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超声在小儿永存第5主动脉弓诊断评估中的临床价值

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中国超声医学杂志 2024年第3期40卷 336-339页

作者：贺新建魏九茹崔云陈娇阳张帅陶曙光赵宁任哲河北省儿童医院超声诊断科河北省小儿心血管重点实验室河北省儿童健康与疾病临床医学研究中心河北省妇幼保健中心胎儿保健科河北省儿童医院心脏外科

目的探讨超声在小儿永存第5主动脉弓(PFAA)诊断评估中的临床指导价值。方法收集超声诊断且经电子计算机断层扫描血管造影(CTA)或手术证实的11例PFAA患儿资料，分析不同分型的超声特征并进行评估。结果 11例超声诊断与CTA或手术结果均... 详细信息

目的探讨超声在小儿永存第5主动脉弓(PFAA)诊断评估中的临床指导价值。方法收集超声诊断且经电子计算机断层扫描血管造影(CTA)或手术证实的11例PFAA患儿资料，分析不同分型的超声特征并进行评估。结果 11例超声诊断与CTA或手术结果均相符。2例右位PFAA合并血管环或法洛四联证，9例左位PFAA均未合并复杂畸形。Weinberg A型4例：1例右位双腔主动脉弓(无血流梗阻)合并法洛四联证及迷走左锁骨下动脉，行法洛四联证根治术；2例左位双腔主动脉弓无梗阻者未手术；1例左位双腔主动脉弓PFAA远端闭锁伴主动脉缩窄，行主动脉缩窄纠治术。B型7例：第4主动脉弓离断伴PFAA缩窄6例，其中4例重度缩窄左心室收缩功能减低者行急诊手术；1例发现后早期行PAFF缩窄纠治术；1例放弃治疗；1例不伴缩窄者只行房间隔缺损修补术。补充1例C型胎儿病例，追踪失访。结论重度缩窄导致左心收缩功能减低是小儿PFAA最常见的危害之一，需急诊手术，右位PFAA易合并血管环及其他复杂畸形。超声在PFAA的诊断评估中具有重要价值。

关键词：先天性心脏病永存第5主动脉弓超声

Effect of erhuangfang on cerebral and spinal demyelination and regeneration as well as expression of glial fibrillary acidic protein in rats with experimental allergic encephalomyelitis

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Neural Regeneration Research 2007年第8期2卷 491-496页

作者： Xiuzhen Liu Yongping Fan Lei Wang yun cui Haiyang Gong Department of Traditional Chinese Medicine Beijing Tiantan Hospital Capital Medical University Beijing 100050 China College of Traditional Chinese Medicine Capital Medical University Bering 100069 China Institute of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

BACKGROUND： It demonstrates that erhuangfang can improve clinical symptoms of multiple sclerosis and relieve side effects of hormone. However, whether erhuangfang can improve experimental allergic encephalomyelitis （EAE） or not needs a further study. OBJECTIVE： To observe the effect of erhuangfang on neuro-pathology and astrocyte in EAE rats and compare with the effect of hormone. DESIGN： Randomized controlled animal study. SETTINGS： Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University; College of Traditional Chinese Medicine, Capital Medical University. MATERIALS： The experiment was carded out in the Laboratory Center of Capital Medical University from August to October 2005. Ten adult guinea pigs （SPF grade, weighing 400 - 450 g） and 70 adult Lewis rats （SPF grade, weighing 200- 220 g） were selected in this study. Erhuangfang consisted of fiudahuang, shengdi, shuizhi, dabeimu, etc. METHODS： ①Experimental intervention： Rats were randomly divided into normal group （n=10）, model group （n=20）, western medicine group （n=20） and Chinese herb group （n=20）. Mixed emulsion, which was consisted of Freund＇s adjuvant and spinal cord homogenate of guinea pigs, was subcutaneously injected into palms of the two hindfeet of rats in the latter three groups to establish EAE models. Foot pads were injected with saline and then rats were perfused with saline in the normal *** the model group, models were established as the same as those mentioned above, and rats were also perfused with saline. Rats in the western medicine group were perfused with saline and then 5 mg/kg prednisone acetate suspension. Rats in the Chinese herb group were perfused with erhuangfang decoction （15 g raw materials per kilogram） at 5 days before model establishment. The dosage in the four groups was 3 mL/day per rat. ②Experimental evaluation： At 28 days after model establishment, rats were randomly selected for cerebral （mainly surrounding cerebral ventricle）

关键词： encephalomyelitis models, animal autoimmunity

miR-99a-5p inhibits target gene FZD5 expression and steroid hormone secretion from goat ovarian granulosa cells

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Journal of Integrative Agriculture 2022年第4期21卷 1137-1145页

作者： ZHU Lu JING Jing QIN Shuai-qi LU Jia-ni ZHU cui-yun ZHENG Qi LIU Ya FANG Fu-gui LI yun-sheng ZHANG yun-hai LING Ying-hui College of Animal Science and Technology Anhui Agricultural UniversityHefei 230036P.R.China Local Animal Genetic Resources Conservation and Biobreeding Laboratory of Anhui Province Hefei 230036P.R.China

MicroRNA(miRNA) has vital regulatory effects on the proliferation, differentiation and secretion of ovarian granulosa cells, but the role of miR-99a-5p in goat ovarian granulosa cells(GCs) is unclear. Both miR-99a-5p and Frizzled-5(FZD5) were found to be expressed in GCs in goat ovaries via fluorescence in situ hybridization and immunohistochemistry, respectively, and FZD5 was verified(P<0.001) as a target gene of miR-99a-5p by double luciferase reporter gene experiments. Furthermore, FZD5 mRNA and protein expression were both found to be regulated(P<0.05) by miR-99a-5p in GCs. Moreover, the overexpression of miR-99a-5p or knockdown of FZD5 suppressed(P<0.05) estradiol and progesterone secretion from the GCs, as determined by ELISA. In summary, miR-99a-5p inhibits target gene FZD5 expression and estradiol and progesterone synthesis in GCs. Our study thus provides seminal data and new insights into the regulatory mechanisms of follicular development in the goat and other animals.

关键词： miRNA Frizzled-5 follicular development estradiol progesterone

Decrease of Photosystem Ⅱ Photochemistry in Arabidopsis ppt1 Mutant Is Dependent on Leaf Age

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Journal of Integrative Plant Biology 2006年第12期48卷 1409-1414页

作者： Jin-Fang Ma Jin-Kui Guo Lian-Wei Peng cui-yun Chen Li-Xin Zhang Key Laboratory of Arid and Grassland Ecology School of Life Sciences Lanzhou University Lanzhou 730000 China Key Laboratory of Photosynthesis and Environmental Molecular Physiology Photosynthesis Research Center Institute of Botany the Chinese Academy of Sciences Beijing 100093 China

In the present study, we compared the effect of leaf age at one development stage on the photosynthetic behavior of a T-DNA-tagged allele of the pptl mutant. Chlorophyll fluorescence （Fv/Fm, where Fm is the maximum fluorescence yield and Fv is variable fluorescence） and fluorescence decay kinetics of the pptl mutant were different in leaves of different ages. The steady state levels of thylakoid membrane proteins in 40-day-old leaves were decreased compared with those in 20-day-old leaves and changes in photosystem （PS） II proteins were correlated with those of the F,/Fm ratio in the pptl mutant. Increased accumulation of leaf sugars was accompanied by decreased photosynthetic gene transcripts and protein content in 40- day-old leaves of the mutant. Thus, the results of the present study provide evidence for the phosphate translocator in maintaining normal photosynthesis at a late leaf age.

关键词： Arabidopsis thaliana leaf age photosynthesis photosystem Ⅱ ppt1 mutant.

γ-aminobutyric acid secreted from isletβ-cells modulates exocrine secretion in rat pancreas

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World Journal of Gastroenterology 2006年第19期12卷 3026-3030页

作者： Yong-Deuk Park Zheng-yun cui Guang Wu Hyung-Seo Park Hyoung-Jin Park Department of MedicoLife Science Youngdong University Chungbuk Korea Department of Physiology College of Medicine and Ilsong Institute of Life Science Hallym University Chuncheon Gangwon-do Korea Department of Physiology College of Medicine Konyang University Daejeon Korea

AIM： To investigate the role of endogenous γ-aminobutyric acid （GABA） in pancreatic exocrine secretion. METHODS： The isolated, vascularly perfused rat pancreas was employed in this study to eliminate the possible influences of extrinsic nerves and hormones. Cholecystokinin （CCK; 10 pmol/L） was intra-arterially given to stimulate exocrine secretion of the pancreas. RESULTS： Glutamine, a major precursor of GABA, which was given intra-arterially at concentrations of 1, 4 and 10 mmol/L, dose-dependently elevated the CCK-stimulated secretions of fluid and amylase in the normal pancreas. Bicuculline （10 μmol/L）, a GABAA receptor antagonist, blocked the enhancing effect of glutamine （4 mmol/L） on the CCK-stimulated exocrine secretions. Glutamine, at concentrations of 1, 4 and 10 mmol/L, dose-dependently increased the GABA concentration in portal effluent of the normal pancreas. The effects of glutamine on the CCK-stimulated exocrine secretion as well as the GABA secretion were markedly reduced in the streptozotocintreated pancreas. CONCLUSION： GABA could be secreted from β-cells into the isletoacinar portal system after administration of glutainine, and could enhance the CCK-stimulated exocrine secretion through GABAA receptors. Thus, GABA in islet β-cells is a hormone modulating pancreatic exocrine secretion.

关键词： GABA GABA receptor GABA secretion Cholecystokinin Islet of langerhans Pancreas

使用飞行时间二次离子质谱法判定痕量氧元素的测试方法

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理化检验（物理分册） 2024年第7期60卷 31-34页

作者：冯殿福崔云陶春先杨峰侯瑶上海理工大学光电信息与计算机工程学院上海200093 中国科学院上海光学精密机械研究所薄膜光学实验室上海201800 中国科学院理化技术研究所功能晶体与激光技术重点实验室北京100190

采用飞行时间二次离子质谱法对CaF_(2)晶体、YF_(3)薄膜和Au薄膜中的痕量氧元素进行测试。结果表明:通过改变分析离子源光阑大小来改变离子束流,进而改变作用在试样表面的单位面积离子剂量,当离子束流增大时,CaF_(2)晶体与YF_(3)薄膜的... 详细信息

采用飞行时间二次离子质谱法对CaF_(2)晶体、YF_(3)薄膜和Au薄膜中的痕量氧元素进行测试。结果表明:通过改变分析离子源光阑大小来改变离子束流,进而改变作用在试样表面的单位面积离子剂量,当离子束流增大时,CaF_(2)晶体与YF_(3)薄膜的氟离子、氧离子产额均增加,表明CaF_(2)晶体与YF_(3)薄膜中存在氧元素,测试结果与CaF_(2)的紫外光谱测试结果和YF_(3)薄膜的红外光谱测试结果相吻合;当离子束流增大时,金离子产额增加,而氧离子产额无明显变化,说明检测到的氧元素来自试验环境中的残余气体,Au膜中不存在氧元素。

关键词：飞行时间二次离子质谱痕量元素残余气体离子束流

Hydrothermal Synthesis and Crystal Structure of a Novel Isophthalate-bridged Copper(II) Polymer with Two-dimensional Network Structure: [Cu_2(phen)(ipt)_2]_(2n)·nH_2O (ipt = isophthalate, phen = 1,10-phenanthroline)

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Chinese Journal of Structural Chemistry 2005年第12期24卷 1411-1415页

作者： cui yun-Cheng LI Xiu-Mei LI Chuan-Bi WANG Qing-Wei LIU Bo LI Guo-Feng Jilin Normal University Siping Jilin 136000 China Department of Chemistry Tonghua Teachers college Tonghua Jilin 134002 China

A novel metal-organic coordination polymer [Cu2（phen）（ipt）2]2n-nH2O 1 has been hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction. The complex crystallizes in monoclinic, space group P21/c with a = 12.338（3）, b = 12.167（3）, c = 18.167（4）A, β= 111.686（14）°, V = 2534.1（10）A^3, C28H18Cu2N2O9, Mr = 653.52, Dc = 1.713 g/cm^3,μ（MoKα） = 1.740 mm^-1, F（000） = 1320, Z = 4, the final R = 0.0443 and wR = 0.0853 for 3543 observed reflections （1 〉 2σ（I））. It exhibits a novel two-dimensional network with tetra-Cu-ipt-as building units.

关键词： isophthalate coordination polymer hydrothermal synthesis crystal structure

World Flu Day: Protecting Health, Keeping away from Flu Troubles

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Biomedical and Environmental Sciences 2023年第12期36卷 1196-1196页

作者： cui yun Shang Chinese Center for Disease Control and Prevention Beijing 102206China

November 1,2023 marks the 6th"World Flu Day".The theme is"Preventing Influenza,Protecting Health"in this *** to data from the World Health Organization,influenza infects approximately 5%-10%of adults and 20%-30%of children worldwide each year,resulting in up to 5million severe cases and 650,000 deaths.A recent study showed that about 88,000 people in China died from respiratory diseases caused by influenza each year,accounting for 8.2%of total respiratory disease deaths,making influenza a serious threat to public health.

关键词： World Health Protectin

Mechanistic Studies on Programmed C—O/C—H Activation with Valence-Adjusted Ti-Complexes

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Chinese Journal of Chemistry 2023年第9期41卷 1015-1022页

作者： Si-Jun Xie yun-Shu cui Yi-Fei Huang Feng Liu Dan-Dan Zhai Zhang-Jie Shi Department of Chemistry Fudan UniversityShanghai 200433ChinaDepartment of ChemistryFudan UniversityShanghai 200433China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Two-electron reduction of[N_(2)NBn]Ti^(Ⅳ)Cl2(3)gave a highly reactive[N_(2)N]Ti^(Ⅱ)species,which underwent C—O bond activation of THF(tetrahydrofuran)to generate[N2NBn]Ti^(Ⅳ)[O(CH2)4](4)through oxidative *** resulted Ti^(Ⅳ)-Csp^(3)bond in oxametallacyclo-hexane was tantamount to the elaborately-designed Ti-alkyl complexes,competent to activate intramolecular Csp^(2)-H bond,forming ortho-cyclometalated complex[N_(2)NCH_(2)C_(6)H_(4)]Ti^(Ⅳ)(O^(n)Bu)(5).Key intermediates were isolated and fully characterized by X-ray *** studies revealed that the oxidative addition of C-O bond took place at Ti^(Ⅱ)-center via a radical intermediate,while a Csp^(2)-H bond activation proceeded byσ-bond metathesis with a kitelike four-centered Ti^(Ⅳ)-transition state.

关键词： Reaction mechanisms Valence-adjusted Ti-complexes C—O oxidative addition C—H activation Metathesis