检索结果-南通市图书馆

Targeting synaptic pathology in Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2024年第4期45卷 875-876页

作者： Jing Cao yun-wu Zhang Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research Institute of NeuroscienceSchool of MedicineXiamen UniversityXiamenFujian 361102China

Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by memory and cognitive *** two primary pathological hallmarks of AD include the accumulation ofβ-amyloid(Aβ)plaques and formation of neurofibrillary tangles(NFTs)composed predominantly of hyperphosphorylated tau protein(Zhang et al.,2023).Moreover,synaptic dysfunction is considered another crucial factor in AD pathogenesis and is closely associated with cognitive ***,synaptic damage,loss,and dysfunction manifest earlier than the pathological features of Aβplaques and NFTs(Knopman et al.,2021).Therefore,understanding the mechanisms underlying synaptic dysfunction in AD is vital for providing insights into disease mechanisms and developing novel therapeutic strategies.

关键词： Alzheimer Aβ tau

Elevational and temporal patterns of pollination success in distylous and homostylous buckwheats(Fagopyrum)in the Hengduan Mountains

在线全文

学校读者我要写书评

暂无评论

Plant Diversity 2024年第5期46卷 661-670页

作者： Ling-yun wu Shuang-Quan Huang Ze-Yu Tong Faculty of Resources and Environmental Science Hubei UniversityWuhan 430062China Institute of Evolution and Ecology School of Life SciencesCentral China Normal UniversityWuhan 430079China

Reproductive strategies of sexually dimorphic plants vary in response to the ***,we ask whether the sexual systems of Fagopyrum species(i.e.,selfing homostylous and out-crossing distylous)represent distinct adaptive strategies to increase reproductive success in changing alpine *** answer this question,we determined how spatial and temporal factors(e.g.,elevation and peak flowering time)affect reproductive success(i.e.,stigmatic pollen load)in nine wild Fagopyrum species(seven distylous and two homostylous)among 28 populations along an elevation gradient of 1299-3315 m in the Hengduan Mountains,southwestern *** also observed pollinators and conducted hundreds of hand pollinations to investigate inter/intra-morph compatibility,self-compatibility and pollen limitation in four Fagopyrum species(two distylous and two homostylous).We found that Fagopyrum species at higher elevation generally had bigger flowers and more stigmatic pollen loads;lateflowering individuals had smaller flowers and lower pollen *** pollen deposition was more variable in distylous species than in homostylous *** seed set was not pollenlimited in all species,we found that fruit set was much lower in distylous species,which rely on frequent pollinator visits,than in homostylous species capable of autonomous *** findings that pollination success increases at high elevations and decreases during the flowering season suggest that distylous and homostylous species have spatially and temporally distinct reproductive strategies related to environment-dependent pollinator activity.

关键词： Biodiversity hotspot Elevation gradient Fagopyrum Stigmatic pollen load Temporal pattern

Improving flight performance of UAVs by ice shape modulation

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第8期37卷 49-62页

作者： Jiajun ZHANG Xuecheng LIU Hua LIANG Like XIE Biao WEI Haohua ZONG yun wu Yinghong Li National Key Lab of Aerospace Power System and Plasma Technology Air Force Engineering UniversityXi’an 710038China Institute of Aero-Engine School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

Aircraft icing poses a great threat to flight *** response to the characteristics of high-power consumption,large volume,and heavy weight of traditional anti-/de-icing technologies,the concept of ice shape modulation is proposed,which is called ice tolerant ***,the flight performance of Unmanned Aerial Vehicle(UAV)was compared in three states:no ice,full ice,and modulated ice through flight *** was found that ice shape modulation has a significant improvement effect on the aerodynamic performance of aircraft under icing *** the three modulated ice shape conditions in this experiment,the lift coefficient of the UAV under different ice shape modulation conditions increased by 18%–33%,and the stalling angle was delayed by 3°-5°.Subsequently,the pressure distribution,streamlines in the flow field,and detached vortex distribution of the UAV model in these three states were obtained through numerical simulation,to study the mechanism of ice shape modulation on the aerodynamic performance of *** simulation found that the reason for the improvement of the wings effect after ice shape modulation is that the modulated area forms a leading-edge protrusion structure similar to a vortex *** structure prolongs the mixed flow region on the wings surface and reduces the trend of flow separation,which plays a role in increasing lift and reducing drag for UAVs under icing ***,a reverse reachable set that can be used for unexpected state recovery is used as the definition of flight safety boundaries,and an aircraft dynamics model is established to obtain flight safety boundaries for different *** has found that the flight safety boundary of the UAV in a no ice state is greater than that in a modulated ice state,and the safety boundary in a modulated ice state is greater than that in a full ice *** with the full ice state,the flight safety boundary after modulation has expanded by 27.0%.The sch

关键词： Ice shape modulation Aerodynamic performance Reachable set Flight safety UAV

Molecular cloning,characterization and promoter analysis of LbgCWIN1 and its expression profiles in response to exogenous sucrose during in vitro bulblet initiation in lily

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticultural Plant Journal 2024年第2期10卷 545-555页

作者： Cong Gao Shiqi Li yunchen Xu Yue Liu Yiping Xia Ziming Ren yun wu Genomics and Genetic Engineering Laboratory of Ornamental Plants Institute of Landscape ArchitectureCollege of Agriculture and BiotechnologyZhejiang UniversityHangzhouZhejiang 310058China Laboratory of Flower Bulbs Department of Landscape ArchitectureSchool of Civil Engineering and ArchitectureZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China

Lily(Lilium spp.) is an important ornamental flower, which is mainly propagated by bulbs. Cell wall invertases(CWINs), which catalyze the irreversibly conversion of sucrose into glucose and fructose in the extracellular space, are key enzymes participating in sucrose allocation in higher plants. Previous studies have shown that CWINs play an essential role in bulblet initiation process in bulbous crops, but the underlying molecular mechanism remains unclear. Here, a CWIN gene of Lilium brownii var. giganteum(Lbg) was identified and amplified from genomic DNA. Quantitative RT-PCR assays revealed that the expression level of LbgCWIN1 was highly upregulated exactly when the endogenous starch degraded in non-sucrose medium during in vitro bulblet initiation in Lbg. Phylogenetic relationship, motif, and domain analysis of LbgCWIN1 protein and CWINs in other plant species showed that all sequences of these CWIN proteins were highly conserved. The promoter sequence of LbgCWIN1 possessed a number of alpha-amylase-, phytohormone-, light-and stress-responsive cis-elements. Meanwhile, β-glucuronidase(GUS) assay showed that the 459 bp upstream fragment from the translational start site displayed maximal promoter activity. These results revealed that LbgCWIN1 might function in the process of in vitro bulblet initiation and be in the response to degradation of endogenous starch.

关键词： Lilium brownii var.giganteum LbgCWIN1 Phylogenetic analysis Promoter analysis Bulblet initiation

Understanding the cooperative effects in the catalysis of homodimeric fluoroacetate dehalogenase

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第7期67卷 2382-2391页

作者： Ke-Wei Chen Jia-Nan Chen Jun Zhang Chao Wang Tian-Yu Sun yun-Dong wu Key Laboratory of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicSchool of Chemical Biology and BiotechnologyPeking University Shenzhen Graduate SchoolShenzhen 518055China Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhen 518132China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Changping Laboratory Beijing 102200China

Fluoroacetate dehalogenases(FAcD),a homodimeric enzyme,catalyzes the conversion of fluoroacetic acid to glycolic acid(GoA).It has been proved that the enzyme has a half-of-the-site ***,its catalytic(C)subunit converts the first substrate to a covalent intermediate;then,the non-catalytic(NC)subunit binds a second substrate and promotes the conversion of the intermediate in the C subunit into the final *** the release of the product,the C subunit becomes the NC subunit,and the previous NC subunit becomes the C *** elucidate the detailed mechanism behind this cooperative catalysis,we have conducted microsecond-scale MD simulations along the reaction *** simulations indicate that the substrate in the NC subunit induces W185 and Y141 adopting an open conformation in the C *** opening of W185(C)facilitates the entry of catalytic water,enhancing the catalytic activity for product formation,while the opening of Y141(C)creates an unfavorable environment for product binding,promoting its *** interaction network analysis reveals that the substrate in the NC subunit can induce conformational changes through a conserved water chain at the interface.

关键词： enzyme catalysis molecular dynamics cooperative effect pre-reaction state

Efficacy and safety of first‐line regimens for advanced HER2‐positive breast cancer:A Bayesian network meta‐analysis

在线全文

学校读者我要写书评

暂无评论

Cancer Innovation 2024年第4期3卷 1-12页

作者： Lixi Li yun wu Bo Lan Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:The current standard of care for advanced human epidermal growth factor receptor 2(HER2)‐positive breast cancer is pertuzumab plus trastuzumab and docetaxel as first‐line ***,with the development of newer treatment regimens,there is a lack of evidence regarding which is the optimal treatment *** aim of this network meta‐analysis was to evaluate the efficacy and safety of first‐line regimens for advanced HER2‐positive breast cancer by indirect ***:A systematic review and Bayesian network meta‐analysis were *** PubMed,EMBASE,and Cochrane Library databases were searched for relevant articles published through to December *** hazard ratio(HR)and 95%credible interval(CrI)were used to compare progressionfree survival(PFS)between treatments,and the odds ratio and 95%CrI were used to compare the objective response rate(ORR)and ***:Twenty randomized clinical trials that included 15 regimens and 7094 patients were *** with the traditional trastuzumab and docetaxel regimen,PFS was longer on the pyrotinib and trastuzumab plus docetaxel regimen(HR:0.41,95%CrI:0.22–0.75)and the pertuzumab and trastuzumab plus docetaxel regimen(HR:0.65,95%CrI:0.43–0.98).Consistent with the results for PFS,the ORR was better on the pyrotinib and trastuzumab plus docetaxel regimen and the pertuzumab and trastuzumab plus docetaxel regimen than on the traditional trastuzumab and docetaxel *** surface under the cumulative ranking curve indicated that the pyrotinib and trastuzumab plus docetaxel regimen was most likely to rank first in achieving the best PFS and *** results were found for grade≥3 AE rates of≥10%.Conclusions:Our results suggest that the pyrotinib and trastuzumab plus docetaxel regimen is most likely to be the optimal first‐line therapy for patients with HER2‐positive breast cancer.

关键词： Bayesian network meta‐analysis first‐line treatment HER2‐positive breast cancer

TCEVis:Visual analytics of traffic congestion influencing factors based on explainable machine learning

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Visual Informatics 2024年第1期8卷 56-66页

作者： Jialu Dong Huijie Zhang Meiqi Cui Yiming Lin Hsiang-yun wu Chongke Bi School of Information Science and Technology Northeast Normal UniversityChangchunChina School of Computing Science Baicheng Normal UniversityBaichengChina St.Pölten University of Applied Sciences Austria College of Intelligence and Computing Tianjin UniversityTianjinChina

Traffic congestion is becoming increasingly severe as a result of urbanization,which not only impedes people’s ability to travel but also hinders the economic development of *** the correlation between congestion and its influencing factors using machine learning methods makes it possible to quickly identify congested road *** to the intrinsic black-box character of machine learning models,it is difficult for experts to trust the decision results of road congestion prediction models and understand the significance of congestion-causing *** this paper,we present a model interpretability method to investigate the potential causes of traffic congestion and quantify the importance of various influencing factors using the SHAP *** to the multidimensionality of these factors,it can be challenging to visually represent the impact of all *** response,we propose TCEVis,an interactive visual analytics system that enables multi-level exploration of road *** three case studies utilizing actual data,we demonstrate that the TCEVis system offers advantages for assisting traffic managers in analyzing the causes of traffic congestion and elucidating the significance of various influencing factors.

关键词： Visual analytics Speed prediction Explainable Traffic congestion

Electrochemical chemoselective thiocarbamylation of late-stage Tyr-containing drugs and peptides

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第10期67卷 3382-3388页

作者： Wan-Jie Wei Xin-Yu Wang Hai-Tao Tang Fei-Hu Cui yun-Qi wu Ying-Ming Pan State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)Collaborative Innovation Center for Guangxi Ethnic MedicineSchool of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China

The synthesis and modification of peptides occupy a unique position in the field of drug development,and the functionalization of amino acids is a valuable strategy as an alternative to peptide ***,the development of tyrosine(Tyr)as a target amino acid is a major challenge in the field of ***,we report an electrochemical radical coupling reaction of labeling tyrosine-containing active drugs and peptides with thiocarbamate derivatives for the first *** tri-component,onepot reaction can be performed smoothly under simple,gentle,and clean electrochemical conditions and is suitable for the functionalization of various Tyr-containing drug molecular derivatives and peptides.

关键词： tyrosine electrochemical radical coupling chemical modification peptides

Monomeric and self-assembled crystal phases of TNBT

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第10期43卷 5442-5448页

作者： yun-Hui wu Hua-Bei You Wei-Kai Cui Zhi-Qian Cao Xiao Dong Zi-Hui Meng Ming Huang School of Chemistry and Chemical Engineering Beijing Institute of Technology Institute of Chemical Materials China Academy of Engineering Physics

（3,3′,5,5′-Tetranitro-4,4′-bi-1,2,4-Triazole） TNBT was designed and predicted more than three decades ago as a high energy *** with many other designed molecules,TNBT has not been successfully synthesized and has not been computationally studied in *** this work,theoretical calculations at density functional theory （DFT）level of theory were carried out for both the gas phase molecule and its possible bulk crystal *** （DFT） computations show that TNBT is comparable to CL-20 with high bulk density,

关键词： Density functional theory