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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi Junsong Cang guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen gang Chen guoming Chen hua-Xing Chen huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng huajie Cheng Shan Cheng Tongguang Cheng yunlong Chi Pietro Chimenti wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran ding Siqin dingl Yadong ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geosciences Beijing china university of Geosciences WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhu&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Endogenous hydrogen sulfide and ERK1/2-STAT3 signaling pathway may participate in the association between homocysteine and hypertension

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Journal of Geriatric Cardiology 2019年第11期16卷 822-834页

作者： Lin SHI Xiao-yun liu Zhi-gang huANG Zhi-Yi MA yang XI Lu-yan WANG Ning-Ling sun Hypertension Research Laboratory Department of CardiologyPeking University People’s HospitalBeijingChina Emergency department Peking University Shenzhen HospitalShenzhenChina

Background Homocysteine(Hcy)is a risk factor for hypertension,although the mechanisms are poorly *** We first explored the relationship between Hcy levels and blood pressure(BP)by analyzing the clinical data of primary hypertensive patients admitted to our ***,we explored a rat model to study the effect of Hcy on blood pressure and the role of *** hyperhomocysteinemia(HHcy)rat model was induced to explore the effect of Hcy on blood pressure and the possible *** carried out tissue histology,extraction and examination of RNA and ***,we conducted cell experiments to determine a likely mechanism through renin-angiotensin-aldosterone system(RAAS)and extracellular signal-regulated kinase 1/2(ERK1/2)signaling *** In primary hypertensive inpatients with HHcy,blood pressure was significantly higher as compared with inpatient counterparts lacking *** the rat model,blood pressure of the Wistar rats was significantly increased with increases in serum Hcy levels and decreased after folate *** converting enzyme 1(ACE1)expression in the Wistar Hcy group was enhanced comparing to controls,but was decreased in the Wistar folate *** II receptor type 1(AGTR1)levels in the kidney tissue increased in the Wistar folate *** serum H2S and kidney cystathionineγ-lyase decreased with elevated levels of serum *** vitro,increased concentrations and treatment times for Hcy were associated with increased expression of collagen type 1 and *** dose and time dependent response was also observed for p-STAT3 and p-ERK1/2 *** Endogenous H2S might mediate the process of altered blood pressure in response to changes in serum Hcy levels,in a process that is partly dependent on activated RAAS and ERK1/2-STAT3 signaling pathway.

关键词： Angiotensin converting enzyme 1 Blood pressure ERK1/2-STAT3 signaling pathway Homocysteine Hydrogen sulfide

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吉林省医疗器械产业发展现状及对策

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医疗卫生装备 2024年第7期45卷 67-71页

作者：杨语恒贾汶沅刘昀闫永正罗云纲刘国民吉林大学第二医院脊柱外科长春130041 吉林大学第一医院净月分院长春130031 吉林省特色资源健康产品与医用材料科技创新中心长春130118

阐述了吉林省医疗器械产业的发展现状,分析了吉林省医疗器械产业发展存在的主要问题,提出了扩大产业规模、建设医疗器械领域企业孵化器,保障产品市场准入、加速注册审批,加强学科交叉建设、组建医工交叉研究院等对策,为吉林省医疗器械... 详细信息

阐述了吉林省医疗器械产业的发展现状,分析了吉林省医疗器械产业发展存在的主要问题,提出了扩大产业规模、建设医疗器械领域企业孵化器,保障产品市场准入、加速注册审批,加强学科交叉建设、组建医工交叉研究院等对策,为吉林省医疗器械产业的发展提供了参考。

关键词：吉林省医疗器械医疗器械产业

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Effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open hepatectomy

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World Journal of Gastroenterology 2017年第36期23卷 6733-6740页

作者： Jing-xian sun Ke-yun Bai yan-Feng liu gang Du Zhi-Hao Fu Hao Zhang Jin-huan yang Ben Wang Xiu-Yu Wang Bin Jin department of Anorectal Surgery Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250011 Shandong Province China department of Hepatobiliary Surgery Qilu Hospital of Shandong UniversityJinan 250012 Shandong Province China department of Anesthesiology Qilu Hospital of Shandong UniversityJinan 250012 Shandong Province China

AIM To prospectively evaluate the effect of local wound infiltration with ropivacaine on postoperative pain relief and stress response reduction after open *** A total of 56 patients undergoing open hepatectomy were randomly divided into two groups:a ropivacaine group(wound infiltration with ropivacaine solution)and a control group(infiltration with isotonic saline solution).A visual analog scale(VAS)at rest and on movement was used to measure postoperative pain for the first 48 h after *** arterial pressure(MAP),heart rate(HR),time to bowel recovery,length of hospitalization after surgery,cumulative sufentanil consumption,and incidence of nausea and vomiting were compared between the two *** stress hormones(epinephrine,norepinephrine,and cortisol)were detected using enzyme-linked immunosorbent assay,and the results were compared. RESULTS VAS scores both at rest and on movement at 24 h and48 h were similar between the two *** lower VAS scores were detected at 0,6,and 12 h in the ropivacaine group compared with the control group(P2,and 24 h(P2,and 24 h(P2,24,and 36 h(P24 and 48 h(P<0.01 for all). CONCLUSION Local wound infiltration with ropivacaine after open hepatectomy can improve postoperative pain relief,reduce surgical stress response,and accelerate postoperative recovery.

关键词： Local wound infiltration Ropivacaine Open hepatectomy Postoperative pain Surgical stress

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11β-羟化类固醇脱氢酶1在饮食诱导性肥胖大鼠组织中的表达

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中国药科大学学报 2006年第6期37卷 527-530页

作者：刘云孙岩胡刚丁国宪南京医科大学第一附属医院老年医学科南京210008 南京医科大学药理学教研室南京210029

目的:探讨11-βhydroxysteroid dehydrogenase type 1(11-βHSD1)在肥胖发生过程中的作用。方法:建立饮食诱导的肥胖(DIO)大鼠模型,应用Western blotting方法检测各组织11-βHSD1的蛋白表达,同时应用实时定量PCR检测LPL、re-sistin、FAS等肥胖相关基因的表达,采用放射免疫分析法检测血糖、血脂、胰岛素、TNFα等指标。结果:DIO组大鼠体重、体脂明显高于正常组,DIO组大鼠脂肪、脑、骨骼肌的11-βHSD1表达明显高于正常组,肥胖相关基因LPLr、esistin、FAS等在DIO组内脏脂肪的表达高于正常组,外周血脂、胰岛素DIO组高于正常组,但血糖、TNF-α两组间无明显差异。结论:11-βHSD1在饮食诱导性肥胖大鼠相关组织的表达高于正常组,具有组织特异性;11-βHSD1在内脏脂肪组织的高表达促进肥胖的发生。

关键词： 11β-羟化类固醇脱氢酶1 饮食诱导肥胖表达

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基于层次分析-客观赋权法的耕地质量等级评价方法研究与实证

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中国土壤与肥料 2024年第4期 17-25页

作者：武岩刘宏金迟文峰罗军张雷苗永茂乔志刚李晓敏郭云汉王跃飞内蒙古自治区农牧业生态与资源保护中心内蒙古呼和浩特010010 内蒙古财经大学资源与环境经济学院内蒙古呼和浩特010051 呼和浩特市农牧业技术推广中心内蒙古呼和浩特010010

耕地质量等级评价是落实“藏粮于地、藏粮于技”战略部署的一项长期性和基础性工作,对指导耕地质量管理、保障国家粮食安全和农业可持续发展具有重要意义。为了准确表达耕地质量评价高维性、复杂性和非线性特点,提高耕地质量评价精度,... 详细信息

耕地质量等级评价是落实“藏粮于地、藏粮于技”战略部署的一项长期性和基础性工作,对指导耕地质量管理、保障国家粮食安全和农业可持续发展具有重要意义。为了准确表达耕地质量评价高维性、复杂性和非线性特点,提高耕地质量评价精度,运用客观赋权(CRITIC)法确定指标权重,以野外调查及检测数据为基础,结合遥感、地理信息系统优化评价指标赋值方法,从地形地貌、土壤性状、农田管理和生态安全4个方面构建耕地质量评价体系,并以呼和浩特市耕地为例进行了实证。结果表明:呼和浩特市平均耕地质量等级为5.84,处于中等水平,总体表现为中部耕地质量较好、西北部次之、东南部最低的空间分布特征,土壤贫瘠、盐渍化和灌排设施不完善成为制约耕地质量提升的主要因素。从耕地质量等级空间分布来看,1~4等较高水平耕地面积为11.19万hm^(2),占比20.13%;5~7等中等质量水平耕地面积35.67万hm^(2),占比64.14%;8~10等较低水平耕地面积为8.75万hm^(2),占比15.73%,总体分布规律基本符合正态分布。研究结果与国标法评价结果基本一致,表明CRITIC耕地质量等级评价方法可以准确、客观反映耕地质量水平,能有效运用于其他区域耕地质量等级评价研究,是对已有耕地质量等级评价方法的重要补充,同时为其他地区耕地质量评价提供借鉴与参考。

关键词：耕地质量客观赋权法评价方法呼和浩特市

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Cefoperazone sodium/sulbactam sodium vs piperacillin sodium/tazobactam sodium for treatment of respiratory tract infection in elderly patients

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World Journal of Clinical Cases 2021年第29期9卷 8694-8701页

作者： Xiao-Xia Wang Cheng-Tai Ma yan-Xia Jiang yun-Jie Ge Fa-yun liu wen-gang Xu department of Cadre Health Qingdao Municipal HospitalQingdao 266011Shandong ProvinceChina department of Emergency Medicine The Affiliated Hospital of Qingdao UniversityQingdao 266011Shandong ProvinceChina department of Pathology The Affiliated Hospital of Qingdao UniversityQingdao 266011Shandong ProvinceChina department of Pulmonary Shandong Qingdao Hospital of Integrated Traditional Chinese and Western MedicineQingdao 266011Shandong ProvinceChina

BACKGROUND Respiratory tract infections in the elderly are difficult to cure and can easily recur,thereby posing a great threat to patient prognosis and quality of *** To investigate the therapeutic effects of different antibiotics in elderly patients with respiratory tract *** Seventy-four elderly patients with respiratory tract infection were randomly allocated to a study(n=37;treated with cefoperazone sodium/sulbactam sodium)or control(n=37;treated with piperacillin sodium/tazobactam sodium on the basis of routine symptomatic support)*** groups were treated for 7 *** to symptom relief(leukocyte recovery;body temperature recovery;cough and sputum disappearance;and rale disappearance time),treatment effect,and laboratory indexes[procalcitonin(PCT),C-reactive protein(CRP),white blood cell count(WBC),and neutrophil percentage(NE)]before and 7 d after treatment and the incidence of adverse reactions were *** In the study group,the time to WBC normalization(6.79±2.09 d),time to body temperature normalization(4.15±1.08 d),time to disappearance of cough and sputum(6.19±1.56 d),and time to disappearance of rales(6.68±1.43 d)were shorter than those of the control group(8.89±2.32 d,5.81±1.33 d,8.77±2.11 d,and 8.69±2.12 d,respectively;P=0.000).Total effective rate was higher in the study group(94.59%vs 75.68%,P=0.022).Serum PCT(12.89±3.96μg/L),CRP(19.62±6.44 mg/L),WBC(20.61±6.38×10^(9)/L),and NE(86.14±7.21%)levels of the study group before treatment were similar to those of the control group(14.05±4.11μg/L,18.79±5.96 mg/L,21.21±5.59×10^(9)/L,and 84.39±6.95%,respectively)with no significant differences(P=0.220,0.567,0.668,and 0.291,respectively).After 7 d of treatment,serum PCT,CRP,WBC,and NE levels in the two groups were lower than those before *** PCT(2.01±0.56μg/L),CRP(3.11±1.02 mg/L),WBC(5.10±1.83×10^(9)/L),and NE(56.35±7.17%)levels were lower in the study group than in the control group(3.29±0.64μg/L,5.67±1.23 mg/L,8.

关键词： Cefoperazone sodium Sulbactam sodium Piperacillin sodium Tazobactam sodium Respiratory tract infection Elderly

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Numerical simulation of the temperature fields of stainless steel with different roller parameters during twin-roll strip casting

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International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 304-308页

作者： Yuan Fang Zhen-min Wang Qing-xiang yang yun-kun Zhang Li-gang liu Hong-yan hu Yue Zhang School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of Metastable Materials Science ＆ Technology College of Materials Science and Engineering Yanshan University Qinhuangdao 066004 China

The temperature field of stainless steel during twin-roll strip casting was simulated by experiment and a finite element （FE） model. By comparing the measured result with the simulated values, it is found that they fit close to each other, which indicates this FE model is effective. Based on this model, the effects of roll gap （t） and roll radius （R） on solidification were simulated. The simulated results give the relationship between t or R and the position of the freezing point. The larger the t is and the smaller the R is, the closer the position of the freezing point is to the exit.

关键词： twin-roll strip casting temperature field roll gap roll radius numerical simulation

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Virome in healthy pangolins reveals compatibility with multiple potentially zoonotic viruses

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Zoological Research 2022年第6期43卷 977-988页

作者： Feng-Juan Tian Jing Li wen-Li liu Yu-Jie liu yun-Jia hu Qi-Hang Tu yang Li Yu Bai Mang Shi Teng-Cheng Que yan-Ling hu Yi-gang Tong College of Life Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Centre for Infection and Immunity Studies School of MedicineShenzhen Campus of Sun Yat-Sen UniversitySun Yat-Sen UniversityShenzhenGuangdong 518107China Faculty of Data Science City University of MacaoMacao 999078China Guangxi Zhuang Autonomous Terrestrial Wildlife Rescue Research and Epidemic Diseases Monitoring Center NanningGuangxi 530025China Life Sciences Institute Guangxi Medical UniversityNanningGuangxi 530021China Center for Genomic and Personalized Medicine Guangxi Medical UniversityNanningGuangxi 530021China

Previous studies have identified multiple viruses in dead or severely diseased pangolins,but descriptions of the virome in healthy pangolins are *** poses a greater risk of cross-species transmission due to poor preventive awareness and frequent interactions with *** this study,we investigated the viral composition of 34 pangolins with no signs of disease at the time of sampling and characterized a large number of arthropodassociated viruses belonging to 11 families and vertebrate viruses belonging to eight families,including those with pathogenic potential in humans and *** important vertebrate viruses were identified in the pangolins,including parvovirus,pestivirus,and *** picobirnavirus was clustered with human and grey teal *** with cross-species transmission ability were also identified,including circovirus,rotavirus,and *** study revealed that pangolins are frequently exposed to arthropod-associated viruses in the wild and can carry many vertebrate viruses under natural *** study provides important insights into the virome of pangolins,underscoring the importance of monitoring potential pathogens in healthy pangolins to prevent outbreaks of infectious diseases in domesticated animals and humans.

关键词： Pangolin Virome Arthropod-associated viruses Cross-species transmission Zoonoses

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Stable Isotope Dilution Analysis of Gibberellin Residues in Tomato Paste by Liquid Chromatography-Tandem Mass Spectrometry

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Chemical Research in Chinese Universities 2012年第5期28卷 797-801页

作者： sun Li ZHAO yan-sheng NIE Xue-mei LING yun Chu Xiao-gang SHANG De-jun DONG Ying Institute of Food Safety Chinese Academy of Inspection and QuarantineBeijing 100123P.R.China School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013P.R.China Xinjiang Extry-exit Inspection and Quarantine Bureau Urumqi 830063P.R.China

An accurate and sensitive method for the simultaneous determination of gibberellic acid（GA3）, gibberellin A4（GA4） and gibberellin A7（GA7） residues in tomato paste was developed by coupling solid phase extraction to high performance liquid chromatography-tandem mass spectrometry（LC-MS/MS） with electrospray ionization based stable isotope dilution analysis（SIDA）. The isotope labeled internal standard can compensate for the losses during the extraction and cleanup steps and for discrimination due to ion suppression. After extraction from methanol, hydrophile lipophilic balance（HLB） solid phase extraction（SPE） column was tested for the capacity of the cleanup of the tomato paste in compared with C18 SPE column which is the common way to the detection of GAs, and the former gained better result. Spiked experiments were performed in the non-contaminated tomato pastes and the recoveries of GA3, GA4 and GA7 were 42.6%―75.0% in external standard method（ESM） and 91.1%―103.8% in internal standard method（ISM） respectively. The validities of this method were investigated and good analytical performance for the three GAs was obtained, including low limits of method detection（2 ng/g for GA3 and GA4, 0.3 ng/g for GA7）, excellent linear dynamic ranges（5―500 ng/g for GA3 and GA4, 1―100 ng/g for GA7） and good relative standard deviation ranges（4.8%―9.4% for the intra-day test and 3.5%―11.9% for the inter-day test）.

关键词： Gibberellin Tomato paste Liquid chromatography-tandem mass spectrometry(LC-MS/MS) Stable isotope dilution analysis(SIDA)

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