induction agent for the osteogenesis of hADSCs. Methods Osteogenic differentiation of hADSCs was induced by osteogenic medium （OM） containing either 10 nmol/L VD or 100 nmol/L DEX. Differentiation of hADSCs into osteoblastic lineage was identified by alkaline phosphatase （ALP） staining, von Kossa staining, and reverse transcription-polymerase chain reaction assays for mRNA expression of osteogenesis-related genes such as type Ⅰ collagen （COL Ⅰ）, bone sialoprotein （BSP）, osteocalcin （OC）, bone morphogenetic protein （BMP）-2, BMP-4, BMP-6, BMP-7, runt-related transcription factor 2/core binding factor α1 （Runx2/Cbfal）, osterix （Osx）, and lim mineralization protein- 1 （LMP- 1）. Results von Kossa staining revealed that the differentiated cells induced by both VD and DEX were mineralized in vitro. They also expressed osteoblast-related markers, such as ALP, COL Ⅰ, BSP, and OC. Runx2/Cbfal, Osx, BMP-6, and LMP-1 were upregulated during VD and DEX-induced hADSC osteoblastic differentiation, but BMP-4, BMP-7 were not. BMP-2 was only expressed in VD-induced differentiated cells. Conclusions VD or DEX-induced hADSCs differentiate toward the osteoblastic lineage in vitro. Runx2/Cbfal, Osx, BMP-2, BMP-6, and LMP-1 are involved in regulating osteoblastic differentiation of hADSCs, but BMP-4, BMP-7 are not.

关键词： human adipose tissue-derived stromal cell osteoblast 1, 25-dihydroxyvitamin D3 dexamethasone

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大白菜的适宜AFLP-Pst Ⅰ/Mse Ⅰ引物组合

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华北农学报 2009年第4期24卷 96-101页

作者：许磊李宏博林荣杓朴钟云沈阳农业大学园艺学院辽宁沈阳110161 忠南大学农业生命科学学院园艺系韩国大田305764

基于PCR的DNA指纹鉴定技术AFLP广泛应用于生物多样性、遗传图谱构建、基因定位、分子系统发育和品种鉴定等方面。为了筛选出大白菜适宜的AFLP引物组合,研究以抗根肿病大白菜双单倍体CR Shinki、感病自交系94SK及其后代F2构成的纯合抗病... 详细信息

基于PCR的DNA指纹鉴定技术AFLP广泛应用于生物多样性、遗传图谱构建、基因定位、分子系统发育和品种鉴定等方面。为了筛选出大白菜适宜的AFLP引物组合,研究以抗根肿病大白菜双单倍体CR Shinki、感病自交系94SK及其后代F2构成的纯合抗病和纯合感病DNA混合池为材料,利用256对Pst Ⅰ/Mse Ⅰ引物组合进行了AFLP分析。结果表明:平均每个组合检测到55条带,共扩增13079条带,平均每1000条带检测到1.30个根肿病抗性基因连锁标记;多态性带数为3167条,双亲间多态性频率约为0.24;扩增带数与多态性带数呈线性正相关,引物组合中的不同GC含量与扩增带数和多态性带数存在显著性差异,并表现出线性负相关。筛选出的适宜53对引物组合共扩增出4381条带,占总扩增片断的33.50%,平均每对扩增出83条,其中9个组合扩增出与抗根肿病基因连锁标记。

关键词：大白菜 AFLP 引物组合 GC含量

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