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Chitosan@Puerarin hydrogel for accelerated wound healing in diabetic subjects by miR-29ab1 mediated inflammatory axis suppression

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Bioactive Materials 2023年第1期19卷 653-665页

作者： Xiaoling Zeng Baohui Chen Luping Wang Yingxiao Sun Zhao Jin Xuanyong Liu Liping Ouyang yun liao Department of Pharmacy Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai200336China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Hongqiao International Institute of Medicine Shanghai Jiao Tong University School of MedicineShanghai200336China School of Chemistry and Materials Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences1 Sub-lane XiangshanHangzhou310024China Cixi Center of Biomaterials Surface Engineering Shanghai Institute of CeramicsChinese Academy of SciencesNingbo315300China

Wound healing is one of the major global health concerns in patients with diabetes.Overactivation of pro-inflammatory M1 macrophages is associated with delayed wound healing in diabetes.miR-29ab1 plays a critical role in diabetes-related macrophage inflammation.Hence,inhibition of inflammation and regulation of miR-29 expression have been implicated as new points for skin wound healing.In this study,the traditional Chinese medicine,puerarin,was introduced to construct an injectable and self-healing chitosan@puerarin(C@P)hydrogel.The C@P hydrogel promoted diabetic wound healing and accelerated angiogenesis,which were related to the inhibition of the miR-29 mediated inflammation response.Compared to healthy subjects,miR-29a and miR-29b1 were ectopically increased in the skin wound of the diabetic model,accompanied by upregulated M1-polarization,and elevated levels of IL-1βand TNF-α.Further evaluations by miR-29ab1 knockout mice exhibited superior wound healing and attenuated inflammation.The present results suggested that miR-29ab1 is essential for diabetic wound healing by regulating the inflammatory response.Suppression of miR-29ab1 by the C@P hydrogel has the potential for improving medical approaches for wound repair.

关键词： Hydrogel Diabetic skin wound healing Macrophages miR-29ab1

Puerarin@Chitosan composite for infected bone repair through mimicking the bio-functions of antimicrobial peptides

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Bioactive Materials 2023年第3期21卷 520-530页

作者： Liping Ouyang Baohui Chen Xingdan Liu Donghui Wang Yang Li yun liao Kelvin W.K.Yeung Xuanyong Liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Hongqiao International Institute of edicine Shanghai Jiao Tong University School of MedicineShanghai200336China Cixi Center of Biomaterials Surface Engineering Ningbo315300China Department of Computational Biology for Individualised Medicine Centre for Individualised Infection Medicine(CiiM)&TWINCOREJoint Ventures Between the Helmholtz-Centre for Infection Research(HZI)and the Hannover Medical School(MHH)HannoverGermany Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma Guangdong Engineering Technology Research Center for Orthopaedic Trauma RepairDepartment of Orthopaedics and TraumatologyThe University of Hong Kong Shenzhen HospitalShenzhenChina

It is important to eliminate lipopolysaccharide(LPS)along with killing bacteria in periprosthetic joint infection(PJI)therapy for promoting bone repair due to its effect to regulate macrophages response.Although natural antimicrobial peptides(AMPs)offer a good solution,the unknown toxicity,high cost and exogenetic immune response hamper their applications in clinic.In this work,we fabricated a nanowire-like composite material,named P@C,by combining chitosan and puerarin via solid-phase reaction,which can finely mimic the bio-functions of AMPs.Chitosan,serving as the bacteria membrane puncture agent,and puerarin,serving as the LPS target agent,synergistically destroy the bacterial membrane structure and inhibit its recovery,thus endowing P@C with good antibacterial property.In addition,P@C possesses good osteoimmunomodulation due to its ability of LPS elimination and macrophage differentiation modulation.The in vivo results show that P@C can inhibit the LPS induced bone destruction in the Escherichia coli infected rat.P@C exhibits superior bone regeneration in Escherichia coli infected rat due to the comprehensive functions of its superior antibacterial property,and its ability of LPS elimination and immunomodulation.P@C can well mimic the functions of AMPs,which provides a novel and effective method for treating the PJI in clinic.

关键词： Osteoimmunomodulation Antibacterial Chitosan Puerarin Lipopolysaccharide

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li yun-Dan liao Zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective biomarkers.Previous studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been identified.Hence,further research is imperative to enhance precision medicine in SCZ treatment.Methods:Participants with SCZ were recruited from two randomized trials.The discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)groups.The external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole groups.Additionally,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic reference.The genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,respectively.The study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin interaction.Machine learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve analysis.Results:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment response.The developed and externally validated prediction model,which incorporated clinical information,

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

A case history study on causation of the landslide in Santa Clara,California, USA

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第2期7卷 185-192页

作者： yun liao Sadek M. Derrega Craig A. Hall Kleinfelder 1330 Broadway Suite 1200 Oakland CA 94612 USA Kleinfelder 4670 Willow Road Suite 100 Pleasanton CA 94588 USA

This paper presents a case history study on the geologic investigation and numerical modeling of areactivated landslide in the County of Santa Clara, California to identify the failure mechanism. Thelandslide occurred on an approximately 18.3-m high, north-facing slope during March 2011. The landslidemeasured about 33.5 m in width and about 51.8 m in length. Along the toe of the slope, a residentialstructure with a swimming pool was built on a cut and fill pad and there are several other structurespresent along the western side of the pad. The landslide occurred immediately to the south of theresidential building and moved northward between the County Road A and the house＇s side yard. Themovement of the landslide resulted in damaging the west-bound traffic lane of County Road A andencroached onto the paved driveway for the residential property. An investigation was performed toidentify the failure mechanism of the landslide to conclude whether Road A re-alignment by the Countyor prominent cutting performed along the lower portion of the slope by the homeowner during 2000through 2004 contributed to the reactivation of the old landslide deposit. The investigation included sitereconnaissance, reviewing available published geologic information, reviewing site-specific geologic andgeotechnical data developed by other consultants, and performing numerical modeling. The outcomes ofthe investigation indicate that the primary causation for the reactivation and failure of the subject preexistinglandslide is the prominent cutting performed along the lower portion of the slope during 2000through 2004 and water tank cut bench. The Road A re-alignment did not contribute to the reactivationof the old landslide deposit. 2015 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting byElsevier B.V. All rights reserved.

关键词： Pre-existing landslide ailure mechanism Slope stability

纽曼系统护理模式联合营养支持对皮肤癌广泛切除术后患者的应用效果

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四川解剖学杂志 2024年第1期32卷 185-187页

作者：廖云王涵信阳职业技术学院附属医院皮肤科信阳464000

目的:探讨纽曼系统护理模式联合营养支持在皮肤癌广泛切除术后患者中的应用效果.方法:选取2020年5月至2022年5月在本院行广泛切除术后皮肤癌患者72例作为研究对象.采用随机数字表法,将其分成观察组(n=36,接受纽曼系统护理模式联合营养支... 详细信息

目的:探讨纽曼系统护理模式联合营养支持在皮肤癌广泛切除术后患者中的应用效果.方法:选取2020年5月至2022年5月在本院行广泛切除术后皮肤癌患者72例作为研究对象.采用随机数字表法,将其分成观察组(n=36,接受纽曼系统护理模式联合营养支持)和对照组(n=36,接受常规护理干预).比较2组干预前、后营养状况[白蛋白、血红蛋白(Hb)、转铁蛋白(TRF)],负面情绪[焦虑自评量表(SAS)、抑郁自评量表(SDS)评分],以及并发症发生率.结果:与对照组比较,干预后观察组白蛋白、Hb、TRF均高于对照组,差异均有统计学意义(P<0.05);干预后观察组SAS、SDS评分明显降低,差异均有统计学意义(P<0.05);观察组并发症发生率(2.78%,1/36)低于对照组(22.22%,8/36),差异有统计学意义(P<0.05).结论:纽曼系统护理模式联合营养支持能改善皮肤癌广泛切除术后患者营养状况,减少其负面情绪.

关键词：纽曼系统护理模式营养支持皮肤癌广泛切除术营养状况负面情绪

Reducing Viral Inhibition of Host Cellular Apoptosis Strengthens the Immunogenicity and Protective Efficacy of an Attenuated HSV-1 Strain

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Virologica Sinica 2019年第6期34卷 673-687页

作者： Xingli Xu Yufeng He Shengtao Fan Min Feng Guorun Jiang Lichun Wang Ying Zhang yun liao Qihan Li yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College

Herpes simplex virus 1(HSV-1),a member of a herpesviruses,shows a high infectivity rate of 30%-60%in populations of various ages.Some herpes simplex(HSV)vaccine candidates evaluated during the past 20 years have not shown protective efficacy against viral infection.An improved understanding of the immune profile of infected individuals and the associated mechanism is needed.HSV uses an immune evasion strategy during viral replication,and various virus-encoded proteins,such as ICP47 and Vhs,participate in this process through limiting the ability of CD8+cytotoxic T lymphocytes to recognize target cells.Other proteins,e.g.,Us3 and Us5,also play a role in viral immune evasion via interfering with cellular apoptosis.In this work,to study the mechanism by which HSV-1 strain attenuation interferes with the viral immune evasion strategy,we constructed a mutant strain,M5,with deletions in the Us3 and Us5 genes.M5 was shown to induce higher neutralizing antibody titers and a stronger cellular immune response than our previously reported M3 strain,and to prevent virus infection more effectively than the M3 strain in an in vivo mouse challenge test.

关键词： Herpes simplex virus 1(HSV-1) Apoptosis M5 Us3 Us5

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胰腺癌疼痛治疗的研究进展

中国疼痛医学杂志 2024年第5期30卷 371-376页

作者：罗凌云廖云华曹新添张学学南昌大学第一附属医院疼痛科南昌330006 江西省卫生健康委员会神经性疼痛重点实验室南昌330006

胰腺癌是一种发病隐匿、进展迅速、治疗效果及预后极差的消化道恶性肿瘤,也是全世界排名第11大最常见癌症。疼痛是胰腺癌的主要症状之一,严重影响病人生活质量。目前胰腺癌疼痛治疗应用最为广泛的是药物镇痛。有创操作治疗主要包括腹腔... 详细信息

胰腺癌是一种发病隐匿、进展迅速、治疗效果及预后极差的消化道恶性肿瘤,也是全世界排名第11大最常见癌症。疼痛是胰腺癌的主要症状之一,严重影响病人生活质量。目前胰腺癌疼痛治疗应用最为广泛的是药物镇痛。有创操作治疗主要包括腹腔神经、内脏大小神经丛毁损和鞘内给药,可显著降低疼痛,应考虑在癌痛早期阶段应用。本文综合分析了目前临床上胰腺癌疼痛治疗方法,为胰腺癌病人疼痛的最佳治疗方式的选择提供参考。

关键词：胰腺癌药物治疗癌性疼痛射频消融神经毁损

校企协同育人视域下高职《物流综合实训》课程教学模式研究

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物流工程与管理 2024年第5期46卷 133-136页

作者：廖韵如江西航空职业技术学院江西南昌330000

校企合作是推动职业教育高质量发展的重要抓手,文中在校企协同育人视域下,对高职《物流综合实训》课程教学模式进行创新研究,提出校企协同“1+N+1”教学模式,即“1”个准备课程、“N”个实训环节、“1”个教学评价,并打造“双主体”师... 详细信息

校企合作是推动职业教育高质量发展的重要抓手,文中在校企协同育人视域下,对高职《物流综合实训》课程教学模式进行创新研究,提出校企协同“1+N+1”教学模式,即“1”个准备课程、“N”个实训环节、“1”个教学评价,并打造“双主体”师资保障平台。同时,在高职物流专业学生中对该教学模式进行对比实验,结果显示:校企协同“1+N+1”教学模式可有效提升学生专业技能和学习动机,可促进“双师型”教师队伍建设,是一种有效的教学创新模式。

关键词：校企协同物流综合实训教学模式

Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation

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Regenerative Biomaterials 2021年第1期8卷 43-51页

作者： Yingxiao Sunt Xingdan Liu Ji Tan Dan Lv Wengang Song Rui Su Ling Li Xuanyong Liu Liping Ouyang yun liao Department of Pharmacy Tongren HospitalShanghai Jiao Tong University School of MedicineShanghai 200336China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesChangning DistrictShanghai 200050China Graduate School of Beihua University Beihua UniversityFengman District Jilin 132013China

Polyetheretherketone(PEEK)has been used as an implant material because it has similar mechani-cal properties to natural bone.However,inferior osseointegration and bioinertness hamper the clinical application of PEEK.In this study,the surfaces of sulfonated three-dimensional(3D)PEEK porous structures were loaded with different concentrations of strontium ranelate,a compound commonly used in the treatment or prevention of osteoporosis by promoting bone formation and inhibiting bone resorption.Field-emission scanning electron microscopy was used to characterize the topography of the structures,elemental carbon,oxygen and strontium contents were mea-sured by X-ray photoelectron spectroscopy,and surface zeta potentials and water-contact angle were also measured.The results indicated that strontium ranelate was successfully loaded onto the 3D porous structures.In vitro cellular results showed that strontium ranelate-treated sulfonated PEEK(SP-SR)strengthened the adhesion of MC3T3-E1 cells.The activity of alkaline phosphatase,collagen secretion and extracellular matrix mineralization deposition of MC3T3-E1 cells were also improved on the surface of SP-SR.These results indicate that SP-SR could serve a new implant candidate for surgical treatment.

关键词： polyetheretherketone sufonation strontium ranelate osseointegr ation