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Imbricate structure of the Otakeyama area, Okayama Permian Yoshii Group in the Prefecture, southwest Japan

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Frontiers of Earth Science 2015年第1期9卷 152-163页

作者： Tsuyoshi ito Atsushi matsuoka State Key Laboratory of Geo-processes and Mineral Resources China University of Geosciences Wuhan 430074 China Department of Geology Faculty of Science Niigata University Niigata 950-2181 Japan

The Yoshii Group of the Akiyoshi terrane is distributed over the Otakeyama area, Okayama Prefecture, southwest Japan. The Yoshii Group is composed of siliceous rocks and clastics, comprising chert-clastic sequences. The Yoshii Group is divided into four structural units （Units Ot 1, Ot 2, Ot 3, and Ot 4） in structurally ascending order. Lithological similarities and radiolarian age suggest that these units exhibit almost identical ocean plate stratigraphy. These units are structurally-repeated to form an imbricate structure. This structure was possibly formed by off-scrape accretion at a toe of an accretionary complex. Additionally, a review of previous studies indicates that an imbricate structure is common in the Akiyoshi terrane. The presence of an imbricate structure in the Akiyoshi terrane, Permian accretionary complex, indicates the possibility that a specific horizon of Permian pelagic sequences acted as a drcollement zone.

关键词： accretionary complex imbricate structure,Permian radiolafia Yoshii Group Okayama Prefecture,southwest Japan

Uneven Distribution of Pseudotormentus De Wever et Caridroit(Radiolaria,Protozoa):Provincialism of a Permian Planktonic Microorganism

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Acta Geologica Sinica(English Edition) 2016年第5期90卷 1598-1610页

作者： ito Tsuyoshi FENG Qinglai matsuoka Atsushi State Key Laboratory of Geo-processes and Mineral Resources China University of Geosciences Graduate School of Science and Technology Niigata University Research Institute of Geology and Geoinformation Geological Survey of Japan Department of Geology Faculty of ScienceNiigata University

The Permian planktonic distribution is not well known,in contrast to other fossil distributions of nekton and *** are representative microfossils of plankton in the Permian *** study compares both correlated radiolarian occurrences（Pseudotormentus De Wever et Caridroit and Quadriremis Nazarov et Ormiston） in literature data from the Pacific Rim and quantitative data from the Liuhuang and Gujingling sections in South *** distributions are concentrated in the Panthalassa,whereas Quadriremis occurrences are distributed over both the Panthalassa and the *** uneven distribution of Pseudotormentus seems to have been controlled by a difference in the oceanic basins,indicating the presence of faunal differences in Permian planktonic microorganisms between the Panthalassa and the *** other words,this study infers the provincialism of Permian planktonic *** uneven distribution is explainable by a hypothesis that Pseudotormentus was strongly affected by a Panthalassan equatorial current.

关键词： palaeobiogeography Palaeotethys Panthalassa Permian radiolaria Pseudotormentus Quadriremis

Guadalupian (Middle Permian) Radiolarian and Sponge Spicule Faunas from the Bancheng Formation of the Qinzhou Allochthon,South China

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Journal of Earth Science 2013年第2期24卷 145-156页

作者： ito Tsuyoshi 张磊冯庆来 matsuoka Atsushi State Key Laboratory for Geological Processes and Mineral Resources China University of Geosciences Graduate School of Science and Technology Niigata University Department of Geology Faculty of ScienceNiigata University

The Gujingling （古井岭） Section in Xiaodong （小董）, Guangxi （广西） Zhuang Autonomous Region, China, consists of cherts and siliceous siltstones, which belongs to the Bancheng （板城）Formation of the Qinzhou （钦州） allochthon. Three successive radiolarian assemblage-zones related to the Guadalupian （Middle Permian） appear in the section in the following ascending order： Pseudoalbaillella sp. aff. Pseudoaibailleila longicornis-Pseudoalbaillella fusiformis, Follicucuilus monacanthus, and Follicucuilus scholasticus-Foilicucullus porrectus. The radiolarian content in this section is generally greater than that of sponge spicules. The radiolarian fauna commonly consists of abundant Albaillellaria and spherical radiolaria with minor Latentifistularia and Entactinaria. The sponge fauna is composed mainly of hexactinellids with minor demosponges. These siliceous fossil faunal features, comparable with those in a deep basin of the western belt of the Phosphoria Basin in the western United States, indicate that the Bancheng Formation in the Gujingling Section was deposited in a basin deeper than 1 000 m. The siliceous siltstones in the section are characterized by inclusion of silt-sized quartz and no inclusion of sand-sized materials, suggesting that the Gujingling Section was located at least a few hundred kilometers from the South China Block in the Guadalupian.

关键词： radiolarian fossil sponge spicule Guadalupian (Middle Permian) Bancheng Formation Qinzhou allochthon paleobathymerry.

Adsorption,selectivity,and phase behavior in organic nanopores for shale gas and oil development

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Petroleum Research 2021年第3期6卷 187-203页

作者： Jinrong Cao Yunfeng Liang Yoshihiro Masuda Kohei Tamura Hiroyuki Tanaka Tomoaki Ishiwata Yoshiharu ito Toshifumi matsuoka Department ofSystemsInnovation TheUniversityofTokyoTokyo113-8656Japan Japan Oil GasandMetalsNationalCorporation(JOGMEC)Chiba261-0025Japan Fukada GeologicalInstitute Tokyo113-0021Japan

In a shale gas and oil reservoir,hydrocarbon fluids are stored in organic nanopores with sizes on the order of~1-100 *** adsorption,selectivity,and phase behavior of hydrocarbons in the nanopores are crucial for estimating the gas-in-place and predicting the *** this study,to understand the characteristics of the phase behavior of multicomponent hydrocarbon systems in shale reservoirs,the phase behavior of a CH_(4)/n-C_(4)H_(10)binary mixture in graphite nanopores was investigated by Grand Ca-nonical Monte Carlo(GCMC)molecular *** method for determining the dew-point pressure and bubble-point pressure in the nanopores was *** condensation phenomenon was observed owing to the difference in the adsorption selectivities of the hydrocarbon molecules on the nanopore surfaces,and hence the dew-point pressure(and bubble-point pressure)of hydrocarbon mixtures in the nanopores significantly *** GCMC simulations reproduced both the higher and lower bubble-point pressures in nanopores in previous *** work highlights the crucial role of the selec-tivity in the phase behavior of hydrocarbons in nanopores.

关键词： Shale gas and oil Nanopores Adsorption Selectivity Phase behavior Bubble point pressure Dew point pressure Molecular simulation

Functional expression of a proliferation-related ligand in hepatocellular carcinoma and its implications for neovascularization

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World Journal of Gastroenterology 2005年第30期11卷 4650-4654页

作者： Hiroshi Okano Katsuya Shiraki Yutaka Yamanaka Hidekazu Inoue Tomoyuki Kawakita Yukiko Saitou yumi Yamaguchi Naoyuki Enokimura Keiichi ito Norihiko Yamamoto Kazushi Sugimoto Kazumoto Murata Takeshi Nakano First Department of Internal Medicine

AIM： To detect the expression of a proliferation-related ligand on human hepatocellular carcinoma （HCC） cell lines （SK-Hepl, HLE and HepG2） and in culture medium. METHODS： APRIL expression was analyzed by Western blotting in HCC cell lines. Effects of APRIL to cell count and angiogenesis were analyzed, too. RESULTS： Recombinant human APRIL （rhAPRIL） increased cell viability of HepG2 cells and, in HUVEC, rhAPRIL provided slight tolerance to cell death from serum starvation. Soluble APRIL （sAPRIL） from HLE cells increased after serum starvation, but did not change in SK-Hepl or HepG2 cells. These cells showed down-regulation of VEGF after incubation with anti-APRIL antibody. Furthermore, culture medium from the HCC cells treated with anti-APRIL antibody treatment inhibited tube formation of HUVECs. CONCLUSION： Functional expression of APRIL might contribute to neovascularization via an upregulation of VEGF in HCC.

关键词： A proliferation-inducing ligand HCC VEGF Cell proliferation Neovascularization

Land-Ocean Linkage: Pelagic Cherts in Mesozoic Neritic-Terrestrial Sequences in East Asia

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Open Journal of Geology 2019年第10期9卷 551-553页

作者： Atsushi matsuoka Tsuyoshi ito Yusuke Sakai Department of Geology Niigata University Niigata Japan Research Institute of Geology and Geoinformation Geological Survey of Japan AIST Tsukuba Japan Graduate School of Science and Technology Niigata University Niigata Japan Ono City Board of Education Ono Japan

Chert clast-bearing epi-continental neritic-terrestrial Jurassic and Cretaceous sequences are sporadically distributed in southwestern Japan. Typical and geological entities are the Torinosu Group and Tetori Group. Radiolarian dating of chert clasts enables us to discuss denudation stages of mid Mesozoic accretionary complexes. Chert clast-dominated conglomerate can be used for identifying marine beds within terrestrial sequences.

关键词： Pelagic Radiolarian Chert Conglomerate Accretionary Complex Neritic-Terrigenous Sediments

Highly accurate colorectal cancer prediction model based on Raman spectroscopy using patient serum

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1311-1324页

作者： Hiroaki ito Naoyuki Uragami Tomokazu Miyazaki William Yang Kenji Issha Kai Matsuo Satoshi Kimura Yuji Arai Hiromasa Tokunaga Saiko Okada Machiko Kawamura Noboru Yokoyama Miki Kushima Haruhiro Inoue Takashi Fukagai yumi Kamijo Digestive Disease Center Showa University Koto Toyosu HospitalTokyo 135-8577Japan Research Division JSR CorporationTokyo 105-0021Japan BaySpec Inc. San JoseCA 95131United States Fuji Technical Research Inc. Yokohama 220-6215Japan Department of Laboratory Medicine and Central Clinical Laboratory Showa University Northern Yokohama HospitalYokohama 224-8503Japan Department of Clinical Laboratory Showa University Koto Toyosu HospitalTokyo 135-8577Japan Department of Clinical Laboratory Showa University HospitalTokyo 142-8555JapanBML Inc.Tokyo 151-0051Japan Department of Hematology Saitama Cancer CenterInamachiSaitama 362-0806Japan Department of Pathology Showa University Koto Toyosu HospitalTokyo 135-8577Japan Department of Urology Showa University Koto Toyosu HospitalTokyo 135-8577Japan Showa University Koto Toyosu Hospital Tokyo 135-8577Japan

BACKGROUND Colorectal cancer(CRC) is an important disease worldwide, accounting for the second highest number of cancer-related deaths and the third highest number of new cancer cases. The blood test is a simple and minimally invasive diagnostic test. However, there is currently no blood test that can accurately diagnose *** To develop a comprehensive, spontaneous, minimally invasive, label-free, bloodbased CRC screening technique based on Raman *** We used Raman spectra recorded using 184 serum samples obtained from patients undergoing colonoscopies. Patients with malignant tumor histories as well as those with cancers in organs other than the large intestine were excluded. Consequently, the specific diseases of 184 patients were CRC(12), rectal neuroendocrine tumor(2), colorectal adenoma(68), colorectal hyperplastic polyp(18), and others(84). We used the 1064-nm wavelength laser for excitation. The power of the laser was set to 200 *** Use of the recorded Raman spectra as training data allowed the construction of a boosted tree CRC prediction model based on machine learning. Therefore, the generalized R^2 values for CRC, adenomas, hyperplastic polyps, and neuroendocrine tumors were 0.9982, 0.9630, 0.9962, and 0.9986, *** For machine learning using Raman spectral data, a highly accurate CRC prediction model with a high R^2 value was constructed. We are currently planning studies to demonstrate the accuracy of this model with a large amount of additional data.

关键词： Colorectal cancer Raman spectroscopy Machine learning Blood Serum Diagnosis

Contrast uptake in primary hepatic angiosarcoma on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging in the hepatobiliary phase

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World Journal of Hepatology 2018年第1期10卷 166-171页

作者： Manabu Hayashi Satoshi Kawana Hirofumi Sekino Kazumichi Abe Naoki matsuoka Masahito Kashiwagi Ken Okai Yukiko Kanno Atsushi Takahashi Hiroshi ito Yuko Hashimoto Hiromasa Ohira Department of Gastroenterology Fukushima Medical University School of Medicine Department of Diagnostic Pathology Fukushima Medical University School of Medicine Department of Radiology Fukushima Medical University School of Medicine

Primary hepatic angiosarcoma is the most common malignant mesenchymal tumor of the liver. It has a poor prognosis and various appearances on magnetic resonance(MR) images. We report a case of hepatic angiosarcoma with a characteristic appearance on gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)-enhanced MR imaging in the hepatobiliary phase. A 72-year-old man was admitted with a complaint of abdominal pain. Gd-EOBDTPA-enhanced MR imaging revealed a liver tumor that showed slight hyperintensity in the hepatobiliary phase. These findings suggested Gd-EOB-DTPA uptake in the tumor. An autopsy revealed the solid proliferation and sinusoidal spreading of hepatic angiosarcoma cells. Immunohistochemistry indicated that the tumor was negative for OATP1B3. Gd-EOB-DTPA uptake in the liver tumor in the hepatobiliary phase suggested sinusoidal tumor invasion with residual normal hepatocytes.

关键词： Hepatic angiosarcoma Gadoliniumethoxybenzyl-diethylenetriamine pentaacetic acid Cirrhosis Hepatocellular carcinoma

Therapeutic Application of High-Frequency rTMS Combined with Intensive Occupational Therapy for Pediatric Stroke Patients with Upper Limb Hemiparesis: A Case Series Study

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Journal of Behavioral and Brain Science 2013年第2期3卷 188-193页

作者： Masachika Niimi Wataru Kakuda Toru Takekawa Ryo Momosaki Takatoshi Hara Hiroshi ito yumi Kameda Masahiro Abo Department of Rehabilitation Medicine The Jikei University School of Medicine Tokyo Japan

Low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) applied to the non-lesional hemisphere is reported to significantly improve motor function of the affected upper limb in adult stroke patients with hemiparesis. For pediatric stroke patients, the beneficial effects of LF-rTMS have been already confirmed in a randomized controlled study. However, there is no report of therapeutic application of high-frequency rTMS (HF-rTMS) in this patient population. In this case series study, we introduced HF-rTMS combined with intensive occupational therapy (OT) in two pediatric hemiparetic patients. We studied two children (8- and 9-year-old boys, both right-handed) with post-stroke upper limb hemiparesis (chronic phase). Both patients underwent 22 treatment sessions of HF-rTMS/OT during 15-day hospitalization. The HF-rTMS was applied over the lesional motor cortex at a frequency of 10Hz for 15 minutes in each session. One session of intensive OT consisted of 30-min one-to-one training and 30-min self-exercise. Motor function of the affected upper limb was serially evaluated with Fugl-Meyer Assessment (FMA), Wolf Motor Function Test (WMFT), Simple Test for Evaluating hand Function (STEF), and Ten-second Test. Neither of the patients showed any adverse effects. Both patients showed improvement of motor function in the affected upper limb and were able to use the affected upper limb in some activities of daily living. In the two post-stroke pediatric patients, HF-rTMS/OT was safe and improved upper limb muscle function. Confirmation of these effects in a larger population is needed.

关键词： Pediatric Stroke Repetitive Transcranial Magnetic Stimulation Occupational Therapy Upper Limb Hemiparesis Motor Recovery