检索结果-南通市图书馆

Inhalation of taraxasterol loaded mixed micelles for the treatment of idiopathic pulmonary fibrosis

Chinese Chemical Letters 2024年第8期35卷 475-480页

作者： Tong Zhang Chao Sun Shubin Yang Zimin Cai Sifeng Zhu Wendian Liu yun luan Cheng Wang Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Central Research Laboratory Department of General Surgerythe Second Hospital of Shandong UniversityJi’nan 250033China Laboratory for Marine Drugs and Bioproducts Pilot National Laboratory for Marine Science and TechnologyQingdao 266237China Orthopedics Dept.1 Rushan people’s hospitalRushan 264500China Department of Cardiology the Second Hospital of Shandong UniversityJi’nan 250033China

Idiopathic pulmonary fibrosis(IPF)is a chronic and fatal lung disease characterized by pulmonary inflam-mation,oxidative stress,and excessive extracellular matrix(ECM)*** anti-fibrotic drugs for IPF treatment in the clinic lack selectivity and demonstrate unsatisfactory efficacy,highlighting the urgent necessity for a novel therapeutic ***(TA),which has biological activities against lung injury induced by various factors,is a potential anti-IPF drug due to its anti-inflammatory,antiox-idant and lung-protective ***,the protective effect of TA on IPF has not been confirmed,and its clinical application is limited due to its poor aqueous *** this study,we demonstrated that TA could inhibit epithelial-mesenchymal transition(EMT)and migration of A549 cells by inhibiting the transforming growth factor-β1(TGF-β1)/Smad signaling *** improve the aqueous solubility and pulmonary administration performance of TA,we prepared TA loaded methoxy poly(ethylene glycol)-poly(d,l-lactide)(mPEG-PLA)/d-α-tocopheryl polyethylene glycol succinate(TPGS)mixed polymeric mi-celles(TA-PM).Then a MicroSprayer^(R) Aerosolizer was used to deliver TA-PM once every two days for three weeks to evaluate their therapeutic effects on bleomycin(BLM)-induced IPF *** results demonstrated that inhaled TA-PM significantly inhibited BLM-induced inflammation,oxidative stress and fibrosis in lung ***,TA-PM exhibited high pulmonary deposition and retention by pul-monary administration,along with a favorable safety ***,this study emphasizes the potential of inhaled TA-PM as a promising treatment for IPF,providing a new opportunity for their clinical appli-cation.

关键词： Taraxasterol Idiopathic pulmonary fibrosis Mixed polymeric micelles Pulmonary administration Bleomycin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

双层多孔板结构相变发汗冷却的数值模拟研究

引用

力学学报 2024年第1期56卷 121-129页

作者：刘韬略吕玉妹栾芸贺菲王建华中国科学技术大学热科学和能源工程系中国科学院材料力学行为和设计重点实验室合肥230026 北京机电工程总体设计部北京100854

为了提高相变发汗冷却的冷却性能,提出不同孔隙率组合的双层多孔板结构设计代替传统的单层多孔板结构.以液态水作为冷却剂,使用修正后的局部热非平衡两相混合流模型,数值研究了不同孔隙率组合的多孔板内流-固耦合传热和冷却剂流动输运特... 详细信息

为了提高相变发汗冷却的冷却性能,提出不同孔隙率组合的双层多孔板结构设计代替传统的单层多孔板结构.以液态水作为冷却剂,使用修正后的局部热非平衡两相混合流模型,数值研究了不同孔隙率组合的多孔板内流-固耦合传热和冷却剂流动输运特性.数值模拟结果表明存在可以降低结构表面温度的双层多孔板设计,并且在冷却剂流量较大、液体水相变发生在上层多孔板内时,该新型结构相较于传统结构的表面温度降低更为明显.与此同时,冷却剂的注射压力被重点关注.由于水蒸气的运动黏度远高于液体水,研究中发现当冷却剂相变发生在多孔板内时,冷却剂的注射压力主要取决于水蒸气所集中的上层多孔板孔隙率.因此基于多孔介质内的渗流特性,采用孔隙率较大的上层多孔板有助于降低结构内的水蒸气压力,从而实现多孔板板底冷却剂注射压力的降低,在某一孔隙率组合中冷却剂注射压力的最大降幅可以达到65%.如果采用相反的孔隙率设计,即下层多孔板的孔隙率较大,虽然也可以在一定程度上降低表面温度,但是注射压力将会数倍增加,不利于相变发汗冷却的实际应用.

关键词：发汗冷却水相变多孔介质热防护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

原位快速检测重金属镉的研究进展

引用

粮油食品科技 2024年第2期32卷 127-135页

作者：闵建锋方梦旗栾云霞中材地质工程勘查研究院有限公司北京100102 北京市农林科学院质量标准与检测技术研究所北京100097 北京城市学院生物医药学部北京100191

镉是一种对环境和人体健康有害的重金属,虽然基于原子吸收光谱仪和电感耦合等离子体质谱仪等大型仪器的常规检测方法准确度高,但不能满足快速现场检测和高通量筛查的需求。镉的原位快速检测技术,可以在粮食安全、农业物联网、生物育种... 详细信息

镉是一种对环境和人体健康有害的重金属,虽然基于原子吸收光谱仪和电感耦合等离子体质谱仪等大型仪器的常规检测方法准确度高,但不能满足快速现场检测和高通量筛查的需求。镉的原位快速检测技术,可以在粮食安全、农业物联网、生物育种和环境监测等领域提供一种新型、高效、实时的方法,特别是在筛选不同镉吸收和积累特性的植物品种方面具有很大的应用潜力。本文从检测技术原理和特点入手,总结了针对动植物体内重金属镉的快速原位检测的不同技术,如电化学传感技术、荧光传感技术、光学传感器技术等,及其在食品安全监测、风险评估和在生物体内的迁移、转化和积累等领域的研究进展、应用前景和发展方向,以期为相关的科研工作提供技术参考。

关键词：重金属镉原位快速检测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spatial impacts of climate factors on regional agricultural and forestry biomass resources in north-eastern province of China

引用

Frontiers of Environmental Science & Engineering 2016年第4期10卷 91-104页

作者： Wenyan Wang Wei Ouyang Fanghua Hao yun luan Bo Hu School of Environment State Key Laboratory of Water Environment Simulation Beijing Normal University Beijing 100875 China Beijing Zhongchi Green Energy and Environmental Technology Co. Ltd. Golden Resources Office Building Beijing 100097 China The Administrative Center for China's Agenda 21 Ministry of Science and Technology of the People's Republic of China Beijing 100038 China Department of Soil and Water Conservation Changjiang River Scientific Research Institute Wuhan 430019 China

The dynamics of agricultural and forestry biomass are highly sensitive to climate change, particularly in high latitude regions. Heilongjiang Province was selected as research area in North-east China. We explored the trend of regional climate warming and distribution feature of biomass resources, and then analyzed on the spatial relationship between climate factors and biomass resources. Net primary productivity （NPP） is one of the key indicators of vegetation productivity, and was simulated as base data to calculate the distribution of agricultural and forestry biomass. The results show that temperatures rose by up to 0.37℃/10a from 1961 to 2013. Spatially, the variation of agricultural biomass per unit area changed from -1.93 to 5.85 ***^-2.a^-1 during 2000,2013. More than 85% of farmland areas showed a positive relationship *** agricultural biomass and precipitation. The results suggest that precipitation exerts an overwhelming climate influence on agricultural biomass. The mean density of forestry biomass varied from 10 to 30 t·km^-2. Temperature had a significant negative effect on forestry biomass in Lesser Khingan and northern Changbai Mountain, because increased temperature leads to decreased Rubisco activity and increased respiration in these areas. Precipitation had a significant positive relationship with forestry biomass in south-western Changbai Mountain, because this area had a wanner climate and stress from insufficient precipitation may induce xylem cavitation. Understanding the effects of climate factors on regional biomass resources is of great significance in improving environmental management and promoting sustainable development of further biomass resource use.

关键词： Biomass resourcesNet primary productivity (NPP)Climate change Heilongjiang Province China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

IFT52 plays an essential role in sensory cilia formation and neuronal sensory function in Drosophila

引用

Insect Science 2023年第4期30卷 1081-1091页

作者： Ya-Nan Hou Ying-Ying Zhang Ya-Ru Wang Zhi-Mao Wu yun-Xia luan Qing Wei Center for Energy Metabolism and Reproduction Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Shenzhen Key Laboratory of Metabolic Health ShenzhenGuangdong ProvinceChina Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of BiotechnologyShanxi UniversityTaiyuanChina Guangzhou Key Laboratory of Insect Development Regulation and Application Research Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouGuangdongChina

Cilia are microtubule-based,hair-like organelles involved in sensory function or motility,playing critical roles in many physiological processes such as reproduction,or-gan development,and sensory *** insects,cilia are restricted to certain sensory neurons and sperms,being important for chemical and mechanical sensing,and *** great progress has been made regarding the mechanism of cilia assembly,the formation of insect cilia remains poorly understand,even in the insect model organism *** transport(IFT)is a cilia-specific complex that traffics protein cargos bidirectionally along the ciliary axoneme and is essential for most *** we investigated the role of IFT52,a core component of IFT-B,in cilia/flagellar formation in *** show that Drosophila IFT52 is distributed along the sensory neuronal cilia,and is essential for sensory cilia *** of Ift52 results in severe defects in cilia-related sensory *** should be noted that IFT52 is not detected in sper-matocyte cilia or sperm flagella of ***,ift52 mutants can produce sperms with normal motility,supporting a dispensable role of IFT in Drosophila sperm flagella ***,IFT52 is a conserved protein essential for sensory cilia formation and sensory neuronal function in insects.

关键词： Drosophila IFT52 sensory cilia sperm flagella

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of rare earth elements on inclusions, microstructure and impact toughness of spring steel

引用

Journal of Iron and Steel Research International 2024年第4期31卷 933-944页

作者： Chun-lei Hao Chao-yun Yang Peng Liu Yi-kun luan Bao-guang Sang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016LiaoningChina School of Mechanical Engineering and Automation Dalian Polytechnic UniversityDalian 116034LiaoningChina

Spring steel is an indispensable basic part manufacturing material in mechanical equipment,which is widely used in transportation tools such as automobiles,railways,construction machinery and other *** effects of rare earth(RE)on inclusions,microstructure,carbides and impact toughness of 50CrV spring steel were studied by means of optical microscope,scanning electron microscope,transmission electron microscope and impact *** results show that the addition of rare earth can modify the main MnS and Al_(2)O_(3) inclusions in steel to form spherical or near-spherical rare earth inclusions,and the size of inclusions is significantly *** the quenched structure,the size of martensite slab becomes smaller and the structure is *** tempering,the carbide changes from sheet to ellipse,which makes it easier for spring steel to form stress concentration cracks under *** becomes finer and more dispersed,which leads to better pinning of grain boundaries and smaller grain *** impact toughness of 50CrV-RE spring steel increased from 21 to 41 J by 95%due to the improvement of inclusions,microstructure and carbides by rare *** is possible to improve the strength and toughness of spring steel for the improvement of railway running speed and the development of vehicle lightweight in China.

关键词： Rare earth-Spring steel Inclusion Microstructure Impact toughness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

超极速脉搏波评估单纯高甘油三酯血症患者颈动脉弹性衰退的研究

引用

重庆医学 2024年第18期53卷 2766-2770页

作者：戴萍朱正球高慧栾云刘文军姜学忠黄辉江苏省中医院/南京中医药大学附属医院超声医学科南京210029 南京信息工程大学数学与统计学院南京210044 江苏省省级机关医院超声诊断科南京210024

目的探讨超极速脉搏波(ufPWV)技术在评估单纯高甘油三酯(TG)血症患者(以下称单TG高人群)颈动脉弹性衰退中的应用价值。方法选取2020年1月至2022年3月于江苏省中医院/南京中医药大学附属医院心内科门诊就诊,血脂满足:TG≥1.7 mmol/L且总... 详细信息

目的探讨超极速脉搏波(ufPWV)技术在评估单纯高甘油三酯(TG)血症患者(以下称单TG高人群)颈动脉弹性衰退中的应用价值。方法选取2020年1月至2022年3月于江苏省中医院/南京中医药大学附属医院心内科门诊就诊,血脂满足:TG≥1.7 mmol/L且总胆固醇(TC)1.0 mmol/L的患者纳入单TG高人群组(n=63);选取同期在江苏省中医院/南京中医药大学附属医院体检中心血脂指标TG、TC、LDL-C、HDL-C均在正常范围内的体检者纳入血脂正常人群组(n=68)。收集所有研究对象的临床资料,利用ufPWV技术检测颈总动脉收缩起始脉搏波速度(PWV-BS)、收缩末期脉搏波速度(PWV-ES)、内-中膜厚度(cIMT)。结果单TG高人群组与血脂正常人群组比较,BMI、收缩压、舒张压、TG、空腹血糖(FBG)、cIMT、PWV-ES值差异均有统计学意义(P<0.05);PWV-BS、PWV-ES、cIMT与年龄均呈正相关,PWV-ES相关性最高(r=0.607,P<0.001),cIMT次之(r=0.590,P<0.001),PWV-BS最低(r=0.325,P<0.001);logistic回归分析显示,PWV-ES可作为单TG高人群颈动脉弹性衰退风险的预测因素,且独立于年龄、性别、BMI、收缩压、舒张压、FBG等因素(OR=1.449,P<0.005)。结论ufPWV技术能够评估单TG高人群的颈动脉弹性衰退现象,PWV-ES增高是该人群颈动脉弹性衰退的独立危险因素。

关键词：超极速脉搏波动脉粥样硬化颈动脉弹性衰退甘油三酯

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Grainy head signaling regulates epithelium development and ecdysis in Blattella germanica

引用

Insect Science 2021年第2期28卷 485-494页

作者： Zheng Zhao Liang Li Min Cheng An-Di Jing Su-Ning Liu Shi-Ming Zhu Er-Xia Du Sheng Li yun-Xia luan Chong-Hua Ren Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina

The transcription factor grainy head(Grh)functions in the protection of the epithelium against the external environment by generating strongly adhesive layers,and this function is conserved in vertebrates and *** Drosophila,the top model for holometabolous insects,Grh is necessary during embryonic development,epidermal differentiation,central nervous system specification and epithelial ***,the function of this gene in hemimetabolous insect epithelia remains *** examine the function of Grh signaling in regulating epithelium development in Hemimetabola,we focused on the Blattella germanica epidermal layer using a gene knockdown *** spatiotemporal expression pattern of BgGrh was detected,and knockdown of Bg-Grh and BgCad96ca,which provide positive feedback to BgGrh,caused severe defects in new epithelium development and impeded the molting process required to discard the old *** of the expression of BgGrh and BgCad96ca caused increased expression of chitin synthase gene{BgCHSl)and chitinase gene{BgCht5),the upregulations of which should be mediated by the higher level of hormone receptor 3{BgHr3)*** conclusion,epithelium development is regulated by Grh signaling,which might represent a potential target for the control of urban pest cockroaches.

关键词： BgCad96ca cockroach ecdysis epithelium Grh signaling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Corilagin alleviates podocyte injury in diabetic nephropathy by regulating autophagy via the SIRT1-AMPK pathway

引用

World Journal of Diabetes 2024年第9期15卷 1916-1931页

作者： Yu Lou Yu-Ting luan Wen-Qing Rong yun Gai Department of Preventive Treatment of Disease Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China Department of Infectious Diseases Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China Department of General Practice(Including Medical Oncology) Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200137China

BACKGROUND Diabetic nephropathy(DN)is the most frequent chronic microvascular consequence of diabetes,and podocyte injury and malfunction are closely related to the development of *** have shown that corilagin(Cor)has hepatoprotective,anti-inflammatory,antibacterial,antioxidant,anti-hypertensive,antidiabetic,and anti-tumor *** To explore the protective effect of Cor against podocyte injury in DN mice and the underlying *** Streptozotocin and a high-fat diet were combined to generate DN mice models,which were then divided into either a Cor group or a DN group(n=8 in each group).Mice in the Cor group were intraperitoneally injected with Cor(30 mg/kg/d)for 12 wk,and mice in the DN group were treated with *** analysis was used to measure the blood lipid *** and eosin staining was used to detect pathological changes in kidney *** and Western blotting were used to assess the protein expression of nephrin and *** podocyte cells(MPC5)were cultured and treated with glucose(5 mmol/L),Cor(50μM),high glucose(HG)(30 mmol/L),and HG(30 mmol/L)plus Cor(50μM).Real-time quantitative PCR and Western blotting RESULTS Compared with the control group,the DN mice models had increased fasting blood glucose,glycosylated hemoglobin,triglycerides,and total cholesterol,decreased nephrin and podocin expression,increased apoptosis rate,elevated inflammatory cytokines,and enhanced oxidative *** of the conditions mentioned above were alleviated after intervention with *** addition,Cor therapy improved SIRT1 and AMPK expression(P<0.001),inhibited reactive oxygen species and oxidative stress,and elevated autophagy in HG-induced podocytes(P<0.01).CONCLUSION Cor alleviates podocyte injury by regulating autophagy via the SIRT1-AMPK pathway,thereby exerting its protective impact on renal function in DN mice.

关键词： Corilagin Podocyte injury Diabetic nephropathy Autophagy High glucose SIRT1-AMPK pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

燃爆弹跳驱动器仿真与试验研究（英文）

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2017年第10期18卷 831-840页

作者： yun-guang luan Hua-ming WANG Dong-biao ZHAO Yang WANG Feng-hong CHEN College of Mechanical and Electronical Engineering Nanjing University of Aeronautics and Astronautics Department of Mechatronics Suzhou Vocational Institute of Industrial Technology State Key State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University

目的:研究燃爆弹跳驱动器热-动力学模型,分析驱动器的输出性能,并通过试验验证驱动器热-动力学模型的正确性。创新点:1.建立了燃爆弹跳驱动器热-动力学模型,得到燃爆弹跳驱动器的相关输出参数随时间的变化规律;2.通过理论仿真与试验测... 详细信息

目的:研究燃爆弹跳驱动器热-动力学模型,分析驱动器的输出性能,并通过试验验证驱动器热-动力学模型的正确性。创新点:1.建立了燃爆弹跳驱动器热-动力学模型,得到燃爆弹跳驱动器的相关输出参数随时间的变化规律;2.通过理论仿真与试验测试分析了驱动器的输出性能。方法:1.根据对燃爆弹跳机器人工作过程分析,推导出燃爆弹跳驱动器工作过程中的动力学模型,并对锁紧力与弹簧刚度参数进行测试;2.根据热-动力学模型推导出燃烧室内压力随时间变化的函数;3.通过试验测试驱动器驱动弹跳过程中压力和位移随时间的变化曲线,将测试结果与热-动力学模型仿真的结果进行比较。结论:1.建立了燃爆弹跳驱动器的热-动力学模型,得到了驱动器的输出性能参数;2.试验测试结果与仿真计算结果吻合,证明了驱动器热-动力学模型的正确性。

关键词：热-动力学模型燃爆驱动器仿真分析试验分析输出性能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：