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Moxibustion of Zusanli(ST36)and Shenshu(BL23)alleviates the inflammation of rheumatoid arthritis in rats through regulating macrophage migration inhibitory factor/glucocorticoids signaling

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Journal of Traditional Chinese Medicine 2024年第2期44卷 353-361页

作者： zhang Linlin ZHONG yumei LU Wenting SHANG Yanan GUO Yanding LUO Xiaochao CHEN Yang LUO Kun HU Danhui YU Huiling ZHOU Haiyan Acupuncture and Moxibustion College Chengdu University of Traditional Chinese MedicineChengdu 610075China Department of Painology First People's Hospital of ChengduChengdu 610095China Chinese Evidence-Based Medicine Centre West China HospitalSichuan UniversityChengdu 610044China Traditional Chinese Medicine College Chongqing Medical UniversityChongqing 400016China External treatment center First People's Hospital of ChengduChengdu 610095China

OBJECTIVE:To test the hypothesis that moxibustion may inhibit rheumatoid arthritis(RA)synovial inflammation by regulating the expression of macrophage migration inhibitory factor(MIF)/glucocorticoids(GCs).METHODS:Fifty male Sprague-Dawley rats were randomly divided into five groups(n=10 each):blank Control(CON)group,RA Model(RA)group,Moxibustion(MOX)group,MIF inhibitor(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester(ISO-1)group,and Moxibustion+MIF inhibitor ISO-1(MOX+ISO-1)*** in the ISO-1 group and ISO-1+MOX group were intraperitoneally injected with the inhibitor *** rats in the RA group,ISO-1 group,MOX group,and ISO-1+MOX group were injected with Freund's complete adjuvant(FCA)in the right hind footpad to establish an experimental RA rat *** the MOX group and MOX+ISO-1 group,rats were treated with *** thickness of the footpads of the rats in each group was measured at three-time points before,after modeling and after moxibustion *** contents of serum MIF,corticosterone(CORT),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were detected by enzyme-linked immunosorbent assay;and the contents of synovial MIF were detected by Western ***-eosin(HE)staining method was used to observe the pathological changes of synovial tissue under a section light microscope,and pathological scoring was performed according to the grading standard of the degree of synovial tissue ***:Moxibustion was found to reduce the level of MIF and alleviate inflammation in RA rats in this *** addition,after inhibiting the expression of MIF,the level of CORT increased,and the level of TNF-α *** RA rats with inhibited MIF by moxibustion,the level of CORT was almost unchanged,but the level of TNF-α further *** correlation analysis data suggested that MIF was positively related to the expression of TNF-α and negatively correlated with the expression of ***:Reducing MIF to

关键词： rheumatoid arthritis macrophage migration inhibitory factor moxibustion corticosterone glucocorticoids

Treatment with β-sitosterol ameliorates the effects of cerebral ischemia/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis

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Neural Regeneration Research 2024年第3期19卷 642-649页

作者： Xiuling Tang Tao Yan Saiying Wang Qingqing Liu Qi Yang Yongqiang zhang Yujiao Li yumei Wu Shuibing Liu Yulong Ma Le Yang Precision Pharmacy&Drug Development Center Department of PharmacyTangdu HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Clinical Pharmacy Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu ProvinceChina Department of Pharmacology School of PharmacyAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Anesthesiology The First Medical Center of Chinese PLA General HospitalBeijingChina Department of Anatomy Histology and Embryology and K.K.Leung Brain Research CentreAir Force Medical UniversityXi’anShaanxi ProvinceChina

β-Sitosterol is a type of phytosterol that occurs naturally in *** studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic *** we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced *** investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic *** addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its *** conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.

关键词： apoptosis blood-brain barrier β-sitosterol cerebral ischemia/reperfusion injury cholesterol overload cholesterol transport endoplasmic reticulum stress ischemic stroke molecular docking NPC1L1

论字象与修辞——以《文心雕龙》《〈文心雕龙〉札记》为例

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当代修辞学 2020年第1期 29-38页

作者：张玉梅上海交通大学人文学院

文章运用陈望道先生关于文辞、语辞的广义修辞观,结合"字象与诗象融合"的观点,以《文心雕龙》和《〈文心雕龙〉札记》为研究对象,展开字象与修辞融通关系的拓展性思考。主要讨论三个方面的问题:一、审美视角的取象造字修辞。以"文""章"... 详细信息

文章运用陈望道先生关于文辞、语辞的广义修辞观,结合"字象与诗象融合"的观点,以《文心雕龙》和《〈文心雕龙〉札记》为研究对象,展开字象与修辞融通关系的拓展性思考。主要讨论三个方面的问题:一、审美视角的取象造字修辞。以"文""章"等字例切入,探源汉字创制之初的字象修辞及其审美效果;二、创作视角的取象用字修辞。讨论在写作阶段取象用字的修辞现象,包括汉字形、音、义的复杂性诸问题;三、中庸思想决定的取象双形修辞及字象修辞整体。以"丽""雔""马"等字为例,并探析字象修辞亦应遵循中庸之道。考察结论:汉语"字象"这个颇具民族特色的文化元素与"广义修辞"概念原本融通,自有其文字学动因与生成肌理,对它的考察也可以丰富和扩展汉语诗文鉴赏与写作的审美维度。

关键词：字象神用象通修辞《修辞学发凡》《文心雕龙》《〈文心雕龙〉札记》

训诂学视角下《教要序论》的中西方修辞实践考

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当代修辞学 2017年第5期 89-95页

作者：张玉梅上海交通大学人文学院上海200240

对比传统训诂语料,穷尽式分析比利时传教士南怀仁《教要序论》的修辞现象得出结论:《教要序论》与传统训诂有三个方面的一致性:解释辞格和使用辞格;以比喻为解释手段;行文既重视积极修辞,也重视消极修辞。本文认为,《教要序论》中西方... 详细信息

对比传统训诂语料,穷尽式分析比利时传教士南怀仁《教要序论》的修辞现象得出结论:《教要序论》与传统训诂有三个方面的一致性:解释辞格和使用辞格;以比喻为解释手段;行文既重视积极修辞,也重视消极修辞。本文认为,《教要序论》中西方修辞实践方面的语料,对修辞与训诂关系的考辨颇具价值,训诂学可以增加一条"以易释难"的下位原则:以形象释抽象。针对读者而恰当使用修辞手段的训诂方法、诠释方法是可取的,训诂学与修辞学、诠释学等学科应加强横向联系,实现贯通研究。

关键词：训诂《教要序论》修辞辞格诠释

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职业汉语教学与ZHC测试之关系初探

语言文字应用 2009年第4期 90-98页

作者：张玉梅上海交通大学中文系上海200240

本文以课堂教学实践为出发点,认为职业汉语(ZHC)课程与ZHC的关系为:课程与ZHC的宗旨和目标基本一致;ZHC可以有效督促课程的教学;课程内容、方法与ZHC的精神是一致的;课程补充和提升了ZHC;实战成绩分析一定程度上说明了ZHC测试的公平性。

关键词：职业汉语课程 ZHC 汉语汉字实践与训练补充和提升

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公共图书馆微信公众平台运营推广研究

图书馆 2015年第3期 45-48页

作者：张钰梅湖南图书馆湖南长沙410011

微信公众平台为用户提供了一种全新的互动模式与阅读体验,给公共图书馆的营销推广带来了颠覆性的影响。文章以湖南图书馆微信公众平台为例,从订阅用户、推送内容、推广模式等方面分析了其运营现状,提出了优化公共图书馆微信推广的策略。

关键词：图书馆微信公众平台运营

血糖和血清联合检验在2型糖尿病诊断中的效果

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糖尿病新世界 2024年第1期27卷 51-53页

作者：徐速徐佳刘培钰张彧梅厦门大学附属第一医院检验科福建厦门361001 潍坊市人民医院检验科山东潍坊261000

目的探究在2型糖尿病诊断中应用血清C肽及糖化血红蛋白、血糖和血清联合检验的效果。方法收集2021年1月—2022年6月厦门大学附属第一医院的60例2型糖尿病患者为观察组,60例健康人群作为对照组,对两组受试者均进行血清和血糖检测,比较... 详细信息

目的探究在2型糖尿病诊断中应用血清C肽及糖化血红蛋白、血糖和血清联合检验的效果。方法收集2021年1月—2022年6月厦门大学附属第一医院的60例2型糖尿病患者为观察组,60例健康人群作为对照组,对两组受试者均进行血清和血糖检测,比较两组空腹血糖、餐后2 h血糖、糖化血红蛋白(glycosylated hemoglobin, HbA1c)、血清C肽水平,并分析血糖和血清联合检验的诊断效能。结果观察组空腹血糖、餐后2 h血糖、HbA1c、血清C肽水平均高于对照组,差异有统计学意义(P均<0.05)。联合检测的灵敏度和特异度高于单独检测。结论血糖和血清联合检验的敏感性和特异性较高,可用于2型糖尿病诊断。

关键词： 2型糖尿病血清C肽糖化血红蛋白联合检测

Research for new method for high-precision non-contact measurement of rotate speed

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微计算机信息 2008年第4期 74-76页

作者： LIU YAN ZUO CHUNCHENG zhang yumei LI LIGANG(College of Mechanical Science and Engineering, Jilin University,Changchun 130025) (ShanDong Institute of Business and Technology,YanTai 264005)

This paper explores a kind of new method of high-precision non-contact measurement of rotate speed, to acquire data with a laser CCD displacement sensor, and separate the low-frequency signal and high-frequency noise of the signal with the small-wave multi-frequency analysis method, to pick up the frequency for the separated low-frequency signal as the Nquist sampling theorem, to get the rotate speed to be measured. The experiment has proved this measurement method has the very good feasibility and effectiveness.

关键词： Laser CCD Non-contact measurement Multi-frequency analysis Rotate speed

20%啶虫脒可溶性液剂对杞柳瘿蚊的防效研究

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现代农业科技 2024年第4期 58-60,68页

作者：张玉美李金叶姚骏六安市农业综合行政执法支队安徽六安237000 六安市农业技术推广中心安徽六安237000 霍邱县种植业发展局安徽霍邱237400

为有效控制杞柳瘿蚊危害,筛选出防治杞柳瘿蚊的理想药剂和最佳的施药剂量,本试验采用茎叶喷雾法研究20%啶虫脒可溶性液剂及其与3种化学混合农药对杞柳瘿蚊的防治效果。结果表明:20%啶虫脒可溶性液剂单剂及其与3种农药混合对杞柳瘿蚊均... 详细信息

为有效控制杞柳瘿蚊危害,筛选出防治杞柳瘿蚊的理想药剂和最佳的施药剂量,本试验采用茎叶喷雾法研究20%啶虫脒可溶性液剂及其与3种化学混合农药对杞柳瘿蚊的防治效果。结果表明:20%啶虫脒可溶性液剂单剂及其与3种农药混合对杞柳瘿蚊均有很好的防治效果,其中以20%啶虫脒可溶性液剂525 mL/hm^(2)对杞柳瘿蚊的综合防治效果最好,其次是20%啶虫脒可溶性液剂375 mL/hm^(2)和20%啶虫脒可溶性液剂150 mL/hm^(2)+40%毒死蜱乳油750 g/hm^(2)。从生产成本、防治效果等因素综合考虑,推荐使用20%啶虫脒可溶性液剂375 mL/hm^(2)或20%啶虫脒可溶性液剂150 mL/hm^(2)+40%毒死蜱乳油750 g/hm^(2)防治杞柳瘿蚊。

关键词： 20%啶虫脒可溶性液剂杞柳瘿蚊防效

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