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Long-term antibiotic use and risk of hepatocellular carcinoma later in life: a nationwide cohort study of 9.8 million participants

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Cancer Communications 2023年第10期43卷 1174-1177页

作者： Seogsong Jeong Sun Jae Park Minseo Kim young Jun Park Seulggie Choi Jooyoung Chang Ji Soo Kim yun h.an oh.ah.young ko Sang Min Park Department of Biomedical Sciences Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Biomedical Informatics CHA University School of MedicineSeongnamSouth Korea Department of Medicine College of MedicineJeonbuk National UniversityJeonjuSouth Korea Medical Research Center Genomic Medicine InstituteSeoul National UniversitySeoulSouth Korea Department of Internal Medicine Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea International healthcare Center Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Family Medicine Chung-Ang University Gwangmyeong HospitalChung-Ang University College of MedicineGwangmyeongSouth Korea Department of Family Medicine Seoul National University HospitalSeoulSouth Korea

Dear Editor,Antibiotics are considered indispensable in numerous treatments against infectious ***,their over-prescription and widespread use are emerging as important global issues,as they lead to resistant bacteria,reducing the efficacy of antibiotics[1].The defined daily doses per 1,000 habitants per day for antibiotics in South korea is 28,which is much higher than the average of Organization for Economic Co-operation and Development countries[1].In animal studies,antibiotic tigecycline was found to inhibit the proliferation and induce apoptosis of hepatocellular carcinoma(hCC)cells[2].In addition,isoprenoid antibiotic was found to suppress the growth.and invasion of hCC by targeting the signal transducer and activator of the transcription 3 signaling cascade[3].Despite evidence of the beneficial effects of antibiotics against hCC,evidence regarding their effects on the longterm development of hCC is *** regarding the incidence of hCC is provided in the Supplementary file.

关键词： doses invasion nationwide

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Risk factors affecting pancreatic fistulas after pancreaticoduodenectomy

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World Journal of Gastroenterology 2008年第45期14卷 6970-6974页

作者： yun-Mee Choe Keon-young Lee Cheong-ah oh Joung-Bum Lee Sun Keun Choi Yoon-Seok hur Sei-Joong Kim young Up Cho Seung-Ik ahn Kee-Chun hong Seok-h.an Shin Kyung-Rae Kim Department of Surgery Inha University Hospital

AIM: To analyze the risk factors of pancreatic leakage after ***: We retrospectively reviewed 172 consecutive patients who had undergone pancreatico-duodenectomy at Inha University hospital between April 1996 and March 2006. We analyzed the pancreatic fistula rate according to the clinical characteristics, the pathologic and laboratory findings, and the anastomotic ***: The incidence of developing pancreatic fistulas in patients older than 60 years of age was 21.7% (25/115), while the incidence was 8.8% (5/57) for younger patients; the difference was significant (P = 0.03). Patients with a dilated pancreatic duct had a lower rate of post-operative pancreatic fistulas than patients with a non-dilated duct (P = 0.001). Other factors, including clinical features, anastomotic methods, and pathologic diagnosis, did not show any statistical difference. CONCLUSION: Our study demonstrated that pancreatic fistulas are related to age and a dilated pancreatic duct. The surgeon must take these risk factors into consideration when performing a pancre-aticoduodenectomy.

关键词：胰腺疾病胰腺瘘管治疗临床

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基于辣椒基因组测序探究辣味在种群中的进化

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辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee hyun-ah Lee Eunyoung Seo Jaeyoung Choi Kyeongchae Cheong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun oh Chungyun Bae Saet-Byul Kim hye-young Lee Shin-young Kim Myung-Shin Kim Byoung-Cheorl Kang Yeong Deuk Jo hee-Bum Yang hee-Jin Jeong Won-hee Kang Jin-Kyung Kwon Chanseok Shin Jae yun Lim June hyun Park Jin hoe huh June-Sik Kim Byung-Dong Kim Oded Cohen Ilan Paran Mi Chung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park young Sam Seo Suk-Yoon Kwon hyun A Kim Jeong Mee Park hyun-Jin Kim Sang-Bong Choi Paul W Bosland Gregory Reeves Sung-h.an Jo Bong-Woo Lee hyung-Taeg Cho hee-Seung Choi Min-Soo Lee Yeisoo Yu Yang Do Choi Beom-Seok Park Allen van Deynze hamid Ashrafi Theresa hill Woo Taek Kim hyun-Sook Pai hee Kyung ahn Inhwa Yeam James J Giovannoni Jocelyn K C Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-young Choi Beom-Soon Choi Jong-Sung Lim Yong-h.an Lee Doil Choi 刘峰张西露 Department of Plant Science Seoul National University Plant Genomics and Breeding Institute Seoul National University Department of Agricultural Biotechnology Seoul National University Department of Bioinformatics and Life Science Soongsil University Vegetable Breeding Research Center Seoul National University Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agricultural Research Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Science and Technology Chonnam National University Genomics Genetics Institute GreenGene BioTech Inc. Codes Division Insilicogen Inc. Ginseng Resources Research Laboratory Korea Ginseng Corporation korea Research Institute of Bioscience and Biotechnology Division of Bioscience and Bioinformatics Myongji University Department of Plant and Environmental Sciences New Mexico State University Chile Pepper Institute New Mexico State University Seeders Inc. Department of Biological Sciences Seoul National University Arizona Genomics Institute University of Arizona Agricultural Genome Center National Academy of Agricultural Science Rural Development Administration Seed Biotechnology Center University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of horticulture and Breeding Andong National University US Department of Agriculture-Agricultural Research Service Robert W. Holley Center Ithaca New York USA Boyce Thompson Institute for Plant Research Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotechnology Institute Nongwoo Bio Yeoju Korea Genome Center University of California Davis Davis California USA National Instrumentation Center for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(Capsicum annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对CM334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 Capsicum 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

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