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Neuroplastin in Ca^(2.)signal regulation and plasticity of glutamatergic synapses

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Neural Regeneration Research 2023年第8期18卷 1705-1706页

作者： Ayse Malci Xiao Lin yun stone Shi Rodrigo Herrera-Molina Center for Neuroscience Research Children’s National Medical CenterWashingtonDCUSA Guangdong Institute of Intelligence Science and Technology ZhuhaiGuangdong ProvinceChina Combinatorial Combinatorial NeuroImaging Leibniz Institute for NeurobiologyMagdeburgGermany Centro Integrativo de Biología y Química Aplicada Universidad Bernardo O’HigginsSantiagoChile

The main function of neurons is information transmission in the form of action *** fulfill this duty,neurons are connected functionally with each other via synapses,the microscopic structures where specialized molecular machinery is strategically placed to release and receive neurotransmitters and to generate and extinguish calcium(Ca^(2.))*** synaptic molecular components are highly dynamic and they influence each other to confer structural and functional adaptability(plasticity)to neuronal communication(Biederer et al.,2.17).

关键词： plasticity specialized structural

基于便携式地物高光谱仪的文物材料分析研究进展

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光谱学与光谱分析 2024年第5期44卷 1218-1226页

作者：王聪 Mara Camaiti 刘呆运铁付德曹颐戬中国-中亚人类与环境“一带一路”联合实验室(西北大学) 陕西西安710127 文化遗产研究与保护技术教育部重点实验室(西北大学) 陕西西安710127 CNR-Institute of Geosciences and Earth Resources Florence 50121Italy 陕西省考古研究院陕西西安710043 考古探测与文物保护技术教育部重点实验室(西北工业大学) 陕西西安710072 西北工业大学文化遗产研究院陕西西安710072

文物承载着灿烂文明,传承着历史文化,是全人类的宝贵遗产。由于文物不可再生的珍贵性,以及最少干预的文物保护基本原则,无损分析技术始终是文物制作工艺研究、劣化机理及保护修复研究中材料分析的最主要技术手段。因此,研发、应用新型... 详细信息

文物承载着灿烂文明,传承着历史文化,是全人类的宝贵遗产。由于文物不可再生的珍贵性,以及最少干预的文物保护基本原则,无损分析技术始终是文物制作工艺研究、劣化机理及保护修复研究中材料分析的最主要技术手段。因此,研发、应用新型无损分析技术是文物保护利用的重要研究方向。近年来,源于遥感领域的便携式地物高光谱仪在文物材料分析中展现出强大应用潜力,并且已在石质古建筑、绘画等文物修复中成功应用。作为一种无需采样的非侵入式光谱技术,便携式地物高光谱仪可在极短时间获取一个涵盖可见光-近红外-短波红外波段(350~2.00 nm)的全波段、高分辨率反射光谱。同时,其便携程度很高,对工作环境、光源等无特殊要求,可在野外文物或遗址现场原位使用。此外,在采集光谱数据的同时还可通过遥感技术实现数据的远程传输和分析。上述技术特点使其在文物材料分析中具有独特的应用优势。以光谱技术的基本原理为基础,首先介绍了目前文物材料分析中常用便携式地物高光谱仪的设备型号及其性能指标;其次细致梳理了近十年来其在有机质/无机质文物材料定性和定量分析、文物保护材料分析,以及文物修复原位、实时监测等方面的应用现状;之后深入探讨了谱图预处理的规范和建立标准波谱库等两个影响该技术应用效果的关键问题;最后展望了该技术的发展趋势,预期在脆弱有机质文物分析、多种分析技术联合应用和定量分析研究方面前景广阔。

关键词：地物高光谱仪文物材料分析无损分析

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太原市地铁2.线与市政道路结合的优化设计

石材 2024年第7期 120-122页

作者：路云太原市市政工程设计研究院山西太原030000

结合工程实例,介绍了太原市地铁2.线大南门站周边道路——迎泽大街、解放路在地铁施工期间、地铁恢复后的交通组织与路面恢复工程,在满足交通组织的情况下,最大程度的利用了原有道路,降低了工程造价,为以后的地铁恢复工作提供了借鉴。

关键词：地铁市政道路路面恢复临时恢复永久恢复

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明清时期贵州桥梁的命名及其文化内涵

贵州文史丛刊 2024年第2期 72-85页

作者：杨云罗权贵州师范大学历史与政治学院贵州师范大学喀斯特生态文明研究中心暨历史地理研究中心贵州贵阳550025

明清时期,随着贵州驿道交通和城镇建设的需求,桥梁的修建数量超越了以往各个时代。这些桥梁的命名多种多样,不同程度地受到桥梁建筑的位置、用材、功用和历史、文化、习俗等因素的影响,前者包括水文、木石、铁索等,后者包括姓氏、嘉名... 详细信息

明清时期,随着贵州驿道交通和城镇建设的需求,桥梁的修建数量超越了以往各个时代。这些桥梁的命名多种多样,不同程度地受到桥梁建筑的位置、用材、功用和历史、文化、习俗等因素的影响,前者包括水文、木石、铁索等,后者包括姓氏、嘉名、人物、传说、形状、纪事等,许多桥名蕴藏着丰厚的历史文化内涵,是研究贵州桥梁建筑史和文化史的重要资料。

关键词：明清时期贵州桥梁命名

基于高光谱图像波段融合的猕猴桃软腐病早期分类检测

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光谱学与光谱分析 2024年第1期44卷 241-249页

作者：高宏盛郭志强曾云流丁港王逍遥李黎武汉理工大学信息工程学院湖北武汉430070 华中农业大学园艺植物生物学教育部重点实验室国家柑橘保鲜技术研发专业中心湖北武汉430070 中国科学院植物种质创新与特色农业重点实验室中国科学院猕猴桃产业技术工程实验室中国科学院种子创新研究院中国科学院武汉植物园湖北武汉430074

软腐病是猕猴桃采后贮藏和销售过程中危害最严重的真菌病害,其潜伏期长,在染病早期还未表现出明显病状时,依靠人工筛选很难将其分类。为此应用高光谱成像技术(470~900 nm)对软腐病的早期分类检测展开研究。采集了健康猕猴桃以及感染软... 详细信息

软腐病是猕猴桃采后贮藏和销售过程中危害最严重的真菌病害,其潜伏期长,在染病早期还未表现出明显病状时,依靠人工筛选很难将其分类。为此应用高光谱成像技术(470~900 nm)对软腐病的早期分类检测展开研究。采集了健康猕猴桃以及感染软腐病的早期和晚期猕猴桃共2.5个高光谱图像,并采用Kennard-stone算法将样本按照7∶3划分为训练集和测试集样本。首先对样本进行感兴趣区域的选择,然后取该区域的平均光谱作为样本的原始光谱曲线。对原始光谱曲线采用主成分分析(PCA)、连续投影算法(SPA)和竞争性自适应重加权算法(CARS)进行光谱特征的提取。与此同时,对SPA求解过程中的8个特征波段使用非下采样轮廓波变换(NSCT)进行波段融合获得融合图像,然后使用灰度共生矩阵法(GLCM)提取融合图像的纹理特征。最后将光谱特征和纹理特征进行融合并分别建立最近邻算法(KNN)、随机森林(RF)以及支持向量机(SVM)分类模型进行猕猴桃软腐病的早期分类检测。此外,还与其他文献中使用主成分图像或特征波段提取的纹理特征进行了对比。该研究主要创新点为:使用NSCT对特征波段图像进行融合后再提取其纹理特征,既降低了特征维度,减少了特征冗余,又融合了不同波段图像的互补信息,提高了分类准确率。实验结果表明,SVM是最适合该研究的分类器,单独使用光谱特征或纹理特征进行分类的结果都不够理想,但两种特征融合后分类准确率最高可达到92.05%,多数猕猴桃软腐病早期样本得到了正确识别,这说明两种特征的融合获得了高光谱图像中光谱和图像的差异性信息,体现了高光谱图像的“空谱合一”。该研究对软腐病早期猕猴桃进行了快速、准确的无损检测,可为猕猴桃的采后品质分级提供一定的参考和指导意义。

关键词：猕猴桃软腐病高光谱图像波段融合空谱合一无损检测

Optimal Design of Bionic Flexible Fixation System for MRI-Guided Breast Biopsy

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Journal of Bionic Engineering 2019年第6期16卷 1116-1126页

作者： Tianxue Zhang yun-hui Liu T stone Robotics Institute the Department of Mechanical and Automation Engineeringthe Chinese University of Hong KongNTHKSARChina

In Magnetic Resonance Imaging(MRI)guided intervention procedures,the flexibility and reliability of the mammary gland fixation device are important indicators for cnsuring the quality of *** paper presents a bionic flexible fixation system for MRI-guided breast biopsy,and establishes a mathematical model of the palm-type curved plate and a breast compression *** bending angle,eccentricity,and tightening stroke of the palm-type curved plate are considered the main influencing *** bending angle and eccentricity of the bionic palm-type curved plate and flexible fingers are optimized,and a prototype of the breast fixation system is *** experimental results show that when the external force is 10 N,the average repetitive accuracy of four lesion points is 0.71 mm,0.60 mm,0.63 mm,and 0.68 mm,*** the pressures are 8 N,10 N,and 12.N,the thickness of the compressed tissue is 76.2. mm,72.8 mm and 68.73 mm,*** has good repetitive accuracy and is compatible with the concept of flexible fixation that reduces the uncomfortable feeling of the human *** propose that by optimizing the flexible tightening mechanism,it is feasible to properly control the external compression force to effectively reduce the compression pain for patients while guaranteeing the tightening reliability in breast biopsy.

关键词： breast biopsy bionic palm flexible fixation optimized design MRI robotics

The Amino Terminal Domain Plays an Important Role in Modifying the Pore Function of Gluk2

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The Amino Terminal Domain Plays an Important Role in Modifyi...

Cost-Effective Machining of Granite by Reducing Tribological Interactions

中国神经科学学会第十二届全国学术会议

作者： Yanjun Li Guifang Duan Shi stone yun Model Animal Research Center Nanjing University

Kainate type glutamate receptors（KARs） localizes pre-and post-synapse in neuron system, plays important roles in modifying neurotransmitters release and intrinsic neuron excitatory. Kainate receptor dysfunction to be reflected to many neuropathic disease, such as autism, chronic pain, epilepsy and so on. However, our learning of KARs is limited, and the drug modifying KAR function is very short. Here, we show that, KAR2.with NTD truncation（KAR2.d NTD） has the normal amplitude and kinetics, however, the modification effect by auxiliary protein Neto1 and Neto2.is changed. Neto1 which can accelerate the desensitization time of KAR2. but slower that for KAR2.d NTD. In addition, Neto2.also can slower the desensitization of KAR2.d NTD as that for KAR2. but its effect is seriously cut down. We examined Neto1/2.modification for KAR2.currents rectification, which was not changed. After NTD truncation, its dose response curve for glutamate move left. Moreover, we detected its sensibility for Con A, the widely used drug to speed up KARs recovery from desensitization stage. And we found that, the Con A effect for KAR2.d NTD is smaller compare to intact KAR2. In brief, from our study for KAR2.d NTD, we found that the NTD is not necessary for KAR2.channel function, but it plays import role in regulating modification of the pore characters.

关键词： KAR2 NTD Kinetics Regulation

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厦门大学学报（自然科学版） 2002年第S1期41卷 123-页

作者： LI Yuan 1, HUANG Hui 1, SHEN Jian-yun 1, XU Xi-peng 1, GAO Yong-sheng 2.(1. Province Key Lab of stone Machining, Huaqiao University, Quanzhou 362.11, China 2. Department of Mechanical Engineering, Hong Kong University of Science and T echnology, Hong Kong, China)

In order to implement cost-effective machining of gr anite materials with diamond impregnated tools, we should realize low tool w ear, low energy consumption, and high cutting efficiency, while the accuracy of the workpiece surfaces are maintained to be satisfactory. It is understood that the main factors affecting the tool wear, the energy, and the efficiency during the machining process are related to the tribological interactions that occur at the interface between the diamond tool surface and the workpiece. Based on this consideration, we propose a new machining method to machine granite materia ls to achieve improved cost effectiveness. In the proposed method, the tribologi cal interactions are maintained to a minimum. Based on the analyses of the experimental results, the following conclusions can be drawn: The wear performance is greatly dependent on the machining parameters and their combination. Therefore, optimum machining parameters must be set up at first in order to optimize the tribological characteristics of segments and thereby sawbl ade performance. These may be realized by balancing the energy expended by frict ion and the mechanical load on diamond crystal. The geometry and structure of diamond segments are another important criterion f or the diamond saw blade. Using a seven-layer structure for multi-blades sawin g and applying segments with side slots for trimming application had greatly red uced the frictions in the sawing processes. The wetting and bonding between diamonds and matrix alloys have been considered as the prerequisite for high wear performance of the segments. Diamonds coated w ith Ti-Cr alloy by a unique technique can effectively improve its wetting c apability and provide more storage space for debris, thereby reducing friction i nteractions.

关键词： granite sawing friction interaction cost-effe ctive

Transmembrane AMPA Receptor Regulatory Protein γ-8 is Associated with Antisocial Personality Disorder

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神经药理学报 2019年第4期 31-32页

作者： PENG Shi-xiao WANG Yue-ying LIU Na yun stone Shi State Key Laboratory of Pharmaceutical Biotechnology Department of NeurologyDrum Tower HospitalMedical School MOE Key Laboratory of Model Animal for Disease Study Model Animal Research CenterNanjing University Department of Medical Psychology Nanjing Medical University affiliated Nanjing Brain Hospital Institute for Brain Sciences Nanjing University

Antisocial personality disorder( ASPD),a common subtype of personality disorder characterized by irresponsible behavior often leading to criminal behavior,has heritability. In current study,we found SNP rs1042.32. in the 1 st intron of CACNG8,the gene encoding transmembrane AMPA receptor regulatory protein γ-8( TARP γ-8),is associated with ASPD in a male prisoner sample in Chinese Han people. The distribution of rs1042.32. G is significantly higher in ASPD subjects relative to the normal healthy males. Using a reportermolecule in which the sequence covering rs1042.32. were fused to the N-terminal of GFP protein,we found the expression level of the reporting GFP protein,mRNA and pre-mRNA relied on the rs1042.32. variants. Furthermore,in 12. fore-cortical brain samples from a Chinese Han brain library,the expression level of TARP γ-8 was associated with the SNP rs1042.32.. The SNP is located in a guanine-rich region. We found it modulated the conformation and stability of a local G-quadruplex DNA structure,which appeared to regulate the transcription of TARP γ-8. Using TARP γ-8 knockout mice,we found that the decrease of TARP γ-8 lead to abnormal social behaviors and aggression. Therefore,the AMPA receptor auxiliary subunit TARP γ-8 contributes to a risk factor for ASPD.

关键词： TARP γ-8 SNP G-quadruplex ASPD aggression