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Collective Molecular Machines: Multidimensionality and Reconfigurability

Nano-Micro Letters 2024年第8期16卷 309-340页

作者： Bin Wang Yuan lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial Biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical work.During the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense research.Effective progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and informatics.However,individual molecular machines are only capable of producing nanometer work and generally have only a single functionality.In order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new paradigm.In this review,we comprehensively discuss recent developments in the collective behaviors of molecular machines.In particular,collective behavior is divided into two paradigms.One is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional materials.The other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale operations.We discuss design strategies for both modes and focus on the modulation of features and properties.Subsequently,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA Biomolecular motors

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Soil inorganic amendments produce safe rice by reducing the transfer of Cd and increasing key amino acids in brown rice

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Journal of Environmental Sciences 2024年第2期136卷 121-132页

作者： Fanyi Kong Shenggao lu Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment Key Laboratory of Environmental Remediation and Ecosystem HealthMinistry of EducationCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China

The digestibility of cadmium(Cd)in brown rice is directly related to amino acid metabolism in rice and human health.In our field study,three kinds of alkaline calcium-rich soil inorganic amendments(SIAs)at three dosages were applied to produce safe rice and improve the quality of rice in Cd-contaminated paddy.With the increased application of SIA,Cd content in iron plaque on rice root significantly increased,the transfer of Cd from rice root to grain significantly decreased,and then Cd content in brown rice decreased synchronously.The vitro digestibility of Cd in brown rice was estimated by a physiologically based extraction test.Results showed that more than 70%of Cd in brown rice could be digested by simulated gastrointestinal juice.Based on the total and digestible Cd contents in brown rice to evaluate the health risk,the application of 2.25 ton SIA/ha could produce safe rice in acidic slightly Cd-contaminated paddy soils.The amino acids(AAs)in brown rice were determined by high-performance liquid chromatography.The contents of 5 key AAs(KAAs)that actively respond to environmental changes increased significantly with the increased application of SIA.The structural equation model indicated that KAAs could be affected by the Cd translocation capacity from rice root to grain,and consequently altered the ratio of indigestible Cd in brown rice.The formation of indigestible KAAs-Cd complexes by combining KAAs(phenylalanine,leucine,histidine,glutamine,and asparagine)with Cd in brown rice could be considered a potential mechanism for reducing the digestibility of Cd.

关键词： Cadmium digestibility Soil inorganic amendments Safe rice Amino acid Priming effect Health risk

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Exogenous ketogenic supplements can mitigate the susceptibility to Alzheimer’s disease induced by chronic sleep deprivation:emerging role of Sirt1 in ferroptosis

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Food Science and Human Wellness 2024年

作者： Yueqi Yang Xueyan Wang lu Chen Ning Zhang Shilei Ji Zhengping Wang Jun Han yuming Wang Min Wen Pet Nutrition Rresearch and Development Center Gambol Pet Group Co. Ltd. Institute of Biopharmaceutical Research Liaocheng University College of Food Science and Engineering Ocean University of China

Emerging evidence supports that sleep disorders are the main risk factor for sporadic Alzheimer’s disease (AD)， and iron dysregulation may be the link between them. Our previous studies have confirmed that ketogenic diet (KD) can prevent chronic sleep deprivation-induced AD. However， it is uncertain whether exogenous ketones supplements (EKS)， as an alternative intervention， have the same effects as KD. Thus， we investigated the prophylactic efficiency of EKS on chronic sleep deprivation-induced AD and reveal the underlying mechanism focus on iron metabolism. We observed that the prophylactic efficacy of EKS against chronic sleep deprivation-induced AD was comparable to that of KD. Meanwhile， our results suggest that both EKS and KD inhibited iron metabolism disorder through regulation of iron metabolism-related proteins. Moreover， we found that both EKS and KD reduced hippocampal mitochondrial dysfunction and iron-mediated lipid peroxides. Furthermore， EX527 (Sirt1 inhibitor)， mostly abrogated these above protections of EKS， suggesting that the prophylactic effect of EKS on AD is partly dependent on Sirt1. Our findings provide novel evidence that EKS can be developed as functional foods to prevent or delay the development of AD， particularly in individuals with sleep disorders.

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ANSI/ASHRAE/ASHE standard 170-2021《医疗设施通风》修订内容简介

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暖通空调 2024年第6期54卷 54-58页

作者：戎戈曹国庆陈紫光谭鹏陆禹名中国建筑科学研究院有限公司北京建科环能科技有限公司北京

对ANSI/ASHRAE/ASHE standard 170-2021《医疗设施通风》的主要修订内容进行了分析,包括:修改医用房间名称,将有较高设计要求的房间与其他房间分开并提出细化指标;增加值班状态,为医疗建筑节能运行提供方法依据;进一步明确各类医疗用房... 详细信息

对ANSI/ASHRAE/ASHE standard 170-2021《医疗设施通风》的主要修订内容进行了分析,包括:修改医用房间名称,将有较高设计要求的房间与其他房间分开并提出细化指标;增加值班状态,为医疗建筑节能运行提供方法依据;进一步明确各类医疗用房排风过滤效率。此外,对ASHRAE 170发展趋势进行了简要介绍,对未来发展进行了展望,以期为我国医疗建筑相关标准规范的制订/修订提供参考。

关键词：医院通风 ASHRAE 170 值班状态医院设施过滤器效率节能

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Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System

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Molecular Plant 2017年第9期10卷 1242-1245页

作者： lu, yuming Ye, Xiao Guo, Renming Huang, Jing Wang, Wei Tang, Jiuyou Tan, Longtao Zhu, Jian-kang Chu, Chengcai Qian, Yangwen Biogle Genome Editing Ctr Changzhou 213125 Jiangsu Peoples R China Chinese Acad Sci Natl Ctr Plant Gene Res Beijing Inst Genet & Dev Biol State Key Lab Plant Genom Beijing 100101 Peoples R China Chinese Acad Sci Shanghai Ctr Plant Stress Biol Shanghai 201602 Peoples R China Chinese Acad Sci Ctr Excellence Mol Plant Sci Shanghai 201602 Peoples R China Chinese Acad Sci Inst Subtrop Agr Key Lab Agroecol Proc Subtrop Reg Changsha 410125 Hunan Peoples R China

Dear Editor Since the completion of the rice （Oryza sativa） genome- sequencing project, a major goal of rice research has been the functional characterization of all annotated genetic loci in various biological processes. One of the most efficient and widely-used strategies for studying gene function is genetic mutagenesis. Several rice mutant libraries have been generated in the past decade, providing a wealth of resources for plant research （Chang et al., 2012）. CRISPR/Cas9 （clustered regularly interspaced short palindromic repeats-associated nuclease 9） has recently emerged as a powerful tool for rice research and breeding （Cong et al., 2013; Feng et al., 2013; Miao et al., 2013;

关键词： Genome-wide Targeted Mutagenesis Rice Using the CRISPR Cas9 System

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基于约束多目标优化算法的夹具定位方案稳健性优化设计

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兵工学报 2022年第3期43卷 686-693页

作者：鲁宇明张祥飞黎明赵闵清南昌航空大学航空制造工程学院江西南昌330063 南昌航空大学信息工程学院江西南昌330063

设计人员通常根据自身经验或某些特定的优化方法获得稳健的夹具定位方案。由于设计人员的经验水平及使用条件等方面的限制,导致该类方法缺乏通用性,为此提出了一种约束多目标优化算法确定夹具定位方案。该算法由稳态演化的可行解搜索阶... 详细信息

设计人员通常根据自身经验或某些特定的优化方法获得稳健的夹具定位方案。由于设计人员的经验水平及使用条件等方面的限制,导致该类方法缺乏通用性,为此提出了一种约束多目标优化算法确定夹具定位方案。该算法由稳态演化的可行解搜索阶段和双种群优化阶段构成,将网格约束分解的方法和基于可行性准则的方法结合,以合作的方式求解约束多目标优化问题。经过测试函数的检验以及与其他算法对比验证该算法的可行性,以工程问题为例,完成了夹具定位方案优化设计。研究结果表明,约束多目标优化算法的设计方法具有更好的通用性和实用性,不仅简化了夹具定位方案设计程序,而且揭示了工件在不同方向上偏移方差之间的相互关系。

关键词：夹具定位方案稳健性约束多目标优化

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Light touch in quantum:an interview with Prof.Serge Haroche

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Advanced Photonics 2024年第1期6卷 10-16页

作者： Chao-Yang lu CAS Centre for Excellence in Quantum Information and Quantum Physics HefeiChina NYU Shanghai NYU-ECNU Institute of PhysicsShanghaiChina University of Science and Technology of China Department of Modern PhysicsShanghaiChina

lu:Hello,Prof.Haroche,nice to see you again!Let us start the interview.In 2012,you and David Wineland won the Nobel Prize in Physics.Can you describe your work in simple terms to a general audience?And can you tell us how you were originally interested in this field and got into this study?Haroche:Maybe I should start with the second part of the question.I got interested in atomic physics when I was a student atÉcole Normale Supérieure(ENS)in Paris in the 1960s.

关键词： quantum interview Serge

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Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 314-330页

作者： Lei Zheng Jia lu Da-lu Kong Department of Colorectal Cancer Surgery National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Infection Management National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China

BACKGROUND Cyclin-dependent kinase 9(CDK9)expression and autophagy in colorectal cancer(CRC)tissues has not been widely studied.CDK9,a key regulator of transcription,may influence the occurrence and progression of CRC.The expression of auto-phagy-related genes BECN1 and drug resistance factor ABCG2 may also play a role in CRC.Under normal physiological conditions,autophagy can inhibit tumorigenesis,but once a tumor forms,autophagy may promote tumor growth.Therefore,understanding the relationship between autophagy and cancer,partic-ularly how autophagy promotes tumor growth after its formation,is a key motivation for this research.AIM To investigate the relationship between CDK9 expression and autophagy in CRC,assess differences in autophagy between left and right colon cancer,and analyze the associations of autophagy-related genes with clinical features and prognosis.METHODS We collected tumor tissues and paracarcinoma tissues from colon cancer patients with liver metastasis to observe the level of autophagy in tissues with high levels of CDK9 and low levels of CDK9.We also collected primary tissue from left and right colon cancer patients with liver metastasis to compare the autophagy levels and the expression of BECN1 and ABCG2 in the tumor and paracarcinoma tissues.RESULTS The incidence of autophagy and the expression of BECN1 and ABCG2 were different in left and right colon cancer,and autophagy might be involved in the occurrence of chemotherapy resistance.Further analysis of the rela-tionship between the expression of autophagy-related genes CDK9,ABCG2,and BECN1 and the clinical features and prognosis of colorectal cancer showed that the high expression of CDK9 indicated a poor prognosis in colorectal cancer.CONCluSION This study laid the foundation for further research on the combination of CDK9 inhibitors and autophagy inhibitors in the treatment of patients with CRC.

关键词： Autophagy Tumorigenesis Tumor tissue Paracarcinoma tissue Expression Left/right colon cancer

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Comprehensive study on the spatial distribution of heavy metals and their environmental risks in high-sulfur coal gangue dumps in China

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Journal of Environmental Sciences 2024年第2期136卷 486-497页

作者： Yingbo Dong Huan lu Hai Lin School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory on Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

The accumulation of coal gangue(CG)from coal mining is an important source of heavy metals(HMs)in soil.Its spatial distribution and environment risk assessment are extremely important for the management and remediation of HMs.Eighty soil samples were collected from the high-sulfur CG site in northern China and analyzed for six HMs.The results showed that the soil was heavily contaminated by Mn,Cr and Ni based on the Nemerow index,and posed seriously ecological risk depended on the geo-accumulation index,potential ecological risk index and risk assessment code.The semi-variogram model and ordinary kriging interpolation accurately portrayed the spatial distribution of HMs.Fe,Mn,and Cr were distributed by band diffusion,Ni was distributed by core,the distribution of Cu had obvious patchiness and Zn was more uniform.The spatial autocorrelation indicated that all HMs had strong spatial heterogeneity.The BCR sequential extraction was employed to qualify the geochemical fractions of HMs.The data indicated that Fe and Cr were dominated by residual fraction;Cu,Ni and Zn were dominated by reducible and oxidizable fractions;Mn was dominated by reducible and acid-extractable(25.38%-44.67%)fractions.Pearson correlation analysis showed that pH was the main control factor affecting the non-residue fractions of HMs.Therefore,acid production from high sulfur CG reduced soil pH by 2-3,which indirectly promoted the activity of HMs.Finally,the conceptual model of HMs contamination at the CG site was proposed,which can be useful for the development of ecological remediation strategies.

关键词： High-sulfur coal gangue Soil contamination Heavy metals Spatial distribution Geochemical fractions Risk assessment

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Analysis of photocatalytic degradation of polyamide microplastics in metal salt solution by high resolution mass spectrometry

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Journal of Environmental Sciences 2024年第5期139卷 473-482页

作者： Yunjin Zhong Lebing Zhuo Wangyang lu National Engineering Lab for Textile Fiber Materials&Processing Technology(Zhejiang) School of Materials Science&EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China

Microplastic pollution has become one of the most concerned focuses in the world.Among many treatment methods,photocatalysis is considered to be one of the most environmentally friendly methods.In this work,the photodegradation behavior of polyamide microplastics is studied by using polyamide 6(PA6)as model microplastics and FeCl_(3) as catalyst.It is hoped that the PA6 fiber can be effectively degraded by utilizing the strong oxidizing active species that can be produced after FeCl_(3) is irradiated in water.The results shows that PA6 fiber can be almost completely degraded after 10 days of irradiation in FeCl_(3) aqueous solution,indicating that it is promising to use this new method to solve the problem of PA6type microplastics.In addition,the chain scission mechanism and degradation process of PA6 are analyzed in detail by ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS),which provides a new insight for the study of polymer degradation mechanism.

关键词： FeCl_(3) Photocatalysis Polyamide 6 Chain scission

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