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在离子液体介质中聚合反应的研究进展

石油化工 2005年第4期34卷 388-393页

作者：张普玉娄帅柴云河南大学化学化工学院河南开封475001

综述了离子液体作为反应介质在高分子合成中应用的研究进展。以离子液体为反应介质可以进行多种聚合反应,如低聚反应、配位聚合、电化学聚合、自由基聚合、活性自由基聚合等。在离子液体作为反应介质的大多数聚合体系中,其聚合速率、聚... 详细信息

综述了离子液体作为反应介质在高分子合成中应用的研究进展。以离子液体为反应介质可以进行多种聚合反应,如低聚反应、配位聚合、电化学聚合、自由基聚合、活性自由基聚合等。在离子液体作为反应介质的大多数聚合体系中,其聚合速率、聚合产物的相对分子质量及其分布等与在传统溶剂中聚合的结果不同,如聚合速率有所加快、相对分子质量分布变窄等。

关键词：离子液体绿色化学配位聚合自由基聚合活性聚合聚合

Body temperature control in patients with refractory septic shock： too much may be harmful

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Chinese Medical Journal 2013年第10期126卷 1809-1813页

作者： YANG Yan-li LIU Da-wei WANG Xiao-ting LONG yun ZHOU Xiang chai Wen-zao Department of Critical Care Medicine Peking Union MedicalCollege Hospital Peking Union Medical College & ChineseCollege Hospital Peking Union Medical College & ChineseAcademy of Medical Sciences Beijing 100730 China

Background The lowering of body temperature is a common, almost reflexive step in the daily care of septic shock patient. However, the effect of different magnitudes of fever control on the outcome of refractory septic patients with a very poor outcome is controversial and has yet to be explored. Methods This prospective trial examined sixty-five refractory septic shock patients with a core temperature higher than 38.5℃. Patients were randomly assigned to a group achieving a ＂low temperature＂ range （LT group： 36.0-37.5 ℃） or to a group achieving a ＂high temperature＂ range （HT group： 37.5-38.3 ℃） by physical methods including a water-flow cooling blanket and ice packs. A target core temperature was achieved in 1-2 hours post-treatment, and maintained for 72 hours. Averaged values of core temperature as well as hemodynamic, respiratory, and laboratory variables were analyzed at baseline and during the first 72 hours after fever control. Results Thirty-four （52.31%） patients were assigned to the LT group and thirty-one （47.69%） patients were assigned to the HT group. The mean core temperature was significantly lower in the LT group than in the HT group （36.61 vs. 37.85 ℃, respectively; P 〈 0.0001）. The average heart rate （HR）（75.5 vs. 91.9 beats/min, respectively; P 〈 0.0001） and the mean cardiac output （CO）（5.35 vs. 6.45 L/min, respectively; P = 0.002） were also statistically significant lower in the LT group than in the HT group. The averaged serum lactate level was significantly higher in the LT group compared to the HT group （5.59 vs. 2.82 mmol/L, respectively; P=0.008）. Fibrinogen and activated partial thromboplatin time were also different between the two groups. The 28 days mortality was significantly higher in the LT group than in the HT group （61.8 vs. 25.8%, respectively; P=0.003）. A Cox-regression model analysis showed that mean core temperature during the 72 h period was an independent predictor of 28 days mortality （odds ratio （OR） = 0.42, 95%C/0.25, 0.6

关键词： septic shock body temperature fever

Synthesis and in vitro Antimycobacterial Activity of Moxifloxacin Methylene and Ethylene Isatin Derivatives

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Chemical Research in Chinese Universities 2012年第1期28卷 61-66页

作者： FENG Lian-shun, LIU Ming-liang, WANG Shuo, chai yun, LI Su-jie and GUO Hui-yuan Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R. China Chinese Acad Med Sci Inst Med Biotechnol Beijing 100050 Peoples R China

A series of novel moxifloxacin methylene and ethylene isatin derivatives with remarkable improvement in lipophilicity, compared to the parent moxifloxacin, was designed, synthesized and characterized by 1H NMR, MS and HRMS. These derivatives were initially evaluated for their in vitro antimycobacterial activity against M. smegmatis CMCC 93202. Compounds 3a―3f, 5a, 5f and 5j were chosen for the further evaluation of their in vitro activity against Mycobacterium tuberculosis（MTB） H37Rv ATCC 27294 and MDR-MTB 09710. All the target com pounds[minimum inhibitory concentration（MIC）： 0.39―〉16 μg/mL] were far more active than rifampin（MIC： 2.0―〉256 μg/mL）, but less active than moxifloxacin（MIC： 0.1―1.0 μg/mL） against the three tested strains. The most active compounds 3a and 3c were found to be 2―64 fold more potent than isoniazid and rifampin against M. smegmatis CMCC 93202, 2 fold more potent than rifampin against MTB H37Rv ATCC 27294, and 16―〉64 fold more potent than ethambutol, isoniazid and rifampin against MDR-MTB 09710.

关键词： Moxifloxacin derivative Antimycobacterial activity Isatin

LINC00707靶向miR-30c-5p对ox-LDL诱导的人血管平滑肌细胞增殖、迁移及炎症因子的影响

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中国药理学通报 2023年第10期39卷 1829-1835页

作者：林云钗王航周强福建医科大学附属第一医院心血管内科福建福州350000 福建医科大学附属第一医院滨海院区国家区域医疗中心心血管内科福建福州350212 福建医科大学附属第一医院药学部福建福州350212 厦门大学附属福州第二医院内分泌科福建福州350000

目的探讨LINC00707对氧化型低密度脂蛋白(oixidized low-density lipoprotein,ox-LDL)诱导的人血管平滑肌细胞功能障碍的影响及其作用机制。方法采用ox-LDL诱导人血管平滑肌细胞HVSMCs建立动脉粥样硬化细胞模型,si-NC、si-LINC00707、mi... 详细信息

目的探讨LINC00707对氧化型低密度脂蛋白(oixidized low-density lipoprotein,ox-LDL)诱导的人血管平滑肌细胞功能障碍的影响及其作用机制。方法采用ox-LDL诱导人血管平滑肌细胞HVSMCs建立动脉粥样硬化细胞模型,si-NC、si-LINC00707、miR-NC、miR-30c-5p mimic分别转染至HVSMCs后,加入100 mg·L-1 ox-LDL处理细胞,si-LINC00707和anti-miR-NC、si-LINC00707和miR-30c-5p Inhibitor分别共转染至HVSMCs后,加入100 mg·L-1 ox-LDL处理细胞;qRT-PCR法检测LINC00707、miR-30c-5p的表达量;CCK-8法、Transwell实验分别检测细胞增殖及迁移;ELISA法检测IL-6、TNF-α、IL-10的水平;双荧光素酶报告实验检测LINC00707与miR-30c-5p的靶向关系;Western blot检测E-cadherin、N-cadherin蛋白表达量。结果ox-LDL诱导的HVSMCs中LINC00707的表达量升高(P<0.05),miR-30c-5p的表达量降低(P<0.05);转染si-LINC00707或miR-30c-5p mimic后,细胞存活率、N-cadherin蛋白水平和IL-6、TNF-α的水平降低(P<0.05),迁移细胞数减少(P<0.05),E-cadherin蛋白水平和IL-10的水平升高(P<0.05);LINC00707可靶向结合miR-30c-5p;共转染si-LINC00707和miR-30c-5p Inhibitor后,细胞存活率、N-cadherin蛋白水平和IL-6、TNF-α的水平升高(P<0.05),迁移细胞数增多(P<0.05),E-cadherin蛋白水平和IL-10的水平降低(P<0.05)。结论下调LINC00707导致miR-30c-5p表达升高从而抑制ox-LDL诱导的HVSMCs增殖、迁移及炎症反应。

关键词：动脉粥样硬化人血管平滑肌细胞 LINC00707 miR-30c-5p 细胞增殖迁移

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大规模RDF图数据上高效率分布式查询处理

软件学报 2019年第3期30卷 498-514页

作者：王鑫徐强柴乐乐杨雅君柴云鹏天津大学智能与计算学部天津300354 天津市认知计算与应用重点实验室天津300354 数字出版技术国家重点实验室北京100871 中国人民大学信息学院北京100872

知识图谱是智能数据的主要表现形式,随着知识图谱领域的不断发展,大量的智能图数据以资源描述框架(resourcedescriptionframework,简称RDF)形式发布出来.RDF图上的SPARQL查询语义对应于图同态,是一个NP-完全问题.因此,如何使用分布式方... 详细信息

知识图谱是智能数据的主要表现形式,随着知识图谱领域的不断发展,大量的智能图数据以资源描述框架(resourcedescriptionframework,简称RDF)形式发布出来.RDF图上的SPARQL查询语义对应于图同态,是一个NP-完全问题.因此,如何使用分布式方法在大规模RDF图上有效回答SPARQL查询是一个富有挑战性的问题.目前已有研究使用MapReduce计算模型处理大规模RDF数据,但其将SPARQL查询拆分成单个的查询子句,没有考虑RDF数据的丰富语义和自身的图特性,导致Map Reduce迭代次数过多.首先,利用RDF数据内嵌的语义和结构信息作为启发式信息,将查询图分解为星形的集合,可以在更少次迭代内得到查询结果.同时,分解算法给出中间结果较少的星形匹配顺序,基于此顺序,每轮Map Reduce操作通过连接操作匹配一个新的星形,直至产生最终的答案.最后,在标准合成数据集WatDiv和真实数据集DBpedia上进行大量的实验评估.实验结果表明:所提基于星形分解的分布式SPARQLBGP匹配算法能够高效回答查询,查询时间比SHARD和S2X算法的查询时间平均提高一个数量级,且优化算法的查询时间与基本算法相比缩短了49.63%～78.71%.

关键词：星形分解分布式基本图模式匹配大规模RDF 图 MapReduce

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毛/涤混纺纱电磁波定捻工艺研究

毛纺科技 2013年第1期41卷 51-53页

作者：牛灵鹏柴云云王利陕西省纺织科学研究所陕西西安710038

探讨利用电磁波定捻装置对毛/涤混纺纱进行定捻的工艺技术。分析了传统热湿定捻方法存在的缺点,通过正交试验确定毛/涤混纺纱电磁波定捻的较优工艺,并测试了定捻前后纱线的相关性能指标,即毛/涤混纺纱电磁波定捻较优工艺为功率4档、时间... 详细信息

探讨利用电磁波定捻装置对毛/涤混纺纱进行定捻的工艺技术。分析了传统热湿定捻方法存在的缺点,通过正交试验确定毛/涤混纺纱电磁波定捻的较优工艺,并测试了定捻前后纱线的相关性能指标,即毛/涤混纺纱电磁波定捻较优工艺为功率4档、时间4 min、纱线回潮率控制在9.7%左右。结果表明:采用较优的电磁波定捻工艺后,纱线断裂强度增加了15.1%左右,断裂伸长率增加了1.9%左右,定捻率达到了83%以上,满足了生产要求。

关键词：羊毛涤纶混纺纱电磁波断裂强度定捻率

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基于二层邻居信息的多智能体系统编队控制

计算机应用 2017年第8期37卷 2264-2269页

作者：柴运熊涛南京邮电大学自动化学院南京210023

为了加快多智能体编队控制过程中的状态收敛,提出基于多跳式网络技术的编队控制方法。首先将多智能体系统(MAS)中的每个智能体之间的相对速度偏移引入到控制协议中,然后引入每个智能体与标准位移之间的位置偏移,最后将多跳式网络技术应... 详细信息

为了加快多智能体编队控制过程中的状态收敛,提出基于多跳式网络技术的编队控制方法。首先将多智能体系统(MAS)中的每个智能体之间的相对速度偏移引入到控制协议中,然后引入每个智能体与标准位移之间的位置偏移,最后将多跳式网络技术应用在已定的通信拓扑之中,更多的机体信息被传递,每一个智能体能够联系上的邻居数量更多。利用一个六智能体系统的编队仿真进行验证,仿真结果表明所提出的编队控制方法可以使得多智能体系统形成指定队形,并且与没有引入多跳式网络技术的控制方法相比,其状态收敛所需时间减少了约10 s,收敛效率更高。

关键词：二阶一致性矩阵分析多智能体系统编队控制二层邻居信息

Two modes of biofilm formation by Bacillus cereus 905

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Two modes of biofilm formation by Bacillus cereus 905

Multi-time Collaborative Restoration for Integrated Electrical-gas Distribution Systems Based on Rolling Optimization

中国植物病理学会2015年学术年会

作者： GAO Tan-tan LUCY Foulston chai yun-rong RICHARD Losick LI Yan WANG Qi Department of Plant Pathology China Agricultural University Department of Molecular and Cellular Biology Harvard University Department of Biology Northeastern University

The ability to form multicellular communities known as biofilms is a widespread adaptive behavior of *** of the Bacillus group of bacteria have been found to form biofilms on plant roots,where they protect against pathogens and promote *** the case of the model bacterium Bacillus subtilis,the genetic pathway controlling biofilm formation and the production of an extracellular matrix is relatively well ***,it is unclear whether other members of this genus utilize similar *** 905,isolated from the roots of the wheat,is a plant-associated strain with function of promoting the growth of the *** determined that it could form biofilms by two seemingly independent *** one mode,the floating biofilms（pellicles） formationof *** appeared to rely on orthologs of many of the genes known to be important for *** biofilm *** the second mode,we reported that *** 905 formed submerged,surface-associated biofilms and in a manner that resembled biofilm formation by the pathogen Staphylococcus *** alternative mode,which did not rely on ***-like genes for pellicle formation,took place under conditions of glucose fermentation and depended on a decrease in the pH of the *** two modes of behavior appeared to be achieved in radically different ways and were likely operating under different environmental *** principal contribution of this investigation is the discovery that a plant-root-associated strain ***（905） could form two kinds of biofilms that are produced by two seemingly unrelated *** toto,our genetic analysis of *** biofilm formation sheds light on how a similar outcome,biofilm formation,can be achieved in different ways and this maybe provide an evidence of that *** can survive ubiquitously in the complicated environment.

关键词： Bacillus cereus biofilm pellicle

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 660-671页

作者： Jingyang yun Zheng Yan yun Zhou Peichao Zhang Weidong Hu Key Laboratory of Control of Power Transmission and Conversion of Ministry of Education Department of Electrical EngineeringShanghai Jiao Tong University

This paper proposes a multi-time collaborative restoration model for integrated electricity-gas distribution sys-tems(IEGDSs)considering multiple resources after extreme weather *** on the linearized power flow constraints of the unbalanced electrical distribution system(EDS)and gas distribution system(GDS),this problem can be formulated as a mixed-integer linear programming(MILP)*** improve the efficiency and veracity of the solution,a rolling optimiza-tion based two-stage method is developed with the first stage solved by a linear approximation model,and the second stage solved by real-time updated rolling *** solving the MILP problem using rolling optimization,the proposed model and solution method achieve efficient and reliable collaborative restoration of IEGDS considering multiple resources and unbal-anced operation characteristics of *** effectiveness of the proposed model and method is validated by using an IEGDS made of a 37-bus unbalanced EDS and 11-node *** Terms-Electricity-gas system,mix-integer linear programming,power system restoration.

关键词： Electricity-gas system mix-integer linear programming power system restoration