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Cellular & Molecular Immunology 2024年第5期21卷 466-478页

作者： Hyo Jeong Kim yun sang lee Bok-Soon lee Chang-Hak Han sang Gyu Kim Chul-Ho Kim Department of Otolaryngology School of MedicineAjou UniversitySuwonRepublic of Korea Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea

Inflammasomes are multiprotein complexes involved in the host immune response to pathogen ***,inflammasomes participate in many conditions,such as ***,it was shown that NETosis,a type of neutrophil cell death,is induced by bacterial infection and is involved in inflammatory diseases such as delayed wound healing in patients with ***,the relationship between inflammasomes and NETosis in the pathogenesis of inflammatory diseases has not been well *** this study,we determined whether NETosis is induced in ***-induced skin inflammation and whether activation of the nucleotide-binding domain,leucine-rich family,and pyrin domain-containing-3(NLRP3)inflammasome is one of the key factors involved in NETosis induction in a mouse model of acne skin *** found that NETosis was induced in ***-induced skin inflammation in mice and that inhibition of NETosis ameliorated ***-induced skin *** addition,our results demonstrated that inhibiting inflammasome activation could suppress NETosis induction in mouse *** results indicate that inflammasomes and NETosis can interact with each other to induce ***-induced skin inflammation and suggest that targeting NETosis could be a potential treatment for inflammasome-mediated diseases as well as NETosis-related diseases.

关键词： P.acnes NETosis NLRP3 inflammasome Skin inflammation

GnRH impairs diabetic wound healing through enhanced NETosis

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Cellular & Molecular Immunology 2020年第8期17卷 856-864页

作者： yun sang lee Sung Un Kang Myung-Hoon lee Haeng-Jun Kim Chang-Hak Han Ho-Ryun Won Young Uk Park Chul-Ho Kim Department of Otolaryngology School of MedicineAjou UniversitySuwonRepublic of Korea Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea Department of Otolaryngology School of MedicineChungnam National UniversityDaejeonRepublic of Korea Department of Orthopedic Surgery Ajou UniversitySuwonRepublic of Korea

It has been reported that neutrophil extracellular traps(NETs)impair wound healing in diabetes and that inhibiting NET generation(NETosis)improves wound healing in diabetic ***-releasing hormone(GnRH)agonists are associated with a greater risk of ***,the role of GnRH in diabetic wound healing is *** determined whether GnRH-promoted NETosis and induced more severe and delayed diabetic wound healing.A mouse model of diabetes was established using five injections with *** with blood glucose levels>250 mg/dL were then used in the *** agonist treatment induced delayed wound healing and increased NETosis at the skin wounds of diabetic *** contrast,GnRH antagonist treatment inhibited GnRH agonist-induced delayed wound *** expression of NETosis markers PAD4 and citrullinated histone H3 were increased in the GnRH-treated diabetic skin wounds in diabetic mice and *** vitro experiments also showed that neutrophils expressed a GnRH receptor and that GnRH agonist treatment increased NETosis markers and promoted phorbol myristate acetate(PMA)-induced NETosis in mouse and human ***,GnRH antagonist treatment suppressed the expression of NETosis markers and PMA-induced NETosis,which were increased by GnRH *** results indicated that GnRH-promoted NETosis and that increased NETosis induced delayed wound healing in diabetic skin ***,inhibition of GnRH might be a novel treatment of diabetic foot ulcers.

关键词： Neutrophils GnRH Diabetic wound healing NETosis

Coronary Artery Complications after Right Ventricular Outflow Tract Reconstruction Surgery

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Congenital Heart Disease 2022年第3期17卷 281-295页

作者： Hye Won Kwon Mi Kyoung Song sang yun lee Gi Beom Kim Sungkyu Cho Jae Gun Kwak Woong-Han Kim Whal lee Eun Jung Bae Department of Pediatrics Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Thoracic and Cardiovascular Surgery Seoul National University HospitalSeoul National University College of MedicineSeoulSouth Korea Department of Radiology Seoul National University HospitalSeoulSouth Korea

Background:Mechanisms and clinical manifestations of coronary artery complications after right ventricular outflow tract reconstruction surgery are not well ***:Patients who had coronary artery complications after pulmonary valve replacement or the Rastelli procedure at a single tertiary centre were retrospectively ***:Coronary artery complications were identified in 20 patients who underwent right ventricular outflow tract reconstruction *** median age at diagnosis of coronary artery complication was 21 years(interquartile range:13–25 years).Mechanisms of coronary artery complications were compression by adjacent materials in 12 patients,dynamic compression of intramural course of coronary artery in two patients,and intraoperative injury in six *** coronary artery anomalies were identified in 50%(10/20)of *** patients presented with early postoperative haemodynamic *** patients showed late onset symptoms or signs of coronary insufficiency,including chest pain,ventricular dysfunction,or ventricular *** artery stenosis was incidentally found on cardiac computed tomography angiography in two asymptomatic *** patients underwent surgical interventions,and one patient underwent percutaneous coronary intervention for coronary *** patient with recurrent ventricular tachycardia required an implantable *** were two deaths in patients with intraoperative coronary ***:Preoperative coronary evaluation and long-term follow-up for the development of coronary artery complications are required in patients undergoing right ventricular outflow tract reconstruction surgery to prevent ventricular dysfunction,arrhythmias,and death,especially among those with congenital coronary anomalies.

关键词： Congenital heart disease right ventricular outflow tract reconstruction surgery coronary artery disease

Actinomycosis of the appendix mimicking appendiceal tumor:A case report

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World Journal of Gastroenterology 2010年第3期16卷 395-397页

作者： sang-yun lee Hee-Jin Kwon Jin-Han Cho Jong-Young Oh Kyung-Jin Nam Jin-Hwa lee Seong-Kuk Yoon Myong-Jin Kang Jin-Sook Jeong Department of Radiology Dong-A University Hospital Department of Pathology Dong-A University Hospital

Actinomycosis is an uncommon chronic infectious disease. Common sites of involvement include the cervicofacial, thoracic and abdominopelvic regions. In abdominopelvic actinomycosis, the ileocecal region, including the appendix, is the most commonly involved site. In some reports, limited appendiceal actinomycosis has revealed a thickened appendiceal wall with peri-appendiceal inflammation as acute appendicitis or perforated appendicitis. We experienced pathologically confirmed intraluminal limited appendiceal actinomycosis without peri-appendiceal infiltration. Here, we report the computed tomography and ultrasound findings.

关键词： Actinomyces Actinomycosis Appendiceal neoplasms Appendicitis

Surgical Repair of Ventricular Septal Defect in Neonates: Indications and Outcomes

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Congenital Heart Disease 2024年第1期19卷 69-83页

作者： Jae Hong lee Sungkyu Cho Jae Gun Kwak Hye Won Kwon Woong-Han Kim Mi Kyoung Song sang-yun lee Gi Beom Kim Eun Jung Bae Department of Thoracic and Cardiovascular Surgery Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanKorea Department of Thoracic and Cardiovascular Surgery Seoul National University Children’s HospitalSeoulKorea Department of Pediatrics Seoul National University Children’s HospitalSeoulKorea

Background:The optimal surgical timing and clinical outcomes of ventricular septal defect(VSD)closure in neo-nates remain *** aimed to evaluate the clinical outcomes of VSD closure in neonates(age≤30 days).Methods:We retrospectively reviewed 50 consecutive neonates who underwent VSD closure for isolated VSDs between August 2003 and June *** for the procedure included congestive heart failure/failure to thrive and pulmonary *** adverse events(MAEs)were deﬁned as the composite of all-cause mortality,reoperation,persistent atrioventricular block,and signiﬁcant(≥grade 2)valvular ***:The median age and body weight at operation were 26.0 days(interquartile range[IQR],18.8–28.3)and 3.7 kg(IQR,3.3–4.2),*** median follow-up duration was 110.4 months(IQR,56.8–165.0).Seven patients required preoperative respiratory support,andﬁve had signiﬁcant(≥grade 2)preoperative valvular *** early mortality occurred due to irreversible cardiogenic shock;no late mortality was *** reopera-tion was due to hemodynamically signiﬁcant residual VSD at 103.8 months *** overall survival,freedom from reoperation,and freedom from MAE at 15-years were 98.0%,96.3%,and 94.4%,***-operative mechanical ventilation was associated with a longer duration of postoperative mechanical ventilation(p<0.001)and a longer length of intensive care unit stay(p<0.001).Conclusions:VSD closure with favorable outcomes without morbidities is feasible even in ***,neonates requiring preoperative respiratory support may require careful postoperative management considering the long-term postoperative ***,surgical VSD closure might be indicated earlier in neonates with respiratory compromise.

关键词： Ventricular septal defect neonate early surgery neonatal surgery

Long-Term Outcome and Risk Factor Analysis of Surgical Pulmonary Valve Replacement in Congenital Heart Disease

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Congenital Heart Disease 2022年第3期17卷 335-350页

作者： Woo Young Park Gi Beom Kim sang yun lee Mi Kyoung Song Hye Won Kwon Hyo Soon An Eun Jung Bae Sungkyu Cho Jae Gun Kwak Woong-Han Kim Department of Pediatrics Seoul National University Children’s HospitalSeoul National University College of MedicineSeoulKorea Department of Thoracic and Cardiovascular Surgery Seoul National University Children’s HospitalSeoul National University College of MedicineSeoulKorea

Objectives:To establish long-term outcome of surgical pulmonary valve replacement(PVR)in congenital heart disease(CHD)and to identify risk factors for overall mortality,operative mortality,and repetitive ***:This is a retrospective study of 375 surgical PVR in 293 patients who underwent surgical PVR for CHD between January 2000 and May *** only included patients with index PVR with previous open-heart surgery regardless of the number of *** previous surgical history of patients who underwent PVR during the study period was also *** who underwent the Rastelli operation,and those who underwent single PVR without previous open-heart surgery were ***:The median age of the patients at the time of surgical PVR was 14.9 years(Interquartile range,IQR,11.0–22.0).The median follow-up duration was 10.5 years(IQR,5.5–14.8 years).There were 3 patients with operative mortality(1.0%)and 15 patients with overall mortality(5.1%).The survival rate was 95.1%over 20 years follow-up *** analysis demonstrated that more than 3 times of previous open-heart surgeries before surgical PVR,older age at the first operation,longer cardiopulmonary bypass(CPB)time and longer intensive care unit(ICU)stay were predictors for overall *** who underwent surgical PVR after more than 3 times of previous open-heart surgeries had significantly higher mortality than those who underwent open-heart surgeries less than 3 times(P<0.001).Age younger than 10 years,male,multiple valve problems and longer ICU stay were significant predictors for repetitive PVR by multivariate ***:Though surgical PVR has excellent long-term outcome,it should be performed with caution for those who previously underwent multiple open-heart surgeries,especially if patient received more than 3 times of open-heart surgeries.

关键词： Pulmonary valve replacement mortality operative mortality repetitive pulmonary valve replacement risk factor analysis childhood

Role of superoxide dismutase 3 in skin inflammation

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Role of superoxide dismutase 3 in skin inflammation

The Prediction of IVIG Retreatment Group or Occurrence of Coronary Arterial Lesion According to the IgG Inhibitory Protective Receptor（FcRp,CD14+CD16+） Monocyte Subpopulation Level at before and after IVIG Treatment in Kawasaki Disease.

The Second Eastern Asia Dermatology Congress(EADC2012)

作者： Myung-Ja Kwon yun sang lee Tae-Yoon Kim Laboratory of Dermato-Immunology Catholic Research Institute of Medical ScienceCatholic University

＜正＞The extracellular superoxide dismutase（SOD） SOD3 is an isoform of SOD that scavenges superoxide radicals. Extensive studies have been focused on role of SOD3 as an ***,the role of SOD3 in the immune responses that contribute to the inhibition of skin inflammation has not been *** we have reported that SOD3 has antiangiogenic effect and is downregulated in lesional skin of *** further study on SOD3

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The Prediction of IVIG Retreatment Group or Occurrence of Co...

LED背光源中的集成电源型LED模块驱动系统

第五届亚洲儿科研究大会

作者： Ji-Hye Shin sang-yun lee Hong-Ryang Kil Department of Pediatrics College of MedicineChungnam National University

＜正＞Introduction About 10-20%of Kawasaki disease（KD） patients have persistent or recurrent fever after IVIG *** patients are at increased risk of developing coronary arterial lesion（CAL）.IVIG is proportioned by IgG mostly,which half-life is similar to serum *** half-life of serum IgG may change as the subpopulation of IgG inhibitory protective receptor（FcRp,CD14+CD16+） monocyte that

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现代显示 2007年第11期 30-34页

作者： sang-yun lee Chang-Hoon Baek Do-Hun Kim Hyung-Suk Kim Myoung-Soo Choi Bang-Won Oh 张进三星机电有限公司光学部东南大学显示技术研究中心

开发了一种用于液晶显示器的RGB-LED背光源中的新型集成电源型的LED模块(IPLM)驱动系统。传统驱动方案中的DC-DC压降转换电路被集成到了主电源电路中,恒流控制电路被合并到了LED模块中。因此,传统背光源中的这两部分驱动板都被省略了。

关键词： LED背光系统驱动系统降压-升压转换器

Spectral Dependence on the Correction Factor of Erythemal UV for Cloud, Aerosol, Total Ozone, and Surface Properties: A Modeling Study

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Advances in Atmospheric Sciences 2016年第7期33卷 865-874页

作者： sang Seo PARK Yeonjin JUNG yun Gon lee Research Institute for Applied Mechanics Kyushu University Department of Atmospheric Sciences Yonsei University Department of Atmospheric Sciences Chungnam National University

Radiative transfer modal simulations were used to investigate the erythemal ultraviolet （EUV） correction factors by separating the UV-A and UV-B spectral ranges. The correction factor was defined as the ratio of EUV caused by changing the amounts and characteristics of the extinction and scattering materials. The EUV correction factors （CFEUV） for UV-A [CFEUV（A）] and UV-B [CFEUV（B）] were affected by changes in the total ozone, optical depths of aerosol and cloud, and the solar zenith angle. The differences between CFEUV（A） and CFEUV（B） were also estimated as a function of solar zenith angle, the optical depths of aerosol and cloud, and total ozone. The differences between CFEUV（A） and CFEUV（B） ranged from -5.0% to 25.0% for aerosols, and from -9.5% to 2.0% for clouds in all simulations for different solar zenith angles and optical depths of aerosol and cloud. The rate of decline of CFEUV per unit optical depth between UV-A and UV-B differed by up to 20% for the same aerosol and cloud conditions. For total ozone, the variation in CFEUV（A） was negligible compared with that in CFEUV（B） because of the effective spectral range of the ozone absorption band. In addition, the sensitivity of the CFEUVs due to changes in surface conditions （i.e., surface albedo and surface altitude） was also estimated by using the model in this study. For changes in surface albedo, the sensitivity of the CFEUVs was 2.9%-4.1% per 0.1 albedo change, depending on the amount of aerosols or clouds. For changes in surface altitude, the sensitivity of CFEUV（B） was twice that of CFEUV（A）, because the Rayleigh optical depth increased significantly at shorter wavelengths.

关键词： Erythemal UV correction factor UV-A UV-B