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The Mechanism of Decreased Serum Phosphorus Levels in Rats with Chronic Kidney Disease after Oral Administration of <i>Bifidobacterium longum</i>

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Advances in Microbiology 2015年第7期5卷 531-540页

作者： nobuo nagano Mayuko Futaya Mamiko Kohno Osami nakano norihisa nishida Yoichi Matsuura Mikiko Shimada Kyoko Ito Tetsuo Ando Takaaki Tsutsui Yoshitaka Ando Kiyotsugu Omae Kosaku nitta Hiroshi Sakura Tetsuya Ogawa Kidney Disease and Dialysis Center Hidaka-kai Takasaki Gunma Japan Department of Medicine Tokyo Women’s Medical University Medical Center East Tokyo Japan Research and Development Division Morishita Jintan Co. Ltd. Osaka Japan Department of Internal Medicine Yoshikawa Clinic Tokyo Japan Department of Medicine Kidney Center Tokyo Women’s Medical University Tokyo Japan

Chronic kidney disease (CKD) patients are prone to disturbances in the intestinal microbiota, which contributes to CKD progression and complications. We previously reported a reduction of serum phosphorus (P) levels in hemodialysis patients receiving oral encapsulated bifidobacteria. The present study was conducted to clarify the mechanisms of P-lowering effect of bifidobacteria on CKD rats. CKD was induced in rats by 5/6 nephrectomy. Five weeks later, the rats were fed for 4 weeks on a powder diet containing encapsulated bifidobacteria. At the end of the study, intestinal contents were sampled for analyses of pH, intestinal flora and short-chain fatty acids (SCFAs). Oral administration of bifidobacteria halted the onset and progression of hyperphosphatemia in CKD rats. The increased number of bifidobacteria was confirmed in the cecum. In addition, the increase in intestinal pH in CKD rats was decreased after bifidobacteria treatment, along with increases in some SCFAs. Furthermore, positive correlation between serum P levels and intestinal pH was observed. In conclusion, the mechanism for the P-lowering effect of bifidobacteria was supposed as follows: CKD conditions increase aerobic bacteria which hydrolyze urea into ammonia. Elevated pH decreases ionization of intestinal calcium (Ca) which leads to an increase in free phosphate ions through reduction of Ca phosphate crystal precipitation. Administered bifidobacteria fermented carbohydrates to produce SCFAs, resulting in acidification of the intestinal lumen. The resulting low intestinal pH increases Ca ionization, which binds with free phosphate ions as an intrinsic P binder, resulting in the reduction of serum P levels.

关键词： Bifidobacteria CKD-MBD Dysbiosis Hyperphosphatemia Intestinal pH Short-Chain Fatty Acids

Leaf Turgor Potential, Plant Growth and Photosynthesis in Organically Fertilized Sweet Corn

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Pedosphere 2004年第2期14卷 165-170页

作者： XUHui-Liant WAnGXiao-Ju WAnGJi-Hua XURong-Ya ZHAOAi-Hua InternationalnatureFarmingResearchCenter HataNagano390-1401（Japan）.E-mail：huilian@janis.or.jp SaitamaCenterofEnvironmentalSciences Saitama347-0115（Japan） BeijingAcademyofAgricultureandForestrySciences Beijing100081（China）

A greenhouse pot experiment was conducted using a complete random design with six replications. A pressure-volume curve analysis was employed to study the effects of organic fertilizers on plant water relations in sweet corn (Zea mays L. cv. Honey-bantam) in terms of leaf osmotic concentration (Cs), osmotic potentials at full turgid status (πFT) and at incipient plasmolysis (πIP), and of symplastic (ζsym) and apoplastic (ζapo) fractions in the tissue water compartment in relation to photosynthetic capacity (Pc) and dry mass accumulation. At the seedling stage (day 15), plants with chemical fertilizer treatments showed lower πFT, πIP and ζapo and higher Cs, ζsym and PC than those with organic fertilizer treatments. Compared to PC and relative growth, where values from day 15 to day 75 were first lower for organic treatments and then higher, ζsym and Cs values were similar, while πFT and πIP were opposite being higher then lower. Dry mass production with organic fertilizer was higher than or close to the chemical fertilizer treatments in the later growth stage (day 75), though dry mass production with chemical fertilizers was much higher in the early and middle growing stages (days 15 and 45). Increased photosynthesis and dry mass production in later growth stages due to organic fertilizers were associated with increased osmotic concentration in the tissue and the symplastic fraction of the tissue water compartment. These might favor stomatal opening and biochemical activities.

关键词： leaf photosynthesis osmotic potential sweet corn (Zea mays L.) turgor potential water potential

Reduction of Ordering Temperature of FePt-Al2O3 Thin Films by n2 Addition During Sputtering

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Chinese Physics Letters 2005年第11期22卷 2899-2902页

作者：曹江伟 n.Katayama 杨正魏福林 M.Matsumoto A.Morisako 刘小晰 S.Takei Research Institute of Magnetic Materials Lanzhou University Lanzhou 730000 Department of Information Engineering Shinshu University 4-17-I Wakasato Nagano 380-8553 Japan

We investigate the effect of n2 addition during sputtering on the microstructure and magnetic properties of FePt-Al2O3 thin films. The texture of FePt phase in FePt-Al2O3 thin films changes from （111） to a more random orientation by n2 addition during sputtering. The ordering temperature of FePt phase reduces about 100℃ with appropriate n2 partial pressure. A larger coercivity of 6.0 × 10^5 Aim is obtained with n2 partial pressure about 15%. Structural analysis reveals that a small quantity of Fe3n phase forms during sputtering and the release of n atoms during the post annealing induces a large number of vacancies in the films, which benefits to the transformation of FePt phase from fcc to fct.

关键词： MAGnETIC-PROPERTIES FEPT MICROSTRUCTURE CU

两个华支睾吸虫半胱氨酸蛋白酶的基因克隆、表达与定性(英文)

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热带医学杂志 2004年第1期4卷 10-14,55页

作者：裴福全 Isao nagano 吴军 WuZhi-liang 崔惠儿 Yuzo Takahashi 潘波方悦怡广东省疾病预防控制中心寄生虫病防治研究所广州510300 Department of Parasitology Gifu University School of MedicineGifu 500-8705Japan

目的寻找对华支睾吸虫病诊断有效的抗原基因,以便生物合成并研究其应用价值。方法选取两个Genbank已报告的基因序列AF271091(CysA)及AF093242(CysB)分别克隆与表达融合蛋白,亲和层析纯化后进行免疫定性。结果 CysA与CysB均获得成功克... 详细信息

目的寻找对华支睾吸虫病诊断有效的抗原基因,以便生物合成并研究其应用价值。方法选取两个Genbank已报告的基因序列AF271091(CysA)及AF093242(CysB)分别克隆与表达融合蛋白,亲和层析纯化后进行免疫定性。结果 CysA与CysB均获得成功克隆与表达,Western blot分析显示CysA与华支睾吸虫病阳性血清有强反应,与日本血吸虫病阳性血清只有很弱的交叉反应,而CysA与华支睾吸虫感染血清无反应。免疫组化显示,被表达的两个半胱氨酸蛋白酶在华支睾吸虫体内的免疫定位无显著不同,主要在成虫肠道及虫卵。结论成功表达的两个半胱氨酸蛋白酶中,CysB针对华支睾吸虫病血清有良好的抗原活性,值得视为诊断抗原候选做进一步的研究。

关键词：华支睾吸虫重组半胱氨酸蛋白酶基因表达克隆华支睾吸虫病诊断

法律评注在日本的发展与价值——作为法学思维方式映射的文献形式

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南大法学 2022年第4期 170-184页

作者：长野史宽张慰(译) 京都大学南京大学法学院暨中德法研究所

日本的法律评注是19世纪末以西方法律为模板颁布法律后的产物。日本国内许多因素共同促成了评注在日本的发展。民法领域中对德国法的“理论继受”以及美国推动的“民主化”对评注的发展均有作用,但仍以德国对日本法律评注发展的影响最... 详细信息

日本的法律评注是19世纪末以西方法律为模板颁布法律后的产物。日本国内许多因素共同促成了评注在日本的发展。民法领域中对德国法的“理论继受”以及美国推动的“民主化”对评注的发展均有作用,但仍以德国对日本法律评注发展的影响最大。日本的法律评注与德国的评注具一定的近似性,但具自身特点。日本的法律评注等文献形式及其相互关系以特别的方式反映出了日本法的特征。日本法律体系中评注的价值地位反映了其体系化的程度以及法律文本的权威性。

关键词：日本法律评注发展特征文献形式

Therapeutic efficacy of ramucirumab after lenvatinib for post-progression treatment of unresectable hepatocellular carcinoma

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Gastroenterology Report 2021年第2期9卷 133-138,I0002页

作者： Atsushi Hiraoka Takashi Kumada Toshifumi Tada Chikara Ogawa Joji Tani Shinya Fukunishi Masanori Atsukawa Masashi Hirooka Kunihiko Tsuji Toru Ishikawa Koichi Takaguchi Kazuya Kariyama Ei Itobayashi Kazuto Tajiri noritomo Shimada Hiroshi Shibata Hironori Ochi Kazuhito Kawata Hidenori Toyoda Hideko Ohama Kazuhiro nouso Akemi Tsutsui Takuya nagano norio Itokawa Korenobu Hayama Taeang Arai Michitaka Imai Yohei Koizumi Shinichiro nakamura Kojiro Michitaka Yoichi Hiasa Masatoshi Kudo Gastroenterology Center Ehime Prefectural Central HospitalEhimeJapan Department of Gastroenterology and Hepatology Ogaki Municipal HospitalGifuJapan Department of Internal Medicine Himeji Red Cross HospitalHyogoJapan Department of Gastroenterology and Hepatology Takamatsu Red Cross HospitalTakamatsuJapan Department of Gastroenterology and Hepatology Kagawa universityKagawaJapan Department of Gastroenterology Osaka Medical CollegeOsakaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical SchoolTokyoJapan Department of Gastroenterology and Metabology Ehime University Graduate School of MedicineEhimeJapan Center of Gastroenterology Teine Keijinkai HospitalSapporoJapan Department of Gastroenterology Saiseikai Niigata HospitalNiigataJapan Department of Hepatology Kagawa Prefectural Central HospitalTakamatsuJapan Department of Gastroenterology Okayama City HospitalOkayamaJapan Department of Gastroenterology Asahi General HospitalAsahiJapan Department of Gastroenterology Toyama University HospitalToyamaJapan Division of Gastroenterology and Hepatology Otakanomori HospitalKashiwaJapan Department of Gastroenterology Tokushima Prefectural Central HospitalTokushimaJapan Hepato-biliary Center Matsuyama Red Cross HospitalMatsuyamaJapan Department of Hepatology Hamamatsu University School of MedicineHamamatsuJapan Department of Gastroenterology Kindai UniversityOsakaJapan

Background:Lenvatinib is used for unresectable hepatocellular carcinoma(u-HCC)as first-line,as well as second-and third-line therapy in *** evaluated the therapeutic efficacy of newly developed ramucirumab when given after lenvatinib for post-progression ***:Of 385 patients with u-HCC and treated with lenvatinib at 16 different institutions in Japan between May 2018 and January 2020,28 who received ramucirumab as the next treatment were enrolled and therapeutic responses were evaluated in a retrospective ***:The median age of the 28 patients given ramucirumab was 70 years and the median albumin-bilirubin score *** the 28 patients,23 were male,21 were classified as Child-Pugh A and 7 as Child-Pugh B,and 25 were Barcelona Clinic Liver Cancer Stage *** was given as second-line therapy in 14,third-line in 9,and fourth-line in *** response was obtained in only 26 patients;the objective response rate was 3.8%(1/26)and the disease-control rate was 42.3%(11/26),with a median period to progression of 2.0 *** reasons for discontinuation of ramucirumab were progression of disease in 16 and Grade 3 adverse events(gastrointestinal bleeding,ascites)in ***:The anticipated therapeutic efficacy of ramucirumab for post-progression treatment following lenvatinib was not seen in our early experience.

关键词： hepatocellular carcinoma ramucirumab lenvatinib sorafenib

动脉注射5-氟尿嘧啶联合皮下注射α干扰素治疗晚期肝癌可导致间质性肺炎

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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 54-55页

作者： Yamamoto S. Tomita Y. Hoshida Y. H. nagano 姜志茹 Dept. of Surgery/Clinical Oncology Osaka Univ. Grad. School of Medicine 2-2 Yamadaoka Suita Osaka 565-0871 Japan

Previously we reported combined chemoimmunotherapy, using interferon (IFn) αand 5-fluorouracil (5-FU) for patients with advanced hepatocellular carcinoma (HCC), and this regimen improved the prognosis. Recently, we experienced an HCC patient who died of severe interstitial pneumonia during the combined IFn αand 5-FU therapy. This is the first report of the occurrence of interstitial pneumonia during combined IFn αand 5-FU treatment. A 60-year old man was admitted to Osaka University Hospital to receive systemic chemo immunotherapy for recurrent HCC. In the second week of the chemo immunotherapy, he showed a decreased level of consciousness, and respiratory insufficiency. Emergency roentgenogram revealed diffuse infiltration in both lungs. Respiratory dysfunction due to interstitial pneumonia was suspected, and steroid pulse therapy was started. However, the patient showed respiratory failure, and he died 32 days after the start of the therapy. Autopsy findings showed atelectasis in the bilateral lungs, which showed elastic hard solidity and a dark red color; esophageal varices were also shown, and there was cirrhosis with a large tumor in the liver. Microscopically, the alveolar wall showed marked fibrous thickness and moderate inflammatory change, which is consistent with acute interstitial pneumonia, and the acute pulmonary change was suspected to have been the cause of death. The association of IFn with the development of interstitial pneumonia has been reported. However, the prognosis of IFn induced interstitial pneumonia has mostly been favorable when the medication was discontinued. It has been postulated that interstitial pneumonia induced by the combination of IFn and 5-FU may be therapy resistant. The combination of IFn αand 5-FU is a useful therapy for patients with advanced HCC, such as that with portal vein invasion or multiple metastatic foci. Thus, interstitial pneumonia in these patients should be carefully managed.

关键词：尿嘧啶动脉注射 α干扰素间质性肺炎肝细胞癌门静脉癌栓首例报道弥漫性浸润预后良好呼吸障碍

Effect of Rhizobium inoculation on Growth and nodulationof Albizzia procera, Albizzia lebbeck and Leucaena leucocephala

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Pedosphere 1999年第2期9卷 153-159页

作者： U. K. ARYAL M. K. HOSSAIn M. A. U. MRIDHA H. L. XU and H. UMEMURA (Institute of Forestry and Environmental Sciences, University of Chittagong (Bangladesh))(International nature Farming Research Center 5632-Hata, nagano-390-1401 (Japan))(Department of Botany, University of Chittagong (Bangladesh)) Institute of Forestry and Environmental Sciences University of Chittagong (Bangladesh) Bangladesh International nature Farming Research Center 5632-Hata Nagano-390-1401 Japan Department of Botany University of Chittagong (Bangladesh) Bangladesh

Effects of inoculation of Rhizobium suspension on nodulation and plant growth were examined withAlbizzia procera, Albizzia lebbeck and Leucaena leucocephala seedlings grown on sterilized and non-sterilizedsoil media. Inoculation resulted in nodule number increases of 28.6, 29.02 and 23.9 times in sterilized soiland 3.4, 3.6 and 3.27 times in non-sterilized soil for A. parocera A. lebbeck and L. leucocephala seedlingsrespectively. Total dry mass increased by 127.6%, 66.7% and 60.7% in sterilized soil and 100%, 95.5%and 52.65% in non-sterilized soil for these three legume trees, respectively, after a period of two *** high inoculation responses of root length, root diameter, collar diameter, shoot length, and drymass of root, shoot, leaves and nodules were also observed in both sterilized and non-sterilized soil media ascompared to respective control treatments. The response to inoculation was strong in sterilized and modestin non-sterilized soils. The significantly higher response to Rhizobium inoculation over control in all thespecies tested suggested that application of Rhizobium greatly enhanced plant growth, nodulation, biomassproduction and nitrogen-fixing activity of the nodules.

关键词： biomass production nitrogen fixation nodulation Rhizobium suspension symbiotic association

华支睾吸虫半胱氨酸蛋白酶的基因表达与在ELISA诊断上的应用研究(英文)

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中国寄生虫病防治杂志 2005年第2期18卷 103-107页

作者：裴福全 Isao nagano Zhiliang Wu 吴军阮彩文崔惠儿 Yuzo Takahashi 方悦怡广东省疾病预防控制中心寄生虫病防治研究所广东广州510300 Department of Parasitology Gifu University School of Medicine Gifu 501-1194 Japan

目的探讨重组华支睾吸虫半胱氨酸蛋白酶在华支睾吸虫病血清学诊断上的应用价值。方法以成虫cDnA为模板PCR扩增GenBank中一个华支睾吸虫半胱氨酸蛋白酶(***093242,简称CysB)的部分基因片段,亚克隆到pTrcHis表达载体,转化入大肠埃希菌DH5... 详细信息

目的探讨重组华支睾吸虫半胱氨酸蛋白酶在华支睾吸虫病血清学诊断上的应用价值。方法以成虫cDnA为模板PCR扩增GenBank中一个华支睾吸虫半胱氨酸蛋白酶(***093242,简称CysB)的部分基因片段,亚克隆到pTrcHis表达载体,转化入大肠埃希菌DH5α。表达出的重组蛋白经亲合层析纯化后用于ELISA检测华支睾吸虫及其他寄生虫感染血清,评价其诊断应用价值。结果成功克隆与表达CysB基因片段,纯化后的重组蛋白用于华支睾吸虫病诊断的敏感性达96.0%(48/50),与其他寄生虫病的总交叉反应为3.8%(1/26),而对比实验中可溶性粗抗原(CAA)用于检测的敏感性为88.0%(44/50),与其他寄生虫感染血清无交叉反应。结论重组华支睾吸虫半胱氨酸蛋白酶(CysB)用于ELISA诊断技术具有较高的敏感性及特异性,有希望成为可溶性粗抗原的替代之一。

关键词：华支睾吸虫重组半胱氨酸蛋白酶基因表达免疫学诊断