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Effects of inorganic nutrients and environmental factors on the removal of n-propylbenzene and isopropylbenzene in seawater by cryptophytes Rhinomonas reticulata S6A

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Journal of Oceanology and limnology 2024年第4期42卷 1200-1215页

作者： Jiali CUI Shuhao DU yumei li Haiping li Ping ZHANG Fanping MENG Key Laboratory of Marine Environment and Ecology Ministry of EducationOcean University of ChinaQingdao 266100China College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China

To effectively remove n-propylbenzene(n-PBZ)and isopropylbenzene(i-PBZ)leaked into seawater using Rhinomonas reticulata S6A(a newly isolated marine microalga),the effects of three inorganic nutrients and four environmental factors on their degradation were determined after 7 d of *** show that NaNO_(3) at 300 mg/L caused a higher removal efficiency of both n-PBZ and i-PBZ(44.79%and 39.26%),while for NaH_(2) PO_(4)·H_(2) O,greater removal rates of two PBZs(47.30%and 42.23%)were achieved at 30 and 20 mg/L,***_(3) supplementation(500-750 mg/L)resulted in a large reduction(43.67%-45.04%)in i-PBZ *** change in seawater pH(from 6 to 9)did not affect the elimination of n-PBZ and *** most suitable salinity and temperature were 30 and 25-30℃,respectively,leading to the PBZs removal of~40%.light intensity exhibited significant influence on elimination of PBZs,and the maximum removal efficiencies of 56.07%(n-PBZ)and 55.00%(i-PBZ)were recorded under 200 and 600μmol/(m^(2)·s),*** addition,the microalga could still remove PBZs when it failed to grow well due to darkness,strong light,low temperature,or low salinity,which might mean that good growth of alga is not always a necessary condition for PBZs ***,attention should be paid to the suitability of nutrient levels and environmental conditions(excluding pH)in seawater when using microalgae for bioremediating PBZs-contaminated seawater.

关键词： propylbenzene(PBZ) Rhinomonas reticulata seawater inorganic nutrient environmental factor

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Combined effects of climate and land-use changes on the alpha and beta functional diversities of terrestrial mammals in China

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Science China life Sciences 2024年第10期67卷 2224-2233页

作者： Chao Zhang yumei li Wei Wang Zexuan Gao Hanqing liu Yonggang Nie Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of Sciences College of life Sciences Hebei University University of Chinese Academy of Sciences

Climate and land-use changes are predicted to impact biodiversity, threatening ecosystem services and functions. However, their combined effects on the functional diversity of mammals at the regional scale remain unclear, especially at the beta level. Here, we use projected climate and land-use changes in China to investigate their potential effects on the alpha and beta functional diversities of terrestrial mammals under low-and high-emission scenarios. In the current projection, we showed strong positive spatial correlations between functional richness and species richness. Functional evenness(FEve), functional specialization(FSpe), and functional originality(FOri)decreased with species richness, and functional divergence(FDiv) increased first and then plateaued. Functional beta diversity was dominated by its nestedness component, in contrast to the taxonomic facet. Potential changes in species richness are more strongly influenced by land-use change under the low-emission scenario, while under the high-emission scenario, they are more strongly influenced by climate change. Changes in functional richness(FRic) were inconsistent with those in species richness, with a magnitude of decreases greater than predicted from species richness. Moreover, mammal assemblages showed potential functional differentiation(FD) across the country, and the trends exceeded those towards taxonomic differentiation(TD). Our findings help us understand the processes underlying biodiversity responses to global changes on multiple facets and provide new insight for conservation plans.

关键词： climate change land-use change functional diversity terrestrial mammals biodiversity conservation

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Straw mulching alters the composition and loss of dissolved organic matter in farmland surface runoff by inhibiting the fragmentation of soil small macroaggregates

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Journal of Integrative Agriculture 2024年第5期23卷 1703-1717页

作者： Shanshan Cai Lei Sun Wei Wang Yan li Jianli Ding liang Jin yumei li Jiuming Zhang Jingkuan Wang Dan Wei College of Land and Environment Shenyang Agricultural UniversityShenyang 110866China Heilongjiang Academy of Black Soil Conservation and Utilization Harbin 150086China Institute of Plant Nutrition Resources and EnvironmentBeijing Academy of Agricultural and Forestry SciencesBeijing 100097China

Straw mulching is a widespread practice for reducing the soil carbon loss caused by ***,the effects of straw mulching on dissolved organic matter(DOM)runoff loss from black soil are not well *** straw mulching affects the composition and loss of runoff DOM by changing soil aggregates remains largely ***,a straw mulching treatment was compared to a no mulching treatment(as a control)on sloping farmland with black soil erosion in Northeast *** divided the soil into large macroaggregates(>2 mm),small macroaggregates(0.25-2 mm),and microaggregates(like acid and protein-like *** straw mulching treatment,the protein-like components in small macroaggregates accumulated and the protein-like components in runoff declined with rain *** spectroscopy technology may help in understanding the hydrological paths of rain events by capturing the dynamic changes of runoff and soil DOM characteristics.A variation partitioning analysis(VPA)indicated that the DOM concentration and composition of microaggregates explained 68.2%of the change in runoff DOM from no mulching plots,while the change in runoff DOM from straw mulching plots was dominated by small macroaggregates at a rate of 55.1%.Taken together,our results demonstrated that straw mulching reduces the fragmentation of small macroaggregates and the loss of microaggregates,thus effecting DOM compositions in soil and reducing the DOM loss in *** results provi

关键词： dissolved organic matter black soil surface runoff aggregates fluorescence spectrum

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Potentials of ribosomopathy gene as pharmaceutical targets for cancer treatment

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Journal of Pharmaceutical Analysis 2024年第3期14卷 308-320页

作者： Mengxin Wang Stephen Vulcano Changlu Xu Renjian Xie Weijie Peng Jie Wang Qiaojun liu Lee Jia Zhi li yumei li Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province Gannan Medical UniversityGanzhouJiangxi341000China School of Rehabilitation Medicine Gannan Medical UniversityGanzhouJiangxi341000China Autoimmunity and Inflammation Program HSS Research InstituteHospital for Special Surgery New YorkNew YorkNY10021USA Division of Oral and Systemic Health Sciences School of DentistryUniversity of CaliforniaLos AngelesCA90095USA School of Medical Information Engineering Gannan Medical UniversityGanzhouJiangxi341000China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Institute of Innovative DrugsInstitute for Liver Diseases of Anhui Medical UniversitySchool of PharmacyAnhui Medical UniversityHefei230032China School of Basic Medicine Gannan Medical UniversityGanzhouJiangxi341000China Institute of Oceanography Minjiang UniversityFuzhou350108China

Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced *** or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenesis can result in different types of ribosomopathies in clinic,collectively known as ribosomopathy *** data suggest that ribosomopathy patients exhibit a significantly heightened susceptibility to *** ribosome biogenesis and dysregulation of some ribosomopathy genes have also been found to be intimately associated with cancer *** correlation between ribosome biogenesis or ribosomopathy and the development of malignancies has been well *** work aims to review the recent advances in the research of ribosomopathy genes among human cancers and meanwhile,to excavate the potential role of these genes,which have not or rarely been reported in cancer,in the disease development across *** plan to establish a theoretical framework between the ribosomopathy gene and cancer development,to further facilitate the potential of these genes as diagnostic biomarker as well as pharmaceutical targets for cancer treatment.

关键词： Ribosome biogenesis Ribosomopathy gene Cancer treatment target Pharmaceutical target

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Efficacy and safety of CM310 in moderate-to-severe atopic dermatitis:A multicenter,randomized,double-blind,placebo-controlled phase 2b trial

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Chinese Medical Journal 2024年第2期137卷 200-208页

作者： Yan Zhao Jianzhong Zhang Bin Yang Jingyi li Yangfeng Ding liming Wu litao Zhang Jinyan Wang Xiaohong Zhu Furen Zhang Xiaohua Tao yumei li Chunlei Zhang linfeng li Jianyun Lu Qingchun Diao Qianjin Lu Xiaoyong Man Fuqiu li Xiujuan Xia Hao Cheng Yingmin Jia Guoqing Zhao Jinchun Yan Bo Chen Department of Dermatology Peking University People’s HospitalBeijing 100044China Department of Dermatology Dermatology HospitalSouthern Medical UniversityGuangzhouGuangdong 510091China Department of Dermatology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology Shanghai Skin Disease HospitalInstitute of PsoriasisTongji University School of MedicineShanghai 200443China Department of Dermatology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310006China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Department of Dermatology Ningbo No.2 HospitalNingboZhejiang 315010China Department of Dermatology The Wuxi Second Affiliated Hospital of Nanjing Medical UniversityWuxiJiangsu 214002China Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Veneorology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China Center for Plastic&Reconstructive Surgery Department of DermatologyZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)HangzhouZhejiang 310014China Department of Dermatology Affiliated Hospital of Jiangsu UniversityZhenjiangJiangsu 212001China Department of Dermatology Peking University Third HospitalBeijing 100191China Department of Dermatology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Dermatology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China Department of Dermatology Chongqing Traditional Chinese Medicine HospitalChongqing 400011China Hunan Key Laboratory of Medical Epigenomics Department of DermatologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Dermatology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Departme

Background:Atopic dermatitis(AD)affects approximately 10%of adults ***310 is a humanized monoclonal antibody targeting interleukin-4 receptor alpha that blocks interleukin-4 and interleukin-13 *** trial aimed to evaluate the efficacy and safety of CM310 in Chinese adults with moderate-to-severe ***:This multicenter,randomized,double-blind,placebo-controlled,phase 2b trial was conducted in 21 medical institutions in China from February to November *** 120 eligible patients were enrolled and randomized(1:1:1)to receive subcutaneous injections of 300 mg CM310,150 mg CM310,or placebo every 2 weeks for 16 weeks,followed by an 8-week follow-up *** primary endpoint was the proportion of patients achieving≥75%improvement in the Eczema Area and Severity Index(EASI-75)score from baseline at week *** and pharmacodynamics were also ***:At week 16,the proportion of EASI-75 responders from baseline was significantly higher in the CM310 groups(70%[28/40]for high-dose and 65%[26/40]for low-dose)than that in the placebo group(20%[8/40]).The differences in EASI-75 response rate were 50%(high ***,95%CI 31%-69%)and 45%(low ***,95%CI 26%-64%),with both P valueslife Quality Index compared with ***310 treatment reduced levels of thymus and activation-regulated chemokine,total immunoglobulin E,lactate dehydrogenase,and blood *** incidence of treatment-emergent adverse events(TEAEs)was similar among all three groups,with the most common TEAEs reported being upper respiratory tract infection,atopic dermatitis,hyperlipidemia,and *** severe adverse events were deemed to be attributed to ***:CM310 at 150 mg and 300 mg every 2 weeks demonstrated significant efficacy and was well-tol

关键词： CM310 Moderate-to-severe atopic dermatitis Interleukin-4 receptor alpha Adults

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基于有限元数据集建立髋臼周围截骨术的骨刀变形预测模型

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医用生物力学 2024年第4期39卷 657-662页

作者：李玉梅韩阳卢鼎北京信息科技大学高动态导航技术北京市重点实验室、现代测控技术教育部重点实验室北京100192

目的建立一种用于髋臼周围截骨(periacetabular osteotomy,PAO)手术的骨刀变形预测模型,快速且精准地预测骨刀变形。方法建立包含皮质骨和松质骨的骨盆-骨刀有限元数值模型,分析节点应变与形变之间的相关性,并优选综合相关性最强的5个... 详细信息

目的建立一种用于髋臼周围截骨(periacetabular osteotomy,PAO)手术的骨刀变形预测模型,快速且精准地预测骨刀变形。方法建立包含皮质骨和松质骨的骨盆-骨刀有限元数值模型,分析节点应变与形变之间的相关性,并优选综合相关性最强的5个节点的应变作为输入,选择刀刃部分节点的位移增量作为输出。通过数据集训练模型后,采用基于有限元数据集的深度学习神经网络回归模型,建立骨刀应变-形变预测模型。在模型预测完成后,利用双目视觉定位系统确定截骨手术过程中骨刀的空间精确位置,以此对骨刀进行术中跟踪。结果预测模型的R^(2)为0.98781,骨刀离散成节点后的平均变形误差为0.07 mm。该预测模型能够快速且精确地获取骨刀变形,在降低PAO手术事故方面显示出巨大的潜力。结论建立的骨刀变形预测模型可通过骨刀的应变信息快速预测骨刀的变形,从而避免伤及组织周围神经和血管等组织,降低PAO术中难度和风险,并为临床应用提供理论支撑。

关键词：截骨术骨刀变形预测神经网络有限元分析

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火灾后钢筋混凝土板力学性能评估方法

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防灾减灾工程学报 2024年第2期44卷 389-395页

作者：李玉梅王广勇戴林山东青年政治学院山东济南250103 烟台大学土木工程学院山东烟台264005 济南市建设工程勘察设计质量监督站山东济南250000

钢筋混凝土楼板是火灾中最容易破坏的结构构件,需要对其火灾后的承载能力进行评估并加固。考虑升温阶段、降温阶段及火灾后阶段材料本构关系的不同,考虑高温下混凝土保护层的爆裂对温度场及力学性能的影响,提出了火灾后钢筋混凝土楼板... 详细信息

钢筋混凝土楼板是火灾中最容易破坏的结构构件,需要对其火灾后的承载能力进行评估并加固。考虑升温阶段、降温阶段及火灾后阶段材料本构关系的不同,考虑高温下混凝土保护层的爆裂对温度场及力学性能的影响,提出了火灾后钢筋混凝土楼板力学性能分析的有限元计算模型。同时,针对典型的钢筋混凝土板加固方法,在前述有限元模型的基础上建立了火灾后加固的钢筋混凝土板有限元计算模型,利用该模型对典型的火灾后加固钢筋混凝土板的承载能力进行了计算分析。模型中采用单元生死技术实现了混凝土高温下的爆裂及火灾后加固的数值模拟,模型可用于火灾后及加固后钢筋混凝土板力学性能的评估。分析表明,经历火灾后,钢筋混凝土板的承载能力降低幅度较大,板存在明显残余挠度。加固后,钢筋混凝土板的承载能力得到较大程度的恢复。

关键词：火灾后钢筋混凝土楼板承载能力升温阶段降温阶段加固

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青海同仁市自然资源资产清查核算处理方法研究

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矿产与地质 2024年第3期38卷 602-608页

作者：李玉梅青海省地质调查院青海西宁810012 青藏高原北部地质过程与矿产资源重点实验室青海西宁810012 青海省遥感大数据工程技术研究中心青海西宁810012

在对同仁市自然资源资产清查过程中,采用准备工作→数据收集→价值估算→成果汇总→检查验收的清查方法流程。针对清查过程中出现的耗费时间长、部分实物量清查信息缺失、部分数据缺失或不完善等问题,在利用现有资料和实地调查的基础上... 详细信息

在对同仁市自然资源资产清查过程中,采用准备工作→数据收集→价值估算→成果汇总→检查验收的清查方法流程。针对清查过程中出现的耗费时间长、部分实物量清查信息缺失、部分数据缺失或不完善等问题,在利用现有资料和实地调查的基础上,创新性提出了针对同仁市清查所采用的宗地图斑编号、不动产数据偏差处理、无矿区范围的处理、矿区范围重叠的处理、空洞无属性图斑处理等技术。通过对同仁市全民所有土地、矿产、森林、草原、湿地等自然资源开展实物量和价值量清查,得到了同仁市自然资源资产情况。结果表明,结合所有自然资源资产清查工作实践,完成各门类自然资源资产数据清查工作的冗余图斑、数据空间信息要素层空洞区域的处理,在一定程度上提升工作成效。研究成果可为自然资源资产清查核算提供参考。

关键词：资产清查自然资源土地资源青海同仁市

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金钗石斛种植田间管理技术

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农业技术与装备 2024年第5期 126-127,130页

作者：李玉梅赤水市种植业发展服务中心贵州赤水564700

金钗石斛具有药用、食用功效,且其花朵盛开时,还具有极高的观赏价值。因此,近年来金钗石斛的种植面积在不断攀升,且所获经济收益较高。从水肥、修剪、除草,以及病虫害防治等几个层面入手,具体介绍了金钗石斛种植技术。

关键词：金钗石斛种植田间管理技术

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PEO模式指导下生活适应课程实施路径探讨——以多重障碍智障学生为例

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绥化学院学报 2024年第7期44卷 44-47页

作者：李玉梅烟台市特殊教育学校山东烟台264001

生活适应课程着重培养智力残疾学生生活适应、自主发展和参与社会的能力。多重障碍智障学生病因不同且复杂,不能到校上课,目前缺乏针对性的课程和教材来提高生活自理能力。PEO模式理念与生活适应课程吻合,将两者有机融合、各取所长,可... 详细信息

生活适应课程着重培养智力残疾学生生活适应、自主发展和参与社会的能力。多重障碍智障学生病因不同且复杂,不能到校上课,目前缺乏针对性的课程和教材来提高生活自理能力。PEO模式理念与生活适应课程吻合,将两者有机融合、各取所长,可以尝试开辟适合多重障碍智障学生的课程路径,实现教学、生活、发展三位一体,帮助他们适应生活和社会,增强社会责任感。

关键词： PEO模式生活适应实施路径

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