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Poorly controlled type Ⅱ diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage Ⅲ colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-yun yuan Zhi-yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-Jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type Ⅱ diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage Ⅲ CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage Ⅲ *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage Ⅲ CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage Ⅲ CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis TypeⅡdiabetes mellitus

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赋权组合模型溯源山楂产地的高光谱方法

光谱学与光谱分析 2025年第2期45卷 584-590页

作者：方澳殷勇于慧春袁云霞河南科技大学食品与生物工程学院河南洛阳471023

不同产地的山楂因生长环境和地理气候的差异,导致其品质的参差不齐,因此确定山楂的地理产区具有重要的意义。为了提高山楂产地溯源模型的稳定性和准确性,提出了一种基于误差倒数赋权的组合鉴别模型。首先,利用高光谱成像技术采集了456... 详细信息

不同产地的山楂因生长环境和地理气候的差异,导致其品质的参差不齐,因此确定山楂的地理产区具有重要的意义。为了提高山楂产地溯源模型的稳定性和准确性,提出了一种基于误差倒数赋权的组合鉴别模型。首先,利用高光谱成像技术采集了456个山楂的高光谱信息,通过对比卷积平滑(SG)、多元散射校正(MSC)和标准正态变量(SNV)3种预处理方法,并使用预处理后的数据和原始数据构建BP神经网络(BPNN)和随机森林(RF)模型,根据其准确率确定了SNV为平均光谱值的预处理方法。然后,对山楂的高光谱图像进行主成分分析,选取第1主成分图像并根据全波段下的权重系数筛选出6个特征波长,对应的平均光谱值作为其光谱信息表征值。其次,分别提取第1主成分图像和特征波长对应灰度图像的纹理特征,并将特征波长的光谱表征值与其对应图像的纹理表征值、主成分图像纹理表征值进行组合以构造产地溯源鉴别模型的输入向量。最后,分别选择BP神经网络(BPNN)、随机森林(RF)和赋权组合模型(BPNN-RF)3种方法进行鉴别模型构建,并选取准确率(Acc)和宏F1分数(macroF1)2个评价指标对不同输入向量所构建的山楂产地鉴别模型进行评价分析。结果表明,相同输入向量所建BPNN-RF模型的准确率和宏F1分数大都优于BPNN模型和RF模型的准确率和宏F1分数,其中采用3种表征值组合而成的输入向量,其所建BPNN-RF模型实测集的准确率由89.01%提高到98.90%,宏F1分数也由89.32%提高到98.95%,说明了基于误差倒数赋权BPNN-RF组合模型对山楂产地的鉴别能力最强,效果最好,优于单一的鉴别模型。该研究为不依赖理化分析、仅靠高光谱信息即可实现山楂产地的溯源提供了一种方法支撑。

关键词：山楂产地溯源高光谱误差倒数赋权赋权组合模型

DIRECT ITERATIVE METHODS FOR RANK DEFICIENT GENERALIZED LEAST SQUARES PROBLEMS

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Journal of Computational Mathematics 2000年第4期18卷 439-448页

作者： Jin-yun yuan Xiao-qing Jin Departamento de Matematica Universidade Federal do ParanaCuritibaBrazil Faculty of Science and Technology University of MacaoMacaoChina

The generalized least squares (LS) problem ... (Ax - b)[sup TW[sup -1](Ax - b) appears in, many application areas. Here W is an m × m symmetric positive definite matrix and A is an m × n matrix with m ≥ n. Since the problem has many solutions in rank deficient case, some special preconditioned techniques are adapted to obtain the minimum 2-norm solution. A block SOR method and the preconditioned conjugate gradient (PCG) method are proposed here. Convergence and optimal relaxation parameter for the block SOR method are studied. An error bound for the PCG method is given. The comparison of these methods is investigated. Some remarks on the implementation of the methods and the operation cost are given as well. [ABSTRACT FROM AUTHOR]

关键词： rank deficient generalized LS problem block SOR method PCG method convergence optimal parameter

Emergency response facility location in transportation networks: A literature review

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Journal of Traffic and Transportation Engineering(English Edition) 2021年第2期8卷 153-169页

作者： Yang Liu yun yuan Jieyi Shen Wei Gao College of Artificial Intelligence Nanjing Agricultural UniversityNanjing 210031China College of Transportation Engineering Dalian Maritime UniversityDalian 116026China College of Engineering University of UtahSalt Lake CityUT 84112USA

Emergency response activity relies on transportation networks. Emergency facility location interacts with transportation networks clearly. This review is aimed to provide a combined framework for emergency facility location in transportation networks. The article reveals emergency response activities research clusters, issues, and objectives according to keywords co-occurrence analysis. Four classes of spatial separation models in transportation networks, including distance, routing, accessibility, and travel time are introduced. The stochastic and time-dependent characteristics of travel time are described. Travel time estimation and prediction method, travel time under emergency vehicle preemption,transportation network equilibrium method, and travel time in degradable networks are demonstrated. The emergency facilities location models interact with transportation networks, involving location-routing model, location models embedded with accessibility,location models embedded with travel time, and location models employing mathematical program with equilibrium constraints are reviewed. We then point out the-state-of-art challenges: ilities-oriented, evolution landscape and sequential decision modelling, datadriven optimization approach, and machine learning-based algorithms.

关键词： Transportation engineering Emergency facility location Transportation networks Travel time Machine learning

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Overexpression of OsJAC1, a Lectin Gene, Suppresses the Coleoptile and Stem Elongation in Rice

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Journal of Integrative Plant Biology 2007年第2期49卷 230-237页

作者： Jia-Fu Jiang yun-yuan Xu Kang Chong Research Center for Molecular & Developmental Biology Key Laboratory of Photosynthesis and Environmental Molecular Physiology the Chinese Academy of Sciences Beijing 100093 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

Lectin plays an Important role In defense signaling In plants, but its function In plant growth and development is not well known. Previously, we cloneds rice （Oryza sativa L.） gene OsJAC1 encoding s msnnose-blndlng Jscslln-relsted lectln, and found that OsJAC1 was Jssmonlc acid （JA） Inducible. Here we cloned the promoter of OsJAC1, and GUS activity was detected In young roots, coleoptlles, sheaths, leaves, nodes of stems, stems, rschlses, pistils, stsmens and lemmss of OsJAC1：：GUS trsnsgenlc rice, suggesting that OsJAC1 Is s constitutive expression gene In rice. Moreover, OsJAC1-overexpressed （Ubi：：OsJAC1） rice showed dwarfism with shorter coleptlles resulting from the failure of cell elongation of coleoptlles. In addition, compared with coleoptlles of wild-type plants, those of OsJAC1 overexpresslon rice were more sensitive to JA treatment. These data revealed that, besides Its roles in defense response, lectin plays an Important role in rice growth and development.

关键词： coleoptile jasmonic acid mannose-binding lectin Oryza sativa OsJAC1.

Preparation of Flaky Hexagonal Nanoporous Au-Cu and Au Particles via Dealloying

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Acta Metallurgica Sinica(English Letters) 2022年第11期35卷 1777-1786页

作者： Jing Deng yuan-yun Zhao Yong Shen Chuntao Chang Qiang Li School of Physics Science and Technology Xinjiang UniversityUrumqi 830046China Neutron Scattering Technical Engineering Research Center School of Mechanical EngineeringDongguan University of TechnologyDongguan 523808China Guangdong-HongKong-Macao Joint Laboratory for Neutron Scattering Science and TechnologyDongguan University of TechnologyDongguan 523808China Instituteof Metal Research Chinese Academy of SciencesShenyang 110016China

Nanoporous metals have attracted signifi cant attention owing to their excellent physical,chemical,and biological ***,preparing ultrafi ne nanoporous metal particles(1–5μm)with specifi c geometries remains ***,we report a simple strategy to prepare ultrafi ne fl aky hexagonal nanoporous Au-Cu and Au particles via ***-based alloy ribbons with ultrafi ne fl aky hexagonal Mg-Au(Cu)-Gd particles dispersed in a Mg-Cu(Au)-Gd metallic glassy matrix were *** size and morphology of the precipitated fl aky hexagonal Mg-Au(Cu)-Gd particles were controlled by the solidifi cation process of a Mg 61 Cu 21 Au 7 Gd 11 alloy *** ne fl aky hexagonal nanoporous Au-Cu particles(diagonal diameter 2.58±0.44μm,ligament size~28 nm),Au-1 particles(diagonal diameter 2.38±0.35μm,ligament size~83 nm)and Au-2 particles(diagonal diameter 2.39±0.44μm,ligament size~66 nm)were prepared via ultrasonic-assisted dealloying of Mg 61 Cu 21 Au 7 Gd 11 alloy ribbons in 0.25 M HCl/ethanol,1 M HCl/ethanol and 0.25 M HNO 3/ethanol solutions,*** ultrafi ne fl aky hexagonal nanoporous Au-Cu and Au particles with a large specifi c surface area have a uniform particle size and shape,implying that they possess adequate powder fl uidity and excellent catalytic ***,the formation mechanism of the MgAu(Cu)Gd phase in solidifi ed Mg-Cu-Au-Gd alloys was *** study provides a novel approach for synthesizing nanoporous metal particles with a specifi c geometry.

关键词： Metallic glasses Mg-based alloys Dealloying Nanoporous particles Mg-Au-Gd phase

Simulations on the multi-shell target ignition driven by radiation pulse in Z-pinch dynamic hohlraum

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Chinese Physics B 2021年第11期30卷 411-418页

作者： Shi-Jia Chen Yan-yun Ma Fu-yuan Wu Xiao-Hu Yang yun yuan Ye Cui Rafael Ramis Department of Physics National University of Defense TechnologyChangsha 410073China IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghai 200240China College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Laboratory of Laser Plasmas School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China E.T.S.I.Aeronautica y del Espacio Universidad Politecnica de MadridSpain

We present the first simulation results of a multi-shell target ignition driven by Z-pinch dynamic hohlraum radiation *** radiation pulse is produced with a special Z-pinch dynamic hohlraum configuration,where the hohlraum is composed of a single metal liner,a low-Z plastic foam,and a high-Z metallic *** implosion dynamics of a hohlraum and a multi-shell target are investigated separately by the one-dimensional code *** the peak drive current is 50 MA,simulations suggest that an x-ray pulse with nearly constant radiation temperature(-310 eV)and a duration about 9 ns can be obtained.A small multi-shell target with a radius of 1.35 mm driven by this radiation pulse is able to achieve volumetric ignition with an energy gain(G)about 6.19,where G is the ratio of the yield to the absorbed *** this research,we better understand the effects of non-uniformities and hydrodynamics instabilities in Z-pinch dynamic hohlraum.

关键词： Z-pinch dynamic hohlraum radiation pulse volumetric ignition

TWO ALGORITHMS FOR LC^1 UNCONSTRAINED OPTIMIZATION

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Journal of Computational Mathematics 2000年第6期18卷 621-632页

作者： Wen-yu Sun R.J.B.de Sampaio Jin-yun yuan School of Mathematics and Computer Science Nanjing Normal UniversityNanjing 210097China Applied Informatics Program Pontifical Catholic University of ParanaCuritibaPR81611-970Brazil Department of Mathematics Federal University of ParanaCuritibaPR81531-990Brazil

Presents two algorithms for LC unconstrained optimization problems which use the second order Dini upper directional derivative. Simplicity of the methods to use and perform; Discussion of related properties of the it... 详细信息

关键词： nonsmooth optimization directional derivative Newton-like method convergence trust region method

Gene Therapy Activates Retinal Pigment Epithelium Cell Proliferation for Age-related Macular Degeneration in a Mouse Model

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Current Medical Science 2023年第2期43卷 384-392页

作者： yun yuan Wen KONG Xiao-mei LIU Guo-hua SHI School of Biomedical Engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaSuzhou215000China Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of ScienceSuzhou215000China

Objective Age-related macular degeneration(AMD)is a degenerative retinal *** degeneration or death of retinal pigment epithelium(RPE)cells is implicated in the pathogenesis of *** study aimed to activate the proliferation of RPE cells in vivo by using an adeno-associated virus(AAV)vector encodingβ-catenin to treat AMD in a mouse *** Mice were intravitreally injected with AAV2/8-Y733F-VMD2-β-catenin for 2 or 4 weeks,andβ-catenin expression was measured using immunofluorescence staining,real-time quantitative reverse transcription polymerase chain reaction(PCR),and Western *** function ofβ-catenin was determined using retinal flat mounts and laser-induced damage ***,the safety of AAV2/8-Y733F-VMD2-β-catenin was evaluated by multiple intravitreal *** AAV2/8-Y733F-VMD2-β-catenin induced the expression ofβ-catenin in RPE *** activated the proliferation of RPE cells and increased cyclin D1 *** was beneficial to the recovery of laser-induced damage by activating the proliferation of RPE ***,it could induce apoptosis of RPE cells by increasing the expression of Trp53,Bax and caspase3 while decreasing the expression of *** AAV2/8-Y733F-VMD2-β-catenin increasedβ-catenin expression in RPE cells,activated RPE cell proliferation,and helped mice heal from laser-induced eye ***,it could induce the apoptosis of RPE ***,it may be a safe approach for AMD treatment.

关键词： gene therapy adeno-associated virus age-related macular degeneration retinal pigment epithelium cells β-catenin