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Development of enterohepatic fistula after embolization in ileal gastrointestinal stromal tumor: A case report

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World Journal of Gastroenterology 2013年第43期19卷 7816-7819页

作者： yun ho lee Ja Seol Koo Chang ho Jung Sang Yoon Chung Jae Joong lee Seung Young Kim Jong Jin Hyun Sung Woo Jung Rok Seon Choung Sang Woo lee Jai Hyun Choi Division of Gastroenterology Department of Internal MedicineKorea University Ansan Hospital516 Gojan-dongDanwon-guAnsan-siGyeonggi-do 425-707South Korea

Gastrointestinal stromal tumor(GIST)is a rare mesenchymal tumor of the gastrointestinal tract that has been associated with the formation of fistulas to adjacent organs in few case ***,GIST with enterohepatic fistula has not been *** we report the case of an enterohepatic fistula that occurred after embolization of a liver mass originating in the distal *** 87-year-old woman was hospitalized for *** initial conventional endoscopy,a bleeding focus in the gastrointestinal tract was not *** of massive hematochezia,enteroscopy was performed through the anus.A protruding,ulcerative mass was found in the distal ileum that was suspected to be the source of the bleeding;a biopsy sample was *** was not successful in controlling the bleeding;therefore,embolization was *** embolization,the patient developed a high fever and severe abdominal tenderness with rebound ***-up abdominopelvic computed tomography revealed an enterohepatic fistula between the liver and distal *** fistula was treated surgically by segmental resection of the distal ileum and unlooping of the liver mass.

关键词： Gastrointestinal stromal tumor Enterohepatic fistula Therapeutic embolization Bleeding Ileal gastrointestinal stromal tumor

Ileal polypoid lymphangiectasia bleeding diagnosed and treated by double balloon enteroscopy

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World Journal of Gastroenterology 2013年第45期19卷 8440-8444页

作者： Min Seon Park Beom Jae lee Dae hoe Gu Jeung-Hui Pyo Kyeong Jin Kim yun ho lee Moon Kyung Joo Jong-Jae Park Jae Seon Kim Young-Tae Bak Division of Gastroenterology Department of Internal Medicine Korea University Guro Hospitial Seoul 152-703 South Korea

Intestinal lymphangiectasia is a rare disease characterized by focal or diffuse dilated enteric lymphatics with impaired lymph *** causes protein-losing enteropathy and may lead to gastrointestinal ***,lymphangiectasia presents as whitish spots or *** our knowledge,small bowel bleeding resulting from polypoid intestinal lymphangiectasia has not been ***,we report a rare case of active bleeding from the small bowel caused by polypoid lymphangiectasia with a review of the relevant *** 80-year-old woman was hospitalized for *** could not identify the source of *** colonoscopy showed fresh bloody material gushing from the small *** abdominal-pelvic contrast-enhanced computed tomography scan did not reveal any abnormal *** capsule endoscopy showed evidence of active and recent bleeding in the *** localize the bleeding site,we performed double balloon enteroscopy by the anal approach.A small,bleeding,polypoid lesion was found in the distal ileum and was successfully removed using endoscopic snare electrocautery.

关键词： Intestinal lymphangiectasia Small bowel bleeding Double balloon endoscopy Solitary ileal polypoid lesion Endoscopic polypectomy

RADIALLY SYMMETRIC SOLUTIONS FOR QUASILINEAR ELLIPTIC EQUATIONS INVOLVING NONhoMOGENEOUS OPERATORS IN AN ORLICZ-SOBOLEV SPACE SETTING

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Acta Mathematica Scientia 2020年第6期40卷 1679-1699页

作者： Jae-Myoung KIM yun-ho KIM Jongrak lee Department of Mathematics Education Andong National UniversityAndong 36729Republic of Korea Department of Mathematics Education Sangmyung UniversitySeoul 03016Republic of Korea Department of Mathematics Jeju National UniversityJeju 63243Republic of Korea

We investigate the following elliptic equations:⎧⎩⎨−M(∫R Nϕ(|∇u|2)dx)div(ϕ′(|∇u|2)∇u)+|u|α−2 u=λh(x,u),u(x)→0,as|x|→∞,in R N,where N≥2,1 详细信息

We investigate the following elliptic equations:⎧⎩⎨−M(∫R Nϕ(|∇u|2)dx)div(ϕ′(|∇u|2)∇u)+|u|α−2 u=λh(x,u),u(x)→0,as|x|→∞,in R N,where N≥2,1how that the problem admits a sequence of small-energy,radially symmetric solutions.

关键词： radial solution quasilinear elliptic equations variational methods Orlicz-Sobolev spaces

Three-dimensional porous graphene-metal oxide composite microspheres： Preparation and application in Li-ion batteries

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Nano Research 2015年第5期8卷 1584-1594页

作者： Seung ho Choi Jung-Kul lee yun Chan Kang Department of Materials Science and Engineering Korea University Anam-Dong Seongbuk-Gu Seou1136-713 Republic of Korea Department of Chemical Engineering Konkuk University 1 Hwayang-Dong Gwangjin-Gu Seou1143-701 Republic of Korea

The use of new three-dimensional （3D） porous graphene-metal oxide composite microspheres as an anode material for Li-ion batteries （LIBs） is first introduced here. 3D graphene microspheres are aggregates of individual hollow graphene nanospheres composed of graphene sheets. Metal oxide nanocrystals are uniformly distributed over the graphene surface of the microspheres. The 3D porous graphene-SnO2 microspheres are selected as the first target material for investigation because of their superior electrochemical properties. The 3D porous graphene-SnO2 and graphene microspheres and bare SnO2 powders deliver discharge capacities of 1,009, 196, and 52 mAh·g^-1, respectively, after 500 cycles at a current density of 2 A·g^-1 .The 3D porous graphene-SnO2 microspheres exhibit uniquely low charge transfer resistances and high Li-ion diffusivities before and after cycling.

关键词： graphene metal oxide nanostructures electrode material batteries

Beneficial Effect of Berberis amurensis Rupr. on Penile Erection

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Chinese Journal of Integrative Medicine 2018年第6期24卷 448-454页

作者： Rui Tan yun Jung lee Kyung Woo Cho Dae Gill Kang ho Sub lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang CardioRenal Syndrome Research Center Wonkwang University Brain Korea 21 Plus Team Professional Graduate School of Oriental MedicineWonkwang University

Objective： To investigate whether the methanol extract of Berberis amurensis Rupr. （BAR） augments penile erection using in vitro and in vivo experiments. Methods： The ex vivo study used corpus cavemosum strips prepared from adult male New Zealand White rabbits. In in vivo studies for intracavernous pressure （ICP）, blood pressure, mean arterial pressure （MAP）, and increase of peak ICP were continuously monitored during electrical stimulation of Sprague-Dawley rats. Results： Preconstricted with phenylephrine （PE） in isolated endothelium- intact rabbit corus cavernosum, BAR relaxed penile smooth muscle in a dose-dependent manner, which was inhibited by pretreatment with NG-nitro-L-arginine methyl ester （L-NAME）, a nitric oxide synthase inhibitor, and 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-l-one, a soluble guanylyl cclase inhibitor. BAR significantly relaxed penile smooth muscles dose-dependently in ex vivo, and this was inhibited by pretreatment with L-NAME 1H-[1,2,4]- oxadiazole-[4,3-α ]-quinoxalin-l-one. BAR-induced relaxation was significantly attenuated by pretreatment with tetraethylammonium （TEA, P〈0.01）, a nonselective K＋ channel blocker, 4-aminopyridine （4-AP, P〈0.01）, a voltage-dependent K＋ channel blocker, and charybdotoxin （P〈0.01）, a large and intermediate conductance Ca2. sensitive-K＋ channel blocker, respectively. BAR induced an increase in peak ICP, ICP/MAP ratio and area under the curve dose dependently. Conclusion： BAR augments penile erection via the nitric oxide/cyclic guanosine monophosphate system and Ca2. sensitive-K＋（BK＋ and IK＋） channels in the corpus cavemosum.

关键词： penile erection Berberis amurensis Rupr. nitric oxide cyclic guanosine monophosphate K+ channel

Specific oceanographic characteristics and phytoplankton responses influencing the primary production around the Ulleung Basin area in spring

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Acta Oceanologica Sinica 2020年第2期39卷 107-122页

作者： Minji lee Jin ho Kim yun-Bae Kim Chan hong Park Kyoungsoon Shin Seung ho Baek South Sea Research Institute Korea Institute of Ocean Science and TechnologyGeoje 53201Korea Ulleungdo/Dokdo Ocean Science Station Korea Institute of Ocean Science and TechnologyUlleungdo 40205Korea Dokdo Research Center East Sea Research InstituteKorea Institute of Ocean Science and TechnologyUljin 36315Korea

The East Sea(Sea of Japan)is a marginal,semi-closed sea in the northwestern *** Ulleung Basin area,which is located near the subpolar front of the East Sea,is known to have high primary production and good fisheries in spring *** episodic wind-driven events during the spring of 2017,horizontal and vertical profiles of physical chemical biological factors were investigated at 29 stations located in the Ulleung Basin *** addition,growth responses of phytoplankton communities to nutrient additions were evaluated by bioassay experiments to understand the fluctuation of phytoplankton *** of strong northwestern wind,phytoplankton biomass was scattered and upwelling phenomenon might be suppressed in this *** phytoplankton abundances in the coastal stations were significantly higher than offshore and island *** contrast,the nutrient and chlorophyll a(Chl a)concentrations and the phytoplankton biomass were quite low in all *** was dominated group(>75.1%for coastal,40.0%for offshore and 43.6%for island stations).In the algal bioassays,the phytoplankton production was stimulated by N *** in vivo Chl a values in the+N and+NP treatments were significantly higher than the values in the control and the+P *** on the field survey,the higher nutrients in coastal waters affected the growth of diatom assemblages,however,little prosperity of phytoplankton was observed in the offshore waters despite the injection of sufficient nutrients in bioassay *** growth of phytoplankton depended on the initial cell *** of results indicated that a dominant northwestern wind led to a limited nutrients condition at euphotic layers,and the low level of biomass supply from the coasts resulted in low primary *** supplying nutrients and introducing phytoplankton through the currents are critical to maintain the high productivity in the Ulleung Basin area of the East Sea.

关键词： Ulleung Basin Ulleungdo and Dokdo spring phytoplankton blooms episodic windstorm algal bioassays primary production

Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch

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Protein & Cell 2019年第6期10卷 395-404页

作者： Daisuke Aki Qian Li Hui Li yun-Cai Liu Jee ho lee Institute for Immunology Tsinghua-Peking Center for Life Sciences School of Medicine Tsinghua University Beijing 100084 China La Jolla Institute for Allergy and Immunology La Jolla CA 92037 USA

Protein ubiquitination is an important means of posttranslational modification which plays an essential role in the regulation of various aspects of leukocyte development and function. The specificity of ubiquitin tagging to a protein substrate is determined by E3 ubiquitin ligases via defined E3-substrate interactions. In this review, we will focus on two E3 ligases, VHL and Itch, to discuss the latest progress in understanding their roles in the differentiation and function of CD4+ T helper cell subsets, the stability of regulatory T cells, effector function of CD8+ T cells, as well as the development and maturation of innate lymphoid cells. The biological implications of these E3 ubiquitin ligases will be highlighted in the context of normal and dysregulated immune responses including the control of homeostasis, inflammation, auto-immune responses and anti-tumor immunity. Further elucidation of the ubiquitin system in immune cells will help in the design of new therapeutic interventions for human immunological diseases and cancer.

关键词： ubiquitin E3ligase VHL HIF Itch WWP2 Cbl-b inflammation autoimmunity

N-terminal pro-B-type natriuretic peptide as prognostic marker for patients of non ST-segment elevation myocardial infarction

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Journal of Central South University 2013年第8期20卷 2226-2232页

作者： ShoN ho Sun HWANG Kyung Kuk BAE Jang Whan KIM Kyung Ah lee Jong yun RYU Keun ho Database and Bioinformatics Laboratory School of Electrical & Computer Engineering also PSM of School of Medicine Chungbuk National University Department of Medicine School of Medicine Chungbuk National University Department of Biomedical Engineering School of Medicine Chungbuk National University Department of Informatics and Convergence Chungbuk National University Cheongju

In this work, we analyzed only the patients of the NSTEMI (non ST-segment elevation myocardial infarction) who arrived at the hospital within 12 h after symptoms started. Using NSTEMI follow-up data within, the characteristics of the clinical data, the risk factor, and the blood tested in the hospital visit were analyzed for MACE (major adverse cardiac events) patients. MACE includes cardiac death, MI (myocardial infarction), Re-PCI, and CABG (coronary artery bypass graft). As a result, from the NSTEMI patients which can be followed up for over 12 m, NT-ProBNP (p=0.014) and age (p=0.045) are found to be the independent risk factors related to MACE. Accordingly, they can be useful for the diagnosis and prognosis for NSTEMI patients as a biomarker.

关键词： non ST-segment elevation myocardial infarction NT-ProBNP cardiovascular disease

Comparison of biochemical characteristics between PAO and DPAO sludges

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Journal of Environmental Sciences 2014年第6期26卷 1340-1347页

作者： Hansaem lee Zuwhan yun Research Institute for Environmental Technology and Sustainable Development Korea University Department of Environmental Engineering Korea University

A successful enhanced biological phosphorus removal （EBPR） was observed in both anaerobic- aerobic sequencing batch reactor （An-Ox SBR） to induce growth of phosphorus accumulating organism （PAO） and anaerobic-anoxic （An-Ax） SBR to induce growth of denitrifying PAO （DPAO）. Although the EBPR performance of An-Ox SBR was higher by 11.3% than that of An-Ax SBR, specific phosphorus release rates in the An-Ax SBR （22.8 ± 3.5 mg P/（g ***）） and the An-Ox SBR （22.4 ± 4.8 mg P/（g ***）） were similar. Specific phosphorus uptake rates under anoxic and aerobic conditions were 26.3 ± 4.8 mg P/（g ***）（An-Ax SBR） and 25.6 ± 2.8 mg P/（g ***）（An-Ox SBR）, respectively, which were also similar. In addition, an analysis of relationship of poly-β-hydroxyalkanoates （PHA） synthesized under anaerobic conditions with phosphorous release （Preleased/PHAsynthesized） and of PHA utilized under anoxic and aerobic conditions with phosphorous uptake （Puptaked/PHAutilized） verified that biological activities of EBPR per unit biomass between DPAO and PAO were similar. An analysis of the specific denitrification rate of DPAO showed that NO3-N can be denitrified at a rate that does not substantially differ from that of an ordinary denitrifier without additional consumption of organic carbon when the PHA stored inside the cell under anaerobic conditions is sufficiently secured.

关键词： denitrifying EBPR poly-β-hydroxyalkanoates specific phosphorus release rate specific phosphorus uptake rate