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Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer

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World Journal of Clinical Cases 2022年第28期10卷 10066-10076页

作者： hee Ryeong Jang Hui-Young Lee Seo-Young Song Kyu-Hyoung lim Department of Internal Medicine Kangwon National University HospitalKangwon National University School of MedicineChuncheon-siGangwon-do 24289South Korea

BACKGROUND The 5-fluorouracil-based chemotherapy combined with oxaliplatin or irinotecan is usually used in colorectal cancer(CRC).The addition of a targeted agent(TA) to this combination chemotherapy is currently the standard treatment for metastatic ***,the efficacy and safety of combination chemotherapy for metastatic CRC in patients aged above 80 years has yet to be *** To assess the clinical outcomes and feasibility of combination chemotherapy using a TA in extremely elderly patients with *** Eligibility criteria were:(1) Age above 80 years;(2) Metastatic colorectal cancer;(3) Palliative chemotherapy na?ve;(4) Eastern Cooperative Oncology Group performance status 0-1;and(5) Adequate organ *** received at least one dose of combination chemotherapy with or without *** was evaluated every 8 *** Of 30 patients,the median age of 15 patients treated with TA was 83.0 years and that of those without TA was 81.3 *** median progression-free survival(PFS) and overall survival(OS) in patients treated with TA were 7.4 mo and 15.4 mo,respectively,compared with 4.4 mo and 15.6 mo,respectively,in patients treated without *** was no significant difference in PFS(P:0.193) and OS(P:0.748) between patients treated with and without *** grade 3/4 hematologic toxicities were anemia(16.7%) and neutropenia(10.0%).After disease progression,the median OS of patients who were treated with and without salvage chemotherapy were 23.5 mo and 7.0 mo,respectively,suggesting significant difference in OS(P = 0.001).CONCLUSION Combination chemotherapy with TA for metastatic CRC may be considered feasible in patients aged above 80 years,when with careful *** chemotherapy can help improve OS in some selected of these elderly patients.

关键词： Combination chemotherapy Targeted agent Colorectal cancer Salvage chemotherapy Elderly patient

Incidental accumulation of Technetium-99m pertechnetate in subacute cerebral infarction: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8400-8405页

作者： Yeon-hee Han Hwan-Jeong Jeong Hyun Goo Kang Seok Tae lim Department of Nuclear Medicine Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJounbuk National University Medical School and HospitalJeonju 54907JeonbukSouth Korea Department of Neurology Jeonbuk National University Medical School and HospitalJeonju 54907JeonbukSouth Korea

BACKGROUND When interpreting nuclear medicine images,unexpected findings are sometimes *** these findings and determining the mechanism of their occurrence could have a significant impact on early diagnosis of critical diseases and the appropriate management of *** SUMMARY A 59-year-old man was admitted to the emergency room due to left hemiparesis,left hemifacial palsy,and mild *** 2 wk of hospitalization,the patient complained of dry eyes and ***,salivary scintigraphy was performed to evaluate the functional status of his salivary *** accumulation in the right frontoparietal area was found on salivary ***-attenuated inversion recovery phase magnetic resonance(FLAIR phase MR)image showed diffuse high signal intensity in the same *** and posterior horns of the right lateral ventricle were obliterated and the midline was slightly shifted to the left side due to right frontoparietal *** salivary scintigraphy,Tc-99m pertechnetate was incidentally accumulated in a subacute cerebral infarction *** years after the diagnosis of acute infarction,the second series of salivary scintigraphy showed no abnormal activity in the *** phase MR image also demonstrated markedly decreased high signal intensity in the previous infarction lesion without evidence of swelling indicating chronic cerebral *** This case highlights that Tc-99m pertechnetate could accumulate in a subacute cerebral infarction *** mechanism of an unexpected uptake of Tc-99m pertechnetate in unusual sites should be evaluated and kept in mind for better interpretation.

关键词： Cerebral infarction Tc-99m pertechnetate Salivary scintigraphy Case report

A case study of customer satisfaction for information technology solutions

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Journal of Central South University 2014年第11期21卷 4279-4285页

作者： Sung yun YU Jinsoo PARK Jin KIM Hyung Jin LEE hee Jun YOON Supercomputing Center Korea Institute of Science and Technology InformationDaejeon 305-806 Korea Department of Management Information Systems Yong In UniversityYongin 449-714 Korea

There are numerous information technology solutions including hardware and software. A company that provides the solution should have knowledge of the customer needs in the purpose of sailing strategy or upgrade policy. The needs are also directly connected to the user satisfaction. However, the users have respective points of view in the needs as well as they may not identify the requirements to improve the solution. SERVQUAL can be an appropriate method to define and measure the customer satisfaction for the information technology solutions. As a case study of the customer satisfaction, the modified SERVQUAL items and scoring method are applied to a cyber-infrastructure system named CyberL ab in Korea. The measurement results of user satisfaction for CyberL ab are provided to confirm that our proposed method performs as we intended. From the results, we can score the satisfaction level of users and identify their needs in the various aspects. The total user satisfaction level for CyberL ab is scored by 88.3.

关键词： cyber-infrastructure customer satisfaction user satisfaction SERVQUAL

Distribution of dinoflagellate cysts in Yellow Sea sediments

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Acta Oceanologica Sinica 2013年第9期32卷 91-98页

作者： SHIN Hyeon Ho lim Dhongil PARK Soung-yun HEO Seung KIM So-Young Library of Marine Samples Korea Institute of Ocean Science and Technology West Sea Fisheries Research Institute National Fisheries Research&Development Institute Division of Polar Climate Research Korea Polar Research Institute

To investigate the distribution, abundance, and species composition of dinoflagellate cysts in the Yellow Sea, surface sediment samples were collected at 37 sites, including the Korean dump site. Twenty-one di- noflagellate cyst taxa were identified, with the assemblages dominated mainly by Spiniferites bulloideus, Operculodinium centrocarpum, and cyst of Alexandrium catenella/tarnarense type. A high frequency of O. centrocarpum in the Yellow Sea was observed for the first time, and it is likely that this can be attributed to the dynamics of the Yellow Sea Cold Water Mass and the Changjiang （Yangtze） River runoff. Total cyst concentrations ranged from 23 to 48 442 cysts/g dry weight, and high cyst concentrations were recorded adjacent to the dumping site. This result suggests that anthropogenic activities such as ocean dumping s- timulate the growth of dinoflagellates in the Yellow Sea, which in turn leads to high levels of dinoflagellate cyst production.

关键词： Yellow Sea dumping site dinoflagellate cyst Alexandrium catenella/tamarense type Operculo- dinium centrocarpum

Pulmonary amyloidosis and multiple myeloma mimicking lymphoma in a patient with Sjogren’s syndrome:A case report

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World Journal of Clinical Cases 2022年第3期10卷 1016-1023页

作者： Joa Kim yun Sung Kim hee Jeong Lee Sang Gon Park Department of Internal Medicine RheumatologyChosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Chosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Hemato-OncologyChosun University HospitalGwangju 501-717South Korea

BACKGROUND Sjogren’s syndrome(SS),which affect salivary gland function,is an autoimmune *** may involve extraglandular *** 10 to 20 percent of SS patients have clinically significant lung disease,but presentation of pulmonary amylodosis is extremly *** incidence of benign monoclonal gammopathy in SS patients is high,but multiple myeloma is *** case involving the simultaneous occurrence of two rare diseases,pulmonary amyloidosis and multiple myeloma,in the same patient with SS has been reported so *** SUMMARY A 41-year-old male patient was referred to our hematology department due to incidentally detected gastric *** had been diagnosed with SS four years *** miliary nodules,ground glass opacity in both lung fields,and enlargement of both inguinal lymph nodes was observed on chest and abdomen computer *** on the pathological findings of lung and lymph node biopsied specimens,the patient was diagnosed with pulmonary amyloidosis and multiple *** amyloidosis and multiple myeloma associated with SS has rarely been *** This is an extremely rare case of simultaneous pulmonary amyloidosis and multiple myeloma in the same patient with SS.

关键词： Case report Sjogren’s syndrome Amyloidosis Multiple myeloma Plasmacytoma

Filiform polyposis in the sigmoid colon: A case series

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World Journal of Gastroenterology 2010年第19期16卷 2443-2447页

作者： Chang Geun Lee yun Jeong lim Jong Sun Choi Jin Ho Lee Department of Internal Medicine Dongguk University-Seoul Graduate School of Medicine Goyang 411-773 South Korea

Filiform polyposis is a rare condition of uncertain patho-genesis that is usually found in association with Crohn’s disease, ulcerative colitis, intestinal tuberculosis or histiocytosis X. We report seven interesting cases of polyposis with various pathologic components, mainly located in the left side of the colon with no associated inflammatory bowel disease, intestinal tuberculosis or histiocytosis X. Multiple finger-like polypoid lesions with the appearance of stalactites were noted on the left side of the colon, especially in the sigmoid area, at the time of colonoscopy. The polyps had a variety of sizes and shapes and were shown to have various histopathologic components among the different patients. Although filiform polyposis localized in the sigmoid colon appears not to have high oncogenic potential, periodic follow-up seems to be needed.

关键词： Filiform polyposis Sigmoid colon Inflammatory bowel disease

Occurrence of human leukocyte antigen B51-related ankylosing spondylitis in a family:Two case reports

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World Journal of Clinical Cases 2022年第3期10卷 992-999页

作者： Mie Jin lim Eul Noh Ro-Woon Lee Kyong-hee Jung Won Park Rheumatology/Internal Medicine Inha UniversityIncheon 22332South Korea Radiology Inha UniversityIncheon 22332South Korea

BACKGROUND Ankylosing spondylitis(AS)is strongly associated with the human leukocyte antigen(HLA)B27 *** regions where conventional polymerase chain reaction for HLA typing is available for antigens such as HLA B27 or HLA B51,it is common to perform the HLA B27 test for evaluation of *** HLA B27-associated clustered occurrences of AS have been reported in families,we report the first case series of HLA B51-related occurrences of AS in a *** SUMMARY A father and his daughters were diagnosed with AS and did not have the HLA B27 *** they were positive for HLA B51,they exhibited no signs of Behçet’s disease(BD).Of the five daughters,one had AS,and three,including the daughter with AS,were positive for HLA *** two daughters with the HLA B51 haplotype(excluding the daughter with AS)exhibited bilateral grade 1 sacroiliitis,whereas the daughters without the HLA B51 haplotype did not have ***,this Korean family exhibited a strong association with the HLA B51 haplotype and clinical sacroiliitis,irrespective of the symptoms of *** It is advisable to check for HLA B51 positivity in patients with AS/spondyloarthropathy who test negative for HLA B27.

关键词： Ankylosing spondylitis Spondyloarthropathy Human leukocyte antigen B51 Human leukocyte antigen B27 Sacroiliitis Case report

BRI1-Associated Receptor Kinase 1 Regulates Guard Cell ABA Signaling Mediated by Open Stomata 1 in Arabidopsis

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Molecular Plant 2016年第3期9卷 447-460页

作者： yun Shang Changbo Dai Myeong Min Lee June M. Kwak Kyoung hee Nam Department of Biological Sciences Sookmyung Women's University Seou1140-742 Republic of Korea Department of Systems Biology Yonsei University Seou1120-749 Republic of Korea Department of New Biology Center for Plant Aging Research Institute for Basic Science Daegu Gyeongbuk Institute of Science and Technology Daegu 711-873 Republic of Korea

Stomatal movements are critical in regulating gas exchange for photosynthesis and water balance between plant tissues and the atmosphere. The plant hormone abscisic acid （ABA） plays key roles in regulating stomatal closure under various abiotic stresses. In this study, we revealed a novel role of BAKI in guard cell ABA signaling. We found that the brassinosteroid （BR） signaling mutant bakl lost more water than wild- type plants and showed ABA insensitivity in stomatal closure. ABA-induced OST1 expression and reactive oxygen species （ROS） production were also impaired in bakl. Unlike direct treatment with H202, overex-pression of OST1 did not completely rescue the insensitivity of bakl to ABA. We demonstrated that BAK1 forms a complex with OST1 near the plasma membrane and that the BAKI/OST1 complex is increased in response to ABA in planta. Brassinolide, the most active BR, exerted a negative effect on ABA-induced formation of the BAK1/OST1 complex and OST1 expression. Moreover, we found that BAK1 and ABI1 oppositely regulate OST1 phosphorylation in vitro, and that ABI1 interacts with BAK1 and inhibits the interaction of BAK1 and OST1. Taken together, our results suggest that BAK1 regulates ABA-induced stomatal closure in guard cells.

关键词： BAK1 OST1 ABA-induced stomatal closure Arabidopsis thaliana

CO_(2)-adsorbent spongy electrode for non-aqueous Li–O_(2) batteries

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Journal of Energy Chemistry 2022年第2期31卷 646-653页

作者： Yiseul Yoo Giseung Lee Min-Gi Jeong Hun-Gi Jung Sunghee Shin Dongjin Byun Taeeun Yim hee-Dae lim Center for Energy Storage Research Korea Institute of Science and Technology(KIST)Hwarang-ro 14-gil 5Seongbuk-guSeoul 02792Republic of Korea Department of Materials Science and Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Chemistry Incheon National University119 Academy-roYeonsu-guIncheon 22012Republic of Korea Department of Chemical and Biological Engineering Korea UniversitySeoul 02841Republic of Korea

Regulation of the Li_(2)CO_(3) byproduct is the most critical challenge in the field of non-aqueous Li–O_(2) *** considerable efforts have been devoted to preventing Li_(2)CO_(3) formation,no approaches have suggested the ultimate solution of utilizing the clean Li_(2)O_(2) reaction instead of that of Li_(2)CO_(3).Even if extremely pure O_(2) is used in a Li–O_(2) cell,its complete elimination is impossible,eventually generating CO_(2) gas during *** this paper,we present the new concept of a CO_(2)-adsorbent spongy electrode(CASE),which is designed to trap the evolved CO_(2) using adsorption *** candidates composed of amine functional groups(–NH2)for capturing CO_(2) were screened,with quadrapurebenzylamine(QPBZA)exhibiting superior CO_(2)-adsorbing ability among the proposed ***,we fabricated the CASE by sandwiching QPBZA between porous carbon layers,which facilitated the transport of gaseous *** new electrode was demonstrated to effectively capture the evolved CO_(2) during charge,therefore altering the reaction pathways to the ideal *** is highly advantageous to mitigate the undesirable CO_(2) incorporation in the next discharge,resulting in improved *** novel concept of a CO_(2)-sponging electrode provides an alternative route to the realization of practically meaningful Li–O_(2) batteries.

关键词： Li-O_(2)battery Benzylamine CO_(2)adsorption Li_(2)CO_(3) Li_(2)O_(2) CO_(2)-sponging electrode