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Nuclear Factor-κB Signaling Mediates Antimony-induced Astrocyte Activation

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Biomedical and Environmental Sciences 2021年第1期34卷 29-39页

作者： ZHANG Tao ZHENG Yu Dan JIAO Man ZH Ye XU Shen Ya ZHU Piao Yu ZHAO Xin Yuan WU qi yun Department of Occupational Medicine and Environmental Toxicology School of Public HealthNantong UniversityNantong 226019JiangsuChina Fudan University Taizhou Institute of Health Sciences Taizhou 225300JiangsuChina

Objective Antimony(Sb)has recently been identified as a novel nerve poison,although the cellular and molecular mechanisms underlying its neurotoxicity remain *** study aimed to assess the effects of the nuclear factor kappa B(NF-κB)signaling pathway on antimony-induced astrocyte *** Protein expression levels were detected by Western ***,cytoplasmic and nuclear fractions separation were used to assess the distribution of *** expression of protein in brain tissue sections was detected by *** levels of mRNAs were detected by Quantitative real-time polymerase chain reaction(qRT-PCR)and reverse transcriptionpolymerase chain reaction(RT-PCR).Results Antimony exposure triggered astrocyte proliferation and increased the expression of two critical protein markers of reactive astrogliosis,inducible nitric oxide synthase(iNOS)and glial fibrillary acidic protein(GFAP),indicating that antimony induced astrocyte activation in vivo and in *** exposure consistently upregulated the expression of inflammatory ***,it induced the NF-κB signaling,indicated by increased p65 phosphorylation and translocation to the ***-κB inhibition effectively attenuated antimony-induced astrocyte ***,antimony phosphorylated TGF-β-activated kinase 1(TAK1),while TAK1 inhibition alleviated antimonyinduced p65 phosphorylation and subsequent astrocyte *** Antimony activated astrocytes by activating the NF-κB signaling pathway.

关键词： Antimony Astrocyte activation Neurotoxicity NF-κB TAK1

温针与南药结合治疗多囊卵巢综合征不孕肾虚痰湿证的随机对照研究

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海南医学 2024年第11期35卷 1560-1565页

作者：王丽娟罗和平李兆萍冯琦钒王韫琪唐南淋柯维华广东省中医院海南医院针灸科海南海口570203 广东省中医院海南医院妇产科海南海口570203 广东省中医院海南医院康复科海南海口570203

目的观察温针与南药结合治疗多囊卵巢综合征不孕肾虚痰湿证的临床疗效。方法选取2022年10月至2023年4月在海南省中医院针灸科、妇产科门诊就诊及招募的多囊卵巢综合征不孕肾虚痰湿证患者60例。采用随机数表法分为观察组和对照组,每组30... 详细信息

目的观察温针与南药结合治疗多囊卵巢综合征不孕肾虚痰湿证的临床疗效。方法选取2022年10月至2023年4月在海南省中医院针灸科、妇产科门诊就诊及招募的多囊卵巢综合征不孕肾虚痰湿证患者60例。采用随机数表法分为观察组和对照组,每组30例。对照组患者采用南药治疗,观察组患者则采用温针与南药结合治疗,两组患者均连续治疗3个月经周期。治疗3个月经周期后,观察两组患者治疗前后的体质量指数(BMI)、中医证候积分及卵泡刺激素(FSH)、黄体生成素(LH)、LH/FSH、睾酮(T)水平,同时比较两组患者治疗后的基础体温(BBT)双相率。治疗结束3个月后进行随访,比较两组患者妊娠率及排卵率,并评价两组患者的临床疗效。结果治疗后,观察组患者的BMI为(23.24±1.88)kg/m^(2),明显低于对照组的(24.51±2.49)kg/m^(2),差异有统计学意义(P0.05);治疗后,观察组患者的BBT双相率为80.0%,明显高于对照组的53.3%,差异有统计学意义(P<0.05);治疗结束3个月后随访,观察组患者的排卵率、妊娠率分别为83.3%、46.7%,明显高于对照组的56.7%、20.0%,差异有统计学意义(P<0.05);观察组患者的总有效率为86.7%,明显高于对照组的56.7%,差异有统计学意义(P<0.05);两组患者在治疗过程中均未出现不良反应。结论温针与南药结合治疗肾虚痰湿证多囊卵巢综合征不孕疗效确切,其能减轻患者临床症状,改善BMI及调节性激素水平,提高排卵率及妊娠率。

关键词：多囊卵巢综合征温针南药肾虚痰湿不孕性激素

A new polyacetylene glycoside from the rhizomes of Atractylodes lancea

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Chinese Chemical Letters 2010年第7期21卷 850-852页

作者： Ying Ji Xu Feng Chao Cheng Xiao yun Fa Dong qi Zhi Wang Ming Wang You Yi Zhao Jiangsu Center for Research & Development of Medicinal Plants Jiangsu Institute of BotanyChinese Academy of Sciences Nanjing Botanical GardenMem.Sun Yat-SenNanjing 210014China

A new polyacetylene glycoside,（1,3Z,11E）-tridecatriene-7,9-diyne-5-hydroxyl-6-O-β-D-glucopyranoside,was isolated from the rhizomes of Atractylodes lancea（Thunb.） *** structure was elucidated on the basis of spect... 详细信息

关键词： Atractylodes lancea Polyacetylene (1 3Z 11E)-Tridecatriene-7 9-diyne-5-hydroxyl-6-O-β-D-glucopyranoside

RING-box proteins regulate leaf senescence and stomatal closure via repression of ABA transporter gene ABCG40

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Journal of Integrative Plant Biology 2022年第5期64卷 979-994页

作者： yun qi Wei Jun Jie Yuan Chen Chen Xiao Gui Xin Li Jing Ying Yan Shao Jian Zheng Zhong Jie Ding State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China Guangdong Laboratory for Lingnan Modern Agriculture College of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China College of Agronomy and Biotechnology Zhejiang UniversityHangzhou 310058China Agricultural Experimental Station Zhejiang UniversityHangzhou 310058China

Plant hormone abscisic acid(ABA)plays an indispensable role in the control of leaf senescence,during which ABA signaling depends on its ***,the role of ABA transport in leaf senescence remains ***,we identified two novel RING-box protein-encoding genes UBIQUITIN LIGASE of SENESCENCE 1 and2(ULS1 and ULS2)involved in leaf *** of ULS1 and ULS2 accelerates leaf senescence,which is specifically promoted by ABA ***,the expression of senescence-related genes is significantly affected in mature leaves of uls1/uls2 double mutant(versus wild type(WT))in an ABA-dependent manner,and the ABA content is substantially ***1 and ULS2 are mainly expressed in the guard cells and aging leaves,and the expression is induced by *** RNA-seq and quantitative proteomics of ubiquitination reveal that ABA transporter ABCG40 is highly expressed in uls1/uls2 mutant versus WT,though it is not the direct target of ULS1/***,we show that the acceleration of leaf senescence,the increase of leaf ABA content,and the promotion of stomatal closure in uls1/usl2 mutant are suppressed by abcg40 loss-of-function *** results indicate that ULS1 and ULS2 function in feedback inhibition of ABCG40-dependent ABA transport during ABA-induced leaf senescence and stomatal closure.

关键词： ABA Arabidopsis E3 ligase leaf senescence stomata transport

Synthesis ofα-D-GlcpNAc-(1→2)-[α-D-ManpNAc-(1→3)-]α-L-Rhap-(1→2)-α-L-Rhap-(1→3)-α-L-Rhap,the repeating unit of O10 antigen from Acinetobacter baumannii

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Chinese Chemical Letters 2008年第4期19卷 415-418页

作者： Jian Jun Zhang Guang Hui Zong Xiao Mei Liang yun qi Li Dao Quan Wang Fan Zuo Kong Key Lab of Pesticide Chemistry and Application Technology Department of Applied ChemistryChina Agricultural UniversityBeijing 100094China Research Center for Eco-Environmental Sciences Academia SinicaR.O.Box 2871Beijing 100085China

An efficient synthesis ofα-D-GlcpNAc-（1→2）-[α-D-ManpNAc-（1→3）-]α-L-Rhap-（1→2）-α-L-Rhap-（1→3）-α-L-Rhap（1）, the repeating unit of the O10 antigen from Acinetobacter baumannii was achieved via sequential assembly of the building blocks,p- methoxylphenyl 2,4-di-O-benzoyl-α-L-rhamnopyranoside（2）;2-O-allyloxycarbonyl-3,4-di-O-bcnzoyl-α-L-rhamnopyranosyl tri- chloroacetimidate（3）;4-methoxylphenyl 3-O-allyloxycarbonyl-4-O-benzoyl-α-L-rhanmopyranoside（4）;2-azido-3-O-benzoyl-2- deoxy-4,6-O-isopropylidene-α-D-mannopyranosyl trichloroacetirnidatc（5）;2-azido-3,4,6-tri-O-benzoyl-2-deoxy-α,β-D-glucopyr- ano syl trichloroacetimidatc（6）.The total yield of 1 from 4 was 4.7%.

关键词： Oligosaccharide Rharmnose Glucosamine Mannosamine

供水管路中驼峰气阻的临界平衡实验研究(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2017年第3期18卷 167-178页

作者： Wu-yi WAN Chen-yu LI yun-qi YU Department of Hydraulic Engineering College of Civil Engineering and Architecture Zhejiang University Hangzhou 310058 China State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Tianjin 310072 China

目的:输水管道的驼峰气阻是指由于管路高峰位置的滞气作用使气体不断聚积在峰顶附近、产生的气体阻碍水流的局部水力现象。它能够导致管路过水断面减小、输水能耗增加、输送效率降低和管路压力振荡等后果,严重威胁海底管道输水的稳定性... 详细信息

目的:输水管道的驼峰气阻是指由于管路高峰位置的滞气作用使气体不断聚积在峰顶附近、产生的气体阻碍水流的局部水力现象。它能够导致管路过水断面减小、输水能耗增加、输送效率降低和管路压力振荡等后果,严重威胁海底管道输水的稳定性和安全性。本文旨在分析滞留气团在供水管道中的力学平衡、能量损失、移动和溢出机理,研究水流流速对气团的推移特性,提出预测和消除驼峰气阻的方法,使输水管道免受驼峰气阻的危害,提高输水管道的供水效率。创新点:1.设计了具有连续坡角变化的圆弧形驼峰管道实验,该实验可以定量模拟气团体积和平衡角度;2.建立了驼峰气阻的水头损失经验公式和恒定流情况下驼峰气阻的管道坡角和流速的对应关系式,可用于预测和消除驼峰气阻的危害。方法:1.通过驼峰气团的受力特性分析,获得满足量纲和谐的力学平衡方程;2.采用试验观察和测试获得有无气泡情况下的水头损失和平衡状态下的坡角,通过等价球体方法对测试数据进行无量纲拟合,获得气阻的水头损失方程系数,并通过流速和平衡坡角建立恒定流情况下的临界平衡方程;3.基于试验拟合获得临界平衡方程,建立预测和评估气阻的准则系数,并提出消除气阻的水流临界流速。结论:1.当管路流速较小时,供水管路的驼峰顶端可能滞留和聚集气体,形成驼峰气阻;气体体积越大对水流阻碍越明显,可能造成的水头损失也越大;2.利用等价球体法可以极大地简化驼峰气阻的形状,并良好地模拟气阻的平衡特性和阻力特性;3.管道流速是影响驼峰气阻临界平衡位置的最重要因素,通过减小管道起伏的坡角或增加水流流速可以防止和消除驼峰气阻的危害。

关键词：驼峰管道管流滞留气团水力试验供水管道

Lattice distortion of holmium doped bismuth ferrite nanofilms

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Journal of Rare Earths 2014年第9期32卷 884-889页

作者：云麒白阿立玛赵世峰 School of Physical Science and Technology Inner Mongolia University Inner Mongolia Key Lab of Nanoscience and Nanotechnology Inner Mongolia University

Single-phase multiferroic BiFeO3 and rare-earth metal of holmium （Ho） doped BiFeO3 nanofilms were prepared on Pt （100）/Ti/SiO2/Si wafer via solution-gelation technique. It was suggested that the lattice distortion happened with the lattice parameter of d decreasing after doping rare-earth metal of Ho. Meanwhile, the structure of nanofilms transformed from hexahedron phase to tetragonal phase after doping Ho. The analysis on X-ray photoelectron spectroscopy （XPS） indicated that the ratio of Fe3~ cations to Fe2＋ cations increased with the increase of binding energy between Fe and O and decrease of that between Bi and O after doping Ho. The present work provided an available way on enhancing multiferroic of BiFeO3 nanofilms.

关键词： lattice distortion holmium bismuth ferrite nanofilms rare earths

Genome-wide identification and characterization of the PbrATG family in Pyrus bretschneideri and functional analysis of PbrATG1a in response to Botryosphaeria dothidea

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Horticultural Plant Journal 2024年第2期10卷 327-340页

作者： yun Wang Xun Sun Zhenwu Zhang Zhihua Xie Kaijie qi Shaoling Zhang Center of Pear Engineering Technology Research State Key Laboratory of Crop Genetics and Germplasm EnhancementCollege of HorticultureNanjing Agricultural UniversityNanjingJiangsu 210095China

The pear is an economic fruit that is widely planted around the world and is loved by people for its rich nutritional value. Autophagy is a self-protection mechanism in eukaryotes, and its occurrence often accompanied by the degradation of damaged substances in cells and the recycling of nutrients. Autophagy is one of the mechanisms through which plants respond to environmental stress and plays an important role in plant development and stress resistance. Functional studies of autophagy-related genes (ATGs) have been performed on a variety of plant species, but little information is available on the ATG family in pear (Pyrus bretschneideri Rehd). Therefore, we analyzed the evolutionary dynamics and performed a genome-wide characterization of the PbrATG gene family. A total of 28 PbrATG members were *** analysis showed that PbrATGs were more closely related to ATGs of European pear and apple. Evolutionary analysis revealed that whole-genome duplication (WGD) and dispersed duplication events were the main driving forces of PbrATG family *** analysis of different pear tissues showed that all the genes were expressed in different pear tissues, and different PbrATGs are expressed at different times and in different locations. Moreover, all PbrATGs also responded to different abiotic stresses, especially salt and drought stress, which elicited the highest expression levels. Pear seedlings were subsequently infected with Botryosphaeria dothidea (***). The results showed that different PbrATGs had different expression patterns at different infection stages. According to the gene expression data, PbrATG1a was selected as a key autophagy gene for further analysis. Silencing of PbrATG1a reduced the resistance of pear to B. dothidea, which resulted in increased lesions, reactive oxygen species (ROS) contents, antioxidant enzyme activity, and gene expression levels in the silenced pear seedlings after B. dothidea inoculation. In this s

关键词： Autophagy Pear PbrATGs Abiotic stress Botryosphaeria dothidea PbrATG1a

Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： qian-yun Guo Jia-qi Yang Xun-Xun Feng Yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar *** changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health *** personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military *** far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart *** the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart *** have emerged from studies in animal models and early clinical *** interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart *** this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms