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Asian Journal of Andrology 2024年第3期26卷 245-249页

作者： Xiaobo Wu Ivan Ching-Ho Ko Cindy Yeuk-Lam Hong Samuel Chi-Hang Yee Jeremy Yuen-Chun Teoh Samson yun-Sang Chan Ho-Man Tam Chi-Kwok Chan Chi-Fai Ng Peter ka-Fung Chiu SH Ho Urology Centre Department of SurgeryFaculty of MedicineThe Chinese University of Hong KongHong KongChina

This study aimed to report the outcomes of active surveillance(AS)in the management of low-risk prostate cancer(PCa).It recruited87 men who were prospectively followed up according to the Prostate Cancer Research International Active Surveillance(PRIAS)protocol with local adaptation at SH Ho Urology Centre,Prince of Wales Hospital,Hong Kong,*** investigated the predictorsof disease progression and found that baseline prostate-specific antigen density(PSAD)and the presence of the highest ProstateImaging-Reporting and Data System(PI-RADS)score 5 lesion on magnetic resonance imaging(MRI)are significantly correlatedwith disease ***,men with PSAD>0.2 ng ml^(−2)or PI-RADS 4 or 5 lesions had significantly worse upgradingfree survival compared to those with PSAD≤0.2 ng ml−2 and PI-RADS 2 or 3 *** study concludes that AS is a safe andeffective management strategy for selected patients to defer radical treatment and that most disease progression can be detectedafter the first repeated *** combination of PSAD>0.2 ng ml^(−2)and PI-RADS 4 or 5 lesions may serve as a useful predictorof early disease progression and provide a guide to optimize follow-up protocols for men in different risk groups.

关键词： active surveillance cohort localized prostate cancer

苯丁酸甘油酯治疗儿童鸟氨酸氨甲酰基转移酶缺乏症1例

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中国当代儿科杂志 2024年第5期26卷 512-517页

作者：杨帆王立瑞李辛胡佳悦应令雯冯碧云李芸芸林卡娜佘佳笑李浩常国营王秀敏上海交通大学医学院附属上海儿童医学中心临床研究病区上海200127 上海交通大学医学院附属上海儿童医学中心内分泌遗传代谢科上海200127 云南省德宏州陇川县人民医院儿科云南德宏678700

苯丁酸甘油酯(glyceryl phenylbutyrate,gPB)是治疗鸟氨酸氨甲酰基转移酶缺乏症(ornithine transcarbamylase deficiency,OTCD)的长期管理药物,可有效控制高氨血症,但国内使用该药的经验匮乏。该文回顾性分析上海交通大学医学院附属上... 详细信息

苯丁酸甘油酯(glyceryl phenylbutyrate,gPB)是治疗鸟氨酸氨甲酰基转移酶缺乏症(ornithine transcarbamylase deficiency,OTCD)的长期管理药物,可有效控制高氨血症,但国内使用该药的经验匮乏。该文回顾性分析上海交通大学医学院附属上海儿童医学中心1例诊断为OTCD的患儿资料,并进行相关文献复习。该患儿确诊后使用gPB治疗,随后进行疗效随访和药学监测。患儿,男,6岁6个月,语言发育差,不听指令,脾气暴躁并伴有攻击性行为。监测血氨最高327μmol/L;尿有机酸分析提示尿嘧啶水平升高;头颅磁共振成像示双侧大脑半球广泛异常信号;基因检测发现OTC基因新生突变(c.241T>C,p.S81P)。予以gPB治疗后1、2、3个月左右的血氨分别为43、80、56μmol/L。患儿治疗期间血氨控制良好,未见与药物相关的不良反应,发育落后情况较前改善,可听指令,脾气好转,无攻击性行为。

关键词：苯丁酸甘油酯鸟氨酸氨甲酰基转移酶缺乏症尿素循环障碍高氨血症药学监测儿童

NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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Cancer Communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu Ting-Mao Xue Zhi-Jie Xiao Pui-Chi Tin Hiu-Ling Fung Hoi-Tang Ma Jing-Ping yun Judy Wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRISPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITC,fluorescein isothiocyanate;gAPDH,glyceraldehyde-3-phosphate dehydrogenase;gM130,golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLC9,solute carrier gene 9;SLiCE,Seamless Ligation Cloning Extract;TCgA,The Cancer genome Atlas;TCL,total cell lysates;TgN,trans-golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSg101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

High formability Mg-Zn-gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang Lizhen Zheng Jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li Patrick Shu-hang yung guangyin Yuan Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of Li ka Shing Institute of Health Sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic Department Peking University Third HospitalBeijingChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-gadolinium(Zg21)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of Zg21 wire are *** rabbit model is used for assessing the biological effects of Zg21 wire by Micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of Zg21 wire as surgical ***-CT shows Zg21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the Zg21 *** SEM/EDS presents Zg21 wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2,and VEgF at the early phase and TgFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with Zg21 wire did not weaken the ultimate loading of human tendon *** conclusion,the Zg21 wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

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上古汉语的第一人称

古汉语研究 2024年第3期 115-125,128页

作者：陈鹏潘悟云西华大学文学与新闻传播学院四川成都610039 复旦大学现代语言学研究院

论汉语史的研究不只是用雅言作材料,而且要用许多通假字的古代方言。因为用了古方言的通假材料,第一人称的上古汉语可以拟作^(*)ηga,到周代变作^(*)ηa,在古代方言中有^(*)ga、^(*)q^(h)a、ga、ka等音变。藏缅语第一人称与上古汉语有... 详细信息

论汉语史的研究不只是用雅言作材料,而且要用许多通假字的古代方言。因为用了古方言的通假材料,第一人称的上古汉语可以拟作^(*)ηga,到周代变作^(*)ηa,在古代方言中有^(*)ga、^(*)q^(h)a、ga、ka等音变。藏缅语第一人称与上古汉语有相同的音变链。上古汉语第一人称的强调式拟作^(*)-al,谦称拟作^(*)-la。

关键词：上古汉语雅言古方言第一人称音变链强调式谦称

异功散中陈皮对脾虚大鼠MTL分泌和人参皂苷Rb1药动学影响及PK-PD相关性分析

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时珍国医国药 2024年第7期35卷 1781-1786页

作者：段新屹兰昀羲沈龙宇朱昕昀黄巍成都中医药大学四川成都610000

目的通过比较异功散全方组与异功散去陈皮方组脾虚大鼠体内MTL分泌结果和人参皂苷Rb1药代动力学特征的差异,分析参数PK-PD相关性,探讨行气药能否增效补益剂。方法采用脾虚大鼠灌胃给药异功散全方(Y组)、异功散去陈皮方(Y-C组)、单味陈皮... 详细信息

目的通过比较异功散全方组与异功散去陈皮方组脾虚大鼠体内MTL分泌结果和人参皂苷Rb1药代动力学特征的差异,分析参数PK-PD相关性,探讨行气药能否增效补益剂。方法采用脾虚大鼠灌胃给药异功散全方(Y组)、异功散去陈皮方(Y-C组)、单味陈皮方(C组)及生理盐水(M组),于颈静脉不同时间点取血,运用液质联用方法检测人参皂苷Rb1血浆浓度、ELISA法检测MTL血浆浓度,拟合PK-PD模型。结果2个组药时曲线均呈双峰,Cmax、Tmax均有两个值,Y组两次达峰浓度均明显高于Y-C组(P0.05),Y组>Y-C组>C组。PD结果为Y组EC_(50)、γ平均值低于Y-C组、Emax平均值高于Y-C组,与PK-PD模型拟合结果基本一致。PK-PD模型拟合结果为Y组ka1、ka2、AUC0-t、CL1、CL2、CL3、F、Tlag、EC_(50)、Emax平均值更大;Y-C组Vd1、Vd2、γ、Ke0值更大。结论脾虚大鼠体内人参皂苷Rb1及MTL血药浓度改变与灌胃所用异功散含陈皮有一定相关性。异功散中陈皮发挥增强补益剂补益功效的作用机制之一可能是通过促进异功散中人参皂苷Rb1的吸收增多、吸收速率增快,分布更集中于效应部位,使人参皂苷Rb1与MTL之间亲和力更强,从而导致MTL分泌增多,促进胃肠运动。

关键词：异功散陈皮脾虚人参皂苷Rb1 MTL 药动学药效学 PK-PD结合模型

基于XRF岩心扫描证据的福建木兰溪河口全新世沉积环境演化重建

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地球科学 2024年第6期49卷 2213-2226页

作者：宋震李亚龙赵云高建华印萍杨守业同济大学海洋地质国家重点实验室上海200092 上海师范大学环境与地理科学学院上海200234 上海交通大学海洋学院上海200240 南京大学地理与海洋科学学院江苏南京210023 中国地质调查局青岛海洋地质研究所山东青岛266237

为精确刻画和揭示强潮控山溪性河流河口全新世的沉积环境演化特征和控制因素,本研究选取福建中部潮控型山溪性河流——木兰溪河口的钻孔(MLX-S)为研究对象,在运用放射性14C和光释光建立沉积年代框架基础上,开展了沉积物粒度、XRF岩心扫... 详细信息

为精确刻画和揭示强潮控山溪性河流河口全新世的沉积环境演化特征和控制因素,本研究选取福建中部潮控型山溪性河流——木兰溪河口的钻孔(MLX-S)为研究对象,在运用放射性14C和光释光建立沉积年代框架基础上,开展了沉积物粒度、XRF岩心扫描及ICP-OES元素分析.研究发现,全新世木兰溪河口相继发育河流相、滨岸沼泽相、浅海相到潮控河口相,沉积环境演变主要受控于研究区的相对海平面变化.福建中部沿岸的相对海平面高度在9.0 ka左右,约为-20 m;此后海侵不断扩大,至5.8 ka左右海平面达到最大高度,随后缓慢下降至今.岩心高分辨率XRF扫描的元素相对强度数据校正后可指示沉积物的物源及古环境变化.钻孔的K/Ti比值表明,约8.8 ka以来,木兰溪河口沉积物主要为流域剥蚀产物和口外长江源细粒物质的混合;岩心Fe/Ti比值在约3.6 ka、4.3 ka、5.4 ka和6.0 ka 4个东亚冬季风较强时期均达到峰值且与东海内陆架泥质沉积记录一致,指示浙闽沿岸流强度的影响.揭示了我国东南沿海潮控型山溪性河口的河海相互作用特征,以及全新世季风-海平面变化驱动下的长江源细粒沉积物在陆架海复杂的源汇沉积过程,也拓展了XRF岩心扫描方法在海陆相互作用强烈的大陆边缘地区应用潜力.

关键词：木兰溪全新世 XRF岩心扫描沉积环境海平面变化东亚冬季风海洋地质

Fluid-chemical modeling of the near-cathode sheath formation process in a high current broken in DC air circuit breaker

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Chinese Physics B 2024年第1期33卷 523-538页

作者：彭世东李静段薇曹云东刘树鑫黄浩 Key Laboratory of Special Electric Machine and High Voltage Apparatus Shenyang University of TechnologyShenyang 110870China

When the contacts of a medium-voltage DC air circuit breaker(DCCB) are separated, the energy distribution of the arc is determined by the formation process of the near-electrode sheath. Therefore, the voltage drop through the near-electrode sheath is an important means to build up the arc voltage, which directly determines the current-limiting performance of the DCCB. A numerical model to describe the near-electrode sheath formation process can provide insight into the physical mechanism of the arc formation, and thus provide a method for arc energy regulation. In this work, we establish a two-dimensional axisymmetric time-varying model of a medium-voltage DCCB arc when interrupted by high current based on a fluid-chemical model involving 16 kinds of species and 46 collision reactions. The transient distributions of electron number density, positive and negative ion number density, net space charge density, axial electric field, axial potential between electrodes, and near-cathode sheath are obtained from the numerical model. The computational results show that the electron density in the arc column increases, then decreases, and then stabilizes during the near-cathode sheath formation process, and the arc column's diameter gradually becomes wider. The 11.14 V–12.33 V drops along the17 μm space charge layer away from the cathode(65.5 k V/m–72.5 k V/m) when the current varies from 20 k A–80 k *** homogeneous external magnetic field has little effect on the distribution of particles in the near-cathode sheath core,but the electron number density at the near-cathode sheath periphery can increase as the magnetic field increases and the homogeneous external magnetic field will lead to arc diffusion. The validity of the numerical model can be proven by comparison with the experiment.

关键词： near-cathode sheath atmospheric pressure air arc fluid-chemical model high current DC air circuit breaker(DCCB)

基于香豆素和寡聚芳酰胺的Hg^(2+)荧光探针性能及应用研究

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分析测试学报 2024年第4期43卷 614-621页

作者：杨永安王媛陈明谢一柳王英伍许肖云西华师范大学环境科学与工程学院四川南充637009 四川省遂宁生态环境监测中心站四川遂宁629000 西华师范大学化学化工学院四川南充637009

该文利用含分子内三中心氢键的寡聚芳酰胺三聚体二酸和3-氨基香豆素的酰胺化反应,高效制备了具有一定刚性骨架的荧光探针,采用核磁共振谱、质谱等手段对其结构进行了表征。深入研究了探针的选择性识别、抗干扰以及可逆性等性能,测定了... 详细信息

该文利用含分子内三中心氢键的寡聚芳酰胺三聚体二酸和3-氨基香豆素的酰胺化反应,高效制备了具有一定刚性骨架的荧光探针,采用核磁共振谱、质谱等手段对其结构进行了表征。深入研究了探针的选择性识别、抗干扰以及可逆性等性能,测定了探针和Hg^(2+)的配位比及检出限,并研究了其定量检测不同水样中Hg^(2+)的能力。结果显示,探针对Hg^(2+)表现出优异的选择性,且不受其他金属离子(K^(+)、Na^(+)、Ca^(2+)、Mg^(2+)、Cu^(2+)、Zn^(2+)、Pb^(2+)、Cd^(2+)、Fe^(3+)、Mn^(2+)、Ni^(2+)、Ag+、Cr^(3+)、Al^(3+)、Co^(2+))的干扰。探针对Hg^(2+)识别具有较好的可逆性,二者配位比为1∶1,其检出限为2.08×10^(-7) mol/L,满足实际水样检测要求。利用红外光谱和核磁共振氢谱对探针识别Hg^(2+)的发光机理进行了推断。此探针可用于不同水样中Hg^(2+)的定量检测,检测结果与原子荧光法基本一致,具有较高的准确度和精密度。

关键词：香豆素寡聚芳酰胺汞离子荧光探针水样

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新文科背景下基于“模块化-情景化”的涉农高校公共政策学课程教学改革研究

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广州开放大学学报 2024年第3期24卷 64-67,93,110页

作者：钟晓华曹云亮杨婧仲恺农业工程学院人文与社会科学学院广东广州510225

在新文科建设背景下,涉农高校的公共政策学课程教学需要在价值、知识、技术等方面改革创新,应该立足于涉农高校的办学定位,针对公共政策学课程教学存在的局限性,以解决农村发展实践中的政策问题为导向,重构模块化知识体系,运用信息技术... 详细信息

在新文科建设背景下,涉农高校的公共政策学课程教学需要在价值、知识、技术等方面改革创新,应该立足于涉农高校的办学定位,针对公共政策学课程教学存在的局限性,以解决农村发展实践中的政策问题为导向,重构模块化知识体系,运用信息技术手段开展情景化教学。课程的“模块化—情景化”教学改革既是对新文科要求的有效回应,又有助于培养涉农高校学生分析和解决农村政策问题的能力。

关键词：新文科涉农高校公共政策学课程模块化—情景化教学改革