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Diagnosis and Treatment of Attention-Deficit Hyperactivity Disorder in Patients with Chronic Pain

Open Journal of Psychiatry 2017年第4期7卷 261-275页

作者： Satoshi Kasahara yumiko okamura Ko Matsudaira Hiroyuki Oka Yoshie Suzuki Yasuko Murakami Toshiharu Tazawa Hayato Shimazaki Shin-ichi Niwa Yoshitsugu Yamada Anesthesiology and Pain Relief Center Faculty of Medicine University of Tokyo Tokyo Japan Department of Neuropsychiatry Faculty of Medicine University of Tokyo Tokyo Japan Department of Medical Research and Management for Musculoskeletal Pain 22nd Century Medical and Research Center Faculty of Medicine University of Tokyo Tokyo Japan Department of Anesthesiology and Pain Medicine Faculty of Medicine Juntendo University Tokyo Japan Department of Anesthesiology and Pain Medicine Yokohama City University Medical Center Yokohama Japan Department of Psychiatry Jikei University School of Medicine Tokyo Japan Department of Psychiatry Aizu Medical Center Fukushima Medical University Fukushima Japan

Aims: To investigate rates of attention-deficit hyperactivity disorder (ADHD) in patients with chronic pain attending a pain clinic, the effects of a screening measure for ADHD in patients with chronic pain, and the effects of ADHD drugs on both pain and ADHD symptoms. Methods: We retrospectively surveyed 110 patients with chronic pain visiting the Anesthesiology and Pain Relief Center at the University of Tokyo in Japan, who had also consulted a psychiatrist, between April 2012 and July 2015. Results: Of the total of 110 patients with chronic pain, 35 (31.8%) were also diagnosed with ADHD, and the average Wender Utah Rating Scale (WURS) score among the ADHD patients was 39.0 ± 22.1 (n = 25). Only 36.0% of these patients exceeded the cutoff value, suggesting that 64.0% of the patients with ADHD were not identified by screening with the WURS. Twenty-six patients initiated treatment with ADHD medication, with dosage adjustment completed in 21. Of these 21 patients 20 (95.0%) had improved ADHD symptoms. Improved pain symptoms were observed in 14 patients (66.6%), with a reduction in the pain numerical rating scale of 64.7% ± 30.1%. Conclusions: This is the first study investigating the comorbidity of ADHD and chronic pain at pain clinics showing a high level of comorbidity and amelioration of pain and ADHD symptoms with treatment. Careful interpretation is required when the WURS is used to screen patients with chronic pain.

关键词： Atomoxetine Attention Deficit Hyperactivity Disorder Chronic Pain Methylphenidate Wender Utah Rating Scale

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The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

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International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro Ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi okamura Akira Yamaguchi Kazuyuki Ishihara Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

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Laser ion source for heavy ion inertial fusion

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Matter and Radiation at Extremes 2018年第2期3卷 61-66页

作者： Masahiro okamura Collider-Accelerator Department Brookhaven National LaboratoryBuilding 930UptonNY 11973USA

The proposed heavy ion inertial fusion(HIF)scenarios require ampere class low charge state ion beams of heavy *** laser ion source(LIS)is recognized as one of the promising candidates of ion beam providers,since it can deliver high brightness heavy ion beams to *** design of LIS for the HIF depends on the accelerator structure and accelerator complex following the *** this article,we discuss the specifications and design of an appropriate LIS assuming two major types of the accelerators:radio frequency(RF)high quality factor cavity type and non-resonant induction core *** believe that a properly designed LIS would satisfy the requirements of both types,while some issues need to be verified experimentally.

关键词： Inertial fusion Accelerator Ion source Laser ablation Heavy ion source

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International Standardization Activities for Optical Amplifiers

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光学学报 2003年第S1期23卷 403-404页

作者： Haruo okamura Corning International 1-14-14 Akasaka Minato-ku 107-0052 Tokyo

International standardization activities for Optical Amplifiers at IECTC86 and ITU-T SG15 are reviewed. Current discussions include Optical Amplifier safety guideline, Reliability standard, Rest methods of Noise and P... 详细信息

关键词： for as in of International Standardization Activities for Optical Amplifiers OA ITU been

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Femtosecond pulses cleaning by transient-grating process in Kerr-optical media

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Chinese Optics Letters 2011年第5期9卷 63-65页

作者： Kotaro okamura Yuichiro Kida Takayoshi Kobayashi Advanced Ultrafast Laser Research Center and Department of Engineering ScienceFaculty of Informatics and EngineeringDepartment of Engineering ScienceThe University of Electro-Communications International Cooperative Research Project (ICORP) Japan Science and Technology Agency Department of Electrophysics National Chiao Tung University Institute of Laser Engineering Osaka University

We use a transient-grating （TG） process in a Kerr bulk medium to clean a femtosecond laser pulse. Using the technique, the temporal contrast of the generated TG signal is improved by more than two orders of magnitude in comparison with the incident pulse in a 0.5-mm-thick fused silica plate. The laser spectrum is smoothed and broadened, and the pulse duration is shortened simultaneously. We expect to extend this technique to a clean pulse with broadband spectral bandwidth at a wide spectral range because it is a phase-matched process.

关键词： Electromagnetic pulse Fused silica Ultrafast lasers

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Genomic alterations in hepatocellular carcinoma and their clinical application to genomic medicine

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 449-452页

作者： Taisuke Imamura Yukiyasu okamura Division of Hepato-Biliary-Pancreatic Surgery Shizuoka Cancer CenterShizuokaJapan Division of Digestive Surgery Department of SurgeryNihon University School of MedicineTokyoJapan

Liver cancer remains a global health problem and its incidence is growing *** cancer is an epidemiologically biased disease and is one of the most common cancers,especially in East *** carcinoma(HCC)is the dominant histological type of liver cancer and the principal etiological factor for HCC in Japan is hepatitis C virus(HCV),while that in other Asian countries is hepatitis B virus(HBV)(1).Other known risk factors include alcohol abuse,autoimmune hepatitis,diabetes,and several metabolic ***,the precise molecular events underlying hepatocarcinogenesis are still not fully understood,and the genetic characteristics associated with the etiologies still remain *** large-scale genomic analyses have revealed the overall landscape and there are active attempts to apply the results to clinical *** on the latest findings,we will describe the overall landscape of genomic alterations in HCC and their application to genomic medicine.

关键词： alterations clinical Liver

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Topical application of glycyrrhizin preparation ameliorates experimentally induced colitis in rats

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World Journal of Gastroenterology 2011年第17期17卷 2223-2228页

作者： Tomohiro Kudo Shinichi okamura Yajing Zhang Takashige Masuo Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Gunma 371-8511 Japan Department of Medical Informatics and Decision Sciences Gunma University School of Medicine Gunma 371-8511 Japan

AIM:To examine the efficacy of glycyrrhizin preparation(GL-p) in the treatment of a rat model of ulcerative colitis(UC).METHODS:Experimental colitis was induced by oral administration of dextran sodium *** with colitis were intrarectally administered GL-p or *** extent of colitis was evaluated based on body weight gain,colon wet weight,and macroscopic damage *** expression levels of pro-inflammatory cytokines and chemokines in the inflamed mucosa were measured by cytokine antibody array *** effect of GL-p on myeloperoxidase(MPO) activity in the inflamed mucosa and purified enzyme was ***:GL-p treatment significantly ameliorated the extent of colitis compared to sham treatment with *** antibody array analysis showed that GL-p treatment significantly decreased the expression levels of pro-inflammatory cytokines and chemokines,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α,cytokine-induced neutrophil chemoattractant-2,and monocyte chemoattractant protein-1 in the inflamed ***,GL-p inhibited the oxidative activity of mucosal and purified ***:GL-p enema has a therapeutic effect on experimental colitis in rats and may be useful in the treatment of UC.

关键词： Glycyrrhizin Colitis Dextran sodium sulfate Ulcerative colitis Cytokine Chemokine Protein array Myeloperoxidase Enema Carboxymethylcellulose

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Analysis of colonoscopic perforations at a local clinic and a tertiary hospital

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World Journal of Gastroenterology 2012年第35期18卷 4898-4904页

作者： Toshihiko Sagawa Satoru Kakizaki Haruhisa Iizuka Yasuhiro Onozato Naondo Sohara Shinichi okamura Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Center of Gastroenterology Maebashi Red Cross Hospital Department of Endoscopy and Endoscopic Surgery Shirakawa Clinic

AIM： To define the clinical characteristics, and to as- sess the management of colonoscopic complications at a local clinic. METHODS： A retrospective review of the medical re- cords was performed for the patients with iatrogenic colon perforations after endoscopy at a local clinic be- tween April 2006 and December 2010. Data obtained from a tertiary hospital in the same region were also analyzed. The underlying conditions, clinical presenta- tions, perforation locations, treatment types （operative or conservative） and outcome data for patients at the local clinic and the tertiary hospital were compared. RESULTS： A total of 10 826 colonoscopies, and 2625 therapeutic procedures were performed at a local clinic and 32 148 colonoscopies, and 7787 therapeutic proce-dures were performed at the tertiary hospital. The clinic had no perforations during diagnostic colonoscopy and 8 （0.3%） perforations were determined to be related to therapeutic procedures. The perforation rates in each therapeutic procedure were 0.06% （1/1609） in polyp- ectomy, 0.2% （2/885） in endoscopic mucosal resection （EMR）, and 3.8% （5/131） in endoscopic submucosal dis- section （ESD）. Perforation rates for ESD were significantly higher than those for polypectomy or EMR （P 〈 0.01）. All of these patients were treated conservatively. On the oth- er hand, three （0.01%） perforation cases were observed among the 24 361 diagnostic procedures performed, and these cases were treated with surgery in a tertiary hospi- tal. Six perforations occurred with therapeutic endoscopy （perforation rate, 0.08%; 1 per 1298 procedures）. Perfo- ration rates for specific procedure types were 0.02% （1 per 5500） for polypectomy, 0.17% （1 per 561） for EMR, 2.3% （1 per 43） for ESD in the tertiary hospital. There were no differences in the perforation rates for each therapeutic procedure between the clinic and the tertiary hospital. The incidence of iatrogenic perforation requiring surgical treatment was quite low in both the clinic

关键词： Colonoscopy Colon perforation Endoscopicclipping Endoscopic submucosal dissection Endoscopicmucosal resection Polypectomy

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Analysis of ABC (D) stratification for screening patients with gastric cancer

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World Journal of Gastroenterology 2011年第43期17卷 4793-4798页

作者： Tomohiro Kudo Satoru Kakizaki Naondo Sohara Yasuhiro Onozato Shinichi okamura Yoshikatsu Inui Masatomo Mori Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashi Department of Endoscopy and Endoscopic Surgery Shirakawa Clinic Inui Clinic of Internal Medicine

AIM:To evaluate the value of ABC(D) stratification [combination of serum pepsinogen and Helicobacter pylori(***) antibody]of patients with gastric ***:Ninety-five consecutive patients with gastric cancer were enrolled into the *** serum pepsinogenⅠ(PGⅠ) /pepsinogenⅡ(PGⅡ) and *** antibody levels were *** were classified into five groups of ABC(D) stratification according to their serological *** findings of atrophic gastritis and histological differentiation were also analyzed in relation to the ABC(D) ***:The mean patient age was(67.9±8.9) *** patients(3.2%) were classified into group A,7 patients(7.4%) into group A',27 patients(28.4%) into group B,54 patients(56.8%) into group C,and 4patients(4.2%) into group D,*** were only three cases in group A when the patients taking acid proton pump inhibitors and those who had undergone eradication therapy for ***(group A') were *** three cases had mucosal atrophy in the grey zone according to the diagnostic manual of ABC(D) ***,the mean age of the patients with well differentiated adenocarcinoma was significantly higher than that of the patients with poorly differentiated adenocarcinoma(P<0.05) .There were no differences in the pattern of atrophy in the endoscopies between the well differentiated and poorly differentiated ***:ABC(D) stratification is a good method for screening patients with gastric *** is needed for grey zone cases to check the extent of mucosal atrophy.

关键词： Gastric cancer Helicobacter pylori Pepsinogen ABC (D) stratification Cancer screening

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Metal complex with terpyrindine derivative ligand as highly selective colorimetric sensor for iron(Ⅲ)

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Chinese Chemical Letters 2013年第1期24卷 20-22页

作者： Peng Wang Taka-aki okamura Hong-Ping Zhou Wei-Yin Sun Yu-Peng Tian Coordination Chemistry Institute State Key Laboratory of Coordination ChemistrySchool of Chemistry and Chemical EngineeringNanjing National Laboratory of MicrostructuresNanjing University Department of Macromolecular Science Graduate School of ScienceOsaka University Department of Chemistry Anhui Province Key Laboratory of Functional Inorganic Materials ChemistryAnhui University

A new metal complex [MnL2]（NO3）***3CN （1） was synthesized by reaction of 4＇-4-（],2,4-triazol-]-yl）- phenyl-2,2＇：6＇,2＂-terpyridine （L） with manganese nitrate. The structure of the complex was determined by X-ray crystallography. The results of UV-vis studies showed that the complex exhibits colorimetric sensing ability for Fe3~, which can be observed by naked eye.

关键词： Terpyridine derivative ligandMn(ll) complexCrystal structureColorimetric sensor

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