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Echocardiographic Measurements in Normal Chinese Adults(EMINCA)II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography

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Frontiers of Medicine 2024年第4期18卷 649-663页

作者： Yingbin Wang Yu Zhang Guihua Yao Hong Tang Lixin Chen Lixue Yin Tiangang Zhu Jianjun Yuan Wei Han Jun Yang Xianhong Shu Ya Yang Yulin Wei Yanli Guo Weidong Ren Dongmei Gao Guilin Lu Ji Wu Hongning Yin yuming mu Jiawei Tian Lijun Yuan Xiaojing Ma Hongyan Dai Yunchuan Ding Mingyan Ding Qing Zhou Hao Wang Di Xu Mei Zhang Yun Zhang State Key Laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan250012China Department of Cardiology Qilu Hospital of Shandong University(Qingdao)Qingdao266000China Department of Ultrasonography West China HospitalSichuan UniversityChengdu610041China Department of Ultrasonography Shenzhen People’s Hospital/The Second Clinical Medical College of Jinan UniversityShenzhen518020China Department of Ultrasonography Electronic Science and Technology University of ChinaThe Affiliated Sichuan Provincial People’s HospitalChengdu610072China Department of Cardiology Peking University People’s HospitalBeijing100044China Department of Ultrasonography Henan Provincial People’s HospitalZhengzhou463599China Department of Cardiology The First Affiliated Hospital of Harbin Medical UniversityHarbin150007China Department of Echocardiology The First Affiliated Hospital of China Medical UniversityShenyang110001China Department of Echocardiology Zhongshan HospitalFudan UniversityShanghai200032China Department of Echocardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing100029China Department of Cardiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China Department of Ultrasonography The Southwest Hospital of AMUChongqing400038China Department of Ultrasonography Shengjing Hospital of China Medical UniversityShenyang110136China Department of Ultrasonography China-Japan Union hospital of Jilin UniversityChangchun130033China Department of Ultrasonography First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi832000China Department of Ultrasonography The First Affiliated Hospital of Guangxi Medical UniversityNanning537406China Department of Echocardiology The Second Hospital of Hebei Medical Uni

Current guidelines encourage large studies in a diverse population to establish normal reference ranges for three-dimensional(3D)echocardiography for different ethnic *** study was designed to establish the normal values of 3D-left ventricular(LV)and left atrial(LA)volume and function in a nationwide,population-based cohort of healthy Han Chinese adults.A total of 1117 healthy volunteers aged 18–89 years were enrolled from 28 collaborating laboratories in *** sets of 3D echocardiographic instruments were used,and full-volume echocardiographic images were recorded and transmitted to a core laboratory for image analysis with a vendor-independent off-line ***,866 volunteers(mean age of 48.4 years,402 men)were qualified for final *** parameters exhibited substantial differences between different sex and age groups,even after indexation by body surface *** normal ranges of 3D-LV and 3D-LA volume and function differed from those recommended by the American Society of Echocardiography and the European Association of Cardiovascular Imaging guidelines,presented by the World Alliance Societies of Echocardiography(WASE)study,and from the 2D values in the EMINCA *** normal reference values of 3D echocardiography-derived LV and LA volume and function were established for the first time in healthy Han Chinese *** ranges of 3D-LV and 3D-LA echocardiographic measurements stratified with sex,age,and race should be recommended for clinical applications.

关键词： three-dimensional echocardiography left ventricle left atrium normal reference values Chinese adults

斑点追踪成像评价慢性重度主动脉瓣关闭不全患者右心室收缩功能

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中华超声影像学杂志 2024年第4期33卷 288-293页

作者：穆凯迪斯·赛米关丽娜穆玉明新疆医科大学第一附属医院心脏超声诊断科、新疆超声医学重点实验室乌鲁木齐830011

目的应用斑点追踪成像技术评价慢性重度主动脉瓣关闭不全(AR)患者右心室形态、功能及心肌力学的变化特点。方法回顾性选取2019年12月至2021年6月于新疆医科大学第一附属医院就诊的AR患者30例作为AR组,同期30例性别和年龄相匹配的健康志... 详细信息

目的应用斑点追踪成像技术评价慢性重度主动脉瓣关闭不全(AR)患者右心室形态、功能及心肌力学的变化特点。方法回顾性选取2019年12月至2021年6月于新疆医科大学第一附属医院就诊的AR患者30例作为AR组,同期30例性别和年龄相匹配的健康志愿者作为对照组。采用彩色多普勒超声心动图测量右心房左右径(RAD)、右心室基底段左右径(RVD)、三尖瓣环收缩期位移(TAPSE)、右心室面积变化分数(RVFAC)、三尖瓣环收缩期峰值速度(S′)及右心室做功指数(RIMP)。通过斑点追踪技术获取右心室整体纵向应变(RVGLS)及各节段(右心室游离壁和室间隔的基底段、中间段和心尖段)的应变数据。比较AR组与对照组之间以上参数的差异。应用Pearson线性相关分析评价RVGLS、右心室游离壁纵向应变(RVFW-LS)与室间隔及各节段应变参数之间的相关性。结果①AR组RAD、RVD、RIMP、LAD高于对照组,RVFAC、TAPSE、S′、LVEF低于对照组,差异有统计学意义(均P<0.05);②与对照组相比,AR组RVGLS、RVFW-LS、右心室间隔长轴应变(RVSLS)及各节段应变明显降低,差异有统计学意义(均P<0.05)。③RVGLS与RVSLS、右心室室间隔基底段应变(RVSBS)呈正相关(r=0.38、0.40,均P<0.05)。结论重度AR可引起右心室各节段收缩功能障碍,包括整体和局部。

关键词：超声心动描记术斑点追踪成像主动脉瓣关闭不全心室功能,右

载ANM33双靶标脂质超声微泡精准胞内释药可行性的体外研究

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中华超声影像学杂志 2024年第7期33卷 617-625页

作者：刘芮宁陈尚珂拜合提亚·塔依尔关丽娜穆玉明新疆医科大学第一附属医院心脏超声诊断科乌鲁木齐830000 新疆超声医学重点实验室乌鲁木齐830000

目的制备载miR-33反义核苷酸(ANM33)的双靶标脂质超声微泡(HA-PANBs),体外评价其分阶段靶向泡沫细胞并实现细胞内精准释药的可行性。方法设计以纳米泡NBs为微泡核心,透明质酸(hyaluronic acid,HA)第一阶段靶向受损内皮细胞,适配子PM1第... 详细信息

目的制备载miR-33反义核苷酸(ANM33)的双靶标脂质超声微泡(HA-PANBs),体外评价其分阶段靶向泡沫细胞并实现细胞内精准释药的可行性。方法设计以纳米泡NBs为微泡核心,透明质酸(hyaluronic acid,HA)第一阶段靶向受损内皮细胞,适配子PM1第二阶段靶向泡沫细胞,ANM33为治疗因子的双靶标脂质超声微泡。完成脂质泡表征的同时检测其稳定性及体外造影能力;随后建立受损人脐静脉内皮细胞(HUVEC)和巨噬细胞(RAW264.7,MΦ)共培养模型,结合流式细胞术、油红O染色和小动物活体成像仪等评价HA-PANBs体外精准定位泡沫细胞并释放ANM33的能力。结果制备的双靶标脂质超声微泡HA-PANBs形态规则,稳定性好,粒径为(1357.53±140.20)nm,表面电位为(-5.61±0.73)mV,HA、PM1及ANM33均有效连接。在受损HUVEC/MΦ共培养模型中,HA-PANBs靶向下层泡沫细胞的效果最佳,且有效摄取量高达(80.65±2.12)%,较NBs组高56.74%;油红O染色显示HA-PANBs组泡沫细胞的胆固醇外排能力明显优于NBs组,差异有统计学意义[(629.80±21.99)a.u.比(1071.00±55.49)a.u.,P<0.05]。结论构建的双靶标脂质超声微泡HA-PANBs能精准靶向泡沫细胞并显著增强其胆固醇外排能力,为实现动脉粥样硬化的早期无创诊疗提供了新策略。

关键词：动脉粥样硬化载ANM33双靶标脂质超声微泡巨噬细胞精准释药

基于多种教学方法相结合模式在本科阶段临床医学超声诊断学专业的应用体会

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中国卫生产业 2024年第3期21卷 202-205页

作者：杨媛媛穆玉明新疆医科大学第一附属医院心脏超声诊断科新疆维吾尔自治区乌鲁木齐830011

目的探讨基于多种教学方法相结合模式在本科阶段临床医学超声诊断学专业的应用效果。方法选取2022年8月—2023年8月新疆医科大学第一附属医院心脏超声诊断科的96名临床医学超声诊断学专业的本科实习生为研究对象,以随机数表法分为对照组... 详细信息

目的探讨基于多种教学方法相结合模式在本科阶段临床医学超声诊断学专业的应用效果。方法选取2022年8月—2023年8月新疆医科大学第一附属医院心脏超声诊断科的96名临床医学超声诊断学专业的本科实习生为研究对象,以随机数表法分为对照组(n=48)、研究组(n=48)。对照组使用传统教学模式,研究组使用基于多种教学方法相结合的教学模式。对比两组出科成绩、教学效果及教学满意度。结果研究组理论知识评分、实践操作技能评分均高于对照组,差异有统计学意义(P均<0.05)。研究组表达能力、学习效率、教学氛围、学习兴趣、思维能力评分及总分均高于对照组,差异有统计学意义(P均<0.05)。研究组教学总满意度(97.92%)较对照组(83.33%)高,差异有统计学意义(P<0.05)。结论本科阶段临床医学超声诊断学专业学生采用基于多种教学方法相结合模式可提高出科成绩与教学效果,提升教学满意度。

关键词：超声诊断学临床医学本科教学方法教学效果

Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal: A nationwide, multicenter study

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中华医学杂志(英文版) 2024年第15期137卷 1802-1810页

作者： Xing Changyang Xie Xiujing Wu Yu Xu Lei Guan Xiangping Li Fan Zhan Xiaojun Yang Hengli Li Jinsong Zhou Qi mu yuming Zhou Qing Ding Yunchuan Wang Yingli Wang Xiangzhu Zheng Yu Sun Xiaofeng Li Hua Zhang Chaoxue Zhao Cheng Qiu Shaodong Yan Guozhen Yang Hong Mao Yinjuan Zhan Weiwei Ma Chunyan Gu Ying Chen Wu Xie Mingxing Jiang Tianan Yuan Lijun Department of Ultrasound Medicine Tangdu Hospital Air Force Medical University Xi’an Shaanxi China Department of Ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Department of Ultrasound Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Ultrasound Xi’an Hospital of Traditional Chinese Medicine Xi’an Shaanxi China Ultrasound Medical Diagnosis Center Shaanxi Provincial People’s Hospital Xi’an Shaanxi China Department of Ultrasound Hospital of Northwestern Polytechnical University Xi’an Shaanxi China Department of Ultrasound Xi’an No. Hospital The First Affiliated Hospital of Northwest University Xi’an Shaanxi China Department of Ultrasound Diagnosis The Second Affiliated Hospital Xi’an Medical College Xi’an Shaanxi China Department of Ultrasound Xi’an Gem Flower ChangQing Hospital Xi’an Shaanxi China Department of Ultrasound The Second Affiliated Hospital of Xi’an Jiaotong University China Xi’an Shaanxi China Department of Echocardiography First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China Department of Ultrasound Renmin Hospital of Wuhan University Wuhan Hubei China Department of Ultrasound Yan’an Hospital The Affiliated Hospital of Kunming Medical University Kunming Yunnan China Department of Ultrasound Yan’an University Xianyang Hospital Xianyang Shaanxi China Department of Function Examination Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China Department of Ultrasound Xi’an Central Hospital Xi’an Shaanxi China Cadre’s Wards Ultrasound Department Diagnostic Ultrasound Center First Hospital of Jilin University Changchun Jilin China Department of Echocardiography Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University Urumqi Xinjiang China Department of Ultrasound First Affiliated Hospital of Anhui Medical University Hefei

Background: Carotid intima-media thickness (IMT) and diameter, stiffness, and wave reflections, are independent and important clinical biomarkers and risk predictors for cardiovascular diseases. The purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical ***: A total of 3053 healthy Han Chinese adults (1922 women) aged 18-79 years were enrolled at 28 collaborating tertiary centers throughout China between April 2021 and July 2022. The real-time tracking of common carotid artery walls was achieved by the radio frequency (RF) ultrasound system. The IMT, diameter, compliance coefficient, β stiffness, local pulse wave velocity (PWV), local systolic blood pressure, augmented pressure (AP), and augmentation index (AIx) were then automatically measured and reported. Data were stratified by age groups and sex. The relationships between age and carotid property parameters were analyzed by Jonckheere-Terpstra test and simple linear regressions. The major clinical determinants of carotid properties were identified by Pearson’s correlation, multiple linear regression, and analyses of ***: All the parameters of carotid properties demonstrated significantly age-related trajectories. Women showed thinner IMT, smaller carotid diameter, larger AP, and AIx than men. The β stiffness and PWV were significantly higher in men than women before forties, but the differences reversed after that. The increase rate of carotid IMT (5.5 μm/year in women and 5.8 μm/year in men) and diameter (0.03 mm/year in both men and women) were similar between men and women. For the stiffness and wave reflections, women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes (allP for age by sex interaction <0.05). The blood pressures, body mass index (BMI), and triglyceride levels were identified as major clinical determinants o

关键词： Intima-media thickness Arterial stiffness Reference values Ultrasound radio frequency signal Wave reflections

Cleaning of two mirrors in the first mirror unit using radiofrequency capacitively coupled plasma

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Plasma Science and Technology 2024年第9期26卷 165-171页

作者： Chenxue WANG Rong YAN yuming LIU Su XU Lei mu Wei ZHENG Rui DING Junling CHEN Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China School of Computer Engineering Anhui Sanlian UniversityHefei 230601People’s Republic of China

First mirror(FM)cleaning,using radio frequency(RF)plasma,has been proposed to recover FM reflectivity in nuclear fusion reactors such as the International Thermonuclear Experimental Reactor(ITER).To investigate the influence of simultaneous cleaning of two mirrors on mirror cleaning efficiency and uniformity,experiments involving single-mirror cleaning and dual-mirror cleaning were conducted using RF capacitively coupled plasma in the *** the test and simultaneous cleaning of two mirrors,the FM and second mirror(SM),both measuring 110 mm×80 mm,were placed inside the first mirror unit(Fmu).They were composed of 16 mirror samples,each with a dimension of 27.5 mm×20 *** mirror samples consist of a titanium-zirconium-molybdenum alloy substrate,a 500 nm Mo intermediate layer and a 30 nm Al_(2)O_(3) surface coating as a proxy for Be *** cleaning of a single first mirror(SFM)and the simultaneous cleaning of the FM and SM(DFM and DSM)lasted for 9 h using Ar plasma at a pressure of 1 *** total reflectivity of mirror samples on the DSM did not fully recover and varied with location,with a self-bias of−140 *** a self-bias of−300 V,the total reflectivity of mirror samples on the SFM and DFM was fully *** energy dispersive spectrometer results demonstrated that the Al_(2)O_(3) coating had been completely removed from these mirror ***,the mass loss of each mirror sample on the SFM and DFM before and after cleaning varied depending on its location,with higher mass loss observed for mirror samples located in the corners and lower loss for those in the *** with SM cleaning,the simultaneous cleaning of two mirrors reduced the difference between the highest and lowest mass ***,this mass loss for the mirror samples of the DFM facing the DSM was *** indicated that mirror samples cleaned face to face in the Fmu simultaneously could influence each other,highlighting the need for special attention in

关键词： first mirror unit dual-mirror cleaning reflectivity sputtering rate

肥厚型心肌病心肌灌注与心肌力学的研究现状与进展

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中华医学超声杂志（电子版） 2020年第5期17卷 391-393页

作者：穆玉明南晶新疆医科大学第一附属医院心脏超声诊断科乌鲁木齐830000

肥厚型心肌病(hypertrophic cardiomyopathy,HCM)是最常见的单基因常染色体显性遗传性心血管疾病,具有高度的临床异质性[1]。研究发现,在排除冠状动脉狭窄的HCM患者心肌缺血是比较显著的病理生理学特征之一,根本原因是冠状动脉微血管结... 详细信息

肥厚型心肌病(hypertrophic cardiomyopathy,HCM)是最常见的单基因常染色体显性遗传性心血管疾病,具有高度的临床异质性[1]。研究发现,在排除冠状动脉狭窄的HCM患者心肌缺血是比较显著的病理生理学特征之一,根本原因是冠状动脉微血管结构受损、功能障碍,最终导致微循环心肌血流量降低[2]。另一方面,HCM患者部分心肌异常增厚、肌纤维排列紊乱打破心肌均衡受力的状态引起心肌力学发生改变,影响心脏功能。因此早期利用超声成像技术对HCM患者心肌灌注情况及心肌力学改变进行评估是非常有必要的,可以更早甄别出进展较快、预后较差的患者。本文利用超声技术对HCM心肌灌注与心肌力学变化研究现状及进展进行综述。

关键词：肥厚型心肌病心肌力学心肌灌注微血管结构超声成像技术病理生理学心血管疾病心脏功能

Traveling Wave Characteristics Based Pilot Protection Scheme for Hybrid Cascaded HVDC Transmission Line

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 971-980页

作者： Dalin mu Sheng Lin Xiaopeng Li the School of Electrical Engineering Southwest Jiaotong UniversityChengdu 611756China the State Grid Sichuan Electric Power Research Institute Chengdu 610041China

The hybrid cascaded high-voltage direct current(HVDC)transmission system has various operation modes,and some operation modes have sharply increasing requirements for protection rapidity,while the traditional pilot differential protection(PDP)has poor rapidity,and even refuses to operate when faults occur on the DC ***,a novel pilot protection scheme based on traveling wave characteristics is ***,the adaptability of the traditional PDP applied in engineering is analyzed for different operation ***,the expressions of the forward traveling wave(FTW)and backward traveling wave(BTW)on the rectifier side and the inverter side are derived for different fault *** the theoretical derivation,the difference between the BTW and FTW on the rectifier side is less than zero,and the same is true on the inverter ***,in the event of an external fault of DC line,the difference between the BTW and FTW at nearfault terminal protection installation point is greater than ***,by summing over the product of the difference between BTW and FTW of the rectifier side and that of the inverter side,the fault identification criterion is *** simulation results show that the proposed pilot protection scheme can quickly and reliably identify the short-circuit faults of DC line in different operation modes.

关键词： Hybrid cascaded high-voltage direct current(HVDC)transmission system DC line operation mode pilot protection

An optimization-oriented modeling approach using input convex neural networks and its application on optimal chiller loading

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Building Simulation 2024年第4期17卷 639-655页

作者： Shanshuo Xing Jili Zhang Song mu Dalian University of Technology Dalian116024China Guangdong Airport Baiyun Information Technology Co. Ltd.Guangzhou510000China

Optimization for the multi-chiller system is an indispensable approach for the operation of highly efficient chiller *** optima obtained by model-based optimization algorithms are dependent on precise and solvable objective *** classical neural networks cannot provide convex input-output mappings despite capturing impressive nonlinear fitting capabilities,resulting in a reduction in the robustness of model-based *** this paper,we leverage the input convex neural networks(ICNN)to identify the chiller model to construct a convex mapping between control variables and the objective function,which enables the NN-based OCL as a convex optimization problem and apply it to multi-chiller optimization for optimal chiller loading(OCL).Approximation performances are evaluated through a four-model comparison based on an experimental data set,and the statistical results show that,on the premise of retaining prior convexities,the proposed model depicts excellent approximation power for the data set,especially the unseen ***,the ICNN model is applied to a typical OCL problem for a multi-chiller system and combined with three types of optimization *** with conventional and meta-heuristic methods,the numerical results suggest that the gradient-based BFGS algorithm provides better energy-saving ratios facing consecutive cooling load inputs and an impressive convergence speed.

关键词： chiller plant input convex neural network optimal load distribution convex optimization