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Science China(Technological Sciences) 2024年第2期67卷 587-596页

作者： TANG Jian WU YuTing MA ShiDong zhang yumin XU RuoJie YAN Tao PAN ZhiJuan College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123China National Engineering Laboratory for Modern Silk Suzhou 215123China

Various yarn-shaped flexible strain sensors have recently been ***,research is lacking on additive manufacturing for smart clothing for integrating yarn sensors with commercial ***,a strain-sensing yarn is sewn into a piece of fabric through a novel stitching technique,and the influence of the stitching method and needle pitch on the sensing performance is investigated using finite element analysis(FEA).The sensing performance could be improved when the sensing yarn is self-locked in the fabric at the needle eyes,and the needle pitch was reduced to 0.5 cm,which is attributed to the enhanced stress and strain ***,the composite sensing fabric featured outstanding performance,including a low detection limit(0.1%),rapid response(280 ms),excellent durability(10000 cycles),and high stability(negligible drift and frequency independence).In addition,the remarkable wear resistance,washability,and anti-interference to ambient humidity and perspiration were ***,the optimal stitch trace lengths of sensing yarn for detecting elbow motion,breathing,and heartbeats are ***,a smart clothing system composed of smart clothing,data acquisition unit,and mobile APP was developed to simultaneously detect human movement and physiological *** work provides a reference to produce intelligent garments based on yarn sensors for health monitoring.

关键词： strain-sensing yarn composite sensing fabric smart clothing system stitching technology health monitoring

Design of antiviral AGO2-dependent short hairpin RNAs

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Virologica Sinica 2024年第4期39卷 645-654页

作者： Yuanyuan Bie Jieling zhang Jiyao Chen yumin zhang Muhan Huang Leike zhang Xi Zhou Yang Qiu Key Laboratory of Virology and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China

The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective *** interference(RNAi)is a sequence-specific gene silencing mechanism that is triggered by small interfering RNAs(siRNAs)or short hairpin RNAs(shRNAs),which exhibits significant promise for antiviral ***2-dependent shRNA(agshRNA)generates a single-stranded guide RNA and presents significant advantages over traditional siRNA and *** this study,we applied a logistic regression algorithm to a previously published chemically siRNA efficacy dataset and built a machine learning-based model with high predictive *** this model,we designed siRNA sequences targeting diverse RNA viruses,including human enterovirus A71(EV71),Zika virus(ZIKV),dengue virus 2(DENV2),mouse hepatitis virus(MHV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),and transformed them into *** validated the performance of our agshRNA design by evaluating antiviral efficacies of agshRNAs in cells infected with different *** the agshRNA targeting EV71 as an example,we showed that the anti-EV71 effect of agshRNA was more potent compared with the corresponding siRNA and ***,the antiviral effect of agshRNA is dependent on AGO2-processed guide RNA,which can load into the RNA-induced silencing complex(RISC).We also confirmed the antiviral effect of agshRNA in ***,this work develops a novel antiviral strategy that combines machine learning-based algorithm with agshRNA design to custom design antiviral agshRNAs with high efficiency.

关键词： AgshRNA Antiviral strategy Machine learning model

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan Jinyi Zhao Sulin zhang Lu Liu yumin zhang Wei Xu Maolin Shao Jingjing Peng Shuai Xia Yan Zhu Keke zhang Xianglei zhang Ruxue zhang jian Li Wenhao Dai Zhen Ge Shulei Hu Changyue Yu Jiang Wang Dakota Ma Mingyue Zheng Haitao Yang Gengfu Xiao Zihe Rao Lu Lu Leike zhang Fang Bai Yao Zhao Shibo Jiang Hong Liu Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several SARS-CoV-2-specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including SARS-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTSL)and calpain-1(CAPN1)are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual target inhibitors against CTSL and *** X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of a-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern(VOCs)with ECso values ranging from 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b also showed effective antiviral activity against HCoV-OC43 infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 14a and 14b exhibited excellent antiinflammatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3286-3290页

作者： Miao Zheng Bo Feng yumin zhang Xin Liu NaZhao Hui Liu Zichao Xu Xinheng He Zhiyan Qu ShizhaoChen Zhidong Jiang Xi Cheng Hong Liu Yi Zang Linxiang Zhao Jie Zheng Leike zhang Jia Li Yu Zhou Key Laboratory of Structure-Based Drugs Design&Discovery of Ministry of Education Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Sciences and Biopharmaceuticals Shenyang Pharmaceutical UniversityShenyang 110016China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203and University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203and University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Lingang Laboratory Shanghai 200031China School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Hubei Jiangxia Laboratory Wuhan 430200China

To the Editor:The papain-like protease(PL^(pro)),as one of the most important proteases of SARS-CoV-2,has emerged as a highly promising target protein,its inhibitor probably holds dual potentials,namely blocking the cleavage of viral polyprotein and intercepting the deubiquitination and deISGylation functions to restore antiviral immunity1.

关键词： Non-covalent PL^(pro)inhibitors Antiviral activity Structural-based drug design Imidazo[4,5-b]pyridine scaffold

藜麦CqAMSlike基因的克隆与功能分析

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西北农业学报 2024年第4期33卷 683-694页

作者：张玉敏林春刘正杰林彤董玉梅毛自朝云南农业大学农学与生物技术学院昆明650201 云南农业大学特色小宗作物研究中心昆明650201

为探究藜麦(Chenopodium quinoa,Willd.)花粉发育的分子机制,基于基因组和转录组数据,经同源比对及RT-qPCR表达分析等,预测藜麦中AMS候选基因并克隆其编码序列,随后经病毒介导的基因沉默(VIGS)及双分子荧光互补(BiFC)法进行候选基因的... 详细信息

为探究藜麦(Chenopodium quinoa,Willd.)花粉发育的分子机制,基于基因组和转录组数据,经同源比对及RT-qPCR表达分析等,预测藜麦中AMS候选基因并克隆其编码序列,随后经病毒介导的基因沉默(VIGS)及双分子荧光互补(BiFC)法进行候选基因的功能验证。结果显示,藜麦中有CqAMSlike1和CqAMSlike2两个基因,其中CqAMSlike1的CDS长1929 bp,而CqAMSlike2的CDS长1920 bp,两基因均在不同发育时期的圆锥花序中表达。与CqAMSlike2相比,CqAMSlike1的表达更与AMS的表达模式相一致,而被进一步用于基因的功能验证。与对照相比,基于烟草脆裂病毒(TRV)沉默CqAMSlike1的藜麦两性花出现部分花丝缩短、花药不裂,花粉败育,单株种子少,种子空瘪率增加的表型。BIFC结果显示CqAMSlike1自身,与CqTDF1和CqMYB80均有互作,预示CqAMSlike1可形成同源或异源聚体调控藜麦绒毡层发育基因的表达。

关键词：藜麦 AMS 病毒介导的基因沉默花粉发育蛋白互作

智识书生:《无声告白》中的新型华裔男性气质建构

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海峡人文学刊 2024年第1期4卷 44-52,157页

作者：张玉敏中南财经政法大学新闻与文化传播学院

美国华裔作家伍绮诗的小说《无声告白》描述了20世纪70年代美国华裔男性詹姆斯在白人霸权和华人族裔性的冲突中建构男性气质身份的困境。伍绮诗在小说文本中对华裔男性气质的建构,展现出对美国男性气质身份中心与边缘二分法的超越。詹... 详细信息

美国华裔作家伍绮诗的小说《无声告白》描述了20世纪70年代美国华裔男性詹姆斯在白人霸权和华人族裔性的冲突中建构男性气质身份的困境。伍绮诗在小说文本中对华裔男性气质的建构,展现出对美国男性气质身份中心与边缘二分法的超越。詹姆斯为了获得美国主流社会的认同,致力于建构白人支配性男性气质,但由于其华裔身份不断被边缘化。随着詹姆斯对支配性男性气质和华裔身份的反思,他逐步建立起一种新的男性气质身份。这种强调智识,融合了中国古代“书生”传统的柔性男性气质从生命感性出发,批判了主流文化强加给边缘人群的男性气质规范,为华裔男性身份气质的建构提供了新的想象和可能性。

关键词：《无声告白》伍绮诗支配性男性气质边缘性男性气质智识书生

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分布式光伏波动事件多级区间滚动预警方法

中国电力 2024年第8期57卷 96-107页

作者：周才期刘静利孙鹏凯张玉敏国家电力调度控制中心北京100031 国网潍坊供电公司山东潍坊261000 电网智能化调度与控制教育部重点实验室(山东大学) 山东济南250061

大范围极端天气影响下的分布式光伏波动事件对电力系统功率平衡问题影响显著,可能引起弃光、切负荷等风险事故。为此,提出了基于区间分析理论的分布式光伏波动事件多级区间滚动预警方法,以针对分布式光伏波动事件可能的危害程度进行滚... 详细信息

大范围极端天气影响下的分布式光伏波动事件对电力系统功率平衡问题影响显著,可能引起弃光、切负荷等风险事故。为此,提出了基于区间分析理论的分布式光伏波动事件多级区间滚动预警方法,以针对分布式光伏波动事件可能的危害程度进行滚动预警。首先,明晰电力系统应对分布式光伏波动的功率调控机理,并制定预警等级,确定不同功率控制手段能够应对的分布式光伏波动幅度区间,即不同预警等级对应的预警界限;然后,依据分布式光伏波动的概率密度,通过对各预警区间内的概率密度积分,计算各预警等级的概率;最后,分析不同时间尺度下光伏波动预测精度的差异水平,通过定时滚动预警校正结果,实现分布式光伏波动事件多级区间滚动预警。算例结果表明,该方法能够在确定各预警区间界限的同时,决策电力系统在不同系统运行状态和光伏波动事件下的预警结果,且与蒙特卡洛法预警结果的均方根误差仅为1.6718%,进而验证了该方法的有效性和适用性。

关键词：分布式光伏波动功率平衡区间分析滚动预警概率密度

基于ZYNQ-7000的飞控计算机PC/104总线数传链路设计

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现代电子技术 2024年第14期47卷 15-19页

作者：晏鹏鹏张玉民盛蔚北京航空航天大学仪器科学与光电工程学院北京100191

针对飞控计算机面向多模块、多种类接口资源方向发展引发的原有飞控计算机固有性能不足、可拓展性差的问题,提出一种基于ARM+FPGA的软硬件协同工作、以PC/104作为多模块间通信总线的飞控计算机框架。该框架中针对PC/104总线与系统主存... 详细信息

针对飞控计算机面向多模块、多种类接口资源方向发展引发的原有飞控计算机固有性能不足、可拓展性差的问题,提出一种基于ARM+FPGA的软硬件协同工作、以PC/104作为多模块间通信总线的飞控计算机框架。该框架中针对PC/104总线与系统主存传输的带宽不匹配问题,设计了双通道数据缓冲路径,通过FPGA设计IP实现PC/104总线时序的控制,以DMA的方式实现总线与主存DDR之间的高速数据缓存。实验结果表明,所设计的飞控数据链路可实现模块间PC/104总线以40 Mb/s的速度进行数据传输,以及通过总线实现外设到系统主存之间微秒级别延迟的高速数据交换,保证了多模块工作时的数据传输效率。

关键词：飞控计算机 PC/104总线 ZYNQ-7000 FPGA DMA数传链路数据交换

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世界华文文学格局中的新移民文学

华文文学 2024年第3期 120-123页

作者：张玉敏中南财经政法大学新闻与文化传播学院

2023年11月3-5日,第七届国际新移民华文作家笔会暨“新移民文学研究”国际学术研讨会在湖北武汉召开。本次会议由国际新移民华文作家笔会、中南财经政法大学新闻与文化传播学院主办,中南财经政法大学世界华文文学与传媒研究中心承办。... 详细信息

2023年11月3-5日,第七届国际新移民华文作家笔会暨“新移民文学研究”国际学术研讨会在湖北武汉召开。本次会议由国际新移民华文作家笔会、中南财经政法大学新闻与文化传播学院主办,中南财经政法大学世界华文文学与传媒研究中心承办。来自美国、加拿大、德国、荷兰、澳大利亚、奥地利、西班牙、捷克、匈牙利、日本、泰国、马来西亚和中国的百余名作家、学者出席了此次盛会。研讨会围绕海外新移民华文文学的历史、现状与未来,新移民华文作家的创作经验与学术反思、以及新移民华文文学的理论阐释与个案研究等方面展开学术探讨,取得了突出成果。

关键词：世界华文文学海外新移民华文文学新移民华文作家新移民文学研究

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基于碳势-能源价格双响应的综合能源系统低碳经济调度

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电力系统自动化 2024年第9期48卷 21-33页

作者：张玉敏孙鹏凯孟祥剑吉兴全杨明李晓宇山东科技大学电气与自动化工程学院山东省青岛市266590 电网智能化调度与控制教育部重点实验室(山东大学) 山东省济南市250061

利用电-气-热多元负荷节点碳势引导需求响应是实现综合能源系统(IES)低碳运行的有效手段。IES中多能流耦合关系复杂、动态特性交织,碳排放特性难以准确表达。文中针对IES中低碳运行潜力挖掘不足的问题进行了研究,提出了一种基于节点碳势... 详细信息

利用电-气-热多元负荷节点碳势引导需求响应是实现综合能源系统(IES)低碳运行的有效手段。IES中多能流耦合关系复杂、动态特性交织,碳排放特性难以准确表达。文中针对IES中低碳运行潜力挖掘不足的问题进行了研究,提出了一种基于节点碳势-能源价格双响应的经济调度方法,用于IES源-荷协同,实现低碳运行。一方面,通过剖析气、热动态特性对碳排放流的影响机理,引入动态特性等价替换思想,得出计及动态特性的碳排放流模型,进而得到负荷节点的碳势,实现碳排放责任的分摊;另一方面,从碳视角出发,考虑多元负荷的碳排放责任,设计了基于多元负荷节点碳势-能源价格双响应的IES源-荷低碳互动机制,充分挖掘IES中多元负荷的低碳潜力。通过对IES中碳排放产生、传输、消费全过程的追踪与计量,制定兼顾经济性与低碳性的调控策略。以电网14节点-热网6节点-天然气网6节点(E14-H6-G6)和E57-H12-G12测试系统为例,验证了所提模型和方法的有效性。

关键词：综合能源系统低碳经济调度碳排放流碳势能源价格动态特性