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Haplotype analysis of long-chain non-coding RNA NONHSAT102891 promoter polymorphisms and depression in Chinese individuals: A case-control association study

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World Journal of Psychiatry 2023年第12期13卷 1005-1015页

作者： Yue Li Yi-Xi Wang Xing-Ming Tang Peng liang Jing-Jie Chen Feng Jiang Qiang Yang yun-Dan liang Department of Pathology and Pathophysiology Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina West China School of Public Health and West China Fourth Hospital Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Our previous study reported that the single-nucleotide polymorphism(SNP)rs155979 GC in the promoter region of long-chain non-coding RNA(lncRNA)NONHSAT102891 affects depression susceptibility in a Chinese *** To explored associations of two SNPs and haplotypes in the lncRNA NONHSAT102891 promoter region with depression susceptibility in Chinese *** This this case-control association study was approved by the Ethics Committee of Chengdu Medical College(approval number:201815).Patient diagnosis was based on DSM-IV *** selected a total of 480 patients with depression and 329 healthy controls with no history of psychopathology,and performed genotyping of two SNPs by extracting peripheral venous blood samples from the *** function of the two lncRNA NONHSAT102891 promoter G/C and A/T haplotypes was detected by dual-luciferase reporter assays of human embryonic kidney 293T transfected *** Stratified analysis of clinical and genotypic characteristics of our cohort showed that the degree of mild depressive episodes associated with the rs6230 TC/CC genotype increased by 1.59 times[TC/CC vs TT:odds ratio(OR)=1.59,95%confidence interval(CI):1.08-2.35,P=0.019].The haploid analysis revealed linkage disequilibrium between rs3792747 and rs6230,and the double SNP CG haplotype was more common in the control group compared to case group,indicating that this haplotype significantly reduced the risk of depression(C/G vs T/A:OR=0.42,95%CI:0.21-0.83,P=0.01).There was no significant difference in the dual-luciferase reporter activity of the G/C and A/T haplotypes compared with the control group(P>0.05),indicating that the double SNP haplotype has no transcrip-tional *** The rs3792747 and rs6230 CG haplotypes of the lncRNA NONHSA T102891 promoter may be related to a reduced risk of depression in the Han Chinese population.

关键词： Long-chain non-coding RNA NONHSAT102891 Depression Susceptibility Single-nucleotide polymorphisms Haplotype Transcriptional activity

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Dark Matter Search in Dwarf Irregular Galaxies with Ten Years of Data from the Ice Cube Neutrino Observatory

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Research in Astronomy and Astrophysics 2024年第3期24卷 75-82页

作者： Yi-Fei Lü Ben-Yang Zhu Rong-Lan Li Xue-Kang Guo Tian-Ci Liu Yong-Bo Huang yun-Feng liang Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi University Nanning 530004China

Dwarf irregular galaxies(dIrrs),as rotationally supported systems,have more reliable J-factor measurements than dwarf spheroidal galaxies and have received attention as targets for dark matter detection in recent *** this paper,we use 10 yr of IceCube muon-track data and an unbinned maximum-likelihood-ratio method to search for neutrino signals beyond the background from the directions of seven dIrrs,aiming to detect neutrinos produced by heavy annihilation dark *** do not detect any significant *** on such null results,we calculate the upper limits on the velocity-averaged annihilation cross section for 1 TeV–10 PeV dark *** limits,although weaker than the strictest constraints in the literature in this mass range,are also a good complement to the existing results considering the more reliable J-factor measurements of dIrrs.

关键词： (cosmology) dark matter-cosmology theory-galaxies dwarf

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Design and verification of a satellite-terrestrial integrated IP network model for the Global Energy Interconnection

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Global Energy Interconnection 2019年第6期2卷 497-504页

作者： yun liang Yao Wang Li Huang Jun Ma Xiaolu Chen Jingtao Huang Global Energy Interconnection Research Institute Co. Ltd.Beijing 102209P.R.China State Grid Laboratory of Electric Power Communication Network Technology Beijing 102209P.R.China State Grid Information&Communication Group Co. Ltd.Beijing 102209P.R.China State Grid Shanghai Information&Telecommunication Co.Ltd. Shanghai 200072P.R.China

In order to meet the pressing demand for wide-area communication required by the Global Energy Interconnection(GEI),accelerating the construction of satellite-terrestrial Integra怕d networks that can achieve network extension and seamless global coverage has become the focus of power communication tech no logy *** this study,we propose a satellite-terrestrial integrated network model that can support interconnection and interoperation on the IP layer between the satellite system and the怕rrestrial segment of the existing power communication ***,the composition and function of the satellite-terrestrial collaborative network are ***,the IP-based protocol stack is described,and a typical applicati on experime nt is con ducted to illustrate the particular process of this protocol *** ally,a use case of IP interconn ection that depends on GEO satellite communication is *** experime ntal study has showed that the satellite-terrestrial collaborative network can efficiently support various IP applications for the GEI.

关键词： Global Energy Interconnection(GEI) Satellite-terrestrial integrated network IP network

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Neuroprotective effects of neural stem cells pretreated with neuregulin1β on PC12 cells exposed to oxygen-glucose deprivation/reoxygenation

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Neural Regeneration Research 2023年第3期18卷 618-625页

作者： Qiu-Yue Zhai Yuan-Hua Ye Yu-Qian Ren Zhen-Hua Song Ke-Li Ge Bao-He Cheng yun-liang Guo Institute of Cerebrovascular Diseases Medical Research CenterThe Affiliated Hospital of Qingdao UniversityTaishan Scholars Construction Project Excellent Innovative Team of Shandong ProvinceQingdaoShandong ProvinceChina Department of Obstetrics The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Research Center of Stem Cells Shandong Haoyun International Hospital of Stem CellsJinanShandong ProvinceChina

Studies on ischemia/reperfusion(I/R)injury suggest that exogenous neural stem cells(NSCs)are ideal candidates for stem cell therapy reperfusion ***,NSCs are difficult to obtain owing to ethical *** addition,the survival,differentiation,and proliferation rates of transplanted exogenous NSCs are low,which limit their clinical *** previous study showed that neuregulin1β(NRG1β)alleviated cerebral I/R injury in *** this study,we aimed to induce human umbilical cord mesenchymal stem cells into NSCs and investigate the improvement effect and mechanism of NSCs pretreated with 10 nM NRG1βon PC12 cells injured by oxygen-glucose deprivation/reoxygenation(OGD/R).Our results found that 5 and 10 nM NRG1βpromoted the generation and proliferation of ***-culture of NSCs and PC12 cells under condition of OGD/R showed that pretreatment of NSCs with NRG1βimproved the level of reactive oxygen species,malondialdehyde,glutathione,superoxide dismutase,nicotinamide adenine dinucleotide phosphate,and nuclear factor erythroid 2-related factor 2(Nrf2)and mitochondrial damage in injured PC12 cells;these indexes are related to *** has reported that p53 and solute carrier family 7 member 11(SLC7A11)play vital roles in ferroptosis caused by cerebral I/R *** data show that the expression of p53 was increased and the level of glutathione peroxidase 4(GPX4)was decreased after RNA interference-mediated knockdown of SLC7A11 in PC12 cells,but this change was alleviated after co-culturing NSCs with damaged PC12 *** findings suggest that NSCs pretreated with NRG1βexhibited neuroprotective effects on PC12 cells subjected to OGD/R through influencing the level of ferroptosis regulated by p53/SLC7A11/GPX4 pathway.

关键词： ferroptosis p53 SLC7A11 GPX4 human umbilical cord-mesenchymal stem cells neural stem cells neuregulin1β neuroprotection oxygen-glucose deprivation/reoxygenation PC12 cell

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A multiple coupling approach to produce high-performance SERS substrates

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Chinese Chemical Letters 2019年第1期30卷 179-182页

作者： Xianpeng Yin Hao Dong Shiqiang Wang yun liang Ning Gao Wanlin Zhang Li Tian Fuwei Sun Guangtao Li Department of Chemistry Key Lab of Organic Optoelectronics and Molecular Engineering Tsinghua University

Creating hotspots with significantly enhanced electromagnetic(EF) field, efficiently placing target molecules in hotspot region, and achieving uniform and reproducible Raman signals are three critical issues for developing high-performance SERS substrates. In this work, large area gold nanoparticle cluster pillar array with a gold mirror at bottom was facilely fabricated by combined use of nanosphere lithography and self-assembly approach. It is both theoretically and experimentally found that through multiple coupling interactions, the electromagnetic fields at interparticle gaps within the gold clusters were significantly enhanced in our three-dimentional(3D) pillar array substrates, which can result in one order of magnitude stronger as compared with random gold clusters on a two-dimentional planar *** to the periodic stucture, our substrates also possess the capbility of producing highly uniform and reproducible SERS signals. Attractively, in our case, a photoresponsive polymer was used for the formation of pillar array structure. Its unique photoinduced deformation makes it possible to reversibly open and close the gaps of the closely packed Au NP array, thus enabling efficient placement or entrapment of probe molecules into hotspot sites between adjacent nanoparticles.

关键词： Hotspots Electromagnetic Nanoparticles Cluster array SERS

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Curative effect of ganglioside sodium for adjuvant therapy on acute severe craniocerebral injury

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Journal of Acute Disease 2017年第1期6卷 18-22页

作者： yun-liang Deng Department of Neurosurgery Zigong Fourth People's HospitalZigong643000Sichuan ProvinceChina

Objective: To study the effect of adjuvant therapy of ganglioside sodium on intracranial pressure (ICP), partial pressure of brain tissue oxygen (PbtO2), nerve injury molecules, nerve protection molecules and indexes of oxidative stress in patients with acute severe craniocerebral injury. Methods: Forty-seven patients with severe craniocerebral injury treated in the emergency department of our hospital during the period time from December 2012 to October 2015 were selected for retrospective analyses. They were divided into the ganglioside group and the normal treatment group according to the usage of ganglioside sodium in the process of the emergency treatment. At days 1, 3, 5 and 7 before and after treatment, theICP and PbtO2 in patients of the two groups were measured. After 7 days of treatment, the nerve injury molecules, nerve protection molecules and the indexes of oxidative stress in serum of the patients of the two groups were determined. Results: At days 1, 3, 5 and 7 before and after treatment, theICP in patients of the ganglioside group were all significantly lower than those of the normal treatment group, while the PbtO2 were all significantly higher than those of normal treatment group. After 7 days of treatment, the contents of serum methane dicarboxylic aldehyde, advanced oxidation protein products, 8-hydroxy-2'-deoxyguanosine urine, S100β, glial fibrillary acidic portein, neuron specific enolase, myelin basic protein, neuroglobin and ubiquitin carboxyl-terminal hydrolase L1 in patients of the ganglioside group were notably lower than those of the normal treatment group, while the contents of superoxidase dismutase, glutathione peroxidase, catalase, nerve growth factor and brain derived neurotrophic factor were significantly higher than those of the normal treatment group. Conclusions: The adjuvant therapy of ganglioside sodium in patients with severe craniocerebral injury can effectively reduceICP, improve PbtO2 and alleviate the injuri

关键词： Ganglioside sodium Adjuvant therapy Severe craniocerebral injury Intracranial pressure Partial pressure of brain tissue oxygen

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Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application

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World Journal of Gastroenterology 2010年第10期16卷 1267-1273页

作者： Zhao, Wei-Feng Shao, You-Lin Chen, liang-yun Wu, Jin-Hua Zhu, Yi-Ling Gan, Jian-He Xiong, Hui Chinese Natl Human Genome Ctr Shanghai Lab Dis & Hlth Genom Shanghai 201203 Peoples R China Soochow Univ Dept Infect Dis Affiliated Hosp 1 Suzhou 215006 Jiangsu Prov Peoples R China

AIM:To establish the more feasible and sensitive assessment approach to the detection of adefovir (ADV) resistance-associated hepatitis B virus (HBV) ***: Based on the characteristics of rtA181V/T and rtN236T mutations, a new approach based on real-time fluorescent quantitative polymerase chain reaction (RT-PCR) was established for the detection of ADV-resistant HBV quasispecies, total HBV DNA, rtA181 and rtN236 mutations in blood samples from 32 chronic hepatitis B (CHB) patients with unsatisfactory curative effect on ADV and compared with routine HBV DNA ***: Both the sensitivity and specificity of this new detection approach to ADV-resistant HBV quasispecies were 100%, which were much higher than those of direct HBV DNA sequencing. The approach was able to detect 0.1% of mutated strains in a total plasmid population. Among the 32 clinical patients, single rtA181 and rtN236T mutation and double rtA181T and rtN236T mutations were detected in 20 and 8, respectively, while ADV-resistant mutations in 6 (including, rtA181V/T mutation alone in 5 patients) and no associated mutations in ***: This new approach is more feasible and efficient to detect ADV-resistant mutants of HBV and ADV-resistant mutations before and during ADV treatment with a specificity of 100% and a sensitivity of 100%.

关键词： Chronic hepatitis B Adefovir Drug resistance Quantitative detection Real-time fluorescent quantitative polymerase chain reaction

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BIG regulates stomatal immunity and jasmonate production in Arabidopsis

BIG regulates stomatal immunity and jasmonate production in ...

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2018全国植物生物学大会

作者： yun-Kuan liang State Key Laboratory of Hybrid Rice Department of Plant SciencesCollege of Life SciencesWuhan University

Plants have evolved an array of responses that provide them with protection from attack by microorganisms and other *** of these mechanisms depend upon interactions between the plant hormones jasmonate(JA) and ethylene(ET).However,the molecular basis of these interactions is insufficiently *** expression in stress responses and physiological assays with mutants were performed to investigate the role of Arabidopsis BIG gene which has been well documented to be required for auxin transport,light signaling as well as vesicle trafficking and *** transcription is strongly down-regulated by methyl JA(MeJA),necrotrophic infection or mechanical *** deficiency promotes JA-dependent gene induction,increases JA production but restricts the accumulation of both ET and salicylic ***-induced anthocyanin accumulation and chlorophyll degradation are enhanced and stomatal immunity is impaired by BIG *** and LPS-induced stomatal closure is reduced in BIG gene mutants,which are hyper-susceptible to microbial pathogens with different lifestyles,but these mutants are less attractive to phytophagous *** results indicate that BIG negatively and positively regulate the MYC2-and ERF1-arms of the JA signalling *** recognition as a new and distinct regulator that regulates JA responses,the synergistic interactions of JA and ET,and other hormonal interactions that reconcile the growth and defense dilemma in Arabidopsis.

关键词： BIG gene biotic stress hormonal interaction jasmonate signalling stomatal immunity

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Antifreezing and Stretchable Organohydrogels as Soft Actuators

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Research 2019年第1期2019卷 14-24页

作者： Yukun Jian Baoyi Wu Xiaoxia Le yun liang Yuchong Zhang Dachuan Zhang Ling Zhang Wei Lu Jiawei Zhang Tao Chen Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Material Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100049China

Inspired by the freezing tolerance performances found in living creatures, an effect approach is presented to develop novelantifreezing polymeric organohydrogel actuators. Through construction of a bilayer hydrogel including a nonresponsivepolyacrylamide (PAAm) layer and a pH-responsive polyacrylic acid (PAA) layer in the presence of a mixed solvent of water andglycerol, organohydrogel actuators that could produce various shape deformations at subzero temperatures have been achieved,and the actuating speed could be tuned by adjusting the temperature and the ratio between glycerol and water. Moreover, aseries of application demonstrations including a weightlifting robot, artificial valve, and robotic arm have been displayed. Inaddition, by introducing the ionic compound KI into the glycerol-based organogel, flexible conductors that could perform stablesensing performance over a wide range of temperatures from -30℃ to 60℃ have been developed.

关键词： freezing hydrogel organo

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Relativistic degenerate effects of electrons and positrons on modulational instability of quantum ion acoustic waves in dense plasmas with two polarity ions

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Chinese Physics B 2015年第2期24卷 295-301页

作者：刘铁路王云良路彦珍 Department of Physics School of Mathematics and PhysicsUniversity of Science and Technology Beijing

The nonlinear propagation of quantum ion acoustic wave（QIAW） is investigated in a four-component plasma composed of warm classical positive ions and negative ions,as well as inertialess relativistically degenerate electrons and positrons.A nonlinear Schrodinger equation is derived by using the reductive perturbation method,which governs the dynamics of QIAW *** modulation instability analysis of QIAWs is considered based on the typical parameters of the white *** results exhibit that both in the weakly relativistic limit and in the ultrarelativistic limit,the modulational instability regions are sensitively dependent on the ratios of temperature and number density of negative ions to those of positive ions respectively,and on the relativistically degenerate effect as well.

关键词： quantum ion acoustic waves modulational instability relativistic degenerate

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