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Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations

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动物学研究 2024年第1期

作者： Shun Wang Peng Zhang fan Fei Tianyang Tong Xiujuan Zhou Yajie Zhou Jing Zhang Mengke Wei Yanqi Zhang Lei Zhang yulong Huang Lin Zhang Xin Zhang Tiantian Cai Can Xie

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六君子汤治疗食管癌的研究进展

中医学报 2024年第4期39卷 765-772页

作者：樊李妍范修琦韩懿存周哲旭陈星彭梦薇菅佳宁陈玉龙高启龙河南中医药大学第一临床医学院河南郑州450000 郑州大学附属肿瘤医院河南郑州450008 河南中医药大学中医学院(仲景学院) 河南郑州450046

六君子汤是健脾和胃的代表方,在晚期食管癌的辅助治疗中发挥着重要作用,能够联合放化疗减毒增效,降低化疗胃肠道不良反应,改善术后相关并发症,同时增强患者免疫力,提高患者生存质量,预防食管癌前病变。实验研究亦证实六君子汤可以调节... 详细信息

六君子汤是健脾和胃的代表方,在晚期食管癌的辅助治疗中发挥着重要作用,能够联合放化疗减毒增效,降低化疗胃肠道不良反应,改善术后相关并发症,同时增强患者免疫力,提高患者生存质量,预防食管癌前病变。实验研究亦证实六君子汤可以调节炎症因子,阻断肿瘤细胞免疫逃逸,抑制食管癌细胞增殖、迁移和侵袭,促进食管癌细胞凋亡和自噬,逆转对化疗药物的耐药性,缓解胃肠高敏状态。但目前六君子汤治疗食管癌的机制研究多集中于单体成分、基因、蛋白等分子水平,需进一步明确其活性成分之间及活性成分与机体间的作用关系,深入诠释中药复方的系统性疗效;其次,亟需加强证据等级较高的大样本、随机、双盲的临床试验研究,以期为中医药治疗食管癌提供更多的理论和临床依据。

关键词：食管癌六君子汤临床应用药理机制研究进展

Effect of six-month standardized tertiary rehabilitation program on the activities of daily living in stroke patients with hemiplegia

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Neural Regeneration Research 2007年第11期2卷 670-674页

作者： Yulian Zhu Yongshan Hu Yi Wu Congyu Jiang Wenke fan Limin Sun Zhen Xie Li Shen BingZhu yulong Bai Department of Rehabilitation Medicine Huashan Hospital Fudan University Shanghai 200040 China

BACKGROUND： At present, there are many studies on the rehabilitation therapy of stroke patients with hemiplegia, but there is deficiency of corresponding standardized rehabilitation program. OBJECTIVE： To explore the effects of standardized tertiary rehabilitation on the activities of daily living in stroke patients with hemiplegia within 6 months after attack. DESIGN： A clinical observation. SETTING： Department of Rehabilitation Medicine, Huashan Hospital of Fudan University. PARTICIPANTS： Eighty-two outpatients and inpatients with acute stroke were selected from the Department of Neurology, Shanghai Huashan Hosptial from January 1999 to June 2003, including 49 males and 33 females, 40 - 80 years of age, with a mean age of （65 ±11） years old. Inclusive criteria： According to the diagnostic standards for cerebrovascular diseases set by Fourth National Academic Meeting for Cerebrovascular Disease in 1995, the patients were diagnosed as new attack of cerebral infarction or cerebral hemorrhage, and confirmed by CT or MRI to be initial patients; They should be accorded with the following conditions, including within 1 week after stabilization of life signs, Glasgow coma score 〉 8 points, 40 - 80 years of age, with disturbance of limb function. Informed consents were obtained from all the patients or their relatives. Exclusive criteria： Patients were excluded due to active liver disease, liver and kidney malfunction, congestive heart failure, malignant tumor, history of dementia, failure in respiratory function, tetraplegia; cerebral infarction or cerebral hemorrhage for more than 3 weeks; unable to be followed up due to in other cities and provinces; psychiatric history; deafness and muteness. According to the will of the patients or their relatives, the patients who accepted the standardized rehabilitation program were enrolled as the treatment group （n =42）, and the others as the control group （n =40）. Approval was obtained from the ethical committee of the hosp

关键词： rehabilitative intervention physical therapy occupational therapy stroke hemiplegia activities of daily living modified Barthel Index

Gut microbiota bridges dietary nutrients and host immunity

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Science China(Life Sciences) 2023年第11期66卷 2466-2514页

作者： Lijuan fan Yaoyao Xia Youxia Wang Dandan Han Yanli Liu Jiahuan Li Jie Fu Leli Wang Zhending Gan Bingnan Liu Jian Fu Congrui Zhu Zhenhua Wu Jinbiao Zhao Hui Han Hao Wu Yiwen He yulong Tang Qingzhuo Zhang Yibin Wang fan Zhang Xin Zong Jie Yin Xihong Zhou Xiaojun Yang Junjun Wang yulong Yin Wenkai Ren Guangdong Laboratory of Lingnan Modern Agriculture National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China College of Animal Science and Technology Northwest A&F UniversityXi’an 712100China State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China College of Animal Sciences Zhejiang UniversityHangzhou 310058China Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Institute of Animal Sciences Chinese Academy of Agricultural SciencesBeijing 100081China Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life SciencesHunan Normal UniversityChangsha 410081China College of Animal Science and Technology Hunan Agricultural UniversityChangsha 410128China

Dietary nutrients and the gut microbiota are increasingly recognized to cross-regulate and entrain each other,and thus affect host health and immune-mediated ***,we systematically review the current understanding linking dietary nutrients to gut microbiota-host immune interactions,emphasizing how this axis might influence host immunity in health and *** relevance,we highlight that the implications of gut microbiota-targeted dietary intervention could be harnessed in orchestrating a spectrum of immune-associated diseases.

关键词： amino acid carbohydrate lipid trace element vitamin gut microbiota immunity

Structural engineering of 3D hierarchical Cd0.8Zn0.2S for selective photocatalytic CO2 reduction

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Chinese Journal of Catalysis 2021年第1期42卷 131-140页

作者： Lei Cheng Dainan Zhang yulong Liao Jiajie fan Quanjun Xiang State Key Laboratory of Electronic Thin Film and Integrated Devices School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054SichuanChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450002HenanChina

The solar-driven catalytic conversion of CO2 to useful chemical fuels is regarded as an environmentally friendly approach to reduce the consumption of fossil fuels and mitigate the greenhouse ***,it is highly intriguing and challenging to promote the selectivity and efficiency of visible-light-responsive photocatalysts that favor the adsorption of CO2 in photoreduction *** this work,three-dimensional hierarchical Cd0.8Zn0.2S flowers(C8Z2S-F)with ultrathin petals were successfully synthesized through an in-situ self-assembly growth process using sodium citrate as a morphology *** flower-like Cd0.8Zn0.2S solid solution exhibited remarkable photocatalytic performance in the reduction of CO2,generating CO up to 41.4μmol g^−1 under visible-light illumination for 3 h;this was nearly three times greater than that of Cd0.8Zn0.2S nanoparticles(C8Z2S-NP)(14.7μmol g^−1).Particularly,a comparably high selectivity of 89.9%for the conversion of CO2 to CO,with a turnover number of 39.6,was obtained from the solar-driven C8Z2S-F system in the absence of any co-catalyst or sacrificial *** time-domain spectroscopy indicated that the introduction of flower structures enhanced the light-harvesting capacity of *** in situ diffuse reflectance infrared Fourier transform spectroscopy unveiled the existence of surface-adsorbed species and the conversion of photoreduction intermediates during the photocatalytic *** characterizations and predictions of the photocatalytic mechanism demonstrated that the flower-like Cd0.8Zn0.2S solid solution possessed desirable CO2 adsorption properties and an enhanced charge-transfer capability,thus providing a highly effective photocatalytic reduction of CO2.

关键词： Cd0.8Zn0.2S flowers Self-assembly growth Photocatalytic CO2 reduction High selectivity Visible-light irradiation

Numerical simulation of a UAV impacting engine fan blades

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Chinese Journal of Aeronautics 2021年第10期34卷 177-190页

作者： Jingyu YU Bingjin LI Jun LIU Naidan HOU Yingchun ZHANG Yafeng WANG yulong LI School of Aeronautics Northwestern Poly technical UniversityXi'an 710072China Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of ChinaChengdu 610213China Shanghai Aircraft Airworthiness Certification Center of CAAC Shanghai 200335China China Aircraft Strength Research Institute Xi'an 710065China

A 3D digital model of a small Unmanned Aerial Vehicle(UAV)is obtained by using the method of scanning reverse modeling and joint mapping.A numerical simulation of a small UAV strikes on rotary engine blades,presented in this paper,was performed with a Transient Nonlinear Finite Element code PAM-CRASH software.A test of motor strike on plate was developed and the dynamic response of the plate were obtained to validate the numerical simulation method of a UAV strike on *** on this,dynamic damage response caused by UAV on the engine blades were *** is indicated that the impact process between the UAV and a single blade can be divided into two typical stages:cutting and *** mainly leads to the failure of the leading edge material,and impact mainly leads to the plastic deformation of the *** the same time,it is compared with the damage impacted by bird with the same *** the same mass of bird and UAV,the damage caused by UAV striking fan blade is more serious,and 1.345 kg UAV striking fan blade of typical civil aviation engine is enough to cause damage to flight safety.

关键词： Airworthiness Bird impact Engine fan blade Explicit dynamics UAV

Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2138-2151页

作者： Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Using chemoproteomic techniques,we first identified EIF2AK2,eEF1A1,PRDX3 and VPS4B as direct targets of berberine(BBR)for its synergistically anti-inflammatory *** them,BBR has the strongest affinity with EIF2AK2 via two ionic bonds,and regulates several key inflammatory pathways through EIF2AK2,indicating the dominant role of ***,BBR could subtly inhibit the dimerization of EIF2AK2,rather than its enzyme activity,to selectively modulate its downstream pathways including JNK,NF-κB,AKT and NLRP3,with an advantage of good safety *** EIF2AK2 gene knockdown mice,the inhibitory IL-1β,IL-6,IL-18 and TNF-a secretion of BBR was obviously attenuated,confirming an EIF2AK2-dependent anti-inflammatory *** results highlight the BBR's network mechanism on anti-inflammatory effects in which EIF2AK2 is a key target,and inhibition of EIF2AK2 dimerization has a potential to be a therapeutic strategy against inflammationrelated disorders.

关键词： Berberine Anti-inflammatory Target identification Chemoproteomic technology Photoaffinity probe EIF2AK2

准噶尔盆地二叠系上乌尔禾组退覆式扇(辫状河)三角洲前缘-滩坝复合砂砾岩沉积特征及控制因素

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古地理学报 2024年第3期26卷 584-599页

作者：郭文建郭瑞婧唐勇纪友亮马铮涛刘笑语梁涛马玉龙中国石油新疆油田分公司勘探开发研究院新疆克拉玛依834000 中国石油大学(北京)地球科学学院北京102249

近年来准噶尔盆地的油气勘探从源外常规圈闭逐渐走向源内岩性圈闭,二叠系上乌尔禾组是该盆地增储上产的主力层系,沉积体系展布对上乌尔禾组岩性油气藏分布具有控制作用。利用岩心数据、薄片资料等,并结合地震数据和钻测井资料,对准噶尔... 详细信息

近年来准噶尔盆地的油气勘探从源外常规圈闭逐渐走向源内岩性圈闭,二叠系上乌尔禾组是该盆地增储上产的主力层系,沉积体系展布对上乌尔禾组岩性油气藏分布具有控制作用。利用岩心数据、薄片资料等,并结合地震数据和钻测井资料,对准噶尔盆地二叠系上乌尔禾组的沉积相类型及沉积体系分布特征进行了识别和刻画,总结了大型退覆式扇(辫状河)三角洲-滩坝复合砂砾岩体的沉积模式,并分析了其控制因素。研究表明:(1)研究区发育扇三角洲、辫状河三角洲、滨浅湖滩坝等沉积相类型,扇三角洲平原亚相和扇三角洲前缘亚相主要发育在盆地西部,辫状河三角洲平原亚相和辫状河三角洲前缘亚相主要发育在盆地东部和北部,滩坝相叠置在扇三角洲和辫状河三角洲前缘之上或在其前端独立分布;(2)准噶尔盆地上乌尔禾组各段沉积体系是在整体湖侵的背景下发育的,乌一段沉积时期湖盆面积较小,沉积的砂体较厚,延伸距离近,靠近凹陷的中央;乌二段沉积时期物源持续供应,湖盆水体加深,湖盆面积增加,沉积砂体厚度薄,分布广;乌三段沉积时期湖侵作用增强,湖盆面积进一步扩大,湖盆内广泛发育湖泛泥岩;(3)扇三角洲与辫状河三角洲前缘在湖平面不断变化与湖浪的改造下,形成了扇(辫状河)三角洲前缘-滩坝复合砂砾岩体;(4)准噶尔盆地上乌尔禾组沉积时期,沉积体系的主要控制因素为气候、物源供给、湖平面变化和沉积时的古地形坡度和古地貌。该研究为上乌尔禾组油气勘探提供了地质依据。

关键词：准噶尔盆地上乌尔禾组扇三角洲辫状河三角洲滩坝复合砂砾岩体沉积模式

雷火灸治疗慢性阻塞性肺疾病急性加重期的疗效观察及对外周血Th17/Treg免疫平衡的影响

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上海针灸杂志 2024年第4期43卷 374-380页

作者：潘小丹林月华黄玉龙范良郑靓林承霞潘燕蝶张美萃符秀曼海口市中医医院海口570216

目的观察雷火灸辅助西医治疗慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)的临床疗效及对患者外周血辅助性T细胞17(T helper cell 17,Th17)/调节性T细胞(regulatory T cells,Treg)免疫平衡的影响。方法选取67例AECOPD患者为研究对象,采用信封随机法分为对照组(32例)和试验组(35例)。对照组予西医常规治疗,试验组予雷火灸辅助西医常规治疗。比较两组临床疗效,观察两组治疗前后中医证候积分、肺功能指标、肺血管阻力指标、血气指标、血清趋化因子配体18(CC-chemokine ligand 18,CCL18)、白介素-5(interleukin-5,IL-5)、白介素-10(interleukin-10,IL-10)和Th17/Treg免疫平衡的变化。比较两组随访1年内急性加重次数和单次急性加重持续时间。结果试验组总有效率高于对照组(P<0.05)。两组治疗后中医证候积分、Th17比例、Th17/Treg、血清CCL18水平、血清IL-5水平和肺血管阻力指标均低于同组治疗前(P<0.05),且试验组均低于对照组(P<0.05)。两组治疗后肺功能指标、血气指标、Treg比例和血清IL-10水平均高于同组治疗前(P<0.05),且试验组均高于对照组(P<0.05)。随访1年内,试验组急性加重次数少于对照组(P<0.05),单次急性加重持续时间短于对照组(P<0.05)。结论雷火灸辅助西医治疗AECOPD可改善患者血气指标,提高肺功能,促进Th17/Treg免疫平衡,减少急性加重次数,疗效优于单一西医治疗。

关键词：灸法雷火灸针药并用慢性阻塞性肺疾病急性期咳嗽胸闷