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Interplay between the glymphatic system and neurotoxic proteins in Parkinson’s disease and related disorders:current knowledge and future directions

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Neural Regeneration Research 2024年第9期19卷 1973-1980页

作者： yumei yue Xiaodan Zhang Wen Lv Hsin-Yi Lai Ting Shen Department of Neurology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Emergency Medicine The University of Hong KongHong Kong Special Administrative RegionChina Department of Neurology of the Second Affiliated Hospital and School of Brain Science and Brain Medicine Interdisciplinary Institute of Neuroscience and TechnologyKey Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhouZhejiang ProvinceChina College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhouZhejiang ProvinceChina MOE Frontier Science Center for Brain Science and Brain-Machine Integration State Key Laboratory of Brain-machine IntelligenceSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina

Parkinson’s disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins,includingα-synuclein,amyloid-β,and tau,in addition to the impaired elimination of these neurotoxic protein.Atypical parkinsonism,which has the same clinical presentation and neuropathology as Parkinson’s disease,expands the disease landscape within the continuum of Parkinson’s disease and related disorders.The glymphatic system is a waste clearance system in the brain,which is responsible for eliminating the neurotoxic proteins from the interstitial fluid.Impairment of the glymphatic system has been proposed as a significant contributor to the development and progression of neurodegenerative disease,as it exacerbates the aggregation of neurotoxic proteins and deteriorates neuronal damage.Therefore,impairment of the glymphatic system could be considered as the final common pathway to neurodegeneration.Previous evidence has provided initial insights into the potential effect of the impaired glymphatic system on Parkinson’s disease and related disorders;however,many unanswered questions remain.This review aims to provide a comprehensive summary of the growing literature on the glymphatic system in Parkinson’s disease and related disorders.The focus of this review is on identifying the manifestations and mechanisms of interplay between the glymphatic system and neurotoxic proteins,including loss of polarization of aquaporin-4 in astrocytic endfeet,sleep and circadian rhythms,neuroinflammation,astrogliosis,and gliosis.This review further delves into the underlying pathophysiology of the glymphatic system in Parkinson’s disease and related disorders,and the potential implications of targeting the glymphatic system as a novel and promising therapeutic strategy.

关键词： atypical parkinsonism glymphatic system magnetic resonance imaging neurotoxic proteins Parkinson’s disease

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Active-passive radial-additive friction stir repairing of mechanical hole out of dimension tolerance of AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2023年第9期11卷 3186-3199页

作者： Hua Liu Zhenlei Liu Shude Ji yumei yue Zhibo Dong Changlong Chen College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

In order to avoid the depth increasing of repaired hole and eliminate the super-fine grain band in stir zone by radial-additive friction stir repairing(R-AFSR), a solid-state repairing technique of active-passive radial-additive friction stir repairing(AP-RAFSR) assisted by the truncated cone-shaped filling material was proposed in this study. The mechanical hole out of dimension tolerance of AZ31 magnesium alloy was chosen as the repaired object. The results indicated that the AP-RAFSR process rather than the R-AFSR process avoided the kissing bond in the bottom of the repairing interface under the condition of the tool pin length equal to the height of the standard mechanical hole.The continuously-distributed and large-length super-fine grain bands were eliminated in the stir zone by AP-RAFSR. The maximum tensile and compressive-shear strengths of repaired hole by AP-RAFSR reached 190.6 MPa and 138.9 MPa at 1200 rpm respectively, which were equivalent to 97.7% and 89.6% of those of the standard mechanical hole. This AP-RAFSR process assisted by the truncated cone-shaped filling material provides a new technique to obtain a no-depth-increasing, defect-free and high-strength repaired mechanical hole.

关键词： Active-passive radial-additive friction stir repairing Mechanical hole out of dimension tolerance Numerical simulation Microstructure Mechanical properties

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基于结晶动力学研究聚丁二酸丁二醇酯/微晶纤维素弱界面相互作用对其结晶行为的影响

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复合材料学报 2024年第5期41卷 2355-2363页

作者：张阳廖壑张玥张玉梅东华大学材料科学与工程学院纤维材料改性国家重点实验室上海201620 东华大学机械工程学院上海201620

为了研究高含量刚性粒子存在下的成核作用和复合材料弱界面相互作用对聚丁二酸丁二醇酯(PBS)结晶行为的影响,采用熔融共混法制备了微晶纤维素(MCC)含量为5wt%~25wt%的PBS/MCC复合材料,利用差示扫描量热仪对PBS/MCC复合单丝的熔融行为和... 详细信息

为了研究高含量刚性粒子存在下的成核作用和复合材料弱界面相互作用对聚丁二酸丁二醇酯(PBS)结晶行为的影响,采用熔融共混法制备了微晶纤维素(MCC)含量为5wt%~25wt%的PBS/MCC复合材料,利用差示扫描量热仪对PBS/MCC复合单丝的熔融行为和非等温结晶动力学进行了表征和分析,并使用由Jeziorny模型修改的Avrami方法和由Vyazovkin修改的Friedman等转化率方法研究了PBS的结晶行为和结晶机制。结晶动力学研究表明:MCC可以作为有效的成核剂显著提高PBS的结晶温度和结晶速率,促进PBS晶体的生长,且不会改变PBS的成核机制和晶体生长几何形状,但PBS/MCC弱界面相互作用会明显抑制PBS自身成核能力,PBS结晶度从34.8%降低至28.8%。本文结果对研究高含量刚性粒子存在下的弱界面相互作用对PBS结晶行为的影响具有一定的指导意义。

关键词：聚丁二酸丁二醇酯微晶纤维素非等温结晶动力学界面相互作用结晶机制

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Large-scale Growth of Copper Oxide Nanowires on Various Copper Substrates

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Journal of Materials Science & Technology 2013年第12期29卷 1156-1160页

作者： yumei yue Mingji Chen Yang Ju Shuai Wang Faculty of Aerospace Engineering Shenyang Aerospace University Shenyang 110136 China Department of Mechanical Science and Engineering Nagoya University Furo-cho Chikusa-ku Nagoya 464-8603 Japan Dalian Dv Valve Co. Ltd Dalian 116037 China

Large-scale growth of copper oxide nanowires was realized on surfaces of various copper-containing substrates, including copper grids, high-purity copper foils, and small copper blocks, by the stress-induced method. A relatively low heating temperature of 340 ~C was demonstrated to give rise to dense nanowire growth with fine crystal structures and high aspect ratio of approximately 300. Gradual cooling process, which is positive for the growth of nanowires on multi-layer substrates, is shown to have no effect on the nanowire growth on other pure copper substrates. Diameter of as-obtained nanowires is mainly dependent on the heating temperature. Moreover, the nanowires growing on copper grids are much longer than those growing on two other substrates.

关键词： Copper oxide nanowires Stress-induced method Gradual cooling process Copper-containing substrate

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Effect of Reverse-threaded Pin on Mechanical Properties of Friction Stir Lap Welded Alclad 2024 Aluminum Alloy

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Journal of Materials Science & Technology 2016年第7期32卷 671-675页

作者： yumei yue Zhengwei Li Shude Ji Yongxian Huang Zhenlu Zhou Faculty of Aerospace Engineering. Shenyang Aerospace University Shenyang 110136 China State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology Harbin 150001 China

In friction stir welding （FSW）, tool geometry plays an important role in joint quality. In order to improve mechanical properties of friction stir lap welding （FSLW）joint, a tool with a reverse-threaded pin was designed in the present study. Using 2024-T4 aluminum alloy as the research object, tools with the full- threaded pin and reverse-threaded pin were used in FSLW. Results showed that, when using the same parameter combination, FSLW joint using the reverse-threaded pin owned bigger effective sheet thick- ness （EST）, bigger lap width and better lap shear failure strength. Compared with the full-threaded pin, fracture mode of the FSLW joint changed from shear fracture mode to tensile fracture mode when the reverse-threaded pin was used. Fracture morphologies presented ductile fracture.

关键词： Friction stir lap weldingReverse-threaded pinHookFracture position

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中国中老年人群甘油三酯葡萄糖指数-腰围身高比与认知障碍关联的队列研究

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中华流行病学杂志 2024年第6期45卷 802-808页

作者：侯丁淳魏玥孙玉梅裴丽君陈功北京大学人口研究所北京100871 北京大学护理学院北京100191 北京大学中国老龄事业发展研究中心北京100871

目的分析中老年人中甘油三酯葡萄糖指数(TyG)-腰围身高比(WHtR)(TyG-WHtR)与认知障碍的关联。方法应用中国健康与养老追踪调查数据,以2011年和2015年的8946名中老年人为基线人群,构建队列数据库。应用Cox比例风险回归模型估计中老年人基... 详细信息

目的分析中老年人中甘油三酯葡萄糖指数(TyG)-腰围身高比(WHtR)(TyG-WHtR)与认知障碍的关联。方法应用中国健康与养老追踪调查数据,以2011年和2015年的8946名中老年人为基线人群,构建队列数据库。应用Cox比例风险回归模型估计中老年人基线TyG-WHtR不同水平与认知障碍风险的关联,并分别进行年龄和性别分层分析。结果8946名研究对象平均随访7.08人年,认知障碍发病密度为21.15/1000人年。与TyG-WHtR的Q1水平相比,其Q3和Q4水平分别使认知障碍风险增加32%(HR=1.32,95%CI:1.09~1.60)和47%(HR=1.47,95%CI:1.14~1.91)。趋势检验显示,认知障碍风险随TyG-WHtR水平升高而增加,且存在剂量-反应关系(P=0.001)。分层分析显示,45~59岁人群中,与TyG-WHtR的Q1水平相比,其Q3水平使认知障碍风险增加34%(HR=1.34,95%CI:1.02~1.78);≥60岁人群中,相比于TyG-WHtR的Q1水平,其Q3和Q4水平分别使认知障碍风险增加31%(HR=1.31,95%CI:1.01~1.72)和63%(HR=1.63,95%CI:1.15~2.31);男性中,TyG-WHtR水平与认知障碍风险无统计学关联(P>0.05);女性中,相比于TyG-WHtR的Q1水平,其Q4水平使认知障碍风险增加76%(HR=1.76,95%CI:1.26~2.46)。结论中老年人中较高的TyG-WHtR水平可增加认知障碍风险,且存在年龄、性别差异,早期的心血管健康管理和科学合理的体重管理对预防认知障碍具有重要意义。

关键词：认知障碍甘油三酯葡萄糖指数-腰围身高比队列研究中老年人

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Numerical simulation of effect of rotational tool with screw on material flow behavior of friction stir welding of Ti6Al4V alloy

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Acta Metallurgica Sinica(English Letters) 2012年第5期25卷 365-373页

作者： Shude JI Aili ZOU yumei yue Guohong L UAN Yanye JIN Fu LI Faculty of Aerospace Engineering Shenyang Aerospace University Shenyang 110136 China Beijing Aeronautical Manufacturing Technology Research Institute Beijing 100024 China

The rotational tool is put forward, which is composed of the one-spiral-flute shoul- der and the rotational pin with screw. Using the turbulent model of the FLUENT software, material plastic flow behavior during the process of friction stir welding of Ti6A14V alloy is researched by the numerical simulation method and then the effect of rotational tool geometry on material flow during the welding process is attained. The results show that the flow direction of the material near the rotational tool is mainly the same as the rotational direction of the tool while the material near tool flows more violently than the other regions. For the tapered rotational pin, the flow velocity of material inside the workpiece decreases with the increase of the distance away from the workpiece surface because of the change of pin diameter. For the rotational tool, the flute added to the shoulder and the screw added to the pin can greatly increase the flow velocity of material during the welding process while the peak value of the flow velocity of material appears on the flute or the screw. Moreover, the rotational tool with the one-spiral-flute shoulder is better than the tool with the concentric- circles-flute shoulder. Decreasing the width of pin screw and increasing the diameter of pin tip are both good for the increase of flow velocity.

关键词： Friction stir welding Titanium alloy Plastic flow Numericalsimulation

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A new approach for inversion of receiver function for crustal structure in the depth domain

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Earth and Planetary Physics 2022年第1期6卷 83-95页

作者： TianYu Zheng yumei He yue Zhu Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of Sciences(CAS)Beijing 100029China University of Chinese Academy of Sciences Beijing 100049China

A method for reconstructing crustal velocity structure using the optimization of stacking receiver function amplitude in the depth domain,named common conversion amplitude(CCA)inversion,is presented.The conversion amplitude in the depth domain,which represents the impedance change in the medium,is obtained by assigning the receiver function amplitude to the corresponding conversion position where the P-to-S conversion occurred.Utilizing the conversion amplitude variation with depth as an optimization objective,imposing reliable prior constraints on the structural model frame and velocity range,and adopting a stepwise search inversion technique,this method efficiently weakens the tendency of easily falling into the local extremum in conventional receiver function inversion.Synthetic tests show that the CCA inversion can reconstruct complex crustal velocity structures well and is especially suitable for revealing crustal evolution by estimating diverse velocity distributions.Its performance in reconstructing crustal structure is superior to that of the conventional receiver function imaging method.

关键词： crustal imaging receiver function depth domain inversion

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铜纳米颗粒修饰多孔氮化硼高效还原对硝基苯酚的研究

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河北科技大学学报 2024年第1期45卷 59-66页

作者：张玉梅高通王岳刘新浩段彦栋河北科技大学理学院河北石家庄050018

为了寻找高催化活性、环境友好、价格低廉、稳定性好的催化剂,研究金属与载体之间的协同催化效应,采用煅烧前驱体法制备了表面富含羟基和氨基的高比表面积多孔h-BN载体,通过简单的液相还原法成功地制备出粒径分布均匀的Cu/h-BN纳米复合... 详细信息

为了寻找高催化活性、环境友好、价格低廉、稳定性好的催化剂,研究金属与载体之间的协同催化效应,采用煅烧前驱体法制备了表面富含羟基和氨基的高比表面积多孔h-BN载体,通过简单的液相还原法成功地制备出粒径分布均匀的Cu/h-BN纳米复合材料,并对复合材料的组成、微观结构和性能进行表征。结果显示,铜纳米粒子的引入并未破坏多孔h-BN的二维片状结构,但比表面积及孔径均有不同程度的下降。以对硝基苯酚(4-NP)还原为对氨基苯酚(4-AP)为模型反应,考察Cu/h-BN复合材料的催化性能,当Cu含量为6%(质量分数)时,复合纳米材料具有最高的催化性能(表观反应速率常数k=4.62×10^(-2) s^(-1))和稳定性,催化活性在5个循环内基本保持不变。因此,具有高比表面积的h-BN载体负载可稳定Cu纳米颗粒,它们之间的协同催化作用使Cu/h-BN具有优异的催化活性和稳定性。此研究为今后进一步研究金属与h-BN协同催化提供了理论基础。

关键词：聚合物基复合材料 Cu/h-BN复合材料多孔氮化硼纳米铜催化还原对硝基苯酚

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高模低缩型聚酯工业丝凝聚态结构与应用特性的关联机制

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东华大学学报（自然科学版） 2024年第3期50卷 32-38页

作者：卫婷陈瑞汤方明张烨张玥张玉梅东华大学纤维材料改性国家重点实验室上海201620 东华大学材料科学与工程学院上海201620 江苏恒力化纤股份有限公司江苏苏州215231

高模低缩(HMLS)型聚酯工业丝的凝聚态结构对其在特定应力和受热条件下应用特性的影响尚不明确。对3种HMLS聚酯工业丝的蠕变、应力松弛、热收缩等性能进行测试,通过广角X射线衍射等方法对其凝聚态结构进行研究,分析结晶度、晶区和非晶区... 详细信息

高模低缩(HMLS)型聚酯工业丝的凝聚态结构对其在特定应力和受热条件下应用特性的影响尚不明确。对3种HMLS聚酯工业丝的蠕变、应力松弛、热收缩等性能进行测试,通过广角X射线衍射等方法对其凝聚态结构进行研究,分析结晶度、晶区和非晶区取向以及晶粒尺寸等参数与HMLS聚酯工业丝应用特性的关联性。结果表明,结晶度和非晶区取向度的协同作用对HMLS聚酯工业丝的蠕变、应力松弛和热收缩性能有重要影响。HMLS2的高结晶度抑制了应力作用和热收缩过程中分子链的滑移,适中的非晶区取向度减少了分子链的收缩解取向。HMLS2在60%的平均断裂载荷作用下蠕变回复率高达83.98%,60 s的应力松弛率为14.65%,195℃热处理后强度损失仅为8%,抗蠕变和热稳定性均较好。

关键词：聚酯工业丝高模低缩凝聚态结构蠕变应力松弛热收缩

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