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Chinese Journal of Integrative Medicine 2022年第2期28卷 138-144页

作者： WEI Jian-xiang LU Zhi-qiang FENG Guan-zhong zhu yun-xia School of Management Nanjing University of Posts and TelecommunicationsNanjing(210003)China School of Internet of Things Nanjing University of Posts and TelecommunicationsNanjing(210003)China

Objective:To compare the safety differences between Chinese medicine(CM)and Western medicine(WM)based on Chinese Spontaneous Reporting Database(CSRD).Methods:Reports of adverse events(AEs)caused by CM and WM in the CSRD between 2010 and 2011 were selected.The following assessment indicators were constructed:the proportion of serious AEs(PSE),the average number of AEs(ANA),and the coverage rate of AEs(CRA).Further comparisons were also conducted,including the drugs with the most reported serious AEs,the AEs with the biggest report number,and the 5 serious AEs of interest(including death,anaphylactic shock,coma,dyspnea and abnormal liver function).Results:The PSE,ANA and CRA of WM were 1.09,8.23 and 2.35 times higher than those of CM,respectively.The top 10 drugs with the most serious AEs were mainly injections for CM and antibiotics for WM.The AEs with the most reports were rash,pruritus,nausea,dizziness and vomiting for both CM and WM.The proportions of CM and WM in anaphylactic shock and coma were similar.For abnormal liver function and death,the proportions of WM were 5.47 and 3.00 times higher than those of CM,respectively.Conclusion:Based on CSRD,CM was safer than WM at the average level from the perspective of adverse drug reactions.

关键词： Chinese medicine Western medicine data analysis adverse drug reaction drug safety

Clinical and laboratory features,treatment,and outcomes of macrophage activation syndrome in 80 children:a multi-center study in China

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World Journal of Pediatrics 2020年第1期16卷 89-98页

作者： Li-Xia Zou yun zhu Li Sun Hui-Hui Ma Si-Rui Yang Hua-Song Zeng Ji-Hong Xiao Hai-Guo Yu Li Guo Yi-Ping Xu Mei-Ping Lu Department of Rheumatology Immunology and Allergy Children's HospitalZhejiang University School of Medicine57 Zhugan LaneHangzhou 310003China Department of Nephrology and Immunology Children's Hospital of Soochow University92 Zhongnan StreetSuzhou 215003China Department of Rheumatology Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China Department of Rheumatology and Immunology Children's Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Department of Pediatric Rheumatology and Allergy The First Hospital of Jilin University71 Xinming StreetChangchun 130021China Pediatric Allergy Immunology and Rheumatology DepartmentGuangzhou Children's HospitalGuangzhou Women and Children's Medical CenterGuangzhou Medical University318 Renminzhong RoadGuangzhou 510120China Department of Pediatric The First Affiliated Hospital of Xiamen University55 Zhenhai RoadXiamen 361003China

Background Macrophage activation syndrome(MAS)is a major cause of morbidity and mortality in pediatric rheumatology.We aimed to further understand the clinical features,treatment,and outcome of MAS in China.Methods A multi-center cohort study was performed in seven hospitals in China from 2012 to 2018.Eighty patients with MAS were enrolled,including 53 cases with systemic juvenile idiopathic arthritis(SJIA-MAS),10 cases of Kawasaki disease(KD-MAS),and 17 cases of connective tissue disease(CTD-MAS).The clinical and laboratory data were collected before(pre-),at onset,and during full-blown stages of MAS.We compared the data among the SJIA-MAS,KD-MAS,and CTD-MAS subjects.Results 51.2%of patients developed MAS when the underlying disease was first diagnosed.In patients with SJIA,22.6%(12/53)were found to have hypotension before the onset of SJIA-MAS.These patients were also found to have significantly increased aspartate aminotransferase(AST)and lactate dehydrogenase(LDH),as well as decreased albumin(P<0.05),but no difference in alanine aminotransferase,ferdtin,and ratio of ferritin/erythrocyte sedimentation rate(ESR)at onset of MAS when compared to pre-MAS stages of the disease.In addition,ferritin and ratio of ferritin/ESR were significantly elevated in patients at full-blown stages of SJIA-MAS compared to pre-MAS stage.Significantly increased ferritin and ratio of ferritin/ESR were also observed in patients with SJIA compared to in KD and CTD.Receiver-operating characteristic analysis showed that 12,217.5μg/L of ferritin and 267.5 of ferritin/ESR ratio had sensitivity(80.0%and 90.5%)and specificity(88.2%and 86.7%),respectively,for predicting full-blown SJIA-MAS.The majority of the patients received corticosteroids(79/80),while biologic agents were used in 12.5%(10/80)of cases.Tocilizumab was the most commonly selected biologic agent.The overall mortality rate was 7.5%.Conclusions About half of MAS occurred when the underlying autoimmune diseases(SJIA,KD,and CTD)were first diagnosed.Hypotension could be an importan

关键词： Connective tissue disease Kawasaki disease Macrophage activation syndrome Systemic juvenile idiopathic arthritis

基于Edem-RecurDyn联合仿真的火车皮厢底冻黏浮煤清扫机构性能优化分析

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机械强度 2024年第3期46卷 626-635页

作者：谢苗李思遥刘怡聂仁东张鸿宇朱昀刘东旭辽宁工程技术大学机械工程学院阜新123000

火车皮作为煤炭运输的主要设备之一,其运输效率一直是煤炭运输行业的关注重点,在北方地区冬季低温条件下,影响运输效率的主要原因是煤炭中所含的水分与凹凸不平的车厢内表面形成黏附,逐渐由车厢表层向煤炭内部扩散,最终产生冻车现象导... 详细信息

火车皮作为煤炭运输的主要设备之一,其运输效率一直是煤炭运输行业的关注重点,在北方地区冬季低温条件下,影响运输效率的主要原因是煤炭中所含的水分与凹凸不平的车厢内表面形成黏附,逐渐由车厢表层向煤炭内部扩散,最终产生冻车现象导致设备无法继续运行。首先,以不同清扫方式现存的问题为出发点,结合实际的工程项目,设计了一款自动化冻黏浮煤清扫机构并对其清扫性能进行优化研究。其次,通过理论研究分析建立浮煤冻黏颗粒模型,分析清扫过程中滚刀的运动情况并建立力学模型和数学模型。最后,联合多体动力学软件RecurDyn对清扫机构底部清扫滚筒性能进行仿真研究,求解不同滚筒转速、牵引速度和清扫深度对清扫性能的影响规律,通过优化寻求清扫阻力最小、能耗最低的性能参数匹配方案。结果表明,清扫机构的清扫效率受滚筒转速影响较小,随滚筒转速提高,清扫阻力大小在一定范围内波动;随着牵引速度不断提高,清扫阻力先降低后逐渐增高;清扫深度对清扫阻力的影响最大,随清扫深度的增加,其清扫阻力不断增加。根据单因素参数对清扫阻力大小影响规律,取合理范围利用响应面法对其综合影响规律进行仿真试验,得到目标函数后,利用Matlab对其数学模型求解最优解,最终得到滚筒转速为78 r/min、牵引速度为0.05 m/s、清扫深度为100 mm时,清扫机构所受阻力最小、清扫比能耗最低为0.22 kWh/m^(3),清扫机构性能达到最优。

关键词：清扫机构冻黏浮煤联合仿真清扫性能参数优化

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绿色食品枇杷标准化生产技术规范解读

中国标准化 2024年第6期 135-140页

作者：姚佳蓉朱作艺李真江云珠戴芬浙江省农业科学院农产品质量安全与营养研究所

随着人们生活水平的提高,绿色、优质、健康的农产品成为人们的首选。发展绿色食品,是践行绿色发展理念、促进生态文明建设的重要举措。本文概述了绿色食品枇杷生产的园地选择与规划、品种与苗木选择、建园定植、土肥水管理、整形修剪、... 详细信息

随着人们生活水平的提高,绿色、优质、健康的农产品成为人们的首选。发展绿色食品,是践行绿色发展理念、促进生态文明建设的重要举措。本文概述了绿色食品枇杷生产的园地选择与规划、品种与苗木选择、建园定植、土肥水管理、整形修剪、花果管理、病虫草害防治、采收和贮藏及档案记录管理等技术内容的要求,可为浙江省绿色食品枇杷标准化生产提供技术指导。

关键词：绿色食品枇杷标准化病虫害防治

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中国不同地区幽门螺杆菌耐药状况的荟萃分析

世界华人消化杂志 2024年第1期32卷 71-87页

作者：王佳悦周显祝王婵娟许诗涵朱惠云杜奕奇海军军医大学第一附属医院消化内科上海市200433

背景中国幽门螺杆菌(Helicobacter pylori,H.pylori)耐药日趋严重,已成为阻碍经验性治疗方案根除效果的主要原因之一.不同地区耐药谱不完全相同,这对经验性根除方案的推广提出了更大挑战.目的通过Meta分析对中国各地区H.pylori耐药情况... 详细信息

背景中国幽门螺杆菌(Helicobacter pylori,H.pylori)耐药日趋严重,已成为阻碍经验性治疗方案根除效果的主要原因之一.不同地区耐药谱不完全相同,这对经验性根除方案的推广提出了更大挑战.目的通过Meta分析对中国各地区H.pylori耐药情况进行系统评价.方法计算机全面检索PubMed、EMBASE、Web of Science、Sinomed、中国知网、万方数据库和维普数据库,收集有关中国各地区H.pylori耐药情况的横断面研究.由2名研究者独立筛选文献、提取文献数据并评价文献质量.采用R 4.3.1软件对各抗生素及其组合耐药率进行Meta分析.结果共纳入符合条件的文献46篇.全国克拉霉素(clarithromycin,CLA)、左氧氟沙星(levofloxacin,LEV)、阿莫西林(amoxicillin,AMX)、四环素(tetracycline,TET)、甲硝唑(metronidazole,MNZ)和呋喃唑酮(furazolidone,FZD)耐药率分别为27.72%(23.80%-31.82%)、31.23%(26.62%-36.02%)、3.97%(1.96%-6.65%)、4.01%(1.36%-7.98%)、75.30%(70.31%-79.97%)和0.64%(0.13%-1.53%).AMX耐药率在全国不同地区间存在显著差异,华南地区最高(7.15%,95%CI:6.16%-76.10%),华北地区最低(1.86%,95%CI:0.67%-3.64%).华东和华中CLA、华东和西北LEV、华北和西南MNZ耐药均随时间推移均显著增长,而华东地区AMX和TET耐药率显著降低.全国CLA+MNZ、LEV+MNZ和CLA+LEV双重耐药率分别达14.05%、15.12%(11.53%-19.10%)和5.16%(2.87%-8.06%),全国CLA+LEV+MNZ、LEV+MNZ+AMX和CLA+MNZ+AMX三重耐药率分别为10.36%(7.45%-13.69%)、0.92%(0.12%-2.44%)和0.85%(0.20%-1.92%).结论中国H.pylori耐药情况较为严峻,其中MNZ耐药率最高,CLA和LEV耐药次之,且部分多重耐药检出率也已达到较高水平.全国不同地区耐药情况存在一定差异,并大多随时间推移呈升高趋势.

关键词：幽门螺杆菌耐药流行病学 Meta分析

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普通渗透与真空渗透对龙虾尾冻融品质的影响

中国调味品 2024年第4期49卷 18-24页

作者：应天昊朱芸杉王陈杨国胜胡杨华中农业大学食品科学技术学院武汉430070 湖北仁尚仁食品有限公司湖北荆门448000 武汉梁子湖水产品加工有限公司武汉430200

文章以感官评分为指标,优化龙虾尾普通渗透与真空渗透处理时间,得到最优处理条件,并以新鲜虾尾与未处理虾尾为对照组,对最优处理条件下的普通渗透、真空渗透组虾尾理化性能进行表征。优化实验结果显示,虾尾普通渗透最优处理时间为120 m... 详细信息

文章以感官评分为指标,优化龙虾尾普通渗透与真空渗透处理时间,得到最优处理条件,并以新鲜虾尾与未处理虾尾为对照组,对最优处理条件下的普通渗透、真空渗透组虾尾理化性能进行表征。优化实验结果显示,虾尾普通渗透最优处理时间为120 min,真空渗透最优处理时间为60 min,在此条件下得到的虾尾硬度适中、弹性较好、口感较佳。实验结果表明,真空渗透处理虾尾的盐溶性蛋白含量、水分含量、离心持水率和质构最接近新鲜组,优于普通渗透处理组,且二者均优于未处理组,证明复配抗冻剂(1%复合磷酸盐、6%海藻糖、6%山梨糖醇)浸泡对熟制虾尾具有一定抗冻保水效果,且相较于常压渗透处理,真空渗透的效果更佳,该研究结果可为虾尾的常压渗透与真空渗透工艺提供理论指导。

关键词：龙虾尾普通渗透真空渗透抗冻品质变化

A Triphenylphosphonium Functionalized AIE Conjugated Macrocyclic Tetramal&mide for Mitochondrial-targeting Bioimaging

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Chinese Journal of Chemistry 2022年第1期40卷 39-45页

作者： Wei Zeng Mao-Hua Lin Ling-yun zhu Mei-Jin Lin Key Laboratory of Molecule Synthesis and Function Discovery College of ChemistryFuzhou UniversityFuzhouFujian 350116China College of Materials Science and Engineering Fuzhou UniversityFuzhouFujian 350116China

Developme nt of subcellular orga nelle-targeted bioimagi ng probes is of great imports nee in the field of early detection of diseases and exploring the behaviors of subcellular organelles.Herein,we present a triphenyIphosphonium functionalized conjugated macrocyclic tetramaleimide(TPP-CMT)as a mitochondrial-targeting bioimaging probe.The core of TPP-CMT is obtained by connecting two pyrenes and two benzenes through four maleimides.This unique structure endows TPP-CMT with exceptional far red/near-i nfirared aggregati on-induced emissi on(FR/NIR-AIE)characteristics.TPP-CMT is an excelle nt fluoresce nt emitter in most solve nts and eve n in solid states.The qua ntum yield of TPP-CMT was higher tha n 27% when dissolved in comm on middle-polarity orga nic solve nt and this value remained at 28.2% in its solid state.The in troducti on of four triphe ny Iphosph onium on maleimide positions endows TPP-CMT with mitochondrial-targeting ability.Thanks to the FR/NIR-AIE characteristics and the mitochondri-al-targeti ng ability,this well-desig ned fluoresce nt probe was successfully employed for mitochondrial targeti ng bioimaging of HeLa and HepG2 cells.

关键词： Fluorescent probes Macrocycles Photophysics FR/NIR-AIE Mitochondrial-targeting bioimaging

基于改进RRT算法的智慧小区物料小车路径规划

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无人系统技术 2024年第2期7卷 92-100页

作者：蔡浩诸云于明爽殷振宇南京理工大学自动化学院南京210094

针对快速搜索随机树(RRT)算法在物料小车路径规划算法中路径转折点多、路径较长、算法运行速度慢等问题,开展了一种基于改进RRT算法的物料小车路径规划算法研究。首先分析了RRT算法与RRT-C算法的原理与优缺点;然后,提出针对优化目标点... 详细信息

针对快速搜索随机树(RRT)算法在物料小车路径规划算法中路径转折点多、路径较长、算法运行速度慢等问题,开展了一种基于改进RRT算法的物料小车路径规划算法研究。首先分析了RRT算法与RRT-C算法的原理与优缺点;然后,提出针对优化目标点寻找的采样优化策略、步长优化策略以及保证物料小车运行安全的转角约束条件;最后,采用剪枝优化以及圆切角路径平滑策略来优化所得路径以符合物料小车实际运行线路,并将障碍物进行膨胀化处理,进而规避安全性不足的问题。优化后的RRT算法比初始方法在规划时长和路径长度上分别有着40%~60%和15%~30%的提升,证明了所提方法的有效性。基于改进RRT算法的智慧小区物料小车路径规划研究具有重要的理论和应用意义,并对未来智慧小区动态物流管理系统的优化提供了基础。

关键词：路径规划物料小车快速搜索随机树算法采样策略剪枝优化路径平滑

TSR: algorithm of image hole-filling based on three-step repairing

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The Journal of China Universities of Posts and Telecommunications 2022年第5期29卷 83-91页

作者： Li Fucheng Deng Junyong zhu yun Luo Jiaying Ren Han School of Electronic Engineering Xi'an University of Posts and TelecommunicationsXi'an 710121China

In order to solve the hole-filling mismatch problem in virtual view synthesis, a three-step repairing(TSR) algorithm was proposed. Firstly, the image with marked holes is decomposed by the non-subsampled shear wave transform(NSST), which will generate high-/low-frequency sub-images with different resolutions. Then the improved Criminisi algorithm was used to repair the texture information in the high-frequency sub-images, while the improved curvature driven diffusion(CDD) algorithm was used to repair the low-frequency sub-images with the image structure information. Finally, the repaired parts of high-frequency and low-frequency sub-images are synthesized to obtain the final image through inverse NSST. Experiments show that the peak signal-to-noise ratio(PSNR) of the TSR algorithm is improved by an average of 2-3 dB and 1-2 dB compared with the Criminisi algorithm and the nearest neighbor interpolation(NNI) algorithm, respectively.

关键词： virtual view point synthesis hole-filling three-step repairing(TSR) Criminisi algorithm curvature driven diffusions(CDD)algorithm

神经纤维瘤病1型患儿22例临床特点及NF1基因变异分析

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中华皮肤科杂志 2024年第7期57卷 637-644页

作者：高莹王建才朱芸张建昭仪晓立白晋丽瞿宇晋首都儿科研究所附属儿童医院皮肤科北京100020 首都儿科研究所附属儿童医院神经内科北京100020 首都儿科研究所附属儿童医院放射科北京100020 首都儿科研究所北京100020

目的探讨神经纤维瘤病1型患儿的临床特点及NF1基因变异的遗传学特点。方法收集并分析2022年1月至2023年9月就诊于首都儿科研究所附属儿童医院皮肤科门诊的22例神经纤维瘤病1型患儿的临床资料,采用二代测序方法对先证者进行致病基因检测... 详细信息

目的探讨神经纤维瘤病1型患儿的临床特点及NF1基因变异的遗传学特点。方法收集并分析2022年1月至2023年9月就诊于首都儿科研究所附属儿童医院皮肤科门诊的22例神经纤维瘤病1型患儿的临床资料,采用二代测序方法对先证者进行致病基因检测,对家系成员应用Sanger测序进行基因突变位点验证,利用同源建模软件对蛋白三维结构进行预测,分析基因突变特点。结果22例神经纤维瘤病1型患儿中男14例,女8例,就诊年龄3个月至12岁。22例患儿均有多发的牛奶咖啡斑,发病年龄为出生时至2岁。9例伴腋窝或腹股沟区雀斑,2例伴皮肤神经纤维瘤,2例伴幼年黄色肉芽肿,2例伴学习障碍,伴虹膜lisch结节、中枢性性早熟和脊柱侧弯各1例,5例头颅磁共振成像显示有神经纤维瘤表现。22例患儿中共检测到5种类型的NF1基因变异,1例为NF1基因整体杂合缺失,4例为错义变异(其中1例携带2种错义变异),8例为移码变异,6例为无义变异,3例为经典剪接位点变异。其中有7种为未报道变异:c.758T>A(p.Val253Glu)、c.2360dupC(p.Thr788Asnfs*5)、c.5513T>G(p.Leu1838*)、c.2774dupT(p.Leu925Phefs*11)、c.6894dupT(p.Val2299Cysfs*7)、c.6882_6883delCT(p.Phe2295Leufs*10)和c.6448A>T(p.Lys2150*);6种为移码变异或者无义变异导致蛋白表达截短,严重影响蛋白功能;而错义变异c.758T>A(p.Val253Glu)经蛋白三维结构预测分析显示,不确定是否影响蛋白构象。2例患儿的NF1变异遗传自母亲;1例同时携带2个NF1错义变异,其中1个可能致病性变异为自发变异,另1个致病性不明的变异遗传自表型正常的患儿父亲;其余19例患儿的变异均为自发变异。结论神经纤维瘤病1型在儿童早期主要表现为多发牛奶咖啡斑,可在早期出现皮肤神经纤维瘤、幼年黄色肉芽肿、虹膜lisch结节等特征性表现;NF1基因发生致病性变异复杂多样,本研究鉴定22个变异,新变异丰富了NF1基因变异谱。

关键词：神经纤维瘤病1型基因神经纤维瘤病1型突变表型皮肤表现多发牛奶咖啡斑