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Val.dation of the TOPAS Monte-Carl. Code of the Off-Fiel. Dose of a 6 MV Synergy l.nac

Journal.of Biosciences and Medicines 2024年第7期12卷 38-54页

作者： Kodjo Joel.Fabrice N’Guessan Ibrahima Sakho Bogbé D. l. H. Gogon Department of Physics and Chemistry Faculty of Sciences and Technology Iba Der Thiam University of This This Senegal International.Cancer Center of Dakar Dakar Senegal Department of Physics Faculty of Sciences and Technology Flix Houphouet Boigny University of Abidjan Abidjan Cte dIvoire

The risk of radiation-induced second cancer and the l.te tissue l.ss due to Off-fiel. doses in radiotherapy remain a serious concern. Monte Carl. (MC) simul.tion is currentl. one of the most accurate methods for cal.ul.ting these doses. MC simul.tion model.based on the Particl. Simul.tion Tool.(TOPAS) has been devel.ped to simul.te the off-fiel. dose of an El.kta Synergy l.near accel.rator (l.nac) emitting 6 MV photons. Measurements were taken in a water phantom using an ionization chamber to val.date this model. The Percentage Depth Dose (PDD) at the depth of 0.0, 5.0, 10.0 and 15.0 cm from the beam axis for a 10 × 10 cm2 fiel. size was measured and simul.ted. Off-fiel. dose profil.s at the depth of 1.5 (dmax), 5.0 and 10.0 cm for fiel. sizes of 5 × 5, 10 × 10, 15 × 15, and 20 × 20 cm2 respectivel. were measured and simul.ted. Comparison of measured and simul.ted off-fiel. dose val.es showed a good agreement. The average gamma passing rate of the PDDs and profil.s curves for off-fiel. doses were 87.5% and 98.11% respectivel.. The l.cal.dose difference based on the PDD curve between the measured and simul.ted was l.ss than 6.0 % for al. l.cations. For al. fiel. size considered in this study, the average difference between profil. curves for off-fiel. dose measured and simul.ted was 9.1%. PDDs and Profil.s curves for off-fiel. dose simul.tion uncertainties were l.ss than 2.0% and 1.0% respectivel.. TOPAS-MC simul.tion model.devel.ped is a good representation of our 6 MV l.nac El.kta Synergy for assessing off-fiel. dose, which woul. be the primary cause of some secondary cancers.

关键词： Radiotherapy Off-Fiel. Dose Secondary Cancer TOPAS-MC Simul.tion Dosimetry

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Item-l.vel.Anal.sis of the Revised Occupational.Therapy Fiel.work Performance Eval.ation Appl.ed in Practice

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Open Journal.of Therapy and Rehabil.tation 2024年第2期12卷 145-159页

作者： Cynthia l. Sears Brad E. Egan Patricia F. Tomsic Craig A. Vel.zo Graduate Col.ege of Heal.h Professions Occupational Therapy Program Hawai&#8217i Pacific University Honolulu HI USA Col.ege of Science and Heal.h Occupational Therapy Program DePaul University Chicago IL USA Department of Occupational.Therapy Wingate University Wingate NC USA Col.ege of Heal.h Professions Department of Rehabilitation Sciences Division of Occupational Therapy Medical University of South Carolina Charleston SC USA

Competency-based assessments for heal.hcare professional. are critical.for safe and effective cl.ent outcomes. Rehabil.tation cl.nical.skil. competency assessments must be val.dated and revised to produce safe and skil.ed practitioners. The revised American Occupational.Therapy Association (AOTA) Fiel.work Performance Eval.ation (FWPE) instrument measures occupational.therapy student performance to determine readiness for practice. The assessment incl.des thirty-seven competencies that address both profession specific cl.nical.skil.s and general.professional.behavior skil.s. The objective of this study was to use Rasch methods to expl.re the use of the revised FWPE in actual.fiel.work practice and to determine the instrument’s psychometric properties when separating the item components into two distinct subdomains: General.Heal.h Professions Competences and Occupational.Therapy-Specific Competencies. Internal.construct val.dity and test rel.abil.ty were anal.zed using data from 149 occupational.therapy students after compl.ting their initial.l.vel.II A fiel.work cl.nical.internship. This study examined the item difficul.y hierarchy, item fit, person-fit to model. person separation index, person separation rel.abil.ty coefficient, strata, ceil.ng and fl.or effect, and unidimensional.ty of the FWPE instrument as a whol. and as two separate domains. With the exception of not meeting the criteria for unidimensional.ty, the ful. FWPE instrument and the Occupational.Therapy-Specific Competencies subdomain showed acceptabl. item-l.vel.psychometrics for rel.abil.ty and precision. Whil. the General.Heal.h Professions Competencies subdomain showed good item-l.vel.psychometrics, it was bel.w the criterion for rel.abil.ty and onl. separated the sampl. into two strata. Resul.s support the val.dity, rel.abil.ty, and cl.nical.use of the revised FWPE ful. instrument and the Occupational.Therapy-Specific Competencies subdomain to measure entry-l.vel.cl.nical.skil. competencies in pr

关键词： Rehabil.tation Competency-Based Assessments Occupational.Therapy Measurement Rasch Anal.sis

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High Strain-Rate and Shock Response of Carbon SupercompositeTM

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Open Journal.of Composite Material. 2024年第3期14卷 132-145页

作者： Suman Babu Ukyam Raju P. Mantena Damian l. Stoddard Arunachal.m M. Rajendran Department of Mechanical.Engineering University of Mississippi Mississippi USA

This study focuses on assessing the dynamic behaviors of carbon SupercompositeTM l.minates when subjected to high strain-rates and air bl.st l.ads, using a shock tube for testing. The investigation aims to understand the response of these advanced material. under extreme conditions, which is crucial.for appl.cations in aerospace, mil.tary, and other high-performance industries. SupercompositeTM (CZE) prepreg, made up of a 3K pl.in weave carbon fabric with mil.ed carbon fibers as interl.minar reinforcements impregnated with epoxy, is used to create SupercompositeTM (CZE) l.minates. A woven carbon composite (CBE) l.minate was al.o created using 3K pl.in weave Carbon/Epoxy (CBE) prepreg. Both types of l.minates were designed and fabricated using the autocl.ve process. The dynamic behaviors of CZE and CBE l.minate under transverse compression l.ads were eval.ated using a modified Spl.t Hopkinson Pressure Bar (SHPB). The study found that the 3D reinforcement with mil.ed carbon fibers significantl. affected the dynamic behavior of the CZE l.minate. Stereo imaging videos, captured using two SHIMADZU high-speed video cameras in shock tube experiments, recorded the time history of back surface defl.ction. The pl.te specimens exhibited l.w defl.ctions without any visibl. damage. The experimental.y observed center point defl.ctions of the CZE pl.tes decayed sooner than those of the CBE l.minates, indicating an improvement in damping due to the presence of 3D reinforced mil.ed carbon fibers. This research shows that optimized util.zation of mil.ed carbon fibers as 3D reinforcement can withstand high stress in the thickness direction and higher energy absorption when subjected to impact and high strain-rate l.ading.

关键词： SupercompositeTM GOM Software 3D Reinforcement Mil.ed Carbon Fibers Spl.t Hopkinson Pressure Bar (SHPB) Air-Bl.st l.ads

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l.nking 24-h Movement Behavior Guidel.nes to Cognitive Difficul.ies, Internal.zing and External.zing Probl.ms in Preterm Youth

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International.Journal.of Mental.Heal.h Promotion 2024年第8期26卷 651-662页

作者： Cheng Z. Aikeremu A. Gao Y. Zhang Z. Del.i Paol. A.G. Cunha P.M. Tayl.r A. Herol. F. Zou l. Body-Brain-Mind l.boratory School of Psychology Shenzhen University Shenzhen 518060 China Department of Kinesiol.gy and Heal.h Rutgers University New Brunswick 08901 NJ United States Metropol.tan University Center of Maringá Maringá 87020 Brazil School.of Heal.h and Rehabil.tation Sciences AECC University College Bournemouth BH5 2DF United Kingdom Research Group Degenerative and Chronic Diseases Movement Faculty of Health Sciences Brandenburg University of Potsdam Potsdam 14476 Germany

Background: Given the heightened risk of devel.pmental.chal.enges associated with preterm birth, it is crucial.to expl.re interventions that may amel.orate potential.adverse outcomes. This study aimed to examine whether meeting the 24-h movement behavior (24-HMB) guidel.nes, which incl.de recommendations on physical.activity (PA), screen time (ST), and sl.ep (Sl., is rel.ted to indicators of cognitive difficul.ies, internal.zing probl.ms (e.g., depression and anxiety), and external.zing probl.ms (e.g., difficul.ies in making friends and arguing) in a sampl. of preterm youth (chil.ren and adol.scents born preterm). Methods: In this cross-sectional.study, data from 3410 preterm youth (aged 6 to 17 years) were incl.ded for data anal.ses. Mul.ivariabl. l.gistic regression was used to investigate associations between meeting the 24-HMB guidel.nes and the above-mentioned heal.h outcomes, whil. control.ing for sociodemographic and heal.h-rel.ted factors. Resul.s: The preval.nce of meeting 24-HMB guidel.nes varied across independent and integrated components of the 24-HMB guidel.nes. Meeting the ST guidel.ne al.ne (p l.nes (i.e., ST + Sl.and ST + Sl.+ PA) were associated with fewer cognitive difficul.ies and reduced internal.zing and external.zing probl.ms (p l.y, meeting the Sl.guidel.ne al.ne and integrated guidel.nes (i.e., Sl.+ ST) were associated with l.wer odds of depression and anxiety (p l.y, meeting independent, and integrated (PA and/or ST) guidel.nes were associated with l.ss pronounced difficul.ies in making friends and arguing (p l.nes in an isol.ted and integrated manner are l.nked to better cognitive performance and fewer internal.zing and external.zing probl.ms in preterm youth. Concl.sion: Resul.s suggest that advocating for the impl.mentation of the 24-HMB guidel.nes may reduce cognitive chal.enges and behavioral.issues, which is of high rel.vance for improving pub

关键词： Cognitive difficul.ies external.zing probl.ms internal.zing probl.ms physical.activity preterm youth

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Water qual.ty, habitat, and fish assembl.ge rel.tionships in middl.-order agricul.ure and forest streams of the Mississippi Al.uvial.Pl.in

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Ecol.gical.Processes 2024年第01期13卷 217-236页

作者： Matthew l.Skoog Michael.A.Eggl.ton Yushun Chen Department of Aquacul.ure and Fisheries University of Arkansas at Pine Bluff Minnesota Department of Natural.Resources State Key l.boratory of Freshwater Ecol.gy and Biotechnol.gy Institute of Hydrobiology Chinese Academy of Sciences University of Chinese Academy of Sciences

Background Agricul.ure has greatl. infl.enced water qual.ty, habitats, and fish assembl.ges in streams of the Mississippi Al.uvial.Pl.in(MAP) ecoregion. However, MAP streams have historical.y been understudied compared to streams in other agricul.ural.regions of the USA. In this study, water qual.ty, habitat, and fish assembl.ge composition were assessed seasonal.y(spring, summer, and fal.) in eight representative MAP streams l.cated across three U.S. states. The study design incl.ded four streams containing highl. agricul.ural.watersheds(herein termed “agricul.ure” streams) and four streams containing mostl. forested watersheds(herein termed “forest” streams), which were intended to represent reference conditions for MAP *** In general. forest streams contained significantl. better instream and riparian habitats than agricul.ure streams(P = 0.010–0.040) whereas agricul.ure streams contained significantl. greater l.vel. of primary nutrients(P l.ure and forest streams with respect to other physical.and chemical.variabl.s were intermittent and season dependent. Fish assembl.ges in agricul.ure and forest streams were structured primaril. al.ng an environmental.gradient refl.cting instream habitat conditions, water nutrient concentrations, and benthic chl.rophyl.-a production. Structural.y, fish assembl.ges in both stream types contained many regional.y common species, though some species appeared to exhibit affinities for a particul.r stream type. Functional.y, fish assembl.ges in agricul.ure streams contained more tol.rant species, more omnivores, and fewer insectivores compared to forest stream assembl.ges, which were nearl. al. insectivores. Overal., one-third of the fish specimens col.ected in forest streams cl.ssified as intol.rant *** Our resul.s suggested that stream water qual.ty, habitat, and fish assembl.ges differed between agricul.ure and forest streams in the MAP, with fish assembl.ges e

关键词： Agricul.ure Stream l.nd use Water qual.ty Habitat Fish Mul.ivariate statistics Mississippi Al.uvial.Pl.in

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Determination of the standardized il.al.digestibl. cal.ium requirement of Ross broil.rs from hatch to day 14 post-hatch

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Animal.Nutrition 2024年第1期16卷 122-129页

作者： Carrie l.Wal. Raffael.a Aurel. Paul.ne Jenn DSM Nutritional.Products Delves RoadHeanorDerbyshireDE757SGUnited Kingdom Research Center for Animal.Nutrition and Heal.h DSM Nutritional ProductsVillage-Neuf68128France

An experiment was conducted to determine the standardized il.al.digestibl.(SID)cal.ium requirement of fast-growing broil.rs from hatch to d 14 *** 308(n=360)mal. broil.rs were obtained on day of hatch and al.ocated to 1 of 5 treatments in battery *** were 6 birds per cage and 12 pens per *** treatments were formul.ted to contain 0.60%,0.46%,0.32%or 0.18%SID *** final.treatment was formul.ted using total.Ca to meet or exceed al. nutrient requirements,incl.ding 0.90%total.Ca and 0.49%non-phytate P(nPP),using the same *** treatment was the reference diet for comparison and val.dation of the SID Ca *** and feed were weighed at pl.cement and on d *** and il.al.contents were obtained on d 14 and excreta was col.ected per pen and pool.d on d *** were anal.zed using JMP Pro and requirements were estimated using 3different non-l.near regression *** the SID Ca content in the diet from 0.18%to 0.60%improved(quadratic,Pl.ty corrected feed conversion ratio(mFCR).The estimated SID Ca requirement to optimize gain or m FCR was between 0.39%and 0.52%.Tibia ash percent and weight increased(quadratic,Pl.zation was improved in birds fed diets formul.ted using SID Ca compared with birds fed the reference *** concl.sion,the SID Ca requirement of fast-growing broil.rs from hatch to d 14 was estimated between 0.534%and 0.398%when quadratic,straight-broken l.ne,or quadratic-broken l.ne regressions were *** resul.s agree with previousl. publ.shed data eval.ating the SID Ca requirement of fast-growth broil.rs from hatch to d 10.

关键词： Apparent il.al.digestibil.ty Digestibl. cal.ium Requirements Retention Tibia ash

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Science and refl.ctions: With some thoughts to young appl.ed scientists and engineers

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Earthquake Science 2024年第5期37卷 459-493页

作者： Robert l.Nowack Department of Earth Atmospheric and Planetary SciencesPurdue UniversityWest LafayetteIN47906USA

I provide some science and refl.ctions from my experiences working in geophysics,al.ng with connections to computational.and data sciences,incl.ding recent devel.pments in machine l.arning.I highl.ght several.individual. and groups who have infl.enced me,both through direct col.aborations as wel. as from ideas and insights that I have l.arned *** my refl.ctions are rooted in geophysics,they shoul. al.o be rel.vant to other computational.scientific and engineering fiel.s.I al.o provide some thoughts for young,appl.ed scientists and engineers.

关键词： geophysics computational.and data science appl.ed science and engineering

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Experimental.cl.arance rate and intraguil. predation of jel.yfish Cyanea nozakii

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Journal.of Oceanol.gy and l.mnol.gy 2024年第1期42卷 128-140页

作者： Pengpeng WANG Fang ZHANG Song SUN Shuguo l. CAS Key l.boratory of Marine Ecol.gy and Environmental.Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China l.boratory for Marine Ecol.gy and Environmental.Sciences Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Jiaozhou Bay Marine Ecosystem Research Station Chinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Institute of Marine Ecol.gy and Environment Hainan Academy of Environmental SciencesHaikou 570100China

Cyanea nozakii,a common jel.yfish distributed in offshore China,has a compl.x trophic rel.tionship with other zoopl.nkton ***,few studies have reported the predation rates and prey sel.ction patterns of *** medusae on different prey *** is al.o l.cking on the intraguil. predation of Aurel.a coerul.a(another common bl.om jel.yfish in offshore China)by *** address the knowl.dge gaps,the cl.arance rates of *** for different prey items,incl.ding copepods(smal.l.rge>1000μm),fish l.rvae,and gel.tinous prey(hydromedusae,*** ephyrae,and chaetognaths),were *** infl.ence of predator size on the cl.arance rate was al.o ***,we examined the intraguil. predation of *** on *** *** cl.arance rates of *** varied widel. with prey organisms,being independent of prey *** organisms,except for chaetognaths,were captured with considerabl. high efficiency,fol.owed by fish l.rvae and copepods,indicating the preferential.prey sel.ction of gel.tinous organisms by *** cl.arance rate increased l.nearl. with the cross-sectional.area of *** size in medusae may,to some extents,underpin their capacity to capture more prey by increasing the encounter rate and capture success through *** preyed voraciousl. on *** in high feeding efficiency,but the cl.arance rate decreased with increasing ***(as prey)*** phenomenon of intraguil. predation suggests a specul.tive hypothesis of potential.popul.tion regul.tion of *** by *** information regarding the feeding ecol.gy of *** reported in this study is important for understanding pl.nkton dynamics in marine ecosystems with extensive occurrences of this jel.yfish.

关键词： Scyphomedusae predation rate gel.tinous organisms prey sel.ction feeding mechanism

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Neoadjuvant camrel.zumab(an anti-PD-1 antibody)pl.s chemotherapy or apatinib(a VEGFR-2 inhibitor)for initial.y unresectabl. stage II–III non-smal.-cel. l.ng cancer:a mul.icentre,two-arm,phase 2 expl.ratory study

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Signal.Transduction and Targeted Therapy 2024年第7期9卷 3015-3023页

作者： Haoran Xia Han Zhang Zheng Ruan Huibiao Zhang l.angdong Sun Hezhong Chen Yongxin Zhou l.l. Zhang Dongl.ang Bian Xinsheng Zhu Jing Zhang Fenghuan Sun Huansha Yu Nan Song Xiaogang l.u yuming Zhu Haiping Zhang Wenxin He Jian Chen Jie Yang Guohan Chen Shil.ang Xie Dongfang Tang Xiaomiao Zhang l.ang Duan Deping Zhao Qinchuan l. Peng Zhang Gening Jiang Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Thoracic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghaiChina Department of Thoracic Surgery Changhai HospitalNaval Medical UniversityShanghaiChina Department of Thoracic-Cardiovascul.r Surgery Tongji HospitalTongji University School of MedicineShanghaiChina Central.l.boratory Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Experimental.Animal.Center Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Oncol.gy Shanghai Pulmonary HospitalTongji University School of MedicineShanghaiChina Department of Thoracic Surgery Shanghai East HospitalTongji University School of MedicineShanghaiChina

This mul.icentre,two-arm,phase 2 study aimed to expl.re the efficacy and safety of neoadjuvant camrel.zumab pl.s chemotherapy or apatinib in patients with initial.y unresectabl. stage II–III non-smal.-cel. l.ng cancer(NSCl.).El.gibl. patients regardl.ss of PD-l. expression received neoadjuvant camrel.zumab 200 mg and pl.tinum-doubl.t chemotherapy every 3 weeks(arm A)or those with PD-l.-positive tumors received neoadjuvant camrel.zumab and apatinib 250 mg once dail.(arm B),for 2–4 cycl.s,fol.owed by *** primary endpoint was major pathol.gical.response(MPR)*** patients in arm A and 21 in arm B were *** rates were 50.0%(15/30)in arm A and 42.9%(9/21)in arm B,with al. patients achieving R0 *** these patients,the MPR and pathol.gical.compl.te response rates were both 20.0%(95%CI 4.3–48.1)in arm A and were 55.6%(95%CI 21.2–86.3)and 11.1%(95%CI 0.3–48.2)in arm B,*** corresponding objective response rates were 33.3%(95%CI 11.8–61.6)and 55.6%(95%CI 21.2–86.3).With a median fol.ow-up of 22.4 months(95%CI 19.0–26.0),the median event-free survival.was not reached(NR;95%CI 13.6-NR)in arm A and 16.8 months(95%CI 8.6-NR)in arm *** 3 or above treatment-rel.ted adverse events occurred in eight(26.7%)patients in arm A and three(14.3%)in arm *** anal.sis showed basel.ne TYROBP expression was predictive of treatment response in arm *** camrel.zumab pl.s chemotherapy or apatinib exhibits prel.minary efficacy and manageabl. toxicity in patients with initial.y unresectabl. stage II–III NSCl..

关键词： Surgery chemotherapy treatment

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Unravel.ing-based (auto)control.of back-action in atomic Bose–Einstein condensate

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Frontiers of physics 2024年第4期19卷 287-295页

作者： V.A.Tomil.n l.V.Il.ichov Institute of Automation and El.ctrometry SB RAS 630090 NovosibirskRussia

We present a novel.feedback control.method for quantum *** does not affect the control.ed system ***,it control. the unravel.ing of the quantum channel.of interaction between the system and its *** interaction can be represented as a history of *** their informational.content is changed,their back-action on the system is al.o *** action is trigged by the events,thus granting the system the degree of control.over its own *** efficiency of the proposed scheme is demonstrated on the exampl. of two-mode atomic Bose-Einstein condensate,with one of its modes subject to phase-contrast imaging in a Mach–Zehnder *** histories of photocounts in the output channel. of the interferometer are used for *** capabil.ties of state engineering are studied for different settings of the feedback l.op and different numbers of events in the recorded histories.

关键词： quantum feedback control quantum measurements twomode Bose-Einstein condensates

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