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Novel PLCZ1 mutation caused polyspermy during in vitro fertilization

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Asian Journal of Andrology 2024年第4期26卷 389-395页

作者： Ke-Ya Tong Wei-Wei Liu Li-Wei Sun Dong-yun Liu Ye-Zhou Xiang Chong Li Lu-Wei chai Ke Chen Guo-Ning Huang Jing-Yu Li Chongqing Key Laboratory of Human Embryo Engineering Center for Reproductive MedicineWomen and Children’s Hospital of Chongqing Medical UniversityChongqing 400012China Chongqing Clinical Research Center for Reproductive Medicine Center for Reproductive MedicineChongqing Health Center for Women and ChildrenChongqing 400012China.

Failure of oocyte activation,including polyspermy and defects in pronuclear(PN)formation,triggers early embryonic developmental *** studies have shown that phospholipase C zeta 1(PLCZ1)mutations cause failure of PN formation following intracytoplasmic sperm injection(ICSI);however,whether PLCZ1 mutation is associated with polyspermy during in vitro fertilization(IVF)remains ***-exome sequencing(WES)was performed to identify candidate mutations in couples with primary *** sequencing was used to validate the *** PLCZ1-mutated sperm were injected into human and mouse oocytes to explore whether PN formation was *** oocyte activation(AOA)after ICSI was performed to overcome the failure of oocyte *** identified three PLCZ1 mutations in three patients who experienced polyspermy during IVF cycles,including a novel missense mutation c.1154C>T,*** formation failure was observed during the ICSI ***,injection of multiple PLCZ1-mutated sperm induced PN formation,suggesting that the Ca2+oscillations induced by the sperm exceeded the necessary threshold for PN *** after ICSI enabled normal fertilization,and all patients achieved successful *** findings expand the mutational spectrum of PLCZ1 and suggest an important role for PLCZ1 in terms of blocking ***,this study may benefit genetic diagnoses in cases of abnormal fertilization and provide potential appropriate therapeutic measures for these patients with sperm-derived polyspermy.

关键词： AOA PLCZ1 polyspermy pronuclear formation

光还原法合成Pt/Fe_(2)O_(3)/氮掺杂还原氧化石墨烯催化剂及其抗烧结性能

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无机化学学报 2022年第1期38卷 73-83页

作者：李志慧王云鹏符婉琳朱明芸柴蕴玲吴敏孙岳明代云茜东南大学化学化工学院南京211189

采用静电纺丝法获得的多孔Fe_(2)O_(3)纳米棒与氮掺杂还原氧化石墨烯(N⁃RGO)的复合材料作为载体,通过光还原法成功制备清洁、高活性的Pt/Fe_(2)O_(3)/N⁃RGO催化剂,并进一步研究其中的光还原反应机理和催化剂的抗烧结性能。研究结果表明... 详细信息

采用静电纺丝法获得的多孔Fe_(2)O_(3)纳米棒与氮掺杂还原氧化石墨烯(N⁃RGO)的复合材料作为载体,通过光还原法成功制备清洁、高活性的Pt/Fe_(2)O_(3)/N⁃RGO催化剂,并进一步研究其中的光还原反应机理和催化剂的抗烧结性能。研究结果表明,在可见光照射下,Fe_(2)O_(3)对光的强吸收作用促使光生电子和空穴的产生,N⁃RGO有效延长光生载流子的寿命,使得电子从O^(2-)转移到Fe^(3+)。Fe_(2)O_(3)/N⁃RGO中部分还原的Fe^(2+)具有较强的还原能力,可使PtCl_(6)^(2-)在Fe_(2)O_(3)表面还原并迅速成核,生长为粒径约2.13 nm的Pt纳米颗粒。此外,甲醇作为空穴清除剂可以快速有效地消耗掉扩散到载体表面的光生空穴,使导带中积累的电子与PtCl_(6)^(2-)发生还原反应,从而提高Pt纳米颗粒的光还原速率。电纺Fe_(2)O_(3)纳米棒独特的粗糙表面为Pt纳米颗粒异相成核提供了大量活性位点。富含点缺陷的N⁃RGO片层能缩短Fe_(2)O_(3)的光生载流子扩散路径,提高光沉积的效率;同时,其特征褶皱结构可以作为物理屏障,防止Pt纳米颗粒聚集。得益于金属与载体间的强相互作用,在500℃高温老化后,Pt纳米颗粒仍能维持较小的尺寸(2.67 nm),表现出优良的抗烧结性能。在对硝基苯酚加氢反应中,Pt/Fe_(2)O_(3)/N⁃RGO在400℃老化后仍具有高达22.2 L·g^(-1)·s^(-1)的反应速率常数,约为老化前的1.6倍。

关键词：静电纺丝光沉积 Fe_(2)O_(3) Pt 还原氧化石墨烯

Nuclear volume effects in kinetic isotope fractionation:A case study of mercury oxidation by chlorine species

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Acta Geochimica 2024年第3期43卷 411-423页

作者： Chenlu Yang Yining Zhang yun Liu Research Center for Planetary Science College of Earth and Planetary SciencesChengdu University of TechnologyChengdu 610059China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

It is well-known that the equilibrium isotope fractionation of mercury(Hg)includes classical massdependent fractionations(MDFs)and nuclear volume effect(NVE)induced mass-independent fractionations(MIFs).However,the effect of the NVE on these kinetic processes is not *** total fractionations(MDFs+NVEinduced MIFs)of several representative Hg-incorporated substances were selected and calculated with ab initio calculations in this work for both equilibrium and kinetic ***-induced MIFs were calculated with scaled contact electron densities at the nucleus through systematic evaluations of their accuracy and errors using the Gaussian09 and DIRAC19 packages(named the electron density scaling method).Additionally,the NVE-induced kinetic isotope effect(KIE)of Hg isotopes are also calculated with this method for several representative Hg oxidation reactions by chlorine *** KIEs for 202 Hg/^(198)Hg ranging from−2.27‰to 0.96‰are *** anomalous^(202)Hg-enriched KIEs(δ^(202)Hg/^(198)Hg=0.83‰,0.94‰,and 0.96‰,)caused by the NVE are observed,which are quite different from the classical view(i.e.,light isotopes react faster than the heavy ones).The electron density scaling method we developed in this study can provide an easier way to calculate the NVE-induced KIEs for heavy isotopes and serve to better understand the fractionation mechanisms of mercury isotope systems.

关键词： Nuclear volume effect Kinetic fractionation Hg isotopes Ab initio calculations

对3-CNB改性煤沥青制备半焦和针状焦性质研究

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高校化学工程学报 2015年第6期29卷 1445-1450页

作者：柴韵杰苏蕾曹青董亚威靳利娥太原理工大学化学化工学院山西太原030024

为提升煤沥青(coal tar pitch-CTP)的潜在价值,以3-氯硝基苯(3-chloronitrobenzene,3-CNB)为改性剂,对甲基苯磺酸为催化剂,对其进行了成功改性。利用偏光显微镜、TG、FT-IR、1H-NMR和XRD对中间产物半焦和针状焦性质进行了分析。偏光显... 详细信息

为提升煤沥青(coal tar pitch-CTP)的潜在价值,以3-氯硝基苯(3-chloronitrobenzene,3-CNB)为改性剂,对甲基苯磺酸为催化剂,对其进行了成功改性。利用偏光显微镜、TG、FT-IR、1H-NMR和XRD对中间产物半焦和针状焦性质进行了分析。偏光显微组织分析表明,改性后煤沥青(modified CTP,MCTP)的碳化产率增加,中间相光学组织呈典型的长程纤维结构;其黏度、β树脂含量、TI和QIs均随3-CNB量的增加而增加;由红外吸收光谱表明,Iar和A880/A1600增加,说明芳香度和聚合度均增加;1H-NMR分析表明,经3-CNB改性的MCTP的Hβ和Hγ数量减少,而Har和Hα数量增加,其芳烃缩合度得到进一步增加;XRD分析表明,由MCTP制得的针状焦d002晶面距变小,晶粒堆积高度增加,其有序性显著增加。在此基础上,分析了3-CNB成功改性CTP的原因。

关键词：光谱法煤沥青改性中间相针状焦

Capture Efficiency Analysis in the Circular Restricted Three-body Problem

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Research in Astronomy and Astrophysics 2024年第5期24卷 198-210页

作者： Yu-Xuan Miao Xi-yun Hou Department of Astronomy and Space Science Nanjing UniversityNanjing 210023China Institute of Space Environment and Astrodynamics Nanjing UniversityNanjing 210023China Key Laboratory of Modern Astronomy and Astrophysics Ministry of EducationNanjing 210023China

Temporary capture efficiency is studied in the framework of the circular restricted three-body problem in two ***, a non-uniform distribution of test particles around the secondary's orbit is obtained by fully accounting the secondary's gravitational influence. Second, the capture efficiency is computed based on the non-uniform distribution. Several factors influencing the result are discussed. By studying the capture efficiency in the circular restricted three-body problem of different mass ratios, a power-law relation between the capture efficiency(p) and the mass ratio(μ) is established, which is given by p ≈ 0.27 × μ^(0.53), within the range of 3.0035 ×10^(-6)≤ μ ≤ 3.0034 × 10^(-5). Taking the Sun–Earth system as an example, the influence from the orbit eccentricity of the secondary on the non-uniform distribution and the capture efficiency is studied. Our studies find that the secondary's orbit eccentricity has a negative influence on the capture efficiency.

关键词： methods numerical-celestial mechanics-planets and satellites dynamical evolution and stability

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图书馆 2017年第6期 1-7+13页

作者：柯平刘旭青柴赟南开大学商学院信息资源管理系山东省图书馆

第六次县级以上公共图书馆评估明确了各级公共图书馆的功能定位,文章基于省级公共图书馆功能定位的特点,主要从资源保障、业务引领和协作协调三个方面对省级公共图书馆的评估标准作出了解读。

关键词：省级公共图书馆图书馆评估评估标准功能定位

Mechanical Performance of Bio-inspired Bidirectional Corrugated Sandwich Pressure Shell Under External Hydrostatic Pressure

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China Ocean Engineering 2024年第2期38卷 297-312页

作者： ZHANG Yi CHEN Yue yun Lai LIANG Xu Ocean College Zhejiang UniversityZhoushan 316000China Hainan Institute Zhejiang UniversitySanya 572000China

This paper aims to enhance the compression capacity of underwater cylindrical shells by adopting the corrugated sandwich structure of *** cuttlebone suffers uniaxial external compression,while underwater cylindrical shells are in a biaxial compressive stress *** suit the biaxial compressive stress state,a novel bidirectional corrugated sandwich structure is proposed to improve the bearing capacity of cylindrical *** static and buckling analysis for the sandwich shell and the unstiffened cylindrical shell with the same volume-weight ratio are studied by numerical *** is indicated that the proposed sandwich shell can effectively reduce the ratio between circumferential and axial stress from 2 to 1.25 and improve the critical buckling load by about 1.63 *** simulation shows that optimizing and adjusting the structural parameters could significantly improve the advantage of the sandwich ***,the hydrostatic pressure tests for shell models fabricated by 3D printing are carried *** to the experimental results,the overall failure position of the sandwich shell is at the center part of the sandwich *** has been found the average critical load of the proposed sandwich shell models exceeds two times that of the unstiffened shell ***,the proposed bio-inspired bidirectional corrugated sandwich structure can significantly enhance the pressure resistance capability of cylindrical shells.

关键词： bio-inspiration bidirectional corrugation sandwich shell external pressure buckling

Adversarial attacks and defenses for digital communication signals identification

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Digital Communications and Networks 2024年第3期10卷 756-764页

作者： Qiao Tian Sicheng Zhang Shiwen Mao yun Lin College of Computer Science and Technology Harbin Engineering UniversityHarbin150001China College of Information and Communication Engineering Harbin Engineering UniversityHarbin150000China Department of Electrical and Computer Engineering Auburn UniversityAuburnAL36849USA

As modern communication technology advances apace,the digital communication signals identification plays an important role in cognitive radio networks,the communication monitoring and management *** has become a promising solution to this problem due to its powerful modeling capability,which has become a consensus in academia and ***,because of the data-dependence and inexplicability of AI models and the openness of electromagnetic space,the physical layer digital communication signals identification model is threatened by adversarial *** examples pose a common threat to AI models,where well-designed and slight perturbations added to input data can cause wrong ***,the security of AI models for the digital communication signals identification is the premise of its efficient and credible *** this paper,we first launch adversarial attacks on the end-to-end AI model for automatic modulation classifi-cation,and then we explain and present three defense mechanisms based on the adversarial *** we present more detailed adversarial indicators to evaluate attack and defense ***,a demonstration verification system is developed to show that the adversarial attack is a real threat to the digital communication signals identification model,which should be paid more attention in future research.

关键词： Digital communication signals identification AI model Adversarial attacks Adversarial defenses Adversarial indicators

Plasma spray coating on interconnector toward promoted solid oxide fuel cells and solid oxide electrolysis cells

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Frontiers in Energy 2024年第3期18卷 390-398页

作者： Junwen CAO yun ZHENG Wenqiang ZHANG Bo YU Institute of Nuclear and New Energy Technology(INET) Collaborative Innovation Center of Advanced Nuclear Energy TechnologyTsinghua UniversityBeijing 100084China Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1Canada Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China

Interconnector is a critical component to construct solid oxide cells (SOCs) stack. Oxidation of metallic interconnectors and Cr poisoning caused by oxidation are important factors that lead to long-term performance degradation of SOCs. Coating on the interconnector surface is an important approach to inhibit the oxidation and Cr migration of the interconnector. Herein, (La0.75Sr0.25)0.95MnO3–δ (LSM) and Mn1.5Co1.5O4 (MCO) are used to fabricate the coatings of interconnector. Two advanced thermal spray technology, atmospheric plasma spraying (APS) and low-pressure plasma spray (LPPS), are adopted for the coating preparation. The electrochemical performance, rising and cooling cycle stability, and Cr diffusion inhibition performance of the coatings are tested and evaluated. The result indicates that MCO can generate more uniform and denser coatings than LSM. In addition, MCO coatings prepared by LPPS shows the best electrochemical performance, rising and cooling cycle stability, and Cr diffusion inhibition. The initial area specific resistance (ASR) is 0.0027 Ω·cm2 at 800 °C. After 4 cooling cycle tests, the ASR increases to 0.0032 Ω·cm2 but lower than other samples. Meanwhile, the relative intense of Cr at the interface of SUS430 with MCO coatings fabricated by LPPS is lower than that of MCO fabricated by APS after 4 rising and cooling cycle operations, showing more favorable Cr diffusion inhibition performance.

关键词： interconnector coating plasma spray electrochemical performance Cr diffusion inhibition solid oxide cells(SOCs)