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中国西部5城市中老年人血清25羟基维生素D与握力的相关性

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北京大学学报（医学版） 2024年第3期56卷 448-455页

作者：靖婷江华李婷申倩倩叶兰曾银丹梁文欣冯罡司徒文佑张玉梅北京大学公共卫生学院营养与食品卫生学系北京100191 北京大学护理学院北京100191 国家乳业技术创新中心呼和浩特010110

目的:探究中国西部5城市中老年人血清25羟基维生素D[25-hydroxyvitamin D,25(OH)D]与握力的相关性。方法:基于2023年2—7月在中国西部5个城市开展的横断面调查数据,通过问卷收集中老年人的相关人口学特征,通过体格检查记录握力,采集空... 详细信息

目的:探究中国西部5城市中老年人血清25羟基维生素D[25-hydroxyvitamin D,25(OH)D]与握力的相关性。方法:基于2023年2—7月在中国西部5个城市开展的横断面调查数据,通过问卷收集中老年人的相关人口学特征,通过体格检查记录握力,采集空腹血液样本分离血清并使用高效液相色谱串联质谱法测定血清25(OH)D浓度,使用卡方检验进行组间比较,使用Logistic回归分析西部5城市中老年人血清25(OH)D与握力的相关性。结果:我国西部5城市中老年人维生素D的缺乏率和不足率分别为52.9%和34.5%[维生素D缺乏定义为血清25(OH)D总浓度<20μg/L,维生素D不足定义为血清25(OH)D总浓度为20~30μg/L],高龄、女性、采样季节在冬季的中老年人血清25(OH)D水平更低(P<0.05)。25.3%的中老年人发生了握力减退,65~80岁25(OH)D缺乏的老年人握力减退的发生率高于25(OH)D不足的老年人(45.0%vs.32.6%)和25(OH)D充足的老年人(45.0%vs.20.6%);25(OH)D缺乏的75~80岁老年人握力减退的发生率最高(62.1%),25(OH)D不足组次之(11.1%,P<0.05)。与25(OH)D充足的中老年人相比,25(OH)D缺乏的中老年人发生握力减退的风险增加1.4倍(OR=2.403,95%CI:1.202~4.804,P=0.013),未发现25(OH)D不足与中老年人握力状况存在显著相关关系;血清总25(OH)D每增加5μg/L,其发生握力减退的风险降低13.1%(OR=0.869,95%CI:0.768~0.982,P=0.025);血清25(OH)D 2每增加5μg/L,其发生握力减退的风险降低24.1%(OR=0.759,95%CI:0.582~0.990,P=0.042);未发现血清25(OH)D 3含量与握力减退风险存在显著相关关系。血清25(OH)D水平每增加一个等级(缺乏、不足和充足),中老年人发生握力减退的风险降低25.2%(OR=0.748,95%CI:0.598~0.936,P=0.011)。在65~80岁和65~69岁的两组调查对象中,血清25(OH)D水平每增加一个等级,发生握力减退的风险降低40.0%,而在75~80岁的调查对象中,25(OH)D水平每增加一个等级,发生握力减退的风险降低80.0%。结论:中国西部5城市中老年人血清总25(OH)D和25(OH)D 2含量与握力状况存在一定关联。

关键词：中国西部老年人 25羟基维生素D 握力

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大豆地方种质资源鲜籽粒可溶性糖含量的全基因组关联分析

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中国农业科学 2024年第11期57卷 2079-2091页

作者：张玉梅丁文涛蓝新隆李清华胡润芳郭娜林国强赵晋铭福建省农业科学院作物研究所/福建省特色旱作物品种选育工程技术研究中心/福建省蔬菜遗传育种重点实验室生物育种钟山实验室南京农业大学农学院/国家大豆生物育种产教融合创新平台/农业农村部大豆生物学与遗传育种重点实验室/作物遗传与种质创新全国重点实验室莆田市农业科学研究所

【目的】可溶性糖含量是鲜食大豆重要的品质性状之一，研究大豆鲜籽粒可溶性糖含量的遗传变异，深入解析可溶性糖含量的遗传机制，为鲜食大豆种质创新及品质育种提供依据。【方法】利用来自东北大豆生态区、北方大豆生态区、黄淮海大豆... 详细信息

【目的】可溶性糖含量是鲜食大豆重要的品质性状之一，研究大豆鲜籽粒可溶性糖含量的遗传变异，深入解析可溶性糖含量的遗传机制，为鲜食大豆种质创新及品质育种提供依据。【方法】利用来自东北大豆生态区、北方大豆生态区、黄淮海大豆生态区和南方大豆生态区的133份大豆地方种质，在2021年连江春季、福清春季和秋季3个环境下对鲜籽粒可溶性糖含量进行表型测定，结合82 187个高质量SNP标记，基于混合线性模型MLM（Q+K）对可溶性糖含量进行全基因组关联分析，挖掘可溶性糖含量显著相关的SNP位点，并以显著SNP位点为中心，两端各扩展119.07 kb连锁不平衡衰减距离为候选区间，根据候选区间内基因的注释和组织表达信息预测候选基因。【结果】3个环境下，鲜籽粒可溶性糖含量的变异范围为3.37—33.84 mg·g-1，遗传变异系数为24.59%—32.69%，可溶性糖含量遗传率为68.14%。通过全基因组关联分析，连江春季、福清春季和秋季3个环境下分别检测到与鲜籽粒可溶性糖含量显著关联的SNP有6、8和22个，表型变异解释率为12.43%—29.27%，以表型变异解释率较高的9个显著SNP位点所在的候选区间进行搜索，共获得86个基因，结合基因注释和组织表达信息，进一步筛选到9个候选基因，主要涉及转录因子、糖蛋白家族和糖类合成转运等生物学过程。其中，Glyma.01g016500、Glyma.13g042100、Glyma.16g131800和Glyma.16g155300在大豆种子及荚中表达水平较高，可作为大豆鲜籽粒可溶性糖的最具潜力候选基因。【结论】通过全基因组关联分析，检测到36个与鲜籽粒可溶性糖含量显著关联的SNP，进一步筛选出9个候选基因可能参与大豆鲜籽粒可溶性糖含量的调控，其中，Glyma.01g016500、Glyma.13g042100、Glyma.16g131800和Glyma.16g155300可作为调控大豆鲜籽粒可溶性糖含量的关键目标基因。

关键词：大豆鲜籽粒可溶性糖含量全基因组关联分析候选基因

Interplay between the glymphatic system and neurotoxic proteins in Parkinson’s disease and related disorders:current knowledge and future directions

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Neural Regeneration Research 2024年第9期19卷 1973-1980页

作者： yumei Yue Xiaodan zhang Wen Lv Hsin-Yi Lai Ting Shen Department of Neurology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Emergency Medicine The University of Hong KongHong Kong Special Administrative RegionChina Department of Neurology of the Second Affiliated Hospital and School of Brain Science and Brain Medicine Interdisciplinary Institute of Neuroscience and TechnologyKey Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhouZhejiang ProvinceChina College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhouZhejiang ProvinceChina MOE Frontier Science Center for Brain Science and Brain-Machine Integration State Key Laboratory of Brain-machine IntelligenceSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina

Parkinson’s disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins,includingα-synuclein,amyloid-β,and tau,in addition to the impaired elimination of these neurotoxic protein.Atypical parkinsonism,which has the same clinical presentation and neuropathology as Parkinson’s disease,expands the disease landscape within the continuum of Parkinson’s disease and related disorders.The glymphatic system is a waste clearance system in the brain,which is responsible for eliminating the neurotoxic proteins from the interstitial fluid.Impairment of the glymphatic system has been proposed as a significant contributor to the development and progression of neurodegenerative disease,as it exacerbates the aggregation of neurotoxic proteins and deteriorates neuronal damage.Therefore,impairment of the glymphatic system could be considered as the final common pathway to neurodegeneration.Previous evidence has provided initial insights into the potential effect of the impaired glymphatic system on Parkinson’s disease and related disorders;however,many unanswered questions remain.This review aims to provide a comprehensive summary of the growing literature on the glymphatic system in Parkinson’s disease and related disorders.The focus of this review is on identifying the manifestations and mechanisms of interplay between the glymphatic system and neurotoxic proteins,including loss of polarization of aquaporin-4 in astrocytic endfeet,sleep and circadian rhythms,neuroinflammation,astrogliosis,and gliosis.This review further delves into the underlying pathophysiology of the glymphatic system in Parkinson’s disease and related disorders,and the potential implications of targeting the glymphatic system as a novel and promising therapeutic strategy.

关键词： atypical parkinsonism glymphatic system magnetic resonance imaging neurotoxic proteins Parkinson’s disease

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一种基于红外图像的空间目标探测方法

航天器环境工程 2024年第1期41卷 27-33页

作者：苏振华刘新颖丁奕冰李季张玉梅尹亮何振东张晓俊航天东方红卫星有限公司北京卫星环境工程研究所北京100094

针对空间环境中的监视高速运动小目标的需求,提出一种基于红外图像的空间目标探测方法,实现对空间非合作目标的检测、跟踪与识别。根据目标红外特性,目标检测过程采用阈值分割算法分割目标,通过重心法提取目标质心,采用星图匹配方法剔... 详细信息

针对空间环境中的监视高速运动小目标的需求,提出一种基于红外图像的空间目标探测方法,实现对空间非合作目标的检测、跟踪与识别。根据目标红外特性,目标检测过程采用阈值分割算法分割目标,通过重心法提取目标质心,采用星图匹配方法剔除恒星背景;目标跟踪识别过程采用轨迹关联算法进行多目标编批及轨迹跟踪,采用基于目标运动速度信息和方向矢量信息的目标分类算法最终识别目标。实验结果表明,应用该方法能够在1 s内实现空间目标探测,满足空间环境监视对目标探测的实时性好、检测概率高、虚警概率低等要求。

关键词：空间环境监视红外图像目标探测目标特性

In^(3+)-doped Sr_(2)Fe_(1.5)Mo_(0.5)O_(6−δ)cathode with improved performance for an intermediate-temperature solid oxide fuel cell

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Nano Research 2024年第1期17卷 407-415页

作者： yumei Ma Lijie zhang Kang Zhu Binze zhang Ranran Peng Changrong Xia Ling Huang State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China Department of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026China

Promoting the oxygen reduction reaction(ORR)is critical for commercialization of intermediate-temperature solid oxide fuel cells(IT-SOFCs),where Sr_(2)Fe_(1.5)Mo_(0.5)O_(6)−δ(SFM)is a promising cathode by working as a mixed ionic and electronic conductor.In this work,doping of In^(3+)greatly increases the oxygen vacancy concentration and the content of adsorbed oxygen species in Sr_(2)Fe_(1.5)Mo_(0.5−x)InxO_(6−δ)(SFMInx),and thus effectively promotes the ORR performance.As a typical example,SFMIn_(0.1)reduces the polarization resistance(R_(p))from 0.089 to 0.046Ω∙cm^(2)at 800°C,which is superior to those doped with other metal elements.In addition,SFMIn0.1 increases the peak power density from 0.92 to 1.47 W∙cm^(−2)at 800°C with humidified H_(2)as the fuel,indicating that In3+doping at the Mo site can effectively improve the performance of SOFC cathode material.

关键词： solid oxide fuel cell cathode In3+doping oxygen reduction reaction(ORR) Sr_(2)Fe_(1.5)Mo_(0.5)O_(6-δ)

基于超星学习通的翻转课堂教学模式在临床营养学中的应用

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中国当代医药 2024年第6期31卷 141-145页

作者：樊颖维张鱼湄朱嘉琪黄娟娟广东医科大学护理学院广东东莞523808

目的探讨基于超星学习通的翻转课堂在临床营养教学中的应用效果。方法2022年9月至10月便利选取广东医科大学2020级护理专业2个教学班的学生作为研究对象,分为翻转组(n=38)和对照组(n=36)。翻转组学生采用基于超星学习通平台的翻转课堂教... 详细信息

目的探讨基于超星学习通的翻转课堂在临床营养教学中的应用效果。方法2022年9月至10月便利选取广东医科大学2020级护理专业2个教学班的学生作为研究对象,分为翻转组(n=38)和对照组(n=36)。翻转组学生采用基于超星学习通平台的翻转课堂教学,对照组采用传统教学法教学。教学结束后,比较两组章节测验得分、自主导向学习能力以及课程满意度。结果两组章节测验得分比较,差异无统计学意义(P>0.05);翻转组自主导向学习能力量表总分高于对照组,差异有统计学意义(P0.05)。结论在本科护生临床营养教学中开展基于超星学习通的翻转课堂有助于提高学生的满意度,提高学生学习自主性。教育工作者应针对特定科目优化翻转课堂方法及教学效果的评价体系,以最大程度发挥其现实意义。

关键词：护理教育教学方法翻转课堂临床营养

Mitophagy in intracerebral hemorrhage:a new target for therapeutic intervention

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Neural Regeneration Research 2024年第2期19卷 316-323页

作者： Yiyang Chen Wenxuan Tang Xinqi Huang yumei An Jiawen Li Shengye Yuan Haiyan Shan Mingyang zhang Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of Justice(Academy of Forensic Science)ShanghaiChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Intracerebral hemorrhage is a life-threatening condition with a high fatality rate and severe sequelae.However,there is currently no treatment available for intracerebral hemorrhage,unlike for other stroke subtypes.Recent studies have indicated that mitochondrial dysfunction and mitophagy likely relate to the pathophysiology of intracerebral hemorrhage.Mitophagy,or selective autophagy of mitochondria,is an essential pathway to preserve mitochondrial homeostasis by clearing up damaged mitochondria.Mitophagy markedly contributes to the reduction of secondary brain injury caused by mitochondrial dysfunction after intracerebral hemorrhage.This review provides an overview of the mitochondrial dysfunction that occurs after intracerebral hemorrhage and the underlying mechanisms regarding how mitophagy regulates it,and discusses the new direction of therapeutic strategies targeting mitophagy for intracerebral hemorrhage,aiming to determine the close connection between mitophagy and intracerebral hemorrhage and identify new therapies to modulate mitophagy after intracerebral hemorrhage.In conclusion,although only a small number of drugs modulating mitophagy in intracerebral hemorrhage have been found thus far,most of which are in the preclinical stage and require further investigation,mitophagy is still a very valid and promising therapeutic target for intracerebral hemorrhage in the long run.

关键词： intracerebral hemorrhage mitochondrial dysfunction mitophagy neuroinflammation neuroprotection reactive oxygen species secondary brain injury therapeutic target

The role of snapin in regulation of brain homeostasis

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Neural Regeneration Research 2024年第8期19卷 1696-1701页

作者： Jiawen Li Xinqi Huang yumei An Xueshi Chen Yiyang Chen Mingyuan Xu Haiyan Shan Mingyang zhang Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeChina(Academy of Forensic Science)ShanghaiChina Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Brain homeostasis refe rs to the normal working state of the brain in a certain period,which is impo rtant for overall health and normal life activities.Currently,there is a lack of effective treatment methods for the adverse consequences caused by brain homeostasis imbalance.Snapin is a protein that assists in the formation of neuronal synapses and plays a crucial role in the normal growth and development of synapses.Recently,many researchers have reported the association between snapin and neurologic and psychiatric disorders,demonstrating that snapin can improve brain homeostasis.Clinical manifestations of brain disease often involve imbalances in brain homeostasis and may lead to neurological and behavioral sequelae.This article aims to explo re the role of snapin in restoring brain homeostasis after injury or diseases,highlighting its significance in maintaining brain homeostasis and treating brain diseases.Additionally,it comprehensively discusses the implications of snapin in other extracerebral diseases such as diabetes and viral infections,with the objective of determining the clinical potential of snapin in maintaining brain homeostasis.

关键词： brain homeostasis diabetes neurological diseases snapin traumatic brain injury vesicle fusion

术前运动训练在老年髋部骨折患者预康复中应用的范围综述

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华西医学 2024年第6期39卷 906-912页

作者：彭涛何永琴易德坤周媛媛张玉梅陆军军医大学第二附属医院骨科重庆400037

目的系统分析术前运动训练在老年髋部骨折患者预康复中应用的相关研究,识别运动干预的具体内容、结局指标和应用效果,以期为医护人员开展相关干预提供参考。方法计算机检索中国知网、万方数据库、中国生物医学文献数据库、维普、Cochr... 详细信息

目的系统分析术前运动训练在老年髋部骨折患者预康复中应用的相关研究,识别运动干预的具体内容、结局指标和应用效果,以期为医护人员开展相关干预提供参考。方法计算机检索中国知网、万方数据库、中国生物医学文献数据库、维普、Cochrane Library、PubMed、Embase,Web of Science数据库,检索时限为建库至2024年1月。采用范围综述的方法对纳入研究进行筛选、汇总和分析。结果共纳入10篇研究。其中,随机对照试验3篇、类实验研究1篇、回顾性研究5篇、个案报道1篇。老年髋部骨折患者术前运动准备包括完善相关检查并充分镇痛,运动类型包含适应性训练、抗阻训练、有氧运动。在运动过程中,需全程监测患者症状、体征及不良反应的发生。结果测量包括躯体活动及功能、疼痛、平均住院日、围手术期并发症等。结论术前运动训练对老年髋部骨折患者有积极作用。老年髋部骨折患者术前运动应做好充分的运动前准备,以适应性训练为基础,抗阻运动为主,同时监测患者运动时体征及不良事件发生。

关键词：老年髋部骨折术前运动预康复范围综述