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Journal of Clinical and Nursing Research 2024年第5期8卷 277-282页

作者： yumiao zhang Suzhou Wujiang Blood Station Suzhou 215200Jiangsu ProvinceChina

Objective:To assess the management effect of comprehensive nursing management on blood donation services in blood ***:Sixty-four individuals who donated blood at a blood station between September 2021 and September 2023 were selected and randomly assigned into two groups of 32 *** first group received comprehensive nursing management,while the second group received routine nursing *** donation indexes and observational indexes such as adverse reactions were compared between the ***:The total blood donation volume and qualified blood donation volume were higher in the first group than in the second *** amount of discarded blood and the rate of blood discards were lower in the first group compared to the second group(P<0.05).Additionally,the adverse reaction rate in the first group was lower,the blood donation comfort scores were higher,the psychological state scores were lower,and the quality of care scores were higher than those in the second group(P<0.05).Conclusion:Comprehensive nursing management can improve the efficiency of blood donation,reduce the rate of blood discards,decrease the incidence of adverse reactions,alleviate negative psychological states of blood donors,and enhance both the comfort level of blood donation and the quality of care provided.

关键词： Comprehensive nursing management Blood donation service at blood stations Adverse reactions Comfort Quality of care

冷弯薄壁折叠翼缘C形不锈钢构件受弯性能分析

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材料导报 2024年第S1期38卷 483-489页

作者：张宇淼陶忠皇甫双娥昆明理工大学建筑工程学院昆明650500 云南省抗震技术研究中心昆明650503

为了在同成本下获得更高效的截面形式,利用ABAQUS对前期六组V形加劲C形截面奥氏体304不锈钢受弯构件建立有限元简化数值分析模型,将得到的结果与试验结果进行了对比验证。对应上述六组受弯构件设计了四组与其用钢量相同,但尺寸分布不同... 详细信息

为了在同成本下获得更高效的截面形式,利用ABAQUS对前期六组V形加劲C形截面奥氏体304不锈钢受弯构件建立有限元简化数值分析模型,将得到的结果与试验结果进行了对比验证。对应上述六组受弯构件设计了四组与其用钢量相同,但尺寸分布不同的折叠翼缘不锈钢受弯构件,共24组;探讨了折叠翼缘截面不锈钢受弯构件在四点受弯作用下的构件承载性能,并将其与C形截面不锈钢受弯构件的承载性能进行了对比。利用现有的设计计算方法计算了24组折叠翼缘截面受弯构件的极限承载力,并将其与有限元得到的结果进行了比较。对比发现:相同用钢量的情况下,当折叠翼缘截面腹板高度与斜翼缘在腹板平面内的投影长度值之和较C形截面腹板高度提升12%以上时,折叠翼缘截面不锈钢梁的极限承载性能比C形截面更优异,截面形式更加高效。现有的计算方法计算腹板V形加劲的折叠翼缘受弯构件得到的结果比较理想,误差较小;而对于平翼缘V形加劲且宽度较小的构件,计算得到的结果偏大,不能准确地预测构件的极限承载能力。

关键词：折叠翼缘C形不锈钢梁卷边C形不锈钢梁极限受弯承载力有限元分析直接强度法

Impacts of pollution heterogeneity on population exposure in dense urban areas using ultra-fine resolution air quality data

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Journal of Environmental Sciences 2023年第3期125卷 513-523页

作者： Wenwei Che yumiao zhang Changqing Lin Yik Him Fung Jimmy C.H.Fung Alexis KHLau Division of Environment and Sustainability The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Guangdong-Hongkong-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality Hong Kong University of Science and TechnologyClear Water BayHong KongChina

Traditional air quality data have a spatial resolution of 1 km or above, making it challenging to resolve detailed air pollution exposure in complex urban areas. Combining urban morphology, dynamic traffic emission, regional and local meteorology, physicochemical transformations in air quality models using big data fusion technology, an ultra-fine resolution modeling system was developed to provide air quality data down to street level. Based on one-year ultra-fine resolution data, this study investigated the effects of pollution heterogeneity on the individual and population exposure to particulate matter(PM_(2.5)and PM_(10)),nitrogen dioxide(NO_(2)), and ozone(O_(3)) in Hong Kong, one of the most densely populated and urbanized cities. Sharp fine-scale variabilities in air pollution were revealed within individual city blocks. Using traditional 1 km average to represent individual exposure resulted in a positively skewed deviation of up to 200% for high-end exposure individuals. Citizens were disproportionally affected by air pollution, with annual pollutant concentrations varied by factors of 2 to 5 among 452 District Council Constituency Areas(DCCAs) in Hong Kong, indicating great environmental inequities among the population. Unfavorable city planning resulted in a positive spatial coincidence between pollution and population, which increased public exposure to air pollutants by as large as 46% among districts in Hong Kong. Our results highlight the importance of ultra-fine pollutant data in quantifying the heterogeneity in pollution exposure in the dense urban area and the critical role of smart urban planning in reducing exposure inequities.

关键词： Particulate matter Nitrogen dioxide Ozone Pollution heterogeneity Urban area

Anti-cancer liposomal chemophototherapy using bilayer-localized photosensitizer and cabazitaxel

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Nano Research 2022年第5期15卷 4302-4309页

作者： Boyang Sun Sanjana Ghosh Xuedan He Wei-Chiao Huang Breandan Quinn Meiling Tian Dushyant Jahagirdar Moustafa T.Mabrouk Joaquin Ortega yumiao zhang Shuai Shao Jonathan F.Lovell Translational Medicine Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Department of Biomedical Engineering University at BuffaloState University of New YorkBuffaloNY 14260USA Department of Anatomy and Cell Biology McGill UniversityMontrealQuebec H3A0C7Canada School of Chemical Engineering and Technology Tianjin UniversityTianjin 300000China

Photodynamic therapy(PDT)is a non-invasive tumor ablation modality that can be enhanced in combination with concurrent ***,we demonstrated that liposomes containing a bilayer-anchored photosensitizer(porphyrin-phospholipid;PoP)can be loaded with drugs in their aqueous core to improve drug delivery and tumor ablation upon target tissue irradiation with *** the present work,we demonstrate that this concept can be extended to drugs loaded within the hydrophobic bilayer of ***(CTX)is a potent second generation taxane anti-cancer drug that was loaded in the bilayer of liposomes also containing 0.1 molar%PoP,generating CTX-loaded PoP liposomes(CTX-PoP-Lip).CTX-PoP-Lip showed unilamellar vesicle morphology,and exhibited integrity in storage and serum,while maintaining drug stability under laser *** vitro cell killing evaluation showed that red-light laser irradiation induced cytotoxicity in cells incubated with CTX-PoP-Lip,compared to control *** vivo pharmacokinetic analysis revealed that following intravenous administration to mice,CTX and PoP exhibited somewhat altered circulation profiles,suggesting that the CTX may have exchanged with serum factors in ***,when a single treatment of CTX-PoP-Lip with laser irradiation was administered to mice bearing human MIA Paca-2 tumors,tumors were effectively ablated whereas the equivalent chemotherapy and PDT monotherapies were *** results demonstrate the versatility of liposome delivery systems for achieving tumor ablation with chemophototherapy.

关键词： photodynamic therapy cabazitaxel liposome chemotherapy porphyrin-phospholipid

Botulinum toxin type A plus rehabilitative training for improving the motor function of the upper limbs and activities of daily life in patients with stroke and brain injury

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Neural Regeneration Research 2006年第9期1卷 859-861页

作者： Fei Guo Wei Yue Li Ren yumiao zhang Jing Yang Department of Rehabilitation Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND:Botulinum toxin type A(BTX-A)is mostly to be used to treat various diseases of motor disorders,whereas its effect on muscle spasm after stroke and brain injury needs further ***:To observe the effect of BTX-A plus rehabilitative training on treating muscle spasm after stroke and brain ***:A randomized controlled ***:Department of Rehabilitation,Department of Neurology and Department of Neurosurgery,the Second Hospital of Hebei Medical ***:Sixty inpatients with brain injury and stroke were selected from the Department of Rehabilitation,Department of Neurology and Department of Neurosurgery,the Second Hospital of Hebei Medical University from January 2001 to August *** were all confirmed by CT and MRI,and had obvious increase of spastic muscle strength in upper limbs,their Ashworth grades were grade 2 or *** patients were randomly divided into treatment group(n=30)and control group(n=30).METHODS:①Patients in the treatment group undertook comprehensive rehabilitative trainings,and they were administrated with domestic BTX-A,which was provided by Lanzhou Institute of Biological Products,Ministry of Health(S10970037),and the muscles of flexion spasm were selected for upper limbs,20-25 IU for each site.②Patients in the treatment group were assessed before injection and at 1 and 2 weeks,1 and 3 months after injection respectively,and those in the control group were assessed at corresponding time *** recovery of muscle spasm was assessed by modified Ashworth scale(MAS,grade 0-Ⅳ;Grade 0 for without increase of muscle strength;GradeⅣfor rigidity at passive flexion and extension);The recovery of motor function of the upper limbs was evaluated with Fugl-Meyer Assessment(FMA,total score was 226 points,including 100 for exercise,14 for balance,24 for sense,44 for joint motion,44 for pain and 66 for upper limb);The ADL were evaluated with Barthel index,the total score was 100 points,60 f

关键词： Botulinum toxin type A plus rehabilitative training for improving the motor function of the upper limbs and activities of daily life in patients with stroke and brain injury type

Predictive value of T cell receptor repertoire profiling for immunosuppressive therapy in severe aplastic anemia

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Genes & Diseases 2024年第1期11卷 95-98页

作者： Cunte Chen Yuling zhang Dongpei Lu Zelong zhang Jun Yang Xiaowei Chen Ming Zhou Wenjian Mo Caixia Wang Qinghua Cai yumiao Li Ruiqing Zhou Shilin Xu Wei Zhou Tingfen Deng Shiyi Pan Yanli Xu Shunqing Wang Yuping zhang Department of Hematology Guangzhou First People's HospitalSouth China University of TechnologyGuangzhouGuangdong 510180China Guangzhou Junruikang Biotechnology Co. LtdGuangzhouGuangdong 510700China

Increasing evidence supports the hypothesis of autologous immune attack in severe aplastic anemia(SAA):the predominant role of activated cytotoxic T cells(CTL)expressing-interferon in inhibiting the growth of bone marrow(BM)cells,putative autoantigens,and oligoclonal expansion of CD8+T cells.1 For SAA patients,the definitive therapies are immunosuppressive therapy(IST)or hematopoietic stem transplantation(HSCT).

关键词： anemia aplastic interferon

急诊中不明原因的呼吸困难患者应用Wells评分及D-二聚体变化对肺栓塞的诊断和风险评估的价值分析

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中国全科医学 2023年第S1期26卷 18-20页

作者：张楼炜张育苗郦巧莲浙江省诸暨市人民医院急诊科 311800

目的探究急诊中不明原因的呼吸困难患者应用Wells评分及D-二聚体(D-D)对肺栓塞的诊断和风险评估的价值。方法纳入2019年1月至2021年7月因不明原因呼吸困难到诸暨市人民医院就诊的74例急性肺栓塞患者、91例非肺栓塞患者为研究对象,分析We... 详细信息

目的探究急诊中不明原因的呼吸困难患者应用Wells评分及D-二聚体(D-D)对肺栓塞的诊断和风险评估的价值。方法纳入2019年1月至2021年7月因不明原因呼吸困难到诸暨市人民医院就诊的74例急性肺栓塞患者、91例非肺栓塞患者为研究对象,分析Wells评分及D-D水平变化对肺栓塞的诊断价值及对预后的预测价值。结果Wells评分及D-D水平联合检测诊断肺栓塞及预测患者预后的AUC均>0.85,D-D≥534.40μg/L是影响急性肺栓塞预后的危险因素(P<0.05)。结论Wells评分及D-D水平检测对肺栓塞具有诊断价值,对肺栓塞患者死亡风险有一定的预测价值。

关键词：肺栓塞急诊呼吸困难 Wells评分 D-二聚体诊断价值风险评估

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CFO变更与企业财务报告质量

南京审计大学学报 2024年第3期21卷 34-49页

作者：余玉苗章志卓武汉大学经济与管理学院湖北武汉430072

在现代风险导向审计模式下,审计师会关注CFO变更这一信号以识别和评估财务报表重大错报风险,但鲜有文献探究财务报告质量是否因此而下降。以2010—2020年沪深两市A股上市公司为对象,研究CFO变更对企业财务报告质量的影响。研究表明,CFO... 详细信息

在现代风险导向审计模式下,审计师会关注CFO变更这一信号以识别和评估财务报表重大错报风险,但鲜有文献探究财务报告质量是否因此而下降。以2010—2020年沪深两市A股上市公司为对象,研究CFO变更对企业财务报告质量的影响。研究表明,CFO变更提高了企业应计盈余管理的程度,增加了企业报告小额盈余、进行财务重述以及被出具非标审计意见的可能性,进而导致财务报告质量显著下降;当CFO未兼任内部董事、发生外部继任或非正常变更、任职于非央企时,上述负向作用更加明显。进一步研究表明,CFO变更通过提高企业的代理成本与信息不对称程度从而降低财务报告质量,并最终使企业面临更大的融资约束。

关键词： CFO变更财务报告质量异常应计小额盈余财务重述审计意见融资约束

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蛇床子素治疗骨关节疾病研究

中国骨质疏松杂志 2023年第6期29卷 881-885页

作者：蔡伟张玉苗王晓博潘亚磊陕西中医药大学陕西咸阳712046 陕西中药资源产业化省部共建协同创新中心秦药特色资源研究开发国家重点实验室(培育)陕西省创新药物研究中心陕西咸阳712083

骨关节疾病的发病率正逐年上升,已严重影响患者的生活质量和社会经济发展。近年来大量研究表明蛇床子素治疗骨关节疾病作用显著。蛇床子素可通过促进成骨细胞骨形成,促进骨髓间充质干细胞成骨分化,抑制破骨细胞分化进而治疗骨质疏松症;... 详细信息

骨关节疾病的发病率正逐年上升,已严重影响患者的生活质量和社会经济发展。近年来大量研究表明蛇床子素治疗骨关节疾病作用显著。蛇床子素可通过促进成骨细胞骨形成,促进骨髓间充质干细胞成骨分化,抑制破骨细胞分化进而治疗骨质疏松症;还可通过调控软骨细胞增殖及抑制炎症治疗骨关节炎和类风湿关节炎,抑制神经节中炎症因子释放从而缓解多种骨痛。后续可制备蛇床子素衍生物以改善其药代动力学特征,并继续明确蛇床子素治疗骨关节疾病的靶点和机制。因此,本文综述了蛇床子素治疗骨关节疾病的研究进展,以期为其在临床上的进一步开发应用提供参考。

关键词：蛇床子素骨质疏松症骨关节炎类风湿关节炎骨痛

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国内外旅游资源非使用价值评估研究综述

热带地理 2017年第1期37卷 130-141页

作者：刘佳张雨苗中国海洋大学管理学院山东青岛266071

梳理和分析国内外旅游资源非使用价值评估的研究历程与阶段特点、研究区域和研究对象,揭示其研究动态与特点。研究表明:国外研究经历了起步、深入和提升3个阶段;研究对象以国家(森林)公园、海洋保护区、自然保护区、文化遗产区、岛屿等... 详细信息

梳理和分析国内外旅游资源非使用价值评估的研究历程与阶段特点、研究区域和研究对象,揭示其研究动态与特点。研究表明:国外研究经历了起步、深入和提升3个阶段;研究对象以国家(森林)公园、海洋保护区、自然保护区、文化遗产区、岛屿等为主;研究内容关注旅游景区的准入费、旅游资源非使用价值支付意愿以及评估修正等方面;研究方法重视假想市场法计量经济模型检验等多种方法的综合运用。相比之下,国内相关研究起步较晚,研究对象以自然景观旅游资源的非使用价值评价为主,研究领域较窄;研究方法以条件价值法为主,较为单一,缺乏多种方法的综合分析;研究的应用性与实践指导作用明显不足。最后对国内研究方向和重点进行了展望,今后应不断拓展旅游资源非使用价值研究领域和视角、提高研究方法的可靠性和系统性,以及增强理论的应用性和实践性,以期协调旅游资源开发与保护以及实现旅游业可持续发展。

关键词：旅游资源非使用价值