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Omadacycline in the treatment of scrub typhus:Three case reports

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World Journal of Clinical Cases 2024年第25期12卷 5832-5838页

作者： Xue-Mei Lang yun Qiu Ya-Juan Jia Hong sun Su-Min Gao Hong-Mei Zhao Department of Emergency Medicine The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuai’an 223000Jiangsu ProvinceChina

BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(***).Omadacycline,a novel tetracycline,exhibits potent antibacterial efficacy against both typical bacteria and atypical ***,omadacycline application in the treatment of scrub typhus remains *** SUMMARY In the present work,we report several cases of scrub typhus,with the main clinical symptoms being fever,the formation of eschars or ulcers,local or systemic lymphadenopathy,headache,myalgia and *** samples were collected before omadacycline was administered,and *** infection was confirmed through targeted next-generation sequencing(tNGS).After two days of treatment,the patients’symptoms,including fever,were alleviated,with no adverse drug *** tNGS is an effective method for diagnosing scrub *** can be considered an alternative option for antiinfective therapy in patients with *** infections.

关键词： Omadacycline Scrub typhus Orientia tsutsugamushi Targeted nextgeneration sequencing Eschar Case report

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行业特色高校学科专业的设置及调整优化

北京社会科学 2024年第9期 96-107页

作者：姚云孙士茹北京师范大学教育学部

学科调整优化布局直接影响到高校立德树人的成效和服务社会的能力与水平。采用案例分析法、访谈法和文本分析法,对东中西部14所行业特色高校学科专业设置的调研发现:高校学科系统向多科型转变,但结构水平欠佳;办学趋向综合化,但特色有... 详细信息

学科调整优化布局直接影响到高校立德树人的成效和服务社会的能力与水平。采用案例分析法、访谈法和文本分析法,对东中西部14所行业特色高校学科专业设置的调研发现:高校学科系统向多科型转变,但结构水平欠佳;办学趋向综合化,但特色有所削弱;主动对接地方需求调整学科专业,但风险管控不够。为凸显特色,坚守主业,行业特色高校须明确办学服务定位,采取“两面向两对标三路径”调整模式;加强质量内涵建设,提高学科专业设置饱和度;优化学科专业生态结构,加强特色学科地位与招生比重;创新组织制度设计,促进多学科交叉育人与联合技术攻关。

关键词：学科专业调整行业特色高校学科体系高等教育

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Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer

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World Journal of Gastroenterology 2024年第38期30卷 4211-4220页

作者： Wei-Ling Zhang Jing sun Rong-Fang Huang Yi Zeng Shu Chen Xiao-Peng Wang Jin-Hu Chen yun-Bin Chen Chun-Su Zhu Zai-Sheng Ye You-Ping Xiao Department of Radiology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Pathology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Gastric Surgery Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Epidemiology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina

BACKGROUND Although surgery remains the primary treatment for gastric cancer(GC),the identification of effective alternative treatments for individuals for whom surgery is unsuitable holds ***2 overexpression occurs in approximately 15%-20%of advanced GC cases,directly affecting treatment-related ***-computed tomography(sCT)enables the quantification of material compositions,and sCT iodine concentration parameters have been demonstrated to be useful for the diagnosis of GC and prediction of its invasion depth,angioge-nesis,and response to systemic *** existing report describes the prediction of GC HER2 status through histogram analysis based on sCT iodine maps(ims).Aim To investigate whether whole-volume histogram analysis of sCT ims enables the prediction of the GC HER2 *** This study was performed with data from 101 patients with pathologically confirmed GC who underwent preoperative sCT *** parameters were extracted via sCT im histogram analysis:The minimum,maximum,mean,standard deviation,variance,coefficient of variation,skewness,kurtosis,entropy,percentiles(1st,5th,10th,25th,50th,75th,90th,95th,and 99th),and lesion *** correlations of the parameters with the HER2 status and clinicopathological parameters were *** operating characteristic curves were used to evaluate the parameters’diagnostic *** Values for the histogram parameters of the maximum,mean,standard deviation,variance,entropy,and percentiles were significantly lower in the HER2+group than in the HER2–group(all Pim histogram parameters correlated positively with the GC HER2 status(r=0.

关键词： Gastric cancer Spectral computed tomography Iodine map Histogram analysis

Extracellular Disintegration of Viral Proteins as an Innovative Strategy for Developing Broad-Spectrum Antivirals Against Coronavirus

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CCS Chemistry 2024年第2期6卷 487-496页

作者： Ke sun Zhe Ding Xiaoying Jia Haonan Cheng Yingwen Li Yan Wu Zhuoyu Li Xiaohua Huang Fangxu Pu Entao Li Guiyou Wang Wei Wang yun Ding Gary Wong Sandra Chiu Jiaming Lan Aiguo Hu Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237 CAS Key Laboratory of Molecular Virology&immunology Chinese Academy of SciencesShanghai 200031 University of the Chinese Academy of Sciences Beijing 100049 State Key Laboratory of Virology Center for Biosafety Mega-ScienceWuhan Institute of VirologyChinese Academy of SciencesWuhan 430071 Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230027 Department of Clinical Laboratory The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001

The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses ***,state-of-the-art treatments still lag behind the continual emergence of new *** to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural ***,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)*** core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the *** EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”

关键词： enediyne broad spectrum antiviral protein disintegration coronavirus polyanions

Aptamer-Based Cell-Surface Profiling with Single-Cell Resolution Enables Precise Cancer Characterization

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CCS Chemistry 2024年第1期6卷 196-207页

作者： Liujun Xu Yawei Feng Tong Wang Shenhuan Li Kangli Xu Yue sun Yi Luo Yishan Ye Yan Miao yun Dong Zhenzhen Guo Qing Zhang Benshang Li He Huang Xue-Qiang Wang Liping Qiu Weihong Tan Molecular Science and Biomedicine Laboratory State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan 410082 The Key Laboratory of Zhejiang Province for Aptamers and Theranostics Zhejiang Cancer HospitalHangzhou Institute of MedicineChinese Academy of SciencesHangzhouZhejiang 310022 Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240 Bone Marrow Transplantation Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 Institute of Hematology Zhejiang UniversityHangzhou 310003 Department of Hematology and Oncology Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200127

Molecular profiling of cell-surface proteins is a powerful strategy for precise cancer *** mass cytometry(MC)enables synchronous detection of over 40 cellular parameters,its full potential in disease classification is challenged by the limited types of recognition probes currently *** this work,we synthesize a panel of heavy isotopeconjugated aptamers to profile cancer-associated signatures on the surface of hematological malignancy(HM)*** on 15 molecular signatures,we performed cell-surface profiling that allowed the precise classification of 8 HM cell *** with machine-learning technology,this aptamer-based MC platform also achieved multiclass identification of HM subtypes in clinical sampleswith 100%accuracy in the training cohort and 80%accuracy in the test ***,we report an effective and practical strategy for precise cancer classification at the singlecell level,paving the way for its clinical use in the near future.

关键词： molecular profiling cancer diagnosis mass cytometry aptamers machine learning

基于IL-6/JAK2/STAT3通路探讨加味三物白散对胃癌裸鼠移植瘤上皮间质转化的抑制作用

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中华中医药杂志 2024年第2期39卷 921-925页

作者：刘芸孙相如朱莹湖南中医药大学长沙410208 湖南中医药大学第一附属医院长沙410008

目的:研究加味三物白散对胃癌裸鼠移植瘤上皮间质转化(EMT)的抑制作用及与白细胞介素-6(IL-6)/非受体型酪氨酸蛋白激酶2(JAK2)/信号转导及转录激活蛋白3(STAT3)通路的关系。方法:40只裸鼠随机分成模型组、加味三物白散组、阳性药物组、... 详细信息

目的:研究加味三物白散对胃癌裸鼠移植瘤上皮间质转化(EMT)的抑制作用及与白细胞介素-6(IL-6)/非受体型酪氨酸蛋白激酶2(JAK2)/信号转导及转录激活蛋白3(STAT3)通路的关系。方法:40只裸鼠随机分成模型组、加味三物白散组、阳性药物组、联合组,每组10只。造模、灌胃干预后,ELISA检测裸鼠血清IL-6、肿瘤坏死因子-α(TNF-α)、CEA、CA199含量,HE染色观察瘤组织病理改变,RT-PCR及Western Blot检测EMT及IL-6/JAK2/STAT3通路相关mRNA、蛋白表达情况。结果:与模型组比较,各给药组第12—18天瘤体体积显著缩小(Pimentin mRNA及STAT3、N-cadherin、Vimentin蛋白表达显著降低(P<0.01,P<0.05),E-cadherin mRNA及蛋白表达显著增加(P<0.01,P<0.05);且联合组各m RNA表达效果优于两单给药组(P<0.05)。结论:加味三物白散可通过调控IL-6/JAK2/STAT3信号通路抑制胃癌裸鼠移植瘤EMT,效果以联合用药为优。

关键词：胃癌加味三物白散 5-氟尿嘧啶白细胞介素-6/非受体型酪氨酸蛋白激酶2/信号转导及转录激活蛋白3信号通路上皮间质转化机制

近20年黄河流域甘肃段植被覆盖度变化与驱动因素分析

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农业机械学报 2024年第7期55卷 365-372,404页

作者：田云刘俊艳白爽孙建欣郑晓雄孙中平甘肃省生态环境信息中心兰州730030 生态环境部卫星环境应用中心北京100094

黄河流域甘肃段作为我国重要水源涵养区和北方防沙带建设区,掌握其植被变化及驱动力对流域生态保护和高质量发展具有重要意义。基于2001—2022年MODIS NDVI数据集,利用像元二分法、变异系数、趋势分析法、Hurst指数和地理探测器,分析了... 详细信息

黄河流域甘肃段作为我国重要水源涵养区和北方防沙带建设区,掌握其植被变化及驱动力对流域生态保护和高质量发展具有重要意义。基于2001—2022年MODIS NDVI数据集,利用像元二分法、变异系数、趋势分析法、Hurst指数和地理探测器,分析了近20年来黄河流域甘肃段植被变化趋势及驱动力。结果表明:2001—2022年黄河流域甘肃段FVC在波动中呈上升趋势,植被生长呈向好趋势。近20年间黄河流域甘肃段近1/2区域具有相对高-高波动性,主要集中分布在流域北部的黄土高原区,中波动性、相对低-低波动性主要分布在甘南高原区和陇南山地等区域。黄河流域甘肃段大部分地区植被呈改善趋势,少部分区域表现为退化,未来植被变化将呈反持续性。驱动力分析表明降水量、植被类型和土壤类型对黄河流域甘肃段植被覆盖起主导作用。

关键词：黄河流域甘肃段植被覆盖度驱动因素 Hurst指数地理探测器

Method for detector description conversion from DD4hep to Filmbox

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Nuclear Science and Techniques 2024年第9期35卷 115-126页

作者： Zhao-Yang Yuan Tian-Zi Song Yu-Jie Zeng Kai-Xuan Huang Yu-Mei Zhang Zheng-yun You School of Physics Sun Yat-sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

DD4hep serves as a generic detector description toolkit recommended for offline software development in next-generation high-energy physics(HEP)***,Filmbox(FBX)stands out as a widely used 3D modeling file format within the 3D software *** this paper,we introduce a novel method that can automatically convert complex HEP detector geometries from DD4hep description into 3D models in the FBX *** feasibility of this method was dem-onstrated by its application to the DD4hep description of the Compact Linear Collider detector and several sub-detectors of the super Tau-Charm facility and circular electron-positron collider *** automatic DD4hep–FBX detector conversion interface provides convenience for further development of applications,such as detector design,simulation,visualization,data monitoring,and outreach,in HEP experiments.

关键词： Detector description DD4hep FBX Geometry Offline software

基质细胞衰老在子宫内膜蜕膜化及容受性建立中的作用机制

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中华生殖与避孕杂志 2024年第1期44卷 98-102页

作者：龙一婧齐家孙贇上海交通大学医学院附属仁济医院生殖医学中心上海市辅助生殖与优生重点实验室上海200135

胚胎着床过程复杂而精密。胚胎质量、子宫内膜容受性以及两者的同步发育是决定胚胎着床的关键因素。蜕膜化是子宫内膜基质细胞转变为分泌型的蜕膜基质细胞的过程,与子宫内膜容受性密切相关。异常蜕膜化可导致胚胎着床失败或不良妊娠结... 详细信息

胚胎着床过程复杂而精密。胚胎质量、子宫内膜容受性以及两者的同步发育是决定胚胎着床的关键因素。蜕膜化是子宫内膜基质细胞转变为分泌型的蜕膜基质细胞的过程,与子宫内膜容受性密切相关。异常蜕膜化可导致胚胎着床失败或不良妊娠结局。最新研究表明子宫内膜蜕膜化中存在子宫内膜基质细胞衰老的现象,一定程度的基质细胞衰老促进蜕膜化和容受性建立,而过度或不足的基质细胞衰老则可能导致蜕膜化异常和容受性受损。本文旨在对基质细胞衰老在子宫内膜蜕膜化及容受性建立中的作用进行综述,以期为容受性相关疾病的发病机制和治疗提供新的启示。

关键词：胚胎植入细胞衰老子宫内膜蜕膜化子宫内膜容受性