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Scientific objectives and payload configuration of the Chang'E-7 mission

National Science Review 2024年第2期11卷 285-300页

作者： Chi Wang Yingzhuo Jia Changbin Xue Yangting Lin Jianzhong Liu Xiaohui Fu Lin Xu yun huang Yufen Zhao Yigang Xu Rui Gao Yong Wei Yuhua Tang Dengyun Yu Yongliao Zou China Aerospace Science and Technology Corporation State Key Laboratory of Space Weather National Space Science Center Chinese Academy of Sciences National Space Science Center Chinese Academy of Sciences Institute of Geology and Geophysics Chinese Academy of Sciences Institute of Geochemistry Chinese Academy of Sciences Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment School of Space Science and Physics Institute of Space SciencesShandong University Institute of Drug Discovery Technology Ningbo University State Key Laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences School of Earth Science and Engineering Sun Yat-sen University Lunar Exploration and Space Engineering Center

As the cornerstone mission of the fourth phase of the Chinese Lunar Exploration Program, Chang'E-7(CE-7) was officially approved, and implementation started in 2022, including a main probe and a communication relay satellite. The main probe, consisting of an orbiter, a lander, a rover and a mini-flying probe, is scheduled to be launched in 2026. The lander will land on Shackleton crater's illuminated rim near the lunar south pole, along with the rover and mini-flying probe. The relay satellite(named Queqiao-2) will be launched in February 2024 as an independent mission to support relay communication during scientific exploration undertaken by Chang'E-4, the upcoming Chang'E-6 in 2024 and subsequent lunar missions.The CE-7 mission is mainly aimed at scientific and resource exploration of the lunar south pole. We present CE-7's scientific objectives, the scientific payloads configuration and the main functions for each scientific payload with its key technical specifications.

关键词： Chang’ E-7 scientific objectives scientific payloads

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Unraveling high efficiency multi-step sodium storage and bidirectional redox kinetics synergy mechanism of cobalt-doping vanadium disulfide anode

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Journal of Energy Chemistry 2024年第7期94卷 148-157页

作者： Enzhi Li Mingshan Wang Yuanlong Feng Lin Yang Qian Li Zhenliang Yang Junchen Chen Bo Yu Bingshu Guo Zhiyuan Ma yun huang Jiangtao Liu Xing Li School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500SichuanChina Institute of Materials China Academy of Engineering PhysicsMianyang 621908SichuanChina State Key Laboratory of Advanced Chemical Power Sources Guizhou Meiling Power Sources Co.Ltd.Zunyi 563003GuizhouChina school of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina

Sodium-based storage devices based on conversion-type metal sulfide anodes have attracted great atten-tion due to their multivalent ion redox reaction ability.However,they also suffer from sodium polysul-fides(NaPSs)shuttling problems during the sluggish Na^(+) redox process,leading to"voltage failure"and rapid capacity decay.Herein,a metal cobalt-doping vanadium disulfide(Co-VS_(2))is proposed to simulta-neously accelerate the electrochemical reaction of VS_(2) and enhance the bidirectional redox of soluble NaPSs.It is found that the strong adsorption of NaPSs by V-Co alloy nanoparticles formed in situ during the conversion reaction of Co-VS_(2) can effectively inhibit the dissolution and shuttle of NaPSs,and ther-modynamically reduce the formation energy barrier of the reaction path to effectively drive the complete conversion reaction,while the metal transition of Co elements enhances reconversion kinetics to achieve high reversibility.Moreover,Co-VS_(2) also produce abundant sulfur vacancies and unsaturated sulfur edge defects,significantly improve ionic/electron diffusion kinetics.Therefore,the Co-VS_(2) anode exhibits ultrahigh rate capability(562 mA h g^(-1) at 5 A g^(-1)),high initial coulombic efficiency(~90%)and 12,000 ultralong cycle life with capacity retention of 90%in sodium-ion batteries(SIBs),as well as impressive energy/power density(118 Wh kg^(-1)/31,250 W kg^(-1))and over 10.000 stable cycles in sodium-ion hybrid capacitors(SIHCs).Moreover,the pouch cell-type SIHC displays a high-energy density of 102 Wh kg^(-1) and exceed 600 stable cycles.This work deepens the understanding of the electrochemical reaction mechanism of conversion-type metal sulfide anodes and provides a valuable solution to the shuttlingofNaPSs inSIBsandSIHCs.

关键词： Sodium-ionbatteries Sodium-ion hybrid capacitors Pouch cells Vanadium disulfide Shuttle effect

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Intermittent fasting boosts antitumor immunity by restricting CD11b^(+)Ly6C^(low)Ly6G^(low) cell viability through glucose metabolism in murine breast tumor model

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Food Science and Human Wellness 2024年第4期13卷 2327-2345页

作者： Chenghao Fu Zhehao Liang Zemiao Niu Ning Chen Yuemin Li Zhenhua Liang Yanwei Huo Hao Xi Rong Wang Yonghuan Yan Xiaoruo Gan Mengtian Wang yun huang Yan Zhang Mingming Gao Pin Lü Postdoctoral Station for Basic Medicine Cardiovascular Medical Science CenterDepartment of Cell BiologyKey Laboratory of Neural and Vascular Biology of Ministry of EducationHebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Forensic Medicine College of Forensic MedicineHebei Medical UniversityShijiazhuang 050017China Hebei Food Safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050091China Laboratory of Lipid Metabolism Department of Biochemistry and Molecular BiologyKey Laboratory of Medical Biotechnology of Hebei ProvinceShijiazhuang 050017China

Intermittent fasting can benefit breast cancer patients undergoing chemotherapy or immunotherapy.However,it is still uncertain how to select immunotherapy drugs to combine with intermittent fasting.Herein we observed that two cycles of fasting treatment significantly inhibited breast tumor growth and lung tissue metastasis,as well as prolonged overall survival in mice bearing 4T1 and 4T07 breast cancer.During this process,both the immunosuppressive monocytic-(M-)and granulocytic-(G-)myeloid-derived suppressor cell(MDSC)decreased,accompanied by an increase in interleukin(IL)7R^(+)and granzyme B^(+)T cells in the tumor microenvironment.Interestingly,we observed that Ly6G^(low)G-MDSC sharply decreased after fasting treatment,and the cell surface markers and protein mass spectrometry data showed potential therapeutic targets.Mechanistic investigation revealed that glucose metabolism restriction suppressed the splenic granulocytemonocyte progenitor and the generation of colony-stimulating factors and IL-6,which both contributed to the accumulation of G-MDSC.On the other hand,glucose metabolism restriction can directly induce the apoptosis of Ly6G^(low)G-MDSC,but not Ly6G^(high)subsets.In summary,these results suggest that glucose metabolism restriction induced by fasting treatment attenuates the immune-suppressive milieu and enhances the activation of CD3^(+)T cells,providing potential solutions for enhancing immune-based cancer interventions.

关键词： Intermittent fasting Ly6G^(low)myeloid-derived suppressor cell apoptosis Extramedullary hematopoiesis Colony stimulating factor Glucose metabolism restriction

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Absorbed Bioactive Compounds Replicate GuanxinⅡ-Induced Endothelium-Associated in/ex vivo Vasodilation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 387-397页

作者： XU Min LIU Hao SU Meng-qing LI Lan YU Ai-ling CHEN Ken huang yun-ke ZHAO Qiu-long huang Wen-ya huang Xi Institute of Traditional Chinese Medicine Related Comorbid Depression Nanjing University of Chinese MedicineNanjing 210029China Department of Gynecology Women's HospitalZhejiang University School of MedicineHangzhou 310053China

Objective:To develop an interference-free and rapid method to elucidate GuanxinⅡ(GXⅡ)'s representative vasodilator absorbed bioactive compounds(ABCs)among enormous phytochemicals.Methods:The contents of ferulic acid,tanshinol,and hydroxysafflor yellow A(FTA)in GXⅡ/rat serum after the oral administration of GXⅡ(30 g/kg)were detected using ultra-performance liquid chromatography-mass spectrometry.Totally 18 rats were randomly assigned to the control group(0.9%normal saline),GXⅡ(30 g/kg)and FTA(5,28 and 77 mg/kg)by random number table method.Diastolic coronary flow velocity-time integral(VTI),i.e.,coronary flow or coronary flow-mediated dilation(CFMD),and endothelium-intact vascular tension of isolated aortic rings were measured.After 12 h of exposure to blank medium or 0.5 mmol/L H_(2)O_(2),endothelial cells(ECs)were treated with post-dose GXⅡof supernatant from deproteinized serum(PGSDS,300μL PGSDS per 1 m L of culture medium)or FTA(237,1539,and 1510 mg/m L)for 10 min as control,H_(2)O_(2),PGSDS and FTA groups.Nitric oxide(NO),vascular endothelial growth factor(VEGF),endothelin-1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA)and phosphorylated phosphoinositide 3 kinase(p-PI3K),phosphorylated protein kinase B(p-AKT),phosphorylated endothelial nitric oxide synthase(p-e NOS)were analyzed.PGSDS was developed as a GXⅡproxy of ex vivo herbal crude extracts.Results:PGSDS effectively eliminates false responses caused by crude GXⅡpreparations.When doses equaled the contents in GXⅡ/its post-dose serum,FTA accounted for 98.17%of GXⅡ-added CFMD and 92.99%of PGSDS-reduced vascular tension.In ECs,FTA/PGSDS was found to have significant antioxidant(lower MDA and higher SOD,P<0.01)and endothelial function-protective(lower VEGF,ET-1,P<0.01)effects.The increases in aortic relaxation,endothelial NO levels and phosphorylated PI3K/Akt/e NOS protein induced by FTA/PGSDS were markedly abolished by NG-nitro-L-arginine methyl ester(L-NA,e NOS inhibitor)and wortmannin(PI3K/AKT inhibitor),respectively,indicating an endothelium-depende

关键词： ultra-performance liquid chromatography-mass spectrometry endothelium-dependent vasodilation herbal extract GuanxinⅡ absorbed bioactive compound

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Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： yun-Zhi huang Xiao-Xiao Liu Lan-Wei Li Guang-Ming huang Zhao-Xia huang Jin-Ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM resonances.Herein,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors simultaneously.The structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene composites.Then,the result showed that CPP-SS can significantly improve theσof samples.Ultimately,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be surpassed.This work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

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Evaluating the Compatibility Mechanism of Shengxian Decoction Based on an Excretion Study of 18 Bioactive Constituents in Rat Biosamples

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 40-52页

作者： Tao Pang Nan Weng Yong Chen Cui-yun huang Mei Sun Feng Zhang Wan-Sheng Chen Department of Pharmacy Changzheng HospitalNaval Medical University(Second Military Medical University)ShanghaiChina Department of Pharmacognosy Shenyang Pharmaceutical University ShenyangLiaoning ProvinceChina Traditional Chinese Medicine Resource and Technology Center Shanghai University of Traditional Chinese MedicineShanghaiChina

Introduction:The Shengxian decoction(SXT),a Chinese herbal medication used to treat heart failure,is composed of Astragali Radix,Anemarrhenae Rhizoma,Bupleuri Radix,Cimicifuage Rhizoma,and Platycodonis Radix.Knowledge of the excretion of the active compounds in this herbal medication is vital for investigating the underlying mechanisms behind its compatibility.However,this remains unclear.Methods:Liquid chromatography coupled with mass spectrometry was performed in both positive and negative modes to assay 18 constituents of SXT from rat urinary,fecal,and biliary samples.Results:The methodology was validated and showed good linearity(r≥0.9),precision,stability,repeatability,and recovery.The relative standard deviations and relative errors for the precision and accuracy did not exceed 15%.The recoveries of all the compounds ranged from 77.37%to 114.82%,and the matrix effect was between 82.53%and 105.71%.The results suggested that,when combined with Platycodonis Radix,the levels of 14 constituents from the four herbs were reduced in the urine,while the levels of six constituents were reduced in the feces.Conclusions:The comparative excretion results indicated that Platycodonis Radix reduced the excretion of compounds in SXT,demonstrating the compatibility mechanism and holistic properties of these compounds,favoring the pharmacological effects of SXT.

关键词： Compatibility excretion liquid chromatography coupled with mass spectrometry Platycodonis Radix Shengxian decoction

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Allowance Extraction Considering of Inner and Outer Contour and Experimental Research on Belt Grinding of Hollow Blade

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Chinese Journal of Mechanical Engineering 2023年第3期36卷 230-240页

作者： yun huang Ming Wei Guijian Xiao Shuai Liu Yuan Wu College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China

Aero-engine fan blades of ten use a cavity structure to improve the thrust-to-weight ratio of the aircraft.However,the use of the cavity structure brings a series of difficulties to the manufacturing and processing of the blades.Due to the limitation of blade manufacturing technology,it is difficult for the internal cavity structure to achieve the designed contour shape,so the blade has uneven wall thickness and poor consistency,which affects the fatigue performance and airflow dynamic performance of the blade.In order to reduce the influence of uneven wall thickness,this paper proposes a grinding allowance extraction method considering the double dimension constraints(DDC)of the inner and outer contours of the hollow blade.Constrain the two dimensions of the inner and outer contours of the hollow blade.On the premise of satisfying the outer contour constraints,the machining model of the blade is modified according to the distribution of the inwall contour to obtain a more reasonable distribution of the grinding allowance.On the premise of satisfying the contour constraints,according to the distribution of the inwall contour,the machining model of the blade is modified to obtain a more reasonable distribution of the grinding allowance.Through the grinding experiment of the hollow blade,the surface roughness is below Ra0.4μm,and the contour accuracy is between-0.05~0.14 mm,which meets the processing requirements.Compared with the allowance extraction method that only considers the contour,the problem of poor wall thickness consistency can be effectively improved.It can be used to extract the allowance of aero-engine blades with hollow features,which lays a foundation for the study of hollow blade grinding methods with high service performance.

关键词： Double dimension constraints Allowance extraction Abrasive belt grinding

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On Energy Assessment of Titanium Alloys Belt Grinding Involving Abrasive Wear Effects

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Chinese Journal of Mechanical Engineering 2023年第6期36卷 185-196页

作者： Mingcong Li Shudong Zhao Heng Li yun huang Lai Zou Wenxi Wang College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China

Improved energy utilisation,precision,and quality are critical in the current trend of low-carbon green manufactur-ing.In this study,three abrasive belts were prepared at various wear stages and characterised quantitatively.The effects of abrasive belt wear on the specific grinding energy partition were investigated by evaluating robotic belt grinding of titanium plates.A specific grinding energy model based on subdivided tangential forces of cutting and sliding was developed for investigating specific energy and energy utilisation coefficient EUC.The surface mor-phology and Abbott–Firestone curves of the belts were introduced to analyse the experimental findings from the per-spective of the micro cutting behaviour.The specific grinding energy increased with abrasive belt wear,especially when the belt was near the end of its life.Moreover,the belt wear could lead to a predominance change of sliding and chip formation energy.The highest EUC was observed in the middle of the belt life because of its retained sharp cutting edge and uniform distribution of the grit protrusion height.This study provides guidance for balancing the energy consumption and energy utilization efficiency of belt grinding.

关键词： Belt grinding Wear Specific grinding energy Microtopography

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Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments

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World Journal of Gastroenterology 2023年第30期29卷 4642-4656页

作者： Xi-Rui Fan yun huang Yu Su Si-Jin Chen Yu-Lu Zhang Wei-Kang huang Hui Wang Department of Gastroenterology The Affiliated Yan’an Hospital of Kunming Medical UniversityKunming 650051Yunnan ProvinceChina Key Laboratory of Tumor Immunological Prevention and Treatment of yunnan Province Yan’an Hospital of KunmingKunming 650051Yunnan ProvinceChina

BACKGROUND Acute pancreatitis(AP)is a disease featuring acute inflammation of the pancreas and histological destruction of acinar cells.Approximately 20%of AP patients progress to moderately severe or severe pancreatitis,with a case fatality rate of up to 30%.However,a single indicator that can serve as the gold standard for prognostic prediction has not been discovered.Therefore,gaining deeper insights into the underlying mechanism of AP progression and the evolution of the disease and exploring effective biomarkers are important for early diagnosis,progression evaluation,and precise treatment of AP.AIM To determine the regulatory mechanisms of tRNA-derived fragments(tRFs)in AP based on small RNA sequencing and experiments.METHODS Small RNA sequencing and functional enrichment analyses were performed to identify key tRFs and the potential mechanisms in AP.Reverse transcription quantitative polymerase chain reaction(RT-qPCR)was conducted to determine tRF expression.AP cell and mouse models were created to investigate the role of tRF36 in AP progression.Lipase,amylase,and cytokine levels were assayed to examine AP progression.Ferritin expression,reactive oxygen species,malondialdehyde,and ferric ion levels were assayed to evaluate cellular ferroptosis.RNA pull down assays and methylated RNA immunoprecipitation were performed to explore the molecular mechanisms.RESULTS RT-qPCR results showed that tRF36 was significantly upregulated in the serum of AP patients,compared to healthy controls.Functional enrichment analysis indicated that target genes of tRF36 were involved in ferroptosisrelated pathways,including the Hippo signaling pathway and ion transport.Moreover,the occurrence of pancreatic cell ferroptosis was detected in AP cells and mouse models.The results of interference experiments and AP cell models suggested that tRF-36 could promote AP progression through the regulation of ferroptosis.Furthermore,ferroptosis gene microarray,database prediction,and immunoprecipitation suggested that tRF-36 accelerated the p

关键词： Acute pancreatitis tRNA-derived fragments tRNA-derived fragments 36 Mouse models Ferroptosis Reverse transcription quantitative polymerase chain reaction

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Nomogram to predict the risk of endoscopic removal failure with forceps/baskets for treating submandibular stones

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World Journal of Clinical Cases 2022年第9期10卷 2710-2720页

作者： yun huang Pei-Sheng Liang Yao-Cheng Yang Wei-Xin Cai Qian Tao Department of Oral and Maxillofacial Surgery Hospital of StomatologyGuanghua School of StomatologySun Yat-Sen UniversityGuangzhou 510055Guangdong ProvinceChina Department of Oral and Maxillofacial Surgery Guangdong Provincial Key Laboratory of StomatologyGuangzhou 510055Guangdong ProvinceChina

BACKGROUND Endoscopic removal with forceps/baskets is favored in treating submandibular stones due to its minimal invasiveness.However,recent studies have found that endoscopic removal failure(ERF)is not unusual,and stones in such cases still need to be removed with other surgical methods.If the risk of ERF can be predicted preoperatively,it could be helpful for surgeons when choosing the appropriate therapy.AIM To develop a predictive nomogram for the risk of ERF when treating submandibular stones based on their preoperative clinical features.METHODS A total of 180 patients with 211 submandibular stones treated from January 2012 to December 2020 were included in the current study.Based on the preoperative clinical features of the stones,independent risk factors for ERF were identified by logistic regression analysis.The stones were then randomly divided into training and testing sets.A nomogram was constructed to predict the risk of ERF using the training set and then validated using both sets.The predictive performance of the nomogram was assessed by calibration curves and the concordance index(Cindex).RESULTS Three independent predictors,location(P=0.040),transverse diameter(P<0.001)and longitudinal diameter(P<0.001)measured on the cone beam computed tomography(CBCT)images of the submandibular stones,were identified and included in the predictive nomogram.Calibration curves of the nomogram showed good agreement between the predicted and observed probabilities in both sets.The C-index in the training set was 0.917(95%CI,0.875-0.959)and that in the testing set was 0.925(95%CI,0.862-0.989).CONCLUSION A nomogram based on the location,transverse and longitudinal diameters on CBCT images of submandibular stones showed satisfactory efficacy in predicting the risk of ERF preoperatively when treating submandibular stones.

关键词： Endoscopic removal failure Submandibular stones Cone beam computed tomography Location Diameter Nomogram

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