检索结果-南通市图书馆

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A versatile synthetic strategy towards rare earth based metal-organic frameworks

引用

Science China Chemistry 2025年

作者： Quan Shi yun-Hao xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Mn基低温脱硝催化剂性能优化研究进展

引用

工程科学学报 2025年第1期47卷 142-157页

作者：许芸邬博宇庄柯张乾徐静馨张深根朱法华张柏林国家能源集团科学技术研究院有限公司低碳智能燃煤发电与超净排放全国重点实验室南京210023 北京科技大学新材料技术研究院北京100083

氮氧化物(NO_(x))是我国首要大气污染物,主要采用选择性催化还原(SCR)技术进行排放控制.研发高效、稳定的低温脱硝催化剂可避免高能耗的烟气再热,具有显著的节能降碳效益.锰氧化物(MnO_(x))因多变的化学态和丰富的晶格缺陷而表现出优良... 详细信息

氮氧化物(NO_(x))是我国首要大气污染物,主要采用选择性催化还原(SCR)技术进行排放控制.研发高效、稳定的低温脱硝催化剂可避免高能耗的烟气再热,具有显著的节能降碳效益.锰氧化物(MnO_(x))因多变的化学态和丰富的晶格缺陷而表现出优良的氧化还原性能,并具有极强的表面酸性,在催化还原NO_(x)反应中表现出良好的低温活性,但N_(2)选择性低、抗H_(2)O/SO_(2)性能差,难以实现长期的高效稳定脱硝.近年来,改性提升Mn基催化剂的研究十分广泛,加快了Mn基催化剂工业应用的步伐.本文从低温活性、N_(2)选择性和稳定性三个方面,总结了Mn基催化剂的脱硝反应机理、元素掺杂改性、催化剂结构设计等最新研究进展,指出了当前的研究重点和难点,可为下一步研究提供参考.

关键词：氮氧化物选择性催化还原锰基催化剂 N2选择性稳定性元素掺杂

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Existence of Three HMOLS of Type 2~nu^1

引用

Acta Mathematica Sinica,English Series 2009年第8期25卷 1325-1336页

作者： yun Qing xu Mathematics Department Ningbo University Ningbo 315211 P. R. Uhina

A Latin squares of order v with ni missing sub-Latin squares （holes） of order hi （1 〈= i 〈 k）, which are disjoint and spanning （i.e. ∑k i=l1 nihi = v）, is called a partitioned incomplete Latin squares and denoted by PILS. The type of PILS is defined by （h1n1 h2n2…hknk ）. If any two PILS inaset of t PILS of type T are orthogonal, then we denote the set by t-HMOLS（T）. It has been proved that 3-HMOLS（2n31） exist for n ≥6 with 11 possible exceptions. In this paper, we investigate the existence of 3-HMOLS（2nu1） with u ≥ 4, and prove that 3-HMOLS（2~u1） exist if n ≥ 54 and n ≥7/4u ＋ 7.

关键词： holey Latin square mutually orthogonal Latin square group divisible design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On the Spectrum of Mutually r-orthogonal Idempotent Latin Squares

引用

Acta Mathematicae Applicatae Sinica 2015年第3期31卷 813-822页

作者： yun-qing xu Mathematics Department Ningbo University

Two Latin squares of order v are r-orthogonal if their superposition produces exactly r distinct ordered pairs. The two squares are said to be r-orthogonal idempotent Latin squares and denoted by r-MOILS（v）if they are all idempotent. In this paper, we show that for any integer v≥28, there exists an r-MOILS（v） if and only if r∈[v, v^2]／ {v ＋ 1, v^2-1}.

关键词： Latin square r-orthogonal idempotent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on Reaction of Thiophene Compounds and Olefins for Deep Desulfurization of Gasoline

引用

China Petroleum Processing & Petrochemical Technology 2019年第3期21卷 53-60页

作者： xu yun SINOPEC Research Institute of Petroleum Processing

The HY,Hβ,HZSM-5,and SAPO-11 zeolites were investigated in the alkylation reaction of thiophene and *** a result,some sulfur-containing impurities could be converted to higher molecular weight components with their boiling point being in the range of diesel ***-5 had the highest activity and selectivity of *** the same time,extensive oligomerization of olefins was not found and coke yield was very low,which could lead to high yield of gasoline *** main reaction mechanism verifies that the second order alkylation reaction can be carried out on the outer surface and/or pores of the *** catalytic performance of the HZSM-5 catalyst which is poisoned by 2,4-dimethylquinoline during alkylation to form larger molecules of sulfur compounds is obviously weakened due to the decrease of the acid sites on the outer surface and at the mouth of pores.

关键词： FCC gasoline HZSM-5 zeolite desulfurization thiophene compounds

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Guidelines for Acute Ischemic Stroke Treatment

引用

Neuroscience Bulletin 2020年第10期36卷 1229-1232页

作者： Shuwei Qiu yun xu Department of Neurology Drum Tower HospitalMedical School and The State Key Laboratory of Pharmaceutical BiotechnologyInstitute of Brain ScienceNanjing UniversityNanjing 210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing 210008China Jiangsu Province Stroke Center for Diagnosis and Therapy Nanjing 210008China Nanjing Medical Center for Neurology Nanjing 210008China

Acute ischemic stroke(AIS)is one of the serious diseases endangering human health worldwide;it usually leads to serious handicap with a high risk of recurrence and *** the global burden of stroke,great advances are still being *** the publication of the 2013 guidelines for the early management of AIS patients,new high-quality evidence has resulted in prominent changes in the evidence-based treatment of AIS,such as image assessment.

关键词： Acute diseases spite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of strain, body mass, and thread tip preparation on the establishment of focal cerebral ischemia mouse models

引用

Neural Regeneration Research 2008年第1期3卷 61-65页

作者： xuemei Chen yun xu Department of Neurology Gulou Hospital Affiliated to Medical College Nanjing University Nanjing 210008 Jiangsu Province China

BACKGROUND： What are the successful factors of the establishment of the thread-blocking method for focal cerebral ischemia/reperfusion mouse models？ OBJECTIVE： To study the effects of strain, body mass, and thread tip preparation for the establishment of focal cerebral ischemia mouse models by using middle cerebral artery occlusion （MCAO）. DESIGN： Observational contrast animal study. SETTING： Gulou Hospital, Medical College of Nanjing University. MATERIALS：（1） The following experiment was performed at the Animal Experimental Center, Gulou Hospital Affiliated to Medical College of Nanjing University from December 2006 to April 2007. Sixty male white Kunming mice, whose body masses were 18-22 g （n =40）, 25-29 g （n =10） and 30-33 g （n =10）, as well as 10 male C57BL/6J mice, whose body mass was 18-22 g, were provided by the Animal Experimental Center, Gulou Hospital Affiliated to Medical College of Nanjing University. All mice were 10-12 weeks old. The project received confirmed consent from the local ethics committee. （2）Experimental materials： tripheryltetrazolium hydrochloride （TTC） and 0.1% poly-L-lysine were provided by Sigma Company, USA; citromint was provided by Shanghai Lingfeng Chemical Company Limited. METHODS：（1） Strain comparison： Ten white Kunming mice （weighing 18-22 g） and ten C57BL/6J mice （weighing 18 - 22 g） were selected. （2） Comparison of body mass： Thirty white Kunming mice, whose body masses were 18-22 g （n =10）, 25-30 g （n =10）, and 30-35 g （n =10）, were divided into groups. （3） Comparison of thread tip preparation： White Kunming mice weighing 18-22 g were divided into a poly-L-lysine line group and general line group, with 10 mice in each group. Mice in these two groups, which were respectively treated with poly-L-lysine or nothing, underwent MCAO. （4） All experimental mice received MCAO. Three hours after ischemia, and 24 hours after reperfusion, neurological deficit scores were measured and a success rate of model establishment was calculate

关键词： mice ischemia/reperfusion animal model thread-blocking method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evidence of the Link between Broad Emission Line Regions and Accretion Disks in Active Galactic Nuclei

引用

Chinese Journal of Astronomy and Astrophysics 2007年第1期7卷 63-70页

作者： yun xu Xin-Wu Cao Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 Graduate School of Chinese Academy of Sciences Beijing 100049

There is observational evidence that broad-line regions （BLRs） exist in most active galactic nuclei （AGNs）, but their origin is still unclear. One scenario is that the BLRs originate from winds accelerated from the hot coronae of the disks, and the winds are suppressed when the black hole is accreting at low rates. This model predicts a relation between rh （m ~ /~f//~fEdd） and the FWHM of broad emission lines. We estimate the central black hole masses for a sample of bright AGNs by using their broad Hβ line-widths and optical luminosities. The dimensionless accretion rates rh = M/MEdd are derived from the optical continuum luminosities by using two different models： using an empirical relation between the bolometric luminosity Lbol and the optical luminosity （rh = Lbol/LEdd, a fixed radiative efficiency is adopted）; and calculating the optical spectra of accretion disks as a function of rh. We find a slgmficant correlation between the denved of and the observed line width of Hβ, FWHMα m^-***, which almost overlaps the disk-corona model calculations, if the viscosity a α≈ 0.1 - 0.2 is adopted. Our results provide strong evidence for the physical link between the BLRs and accretion disks in AGNs.

关键词： accretion, accretion disks-galaxies active-galaxies theory-radiation mechanisms emission lines-black hole physics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On Splitting Training and Validation Set:A Comparative Study of Cross-Validation,Bootstrap and Systematic Sampling for Estimating the Generalization Performance of Supervised Learning

引用

Journal of Analysis and Testing 2018年第3期2卷 249-262页

作者： yun xu Royston Goodacre School of Chemistry Manchester Institute of BiotechnologyThe University of ManchesterManchester M17DNUK Department of Biochemistry Institute of Integrative BiologyUniversity of LiverpoolBiosciences BuildingCrown StreetLiverpool L697ZBUK

Model validation is the most important part of building a supervised *** building a model with good generalization performance one must have a sensible data splitting strategy,and this is crucial for model *** this study,we con-ducted a comparative study on various reported data splitting *** MixSim model was employed to generate nine simulated datasets with different probabilities of mis-classification and variable sample *** partial least squares for discriminant analysis and support vector machines for classification were applied to these *** splitting methods tested included variants of cross-validation,bootstrapping,bootstrapped Latin partition,Kennard-Stone algorithm(K-S)and sample set partitioning based on joint X-Y distances algorithm(SPXY).These methods were employed to split the data into training and validation *** estimated generalization performances from the validation sets were then compared with the ones obtained from the blind test sets which were generated from the same distribution but were unseen by the train-ing/validation procedure used in model *** results showed that the size of the data is the deciding factor for the qualities of the generalization performance estimated from the validation *** found that there was a significant gap between the performance estimated from the validation set and the one from the test set for the all the data splitting methods employed on small *** disparity decreased when more samples were available for training/validation,and this is because the models were then moving towards approximations of the central limit theory for the simulated datasets *** also found that having too many or too few samples in the training set had a negative effect on the estimated model performance,suggesting that it is necessary to have a good balance between the sizes of training set and validation set to have a reliable estimation of model *** a

关键词： Cross-validation Bootstrapping Bootstrapped Latin partition Kennard-Stone algorithm SPXY Model selection Model validation Partial least squares for discriminant analysis Support vector machines

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：