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Doping engineering of iron oxide nanoparticles towards high performance and biocompatible T_(1)-weighted MRI contrast agents

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Rare Metals 2024年第1期43卷 298-308页

作者： Xue Xu Ping-Li Dong Yu-yun chai Run Yang Zhen-Hui Ma Chi-Chong Lu Department of Chemistry College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityBeijing 100048China Department of Physics Beijing Technology and Business UniversityBeijing 100048China

Extremely small-sized iron oxide nanoparticles(IONPs) are of great interest in magnetic resonance imaging(MRI) due to their biosafety as an alternative to clinical gadolinium(Ⅲ) complexes-based contrast *** when the particle size is less than 10 nm,it has strong diffusion ability and deep penetration distance in tumor *** doping can significantly enhance the T_(1)contrast effect of nanoparticles by regulating the surface exposed ***,the nucleation and growth processes of multi-component synthesis systems are complex and difficult to be accurately controlled,leading to great challenges in the synthesis of ultra-small-sized nanoparticles with different components and ***,extremely smallsized superparamagnetic gadolinium-doped iron oxide nanoparticles(GdIONPs,Gd_(x)Fe_(3-x)O_(4) NPs) with adjustable doping amount and controllable size in the range of 3.5-7.5 nm were synthesized by thermal ***,as-synthesized GdIONPs were surface modified with a highly water-soluble and biocompatible carboxyl-polyethylene glycol-phosphoric acid ligand with high binding ***_(0.65)Fe_(2.35)O_(4) NPs exhibited very high r_(1) relaxivity of 10.6 mmol^(-1)·L·s^(-1) in terms of all metal concentrations and 49.0 mmol^(-1)·L·s^(-1) in terms of gadolinium alone,respectively,3 and 14 times higher than clinical T_(1) contrast agents(Gd-DTPA).GdIONPs can continuously obtain high resolution images of blood vessels,and can be used as an efficient and multifunctional contrast agent for MR T_(1)*** stable and efficient doping strategy provides an easy and effective method to individually optimize the magnetic properties of complex oxides and their relaxation effects for a variety of biomedical applications.

关键词： Iron oxide nanoparticles Small size Magnetic resonance imaging Substitutional doping Gd dopant

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Gestational diabetes mellitus combined with fulminant type 1 diabetes mellitus, four cases of double diabetes: A case report

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World Journal of Clinical Cases 2024年第4期12卷 787-794页

作者： Hui Li yun chai Wei-Hong Guo Yu-Meng Huang Xiao-Na Zhang Wen-Li Feng Qing He Jin Cui Ming Liu Department of Endocrinology and Metabolism Tianjin Medical University General HospitalTianjin 300052China

BACKGROUND Fulminant type 1 diabetes mellitus(FT1DM)that occurs during pregnancy or the perinatal period is known as pregnancy-related FT1DM(PF),always without history of abnormal glucose ***,we present four patients who developed FT1DM during treatment but were first diagnosed with gestational diabetes mellitus(GDM).CASE SUMMARY The clinical data of four patients with GDM combined with FT1DM admitted to our hospital between July 2018 and April 2021 were collected,and the patients and their infants were followed *** patients were diagnosed with GDM during the second trimester and were *** blood glucose level elevated suddenly during the third trimester and then were diagnosed with *** patients had an insulin allergy,and two had symptoms of upper respiratory tract infection before *** patient developed ketoacidosis,and three developed *** patients had cesarean section deliveries,and two had vaginal *** growth and development of the infants were normal.C-peptide levels were lower than those at onset,suggesting progressive impairment of islet *** frequencies of the DRB109:01,DQB103:03,DQA103:02,DPA101:03,DPA102:02,DPB105:01,DRB401:03,G 01:01,and G 01:04 human leukocyte antigen(HLA)-G alleles were high in the present *** In comparison with pregnancy-associated FT1DM(PF),patients with GDM combined with FT1DM had an older age of onset,higher body mass index,slower onset,fewer prodromal symptoms,and less *** pathogenesis may be due to various factors affecting the already fragileβ-cells of GDM patients with genetically susceptible class II HLA *** speculate that GDM combined with FT1DM during pregnancy,referred to as“double diabetes,”is a subtype of PF with its own unique characteristics that should be investigated further.

关键词： Fulminant type 1 diabetes mellitus Gestational diabetes mellitus Pregnancy-related fulminant type 1 diabetes mellitus Double diabetes Case report

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WATuning:A Workload-Aware Tuning System with Attention-Based Deep Reinforcement Learning

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Journal of Computer Science & Technology 2021年第4期36卷 741-761页

作者： Jia-Ke Ge Yan-Feng chai yun-Peng chai Key Laboratory of Data Engineering and Knowledge Engineering of Ministry of Education Renmin University of China Beijing 100872China School of Information Renmin University of ChinaBeijing 100872China College of Computer Science and Technology Taiyuan University of Science and TechnologyTaiyuan 030027China

Configuration tuning is essential to optimize the performance of systems(e.g.,databases,key-value stores).High performance usually indicates high throughput and low *** present,most of the tuning tasks of systems are performed artificially(e.g.,by database administrators),but it is hard for them to achieve high performance through tuning in various types of systems and in various *** recent years,there have been some studies on tuning traditional database systems,but all these methods have some *** this article,we put forward a tuning system based on attention-based deep reinforcement learning named WATuning,which can adapt to the changes of workload characteristics and optimize the system performance efficiently and ***,we design the core algorithm named ATT-Tune for WATuning to achieve the tuning task of *** algorithm uses workload characteristics to generate a weight matrix and acts on the internal metrics of systems,and then ATT-Tune uses the internal metrics with weight values assigned to select the appropriate ***,WATuning can generate multiple instance models according to the change of the workload so that it can complete targeted recommendation services for different types of ***,WATuning can also dynamically fine-tune itself according to the constantly changing workload in practical applications so that it can better fit to the actual environment to make *** experimental results show that the throughput and the latency of WATuning are improved by 52.6%and decreased by 31%,respectively,compared with the throughput and the latency of CDBTune which is an existing optimal tuning method.

关键词： attention mechanism auto-tuning system reinforcement learning(RL) workload-aware

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孕妇血清内脂素水平与糖代谢异常严重程度的相关性分析

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中国妇幼保健 2024年第10期39卷 1747-1750页

作者：文彩荷喻晴柴芸杭州市妇产科医院产科浙江杭州310001

目的通过检测孕妇口服葡萄糖耐量试验(OGTT)血糖、内脂素及胰岛素水平,了解血清内脂素水平与孕妇糖代谢异常严重程度的关系。方法选取2020年6月—2021年5月在杭州市妇产科医院门诊常规产检并有分娩意向的孕24~28周的孕妇共66例,检测... 详细信息

目的通过检测孕妇口服葡萄糖耐量试验(OGTT)血糖、内脂素及胰岛素水平,了解血清内脂素水平与孕妇糖代谢异常严重程度的关系。方法选取2020年6月—2021年5月在杭州市妇产科医院门诊常规产检并有分娩意向的孕24~28周的孕妇共66例,检测空腹和服糖后1 h、2 h血糖、内脂素及胰岛素水平。按照孕妇血糖结果分为4组:血糖均正常的为对照组(22例),血糖升高1次的为GDM1组(14例),血糖升高2次的为GDM2组(22例),血糖升高3次的为GDM3组(8例)。比较组间孕妇的临床资料、血糖、内脂素及胰岛素水平,采用Pearson相关性检验分析内脂素与血糖、胰岛素水平及胰岛素拮抗指数(HOMA-IR)的相关性。结果 4组孕妇的HOMA-IR、空腹血糖(G0)、服糖后1 h血糖(G1)、服糖后2 h血糖(G2)、空腹内脂素(V0)、服糖后1 h内脂素(V1)、服糖后2 h内脂素(V2)、空腹胰岛素(I0)、服糖后1 h胰岛素(I1)及服糖后2 h胰岛素(I2)比较差异均有统计学意义(均P0.05);V2与G2呈正相关,与I2呈负相关(r=0.275,-0.252,均P<0.05)。结论 GDM患者糖代谢异常严重程度可能与空腹内脂素水平相关,临床可通过测定空腹内脂素水平来评估GDM患者糖代谢异常严重程度。

关键词：妊娠期糖尿病内脂素口服葡萄糖耐量试验血糖胰岛素

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Distributed UAV Formation Control with Two-Hop Relay Protocol

Distributed UAV Formation Control with Two-Hop Relay Protoco...

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第36届中国控制会议

作者： yun chai Ke-cai Cao Nanjing University of Posts and Telecommunications Nanjing University of Aeronautics and Astronautics

ISBN: (纸本)9781538629185

Distributed formation control of Unmanned Aerial Vehicle（UAV） in three-dimensional space is discussed in this *** order to achieve a faster consensus seeking,a consensus-based cooperative formation control strategy with the tow-hop relay protocol is ***’s nonlinear kinetic model is transformed into linear model by feedback linearization and the original control inputs are also transformed into the accelerations in inertial coordinate system ’s three *** consensus protocol in this paper can increase the algebraic connectivity without physically adding or changing any edges in the *** consensus based UAV formation control strategy makes UAVs can build up stable and desired formation and move at expected *** conditions under which second-order consensus can be reached are proposed.A multi-vehicle formation control example is shown in simulation as an illustrative example.

关键词： UAV Second-order consensus Convergence speed Two-hop relay protocol Formation control

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Endurable SSD-Based Read Cache for Improving the Performance of Selective Restore from Deduplication Systems

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Journal of Computer Science & Technology 2018年第1期33卷 58-78页

作者： Jian Liu yun-Peng chai Xiao Qin Yao-Hong Liu Division of Computer Science and Engineering Louisiana State University Baton Rouge LA 70803 U.S.A. Key Laboratory of Data Engineering and Knowledge Engineering Ministry of Education of China Beijing 100872 China School of Information Renmin University of China Beijing 100872 China Shelby Center for Engineering Technology Department of Computer Science and Software Engineering Samuel Ginn College of Engineering Auburn University Auburn AL 368~9-53~7 U.S.A.

Deduplication has been commonly used in both enterprise storage systems and cloud storage. To overcome the performance challenge for the selective restore operations of deduplication systems, solid-state-drive-based （i.e., SSD-based） re^d cache cm, be deployed for speeding up by caching popular restore contents dynamically. Unfortunately, frequent data updates induced by classical cache schemes （e.g., LRU and LFU） significantly shorten SSDs＇ lifetime while slowing down I/O processes in SSDs. To address this problem, we propose a new solution -- LOP-Cache to greatly improve tile write durability of SSDs as well as I/O performance by enlarging the proportion of long-term popular （LOP） data among data written into SSD-based cache. LOP-Cache keeps LOP data in the SSD cache for a long time period to decrease the number of cache replacements. Furthermore, it prevents unpopular or unnecessary data in deduplication containers from being written into the SSD cache. We implemented LOP-Cache in a prototype deduplication system to evaluate its pertbrmance. Our experimental results indicate that LOP-Cache shortens the latency of selective restore by an average of 37.3% at the cost of a small SSD-based cache with only 5.56% capacity of the deduplicated data. Importantly, LOP-Cache improves SSDs＇ lifetime by a factor of 9.77. The evidence shows that LOP-Cache offers a cost-efficient SSD-based read cache solution to boost performance of selective restore for deduplication systems.

关键词： data deduplication solid state drive (SSD) flash cache endurance

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双膜日光温室土壤-空气换热器土壤温度试验研究

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科学技术与工程 2024年第5期24卷 1930-1936页

作者：魏巍杨林艳柴云娥顾金寿刘孝敏刘叶瑞甘肃自然能源研究所兰州730046 甘肃省低碳建筑工程技术研究中心兰州730046

为了解双膜日光温室土壤-空气换热器对周围土壤及根系的影响,对兰州市一个新建双膜日光温室和单膜普通温室进行测试对比。结果表明:阴天时,土壤温度受换热器影响较大;晴天时,土壤温度受太阳辐射影响较大。双膜日光温室的浅层土壤温度高... 详细信息

为了解双膜日光温室土壤-空气换热器对周围土壤及根系的影响,对兰州市一个新建双膜日光温室和单膜普通温室进行测试对比。结果表明:阴天时,土壤温度受换热器影响较大;晴天时,土壤温度受太阳辐射影响较大。双膜日光温室的浅层土壤温度高于单膜普通温室,单膜普通温室土壤表面温度的波动幅度明显强于双膜日光温室。双膜日光温室能有效提高土壤温度,并且双膜温室的室内热环境稳定性强于单膜温室。

关键词：双膜日光温室土壤-空气换热器土壤温度波动幅度

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含高比例分布式光伏的主配网紧急切负荷策略研究

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电网与清洁能源 2024年第1期40卷 40-51,61页

作者：王振浩王正韬梁志峰柴赟于若英边竞现代电力系统仿真控制与绿色电能新技术教育部重点实验室(东北电力大学) 吉林吉林132012 国家电网有限公司国家电力调度控制中心北京100031 国网江苏省电力有限公司江苏南京210024 中国电力科学研究院有限公司南京分院江苏南京210003

随着新型电力系统接入高比例分布式光伏和不同等级的重要负荷,传统紧急切负荷策略对于日益紧密的互联电网适应性较差,导致分布式光伏或重要负荷脱网,随即引起更严重的连锁故障。提出了一种含高比例分布式光伏的主配网紧急切负荷策略。... 详细信息

随着新型电力系统接入高比例分布式光伏和不同等级的重要负荷,传统紧急切负荷策略对于日益紧密的互联电网适应性较差,导致分布式光伏或重要负荷脱网,随即引起更严重的连锁故障。提出了一种含高比例分布式光伏的主配网紧急切负荷策略。分析提取主配电网极端运行参数,通过风险评估构建紧急场景集;在主网层提出基于事件和响应的双驱动切负荷策略,通过主网切负荷优化模型求取紧急场景各配网切负荷量,并存入离线数据库用于事件驱动模块,基于离线数据库构建的随机森林模型用于响应驱动模块;在配网层通过分析各馈线重要度,以切负荷后果严重度最小为目标构建配电网最优切负荷模型,将可中断负荷参与减载作为切负荷的第一轮次,求取切负荷量和切负荷地点;在含高比例分布式光伏的105节点系统中进行仿真分析,与另2种切负荷策略对比,验证了所提策略能够使电网风险有效下降的同时降低分布式光伏和重要负荷脱网对系统的影响。

关键词：风险评估随机森林分层分区切负荷可中断负荷切负荷后果严重度

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基于SIR模型的最小支配集溯源研究

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计算机与数字工程 2024年第7期52卷 1950-1954页

作者：赵佳楠王友国柴允南京邮电大学通信与信息工程学院南京210003 南京邮电大学理学院南京210046

论文研究了在SIR模型基础上,通过有限的观测者定位谣言爆发来源的估计问题。出于对观测节点遍历性的考虑,论文利用贪婪算法求取图的最小支配集作为观测节点,通过观测节点记录感染信息,然后利用皮尔逊相关系数,计算每个候选节点到观测节... 详细信息

论文研究了在SIR模型基础上,通过有限的观测者定位谣言爆发来源的估计问题。出于对观测节点遍历性的考虑,论文利用贪婪算法求取图的最小支配集作为观测节点,通过观测节点记录感染信息,然后利用皮尔逊相关系数,计算每个候选节点到观测节点的最短路径和其感染时间序列之间的相关性,相关性最高的判定为源节点。最后在仿真实验中验证了算法的准确性。

关键词：传染病模型溯源最小支配集观测节点

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MacroTrend: A Write-Efficient Cache Algorithm for NVM-Based Read Cache

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Journal of Computer Science & Technology 2022年第1期37卷 207-230页

作者： Ning Bao yun-Peng chai Xiao Qin Chuan-Wen Wang Key Laboratory of Data Engineering and Knowledge Engineering Ministry of EducationBeijing 100872China School of Information Renmin University of ChinaBeijing 100872China Samuel Ginn College of Engineering Auburn UniversityAlabama 36830U.S.A.

The future storage systems are expected to contain a wide variety of storage media and layers due to the rapid development of NVM(non-volatile memory)*** NVM-based read caches,many kinds of NVM devices cannot stand frequent data updates due to limited write endurance or high energy consumption of ***,traditional cache algorithms have to update cached blocks frequently because it is difficult for them to predict long-term popularity according to such limited information about data blocks,such as only a single value or a queue that reflects frequency or *** this paper,we propose a new MacroTrend(macroscopic trend)prediction method to discover long-term hot blocks through blocks'macro trends illustrated by their access count *** then a new cache replacement algorithm is designed based on the MacroTrend prediction to greatly reduce the write amount while improving the hit *** conduct extensive experiments driven by a series of real-world traces and find that compared with LRU,MacroTrend can reduce the write amounts of NVM cache devices significantly with similar hit ratios,leading to longer NVM lifetime or less energy consumption.

关键词： non-volatile memory(NVM) solid state disk(SSD) cache endurance

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