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核心素养视域下初中英语课内课后语法教学进阶和衔接机制研究

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英语教师 2024年第14期24卷 166-168页

作者：潘雨濛江苏省苏州市吴江区盛湖学校江苏苏州215228

阐述新课改背景下初中英语语法教学情况,即仍以传统的“教—学—练”模式为主;追求高分,忽视能力提升和进阶教育。为提升学生的英语语法学习效率,结合教学实例,探索如何在核心素养视域下构建初中英语课内课后语法教学进阶和衔接机制。... 详细信息

阐述新课改背景下初中英语语法教学情况,即仍以传统的“教—学—练”模式为主;追求高分,忽视能力提升和进阶教育。为提升学生的英语语法学习效率,结合教学实例,探索如何在核心素养视域下构建初中英语课内课后语法教学进阶和衔接机制。提出创设情境教学方式,课内教学,课后引导;创设任务教学方式,课后注重教学任务的衔接,有序提升进阶;创设“课内—课后认知关联模式”,鼓励学生在不断“试错”中得到进阶提升等措施。

关键词：初中英语核心素养语法教学

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101例住院梅毒患者的临床特征分析

皮肤病与性病 2024年第5期46卷 289-293页

作者：潘雨萌杨琼斓杨央李玉叶昆明医科大学第一附属医院皮肤性病科云南昆明650032

目的探讨某综合医院皮肤科近4年住院梅毒患者的临床特征,为提高梅毒患者的诊治水平及早期识别神经梅毒提供帮助。方法回顾性收集2019年1月至2022年12月某综合医院皮肤科101例梅毒住院患者的临床资料,包括一般情况、首发表现、血清及脑脊... 详细信息

目的探讨某综合医院皮肤科近4年住院梅毒患者的临床特征,为提高梅毒患者的诊治水平及早期识别神经梅毒提供帮助。方法回顾性收集2019年1月至2022年12月某综合医院皮肤科101例梅毒住院患者的临床资料,包括一般情况、首发表现、血清及脑脊液(CSF)检测结果等。结果101例梅毒患者男女比例为1∶1.5,发病平均年龄36.68±13.84岁,以隐性梅毒患者居多,占78.22%。将行腰椎穿刺的89例住院患者分为神经梅毒CSF TRUST阳性组、神经梅毒CSF TRUST阴性组及非神经梅毒组,发现脑脊液白细胞、蛋白量差异有统计学意义(P<0.001)。比较血清TRUST或RPR滴度≥1∶32组与滴度<1∶32组,发现两组患者的血小板体积(MPV)、血小板分布宽度(PDW)、IgG的差异有统计学意义。在病程小于24个月组与高于24个月两组患者中,白细胞(WBC)计数差异有统计学意义(P<0.05)。结论①住院梅毒患者女性多于男性,发病率最高的是青年组(18~40岁)。②隐性梅毒患者居多(78.22%)。③梅毒患者脑脊液TPPA阳性、脑脊液TRUST或RPR阴性,但脑脊液蛋白量和白细胞异常,应高度警惕是否为神经梅毒。④血清MPV、PDW、WBC、IgG的变化可能与梅毒活动有关。

关键词：梅毒神经梅毒脑脊液血细胞参数

Corrosion mechanism of CuAl-NiC abradable seal coating system——The influence of porosity,multiphase,and multilayer structure on the corrosion failure

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Journal of Materials Science & Technology 2021年第29期88卷 258-269页

作者： yumeng Ni Fan Zhang Demian I.Njoku Yingjie Yu Jinshan pan Meijiang Meng Ying Li Corrosion and Protection Division Shenyang National Laboratory for Materials ScienceInstitute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Material Science and Technology University of Science and Technology of ChinaShenyang110016China Department of Engineering and Design School of Engineering and InformaticsUniversity of SussexBrightonBN19RHUnited Kingdom Division of Surface and Corrosion Science KTH Royal Institute of TechnologyDrottning Kristinas väg.51SE-10044StockholmSweden Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang110819China

In this study,the corrosion behavior of the CuAl-NiC abradable seal coating system in chloride solution was investigated to systematically research the effect of porosity,multiphase,and multilayer structure on the corrosion *** the composition and structure analysis,the corrosion process of the system was predicted and then verified with mercury intrusion porosimetry,cross-section SEM/EDS analysis,and electrochemical *** results demonstrated that the interphase selective corrosion caused the porosity of the top layer to decrease first and then increase during the corrosion *** interlayer galvanic corrosion,determined by the pore connectivity,is crucial for corrosion failure.

关键词： Abradable seal coating system Galvanic corrosion Multilayer Porosity

振动远红外干燥对蒲公英干后复水比的试验研究

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农产品加工 2024年第21期 21-23,30页

作者：牛柏胜厚宝龙李庆彬潘雨蒙杨莎王鑫黑龙江八一农垦大学工程学院黑龙江省智能装备重点实验室黑龙江大庆163319

运用对干制品影响较小的振动远红外干燥方法对蒲公英进行干燥试验研究,采用三因素三水平正交试验设计方法,探讨干燥温度、振动频率、物料厚度对蒲公英干后复水比的影响规律。利用双因素分析法探究三因素与复水比之间的关系,确定三因素... 详细信息

运用对干制品影响较小的振动远红外干燥方法对蒲公英进行干燥试验研究,采用三因素三水平正交试验设计方法,探讨干燥温度、振动频率、物料厚度对蒲公英干后复水比的影响规律。利用双因素分析法探究三因素与复水比之间的关系,确定三因素在二次非线形模型中的主次顺序。结果表明,热风温度对蒲公英干后复水比影响最大,振动频率次之,物料厚度的影响最小;确定最佳的干燥工艺参数组合为加热温度70℃,振动频率40 Hz,材料厚度10 mm。

关键词：远红外振动干燥复水性蒲公英

Extraction and analysis of tree canopy height information in high-voltage transmission-line corridors by using integrated optical remote sensing and LiDAR

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Geodesy and Geodynamics 2023年第3期14卷 292-303页

作者： Jinpeng Hao Xiuguang Li Hong Wu Kai Yang yumeng Zeng Yu Wang Yuanjin pan State Grid Ningxia Electric Power Research Institute Yinchuan 750011China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430061China School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China Hubei LuoJia Laboratory Wuhan UniversityWuhan 430079China

Traditional inspection methods cannot quickly and accurately monitor tree barriers and safeguard the transmission *** solve these problems,in this study,we proposed a rapid canopy height information extraction method using optical remote sensing and LiDAR,and used UAV optical imagery with LiDAR to monitor the height of trees in a university and a high-voltage transmission line corridor in the Ningxia *** results showed that the relative error of tree height extraction using UAV optical images was less than 5%,and the lowest relative error was 0.11%.The determination coefficient R^(2) between the optical image tree height extraction results and the measured tree height was 0.97,thus indicating a high correlation for *** the field of tree barrier monitoring,the determination coefficient R^(2) of tree height extracted using airborne LiDAR point cloud,and canopy height model(CHM)and of the measured tree height were 0.947 and 0.931,*** maximum and minimum relative error in tree height extraction performed using point cloud was 2.91%and 0.2%,respectively,with an extraction accuracy of over 95%.The experimental results demonstrated that it is feasible to use UAV optical remote sensing and LiDAR in monitoring tree barriers and tree height information extraction quickly and accurately,which is of great significance for the risk assessment and early warning of tree barriers in transmission-line corridors.

关键词： UAV LiDAR Power line Tree height

Molecular insights on Ca^(2+)/Na+separation via graphene-based nanopores:The role of electrostatic interactions to ionic dehydration

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Chinese Journal of Chemical Engineering 2022年第1期35卷 220-229页

作者： yumeng Zhang Yingying Zhang Xueling pan Yao Qin Jiawei Deng Shanshan Wang Qingwei Gao Yudan Zhu Zhuhong Yang Xiaohua Lu College of Chemical Engineering State Key Laboratory of Materials-oriented Chemical EngineeringNanjing Tech UniversityNanjing 211816China College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China School of Chemical Engineering State Key Laboratory of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China

Ca^(2+)/Na+separation is a common problem in industrial applications,biological and medical ***,Ca^(2+)and Na+have similar ionic radii and hydration radii,thus Ca^(2+)/Na+separation is *** by biological channels,group modification is one of the effective methods to improve the separation *** this work,molecular dynamics simulations were performed to investigate the effects of different functional groups(COO,NH3+)on the separation performance of Ca^(2+)and Na+through graphene nanopores under an electric *** pristine graphene nanopore was used for *** showed that three types of nanopores preferred Ca^(2+)to Na+,and Ca^(2+)/Na+selectivity followed the order of GE-COO(4.06)>GE(1.85)>GE-NH3+(1.63).Detailed analysis of ionic hydration microstructure shows that different nanopores result in different hydration factors for the second hydration layer of Ca^(2+)and the first layer of Na+.Such different hydration factors corresponding to the dehydration ability can effectively evaluate the separation *** addition,the breaking of hydrogen bonds between water molecules due to electrostatic effects can directly affect the dehydration ***,the electrostatic effect generated by group modification will affect the ionic hydration microstructure,thus reflecting the differences in dehydration *** in turn affects the permeable and separation performance of *** results of this work provide perceptive guidelines for the application of graphene-based membranes in ion separation.

关键词： Separation Microstructure Molecular simulation Modified graphene nanopores Metal-ions Nanoconfinement

Development of small molecule extracellular signal-regulated kinases(ERKs) inhibitors for cancer therapy

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2171-2192页

作者： Xiaoli pan Junping Pei Aoxue Wang Wen Shuai Lu Feng Faqian Bu yumeng Zhu Lan Zhang Guan Wang Liang Ouyang State Key Laboratory of Biotherapy and Cancer Center Innovation Center of Nursing ResearchNursing Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsWest China Hospitaland Collaborative Innovation Center of BiotherapySichuan UniversityChengdu 610041China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

The mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase 1/2(ERK1/2) signaling pathway is widely activated by a variety of extracellular stimuli, and its dysregulation is associated with the proliferation, invasion, and migration of cancer cells. ERK1/2 is located at the distal end of this pathway and rarely undergoes mutations, making it an attractive target for anticancer drug development. Currently, an increasing number of ERK1/2 inhibitors have been designed and synthesized for antitumor therapy, among which representative compounds have entered clinical trials. When ERK1/2 signal transduction is eliminated, ERK5 may provide a bypass route to rescue proliferation, and weaken the potency of ERK1/2 inhibitors. Therefore, drug research targeting ERK5 or based on the compensatory mechanism of ERK5 for ERK1/2 opens up a new way for oncotherapy. This review provides an overview of the physiological and biological functions of ERKs, focuses on the structure-activity relationships of small molecule inhibitors targeting ERKs, with a view to providing guidance for future drug design and optimization, and discusses the potential therapeutic strategies to overcome drug resistance.

关键词： Mitogen-activated protein kinases Cancer Extracellular signalregulated kinase 1/2 inhibitors Extracellular signalregulated kinase 5 inhibitors Inhibition Selectivity

The roles of computer-aided drug synthesis in drug development

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Green Synthesis and Catalysis 2022年第1期3卷 11-24页

作者： Pengfei Jia Junping Pei Guan Wang Xiaoli pan yumeng Zhu Yong Wu Liang Ouyang Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry West China School of PharmacySichuan UniversityChengdu 610041China State Key Laboratory of Biotherapy and Cancer Center Innovation Center of Nursing ResearchNursing Key Laboratory of Sichuan ProvinceWest China Hospitaland Collaborative Innovation Center of BiotherapySichuan UniversityChengdu 610041China

With the improvements in computer computing ability,data accumulation and rapid algorithm development,the integration of artificial intelligence(AI)and drug synthesis has been accelerated,significantly improving the design and synthesis of drug ***,data-driven computer-aided synthesis tools have been quickly and widely applied in retrosynthetic analysis,reaction prediction and automated synthesis,which can effectively accelerate the process of drug discovery and development and improve the quality of designed and synthesized drug ***,we review the development and applications of computer-aided synthesis technology and introduce recent advances in computer-aided drug development from three aspects:computer-aided drug design,computer-aided drug synthesis route design and computer-aided intelligent drug synthesis ***,the challenges and opportunities of computer-aided drug synthesis technology are discussed.

关键词： Computer-aided drug development Computer-aided drug synthesis Retrosynthetic analysis Reaction prediction Automated synthesis

Enhancing low-resource cross-lingual summarization from noisy data with fine-grained reinforcement learning

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Frontiers of Information Technology & Electronic Engineering 2024年第1期25卷 121-134页

作者： Yuxin HUANG Huailing GU Zhengtao YU yumeng GAO Tong pan Jialong XU Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming 650504China Yunnan Key Laboratory of Artificial Intelligence Kunming University of Science and TechnologyKunming 650504China

Cross-lingual summarization(CLS)is the task of generating a summary in a target language from a document in a source ***,end-to-end CLS models have achieved impressive results using large-scale,high-quality datasets typically constructed by translating monolingual summary corpora into CLS ***,due to the limited performance of low-resource language translation models,translation noise can seriously degrade the performance of these *** this paper,we propose a fine-grained reinforcement learning approach to address low-resource CLS based on noisy *** introduce the source language summary as a gold signal to alleviate the impact of the translated noisy target ***,we design a reinforcement reward by calculating the word correlation and word missing degree between the source language summary and the generated target language summary,and combine it with cross-entropy loss to optimize the CLS *** validate the performance of our proposed model,we construct Chinese-Vietnamese and Vietnamese-Chinese CLS *** results show that our proposed model outperforms the baselines in terms of both the ROUGE score and BERTScore.

关键词： Cross-lingual summarization Low-resource language Noisy data Fine-grained reinforcement learning Word correlation Word missing degree