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Polymeric coating lubricates nanocontainers to escape macrophage uptake for bioreceptor recognition

Bioactive Materials 2022年第8期7卷 120-133页

作者： yulong sun Yanxin Han Yannong Dou Xinqi Gong Haimang Wang Xiaoyu Yu Qiang Wang Yixin Wang Yue Dai Fangfu Ye Wei Jin Hongyu Zhang State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing100084China Department of Cardiovascular Medicine Heart Failure CenterRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Department of Pharmacology of Chinese Materia Medica China Pharmaceutical UniversityNanjing210009China Institute for Mathematical Sciences Renmin University of ChinaBeijing100872China Lab of Soft Matter and Biological Physics Institute of PhysicsChinese Academy of SciencesBeijing100190China Institute of Wenzhou University of Chinese Academy of SciencesWenzhou325001China

Accurate drug delivery to the lesion has been deliberated for several decades,but one important phenomenon is usually neglected that the immune system can prevent smooth transportation of *** injection would reduce first-pass effect,macrophages in the blood can still recognize and phagocytose *** we show that a lubricated nanocontainer,which is prepared based on polyelectrolytes and mesoporous silica nanoparticles,can accurately target muscarinic bioreceptor while escaping from the identification of *** in vitro and in vivo studies,this nanocontainer,combining both immune escape and bioreceptor targeting,has greatly improved the drug ***,this nanocontainer shows good biocompatibility,and the targeted heart tissues and other important metabolic organs,such as liver and kidney,keep physiological structures and functions without the detection of side ***,the mechanism of immune escape for the developed nanocontainer has been investigated by lubrication test and molecular *** anticipate that our study will establish a new perspective on the achievement of immune escape-based targeted drug delivery,which can provide a fundamental approach for the design of related biomaterials.

关键词： Mesoporous silica nanoparticles Polyelectrolytes Lubrication Macrophage escape Drug delivery

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Rapid and stable calcium-looping solar thermochemical energy storage via co-doping binary sulfate and Al±Mn±Fe oxides

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Green Energy & Environment 2024年第8期9卷 1290-1305页

作者： Changjian Yuan Xianglei Liu Xinrui Wang Chao Song Hangbin Zheng Cheng Tian Ke Gao Nan sun Zhixing Jiang Yimin Xuan yulong Ding School of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics Key Laboratory of Thermal Management and Energy Utilization of Aviation Vehicles Ministry of Industry and Information Technology Birmingham Centre for Energy Storage School of Chemical Engineering University of Birmingham

Solar thermochemical energy storage based on calcium looping（CaL） process is a promising technology for next-generation concentrated solar power（CSP） systems. However, conventional calcium carbonate（CaCO3） pellets suffer from slow reaction kinetics, poor stability, and low solar absorptance. Here, we successfully realized high power density and highly stable solar thermochemical energy storage/release by synergistically accelerating energy storage/release via binary sulfate and promoting cycle stability, mechanical strength, and solar absorptance via Al±Mn±Fe oxides. The energy storage density of proposed CaCO3pellets is still as high as 1455 kJ kg-1with only a slight decay rate of 4.91% over 100 cycles, which is higher than that of state-of-the-art pellets in the literature, in stark contrast to 69.9% of pure CaCO3pellets over 35cycles. Compared with pure CaCO3, the energy storage power density or decomposition rate is improved by 120% due to lower activation energy and promotion of Ca2+diffusion by binary sulfate. The energy release or carbonation rate rises by 10% because of high O2-transport ability of molten binary sulfate. Benefiting from fast energy storage/release rate and high solar absorptance, thermochemical energy storage efficiency is enhanced by more than 50% under direct solar irradiation. This work paves the way for application of direct solar thermochemical energy storage techniques via achieving fast energy storage/release rate, high energy density, good cyclic stability, and high solar absorptance simultaneously.

关键词： Calcium looping (CaL) Solar thermochemical Energy storage Binary sulfate Fast reaction kinetics

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Precursor engineering enables high-performance all-inorganic CsPbIBr_(2) perovskite solar cells with a record efficiency approaching 13%

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Journal of Energy Chemistry 2024年第3期90卷 16-22,I0003页

作者： Qingyan Chang Yidan An Huaiman Cao Yuzhen Pan Liangyu Zhao yulong Chen Yi We Sai-Wing Tsang Hin-Lap Yip Licheng sun Ze Yu State Key Laboratory of Fine Chemicals Dalian University of Technology(DUT)Dalian 116024LiaoningChina Department of Materials Science and Engineering City University of Hong KongKowloon 999077Hong KongChina School of Chemistry Dalian University of Technology(DUT)Dalian 116024LiaoningChina Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)Dalian University of Technology(DUT)Dalian 116024LiaoningChina School of Energy and Environment City University of Hong KongKowloon 999077Hong KongChina Center of Artificial Photosynthesis for Solar Fuels and Department of Chemistry School of ScienceWestlake UniversityHangzhou 310024ZhejiangChina Department of Chemistry School of Engineering Sciences in ChemistryBiotechnology and HealthKTH Royal Institute of Technology10044 StockholmSweden

All-inorganic CsPbIBr_(2) perovskite has attracted widespread attention in photovoltaic and other optoelectronic devices because of its superior thermal ***,the deposition of high-quality solutionprocessed CsPbIBr_(2) perovskite films with large thicknesses remains ***,we develop a triple-component precursor(TCP) by employing lead bromide,lead iodide,and cesium bromide,to replace the most commonly used double-component precursor(DCP) consisting of lead bromide and cesium ***,the TCP system significantly increases the solution concentration to 1.3 M,leading to a larger film thickness(~390 nm) and enhanced light *** resultant CsPbIBr_(2) films were evaluated in planar n-i-p structured solar cells,which exhibit a considerably higher optimal photocurrent density of 11.50 mA cm^(-2) in comparison to that of DCP-based devices(10.69 mA cm^(-2)).By adopting an organic surface passivator,the maximum device efficiency using TCP is further boosted to a record efficiency of 12.8% for CsPbIBr_(2) perovskite solar cells.

关键词： All-inorganic perovskite solar cells CsPbIBr_(2) Precursor engineering Solubility High performance

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摄影：工具还是语言？

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北京电影学院学报 2009年第1期 85-90页

作者：孙宇龙北京电影学院摄影学院2006级硕士研究生

本文探讨作为纪录工具的摄影与作为艺术语言的摄影之间的差异,两者在当今摄影创作中的理论暗示与实践探索,以及两者差异给创作带来的现实困境与实践选择。

关键词：摄影差异影像评价体系影像创作选择

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Efficient solar-driven CO_(2)-to-fuel conversion via Ni/MgAlO_(x)@SiO_(2)nanocomposites at low temperature

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Fundamental Research 2024年第1期4卷 131-139页

作者： Xianglei Liu Yueyue Ling Chen sun Hang Shi Hangbin Zheng Chao Song Ke Gao Chunzhuo Dang Nan sun Yimin Xuan yulong Ding School of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Birmingham Centre for Energy Storage School of Chemical EngineeringUniversity of BirminghamBirmingham B152TTUnited Kingdom

Solar-driven CO_(2)-to-fuel conversion assisted by another major greenhouse gas CH_(4)is promising to concurrently tackle energy shortage and global warming ***,current techniques still suffer from drawbacks of low efficiency,poor stability,and low ***,a novel nanocomposite composed of interconnected Ni/MgAlOx nanoflakes grown on SiO_(2)particles with excellent spatial confinement of active sites is proposed for direct solar-driven CO_(2)-to-fuel *** ultrahigh light-to-fuel efficiency up to 35.7%,high production rates of H_(2)(136.6 mmol min^(-1)g^(-1))and CO(148.2 mmol min^(-1)g^(-1)),excellent selectivity(H_(2)/CO ratio of 0.92),and good stability are reported *** outstanding performances are attributed to strong metal-support interactions,improved CO_(2)absorption and activation,and decreased apparent activation energy under direct light ***_(x)@SiO_(2)support helps to lower the activation energy of CH^(*) oxidation to CHO^(*) and improve the dissociation of CH_(4)to CH_(3)^(*) as confirmed by DFT ***,the lattice oxygen of MgAlO_(x) participates in the reaction and contributes to the removal of carbon *** work provides promising routes for the conversion of greenhouse gasses into industrially valuable syngas with high efficiency,high selectivity,and benign sustainability.

关键词： Solar fuel CO_(2)reduction Dry reforming of methane Photothermocatalysis Stability

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基于过程荷载的超大跨扁平地下洞室围岩压力计算研究

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现代隧道技术 2020年第5期57卷 91-98页

作者：孙玉龙闫治国同济大学地下建筑与工程系上海200092

60 m级跨度的扁平地下洞室围岩压力计算,超出了已有计算方法的适用范围。文章对比分析了采用已有的公式计算超大跨扁平地下洞室围岩压力荷载值及其影响因素,最终以普氏公式为基础,结合过程荷载的理念及施工方法,把超大跨的横断面离散成... 详细信息

60 m级跨度的扁平地下洞室围岩压力计算,超出了已有计算方法的适用范围。文章对比分析了采用已有的公式计算超大跨扁平地下洞室围岩压力荷载值及其影响因素,最终以普氏公式为基础,结合过程荷载的理念及施工方法,把超大跨的横断面离散成若干小跨洞室,最后得出考虑施工过程的超大跨扁平地下洞室围岩压力荷载值。用有限差分软件进行三维数值模拟,得到了拱顶沉降随开挖面推进的关系、地表沉降范围及其最大值随开挖面推进的变化关系。以0.00025的竖向应变作为临界应变得出洞室顶部围岩的松动范围,即求得松动围岩压力荷载值。对比分析三种方法(一次开挖,过程荷载,数值计算)的计算结果可知,直接将已有的经验公式应用于文章的研究对象得出的围岩压力值大于过程荷载值和数值计算结果,而数值计算结果和过程荷载值相近。因此,把过程荷载用于超大跨扁平地下洞室围岩压力计算具有一定的实际工程意义。

关键词：超大跨扁平洞室围岩压力过程荷载数值模拟塌落区

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CH₄ Monitoring and Background Concentration at Zhongshan Station, Antarctica

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Atmospheric and Climate Sciences 2016年第1期6卷 135-144页

作者： Lingen Bian Zhiqiu Gao yulong sun Minghu Ding Jie Tang Russell C. Schnell Chinese Academy of Meteorological Sciences Beijing China Climate and Weather Disasters Collaborative Innovation Center Nanjing University of Information Science & Technology Nanjing China NOAA ESRL Global Monitoring Division R/GMD Boulder CO USA

Background CH4 concentration and seasonal variations measured at Zhongshan Station (69°22'2''S, 76°21'49''E, 18.5 m) in Antarctica from 2008 through 2013 are presented and discussed. From 2008-2013 CH4 was measured in weekly flask samples and started on line measurement by Picarro CO2/CH4/H2O analyzer from March, 2010-2013. These CH4 measurements show the expected growth period of CH4 concentration during February (Antarctic spring) with a peak in September (fall). Irrespective of wind direction, CH4 concentrations distribute evenly after the removal of polluted air from station operations, accounting for 1% of the data. The mean daily cycle of CH4 concentration in all four seasons is small. The monthly mean CH4 concentration at Zhongshan station is similar to those at other stations in Antarctica showing that CH4 observed in Antarctica is fully mixed in the atmosphere as it is transported from the northern through the southern hemisphere. The annual CH4 increase in recent years at Zhongshan station is 4.8 ppb·yr-1.

关键词： Antarctica Zhongshan Station CH4 Background CH4 Characteristics

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国家级和省市级体育类精品课程网络化建设现状的研究

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体育与科学 2009年第6期30卷 17-20页

作者：阿英嘎孙育龙南京师范大学体育科学学院

对现有的国家级和省市级体育类精品课程的网络化现状进行了分析,发现我国现有的国家级和省市级体育类精品课程中大部分的网站运行情况良好;教学资源网络化已经取得了一定的进展。总体来看国家级精品课程教学资源的网络化情况好于省市级... 详细信息

对现有的国家级和省市级体育类精品课程的网络化现状进行了分析,发现我国现有的国家级和省市级体育类精品课程中大部分的网站运行情况良好;教学资源网络化已经取得了一定的进展。总体来看国家级精品课程教学资源的网络化情况好于省市级,存在问题是,绝大多数网站内容的呈现方式缺乏对学习者的引导作用,不能够满足学习者进行研究性学习和自主学习的需要;教学活动反馈途径的网络化情况有待进一步增强。主要表现在两个方面:一是能够在网上实现师生交流的网站不多,二是所有的精品课程都不能够在网上完成对教学结果的评价;总体来说,目前体育类精品课程的网络化尚未达到网络教学所需水平,教学资源和教学评价等方面的网络化还处于辅助教学的阶段。

关键词：体育类精品课程网络化网络化建设

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基于认知结构的高速列车对标停车控制算法

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北京交通大学学报 2021年第5期45卷 8-15页

作者：郭北苑孙玉龙北京交通大学轨道交通控制与安全国家重点实验室北京100044 北京交通大学电子信息工程学院北京100044

高速列车进站停车是列车自动驾驶系统(Automatic Train Operation,ATO)的一个重要功能,该功能需要在保证乘客舒适性的同时实现精确的对标停车.针对高速列车自动驾驶系统的精确进站停车问题,首先分析了人类高速列车司机在停车过程中的认... 详细信息

高速列车进站停车是列车自动驾驶系统(Automatic Train Operation,ATO)的一个重要功能,该功能需要在保证乘客舒适性的同时实现精确的对标停车.针对高速列车自动驾驶系统的精确进站停车问题,首先分析了人类高速列车司机在停车过程中的认知处理过程;结合认知结构理论对这一过程进行建模,构建了高速列车停车对标任务认知结构模型,基于该模型提出了一种基于认知结构的对标停车控制算法.最后对设计的算法进行了评估与分析.结果表明:该算法与人类高速列车司机具有相似的驾驶特征,与PID控制算法相比在调整次数、冲击率等性能指标上更加优异,对不同的初始条件也有良好的适应性.

关键词：交通信息工程及控制列车自动驾驶停车对标认知结构 ACT-R

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Collective cell behaviors manipulated by synthetic DNA nanostructures

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Fundamental Research 2023年第5期3卷 809-812页

作者： Xiaochen Wang Xiwen Xing Shuang Lu Guangle Du Yi Zhang Yubin Renyulong sun Jing sun Qihui Fan Kai Liu Fan Wang Fangfu Ye Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou 325001China Department of Biotechnology College of Life Science and TechnologyJinan UniversityGuangzhou 510632China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Organic Chemistry I University of UlmAlbert-Einstein-Allee 1189081 UlmGermany Songshan Lake Materials Laboratory Dongguan 523808China

Cellular collective motion in confluent epithelial monolayers is involved in many processes such as embryo development,carcinoma invasion,and wound *** development of new chemical strategies to achieve largescale control of cells’collective motion is essential for biomedical *** a series of DNA nanostructures with different dimensions were synthesized and their influences on cells’collective migration and packing behaviors in epithelial monolayers were *** found that the framed DNA nanoassemblies effectively reduced the cells’speed by increasing the rigidity of cells,while the lipid-DNA micelles had a more pronounced effect on cells’projection area and shape *** DNA nanostructures all significantly enhanced the dependence of cells’speed on their shape *** results indicate that cells’mobility in monolayers can be manipulated by chemical intercellular interactions without any genetic *** may provide a new chemical strategy for tissue engineering and tumor therapy.

关键词： DNA materials Nanomaterial Cell monolayer Collective motion Tissue engineering

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