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Signal Transduction and Targeted Therapy 2021年第9期6卷 2631-2633页

作者： Chen Hua Qinhai Ma yun zhu Shuai Xia Zezhong Liu Lin Li Lu Lu Nanshan Zhong Shuwen Liu Zifeng Yang Shibo Jiang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghaiChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijingChina State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouChina Guangzhou Laboratory Bio-IslandGuangzhouChina

Dear Editor,Fan et al.have shown that whey protein,such as that found in human,bovine,and goat milk,could effectively inhibit SARS-CoV-2 infection,but they did not identify the components in whey protein having this activity.1 Since p-lactoglobulin(P-LG)is the main component of whey protein,we herein tested the anti-SARS-CoV-2 activity of p-LG and 3-hydroxyphthalic anhydride(3HP)-modified P-LG(3HP-P-LG),an active component in anti-human papillomavirus(HPV)biological dressing(JB01-BD)that has been used in clinics since 2013 to block cervical infection of HPV.

关键词： infection nasal

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中医外治银屑病研究进展

光明中医 2024年第6期39卷 1236-1240页

作者：包海兰朱赟徐伟内蒙古自治区人民医院中西医结合科内蒙古呼和浩特010010

银屑病是一种慢性炎症性皮肤病,因其病因和发病机制未完全明确,属于皮肤科难治性疾病之一。中医药对银屑病的防治具有重要意义,在治疗银屑病方面具有不良反应小,经济实惠等诸多优势,而中医外治法是中医药治疗银屑病的特色疗法之一,通过... 详细信息

银屑病是一种慢性炎症性皮肤病,因其病因和发病机制未完全明确,属于皮肤科难治性疾病之一。中医药对银屑病的防治具有重要意义,在治疗银屑病方面具有不良反应小,经济实惠等诸多优势,而中医外治法是中医药治疗银屑病的特色疗法之一,通过多种途径直接作用于体表,具有操作简便、全身不良反应小等特点,此文将从外涂法、药浴法等方面综述银屑病的治疗进展。

关键词：白疕银屑病中医外治法综述

行为转变理论干预对冠心病患者动脉狭窄程度、体征及生活方式和质量影响

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心血管康复医学杂志 2024年第2期33卷 175-179页

作者：魏洪佘会朱云六安市中医院心血管内科安徽六安237000 六安市中医院护理部安徽六安237000

目的:探索基于行为转变理论的干预措施对冠心病患者动脉狭窄程度、症状、生命体征、生活方式和生活质量的影响。方法:选择2019年10月~2022年12月我院收治的126例冠心病患者并随机分为对照组、研究组,每组63例。所有患者均给予基础护理,... 详细信息

目的:探索基于行为转变理论的干预措施对冠心病患者动脉狭窄程度、症状、生命体征、生活方式和生活质量的影响。方法:选择2019年10月~2022年12月我院收治的126例冠心病患者并随机分为对照组、研究组,每组63例。所有患者均给予基础护理,包括用药指导、心理干预等,研究组联合应用基于行为转变理论的干预措施,两组均持续干预3个月。比较两组患者干预前后的动脉狭窄程度、临床症状、体征、生活方式和生活质量。结果:与对照组比较,干预后研究组左室射血分数(LVEF)[(46.84±2.09)%比(52.87±2.44)%]、健康促进生活方式量表Ⅱ(HPLP-Ⅱ)[(105.73±8.79)分比(133.05±9.87)分]、生活质量综合评定问卷-74(GQOLI-74)[(179.72±4.28)分比(195.02±4.11)分]与西雅图心绞痛量表(SAQ)[(71.16±4.35)分比(88.68±10.82)分]评分均显著升高,左室舒张末容积(LVEDV)[(72.50±3.25)ml比(66.81±3.70)ml]、左室舒张末内径(LVEDd)[(50.76±2.81)mm比(43.48±2.27)mm]和Gensini积分[(28.39±1.64)分比(21.41±2.05)分]均显著降低,P均=0.001。结论:基于行为转变理论干预能够显著改善冠心病患者动脉狭窄程度、临床症状和体征,促进患者健康生活方式的养成,提高生活质量。

关键词：冠状动脉疾病护理心室功能,左生活质量

Comparison between modified lateral supraorbital approach and pterional approach in the surgical treatment of middle cerebral artery aneurysms

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Chinese Neurosurgical Journal 2018年第1期4卷 1-6页

作者： Zhouqing Chen Xiaoou Sun Tai Lu Zhengyang Lu Ming Jiang Chongshun Zhao Wanchun You yun zhu Zhong Wang Department of Neurosurgery The First Affiliated Hospital of Soochow University188 Shizi StreetSuzhouJiangsu Province 215006China

Background:The Middle cerebral artery (MCA) aneurysm is a common type of craniocerebral aneurysm that is prone to rupture and high mortality. The classic surgical approaches are the Pterional approach and the Lateral Supraorbital (LSO) approach, but there are shortcomings. Methods:This study retrospectively analyzed clinical and imaging data from 181 patients with MCA aneurysm clipping in the Department of Neurosurgery, First Affiliated Hospital of Soochow University between 2011 and 2017. Statistical analysis using parametric and nonparametric tests showed that P values below 0.05 were considered statistically significant. Results: The preoperative GCS score (P=0.003), Hunt-Hess scale (P < 0.001) and the operating habits of the surgeon (P < 0.001) affected the surgeon to choose a surgical approach. The choice of two surgical methods on the operation time (P < 0.001), skin incision (P < 0.001), complications (P=0.026), tracheotomy (P=0.014), prognosis (P=0.002) were significantly different. Different surgical approaches (P=0.002), Hunt-Hess scale (P <0.001), GCS scale (P < 0.001), GCS sorse (P < 0.001), skin incision (P=0.031) and complications (P < 0.001) are closely related to the prognosis of patients. Conclusions: Modified LSO approach provides another surgical approach for MCA aneurysm clipping, while avoiding the drawbacks of the LSO approach in the clipping of MCA distal aneurysm.

关键词： Aneurysm clipping Middle cerebral artery aneurysms Modified lateral supraorbital approach Lateral supraorbital approach Pterional approach

不同物理预防方法对颅脑损伤病人术后凝血功能、下肢深静脉血栓形成和预后的影响

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循证护理 2024年第11期10卷 2025-2029页

作者：朱贇朱柳花蔡凤婷陈黎芸上海交通大学医学院附属仁济医院上海200127

目的:分析比较不同物理预防方法,包括间歇充气加压(IPC)、逐级加压弹力袜(GCS)和IPC+GCS,对颅脑损伤病人术后凝血功能、下肢深静脉血栓(DVT)形成和预后的影响。方法:选取2021年12月—2022年12月我院收治的90例颅脑损伤病人,随机分为IPC... 详细信息

目的:分析比较不同物理预防方法,包括间歇充气加压(IPC)、逐级加压弹力袜(GCS)和IPC+GCS,对颅脑损伤病人术后凝血功能、下肢深静脉血栓(DVT)形成和预后的影响。方法:选取2021年12月—2022年12月我院收治的90例颅脑损伤病人,随机分为IPC组、GCS组和IPC+GCS组,各30例。于术前24 h和术后24 h、7 d时,测定凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和D-二聚体(D-D)水平。于术前24 h和术后12 h、24 h时,利用彩色多普勒超声技术检测下肢股静脉管径和血液流速。于术前24 h和术后24 h时,采用全自动血液黏度分析仪,检测全血高切黏度、全血低切黏度和红细胞聚集指数(EAI)。于术后3、7 d时,统计下肢DVT发生率。结果:术后24 h、7 d时,IPC+GCS组PT、APTT水平高于IPC组和GCS组(P0.05)。术后12、24 h时,IPC+GCS组下肢股静脉管径和血液流速大于IPC组和GCS组(P0.05);术后7 d,IPC+GCS组下肢DVT发生率低于IPC组和GCS组(P0.05)。结论:IPC与GCS联合应用较单独应用IPC或GCS更能有效改善颅脑损伤病人术后凝血功能,提高下肢静脉血液流动性,降低下肢血液黏稠度,减少下肢DVT的发生,有利于病人预后。

关键词：物理预防颅脑损伤凝血功能下肢深静脉血栓预后

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The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

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Signal Transduction and Targeted Therapy 2020年第1期5卷 1630-1632页

作者： Shuai Xia Qiaoshuai Lan Shan Su Xinling Wang Wei Xu Zezhong Liu yun zhu Qian Wang Lu Lu Shibo Jiang Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesFudan University130 Dong An RoadShanghai 200032China National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

Dear Editor,The rapid spread of SARS-CoV-2(also known as 2019-nCoV and HCoV-191),a novel lineage B betacoronavirus(βCoV),has caused a global pandemic of coronavirus disease(COVID-19).It has been speculated that RRAR,a unique furin-like cleavage site(FCS)in the spike protein(S),which is absent in other lineage BβCoVs,such as SARS-CoV,is responsible for its high infectivity and transmissibility.

关键词： cleavage absence trypsin

江西北武夷地区老虎洞铅锌矿床成因研究——硫化物原位微量元素及硫同位素证据

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岩石矿物学杂志 2024年第4期43卷 956-972页

作者：范诗妮朱云李桂贤石得凤贾梦洁湖南科技大学地球科学与空间信息工程学院湖南湘潭411201 江西省地质局第十地质大队江西鹰潭335000

江西北武夷地区处于钦杭成矿带上的萍乡-广丰结合带南侧,多期构造事件和岩浆活动在该区形成了复杂的地质构造格局,铜铅锌多金属矿床成矿潜力巨大。但由于江西北武夷地区铅锌矿床普遍规模较小,研究程度不足,缺乏物质来源、成矿条件、矿... 详细信息

江西北武夷地区处于钦杭成矿带上的萍乡-广丰结合带南侧,多期构造事件和岩浆活动在该区形成了复杂的地质构造格局,铜铅锌多金属矿床成矿潜力巨大。但由于江西北武夷地区铅锌矿床普遍规模较小,研究程度不足,缺乏物质来源、成矿条件、矿床成因等问题的深入认识。本文以铅山老虎洞铅锌矿床为研究对象,通过原位主量、微量元素和硫同位素分析技术,揭示主要硫化物的主量、微量元素和硫同位素组成特征,以此探讨成矿温度、物质来源和矿床成因。EPMA测试显示闪锌矿内Fe含量(质量分数)在7.58%~8.27%之间,结合LA-ICP-MS微量元素测试结果,闪锌矿富集Fe、Mn、Cu、Cd元素,Co、Ni、Ag、In、Pb元素含量次之,Ga、Ge、As、Se、Sn、Bi元素含量相对较低。其中,Mn、Fe、Cd、In、Co主要以类质同象的形式赋存于闪锌矿中,Cu、Ag、Pb以类质同象和显微包体两种形式赋存于闪锌矿中。闪锌矿的Fe元素含量、Ga/In值(0.001~0.129)、Zn/Cd值(262~312)及相关公式计算结果均指示闪锌矿形成于中高温条件(327~337℃)。闪锌矿和黄铁矿的δ34S值分别集中在2.07‰~4.16‰和0.82‰~3.19‰之间,指示矿床硫源为岩浆硫。与国内多个典型矿床相比,老虎洞铅锌矿床内闪锌矿微量元素组成与典型矽卡岩型矿床的闪锌矿相吻合。老虎洞铅锌矿床与葛仙山花岗岩杂岩体具有密切的成因联系,矿区附近黑云母花岗斑岩和二长花岗岩的成岩时代(153.9±2.7 Ma和162.8±1.2 Ma)可代表成矿时间的下限,与北武夷地区主要多金属铅锌矿床成矿时代范围一致。

关键词：闪锌矿微量元素硫同位素原位分析矽卡岩型矿床老虎洞铅锌矿床江西北武夷地区

Development of an integrated policy making tool for assessing air quality and human health benefits of air pollution control

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Frontiers of Environmental Science & Engineering 2015年第6期9卷 1056-1065页

作者： Xuezhen QIU yun zhu Carey JANG Che-Jen LIN Shuxiao WANG Joshua FU Junping XIE Jiandong WANG Dian DING Shicheng LONG Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control College of Environment and Energy South China University of Technology Guangzhou Higher Education Mega Center Guangzhou 510006 China USEPA/Office of Air Quality Planning & Standards RTP NC 27711 USA Department of Civil Engineering Lamar University Beaumont TX 77710-0024 USA State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University Beijing 100084 China Department of Civil & Environmental Engineering University of Tennessee Knoxville TN 37996-2010 USA

Efficient air quality management is critical to protect public health from the adverse impacts of air pollution. To evaluate the effectiveness of air pollution control strategies, the US Environmental Protection Agency （US EPA） has developed the Software for Model Attainment Test-Community Edition （SMAT-CE） to assess the air quality attainment of emission reductions, and the Environmental Benefits Mapping and Analysis Program- Community Edition （BenMAP-CE） to evaluate the health and economic benefits of air quality improvement respectively. Since scientific decision-making requires timely and coherent information, developing the linkage between SMAT-CE and BenMAP-CE into an integrated assessment platform is desirable. To address this need, a new module linking SMAT-CE to BenMAP-CE has been developed and tested. The new module streamlines the assessment of air quality and human health benefits for a proposed air pollution control strategy. It also implements an optimized data gridding algorithm which significantly enhances the computational efficiency without compro- mising accuracy. The performance of the integrated software package is demonstrated through a case study that evaluates the air quality and associated economic benefits of a national-level control strategy of PM2.5. The results of the case study show that the proposed emission reduction reduces the number of nonattainment sites from 379 to 25 based on the US National Ambient Air Quality Standards, leading to more than USS334billion ofeconomic benefits annually from improved public health. The integration of the science-based software tools in this study enhances the efficiency of developing effective and optimized emission control strategies for policy makers.

关键词： air quality assessment human health benefit,economic benefit air quality attainment assessment airpollution control strategy decision support system

Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury

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Science Bulletin 2017年第11期62卷 748-751页

作者： Lanzhi He Ping Yin Yakun Meng Jinfa Tang Tingting He Ming Niu Yuming Guo yun zhu Jing Jing Chunyu Li Zhijie Ma Jiabo Wang Zhaofang Bai Xiaohe Xiao China Military Institute of Chinese Medicine 302 Military Hospital Beijing 100039 China School of Pharmacy Hunan University of Traditional Chinese Medicine Changsha 410208 China Integrative Medical Center 302 Military Hospital Beijing 100039 China

Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ-

关键词：肝损伤二苯乙烯苷增效机制异性反式免疫临床病例毒性剂量

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水环境综合整治PPP项目绩效评价研究

水利技术监督 2024年第7期 44-48页

作者：祝韻楚心茹陈冲贵州黔元会计师事务所贵州贵阳550000 北京联合大学北京100101

为推动水环境综合整治PPP项目的可持续发展和绩效评价的顺利开展,文章从产出、效果、管理3个角度,项目公司(社会方)和实施机构(政府方)2个对象出发,分别构建不同评价指标,同时运用该指标以某水环境整治项目为例进行绩效评价分析。结果表... 详细信息

为推动水环境综合整治PPP项目的可持续发展和绩效评价的顺利开展,文章从产出、效果、管理3个角度,项目公司(社会方)和实施机构(政府方)2个对象出发,分别构建不同评价指标,同时运用该指标以某水环境整治项目为例进行绩效评价分析。结果表明,PPP项目绩效评价在协调管理、培训立法、指标设立、监管机制等方面都有进一步发展的空间。深入研究水环境综合整治PPP项目绩效评价,对我国PPP项目管理实践具有重要意义。

关键词： PPP项目绩效评价水环境整治