检索结果-南通市图书馆

Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets

引用

Journal of Animal Science and Biotechnology 2024年第2期15卷 878-897页

作者： Chang Cui yulong wei Yibo Wang Wen Ma Xiaoyu Zheng Jun Wang Ziwei Ma Caichi Wu Licui Chu Shihai Zhang Wutai Guan Fang Chen Guangdong Provincial Key Laboratory of Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China

Background The benefits of combining benzoic acid and essential oils(BAO)to mitigate intestinal impairment during the weaning process have been well established,while the detailed underlying mechanism has not been fully elucidated.Previous research has primarily focused on the reparative effects of BAO on intestinal injury,while neglecting its potential in enhancing intestinal stress resistance.Methods In this study,we investigated the pre-protective effect of BAO against LPS-induced stress using a modified experimental procedure.Piglets were pre-supplemented with BAO for 14 d,followed by a challenge with LPS or saline to collect blood and intestinal samples.Results Our findings demonstrated that BAO supplementation led to significant improvements in piglets’final weight,average daily gain,and feed intake/body gain ratio.Additionally,BAO supplementation positively influenced the composition of intestinal microbiota,increasing beneficial Actinobacteriota and Alloprevotella while reducing harmful Desulfobacterota,Prevotella and Oscillospira.Furthermore,BAO supplementation effectively mitigated oxidative disturbances and inflammatory responses induced by acute LPS challenge.This was evidenced by elevated levels of T-AOC,SOD,and GSH,as well as decreased levels of MDA,TNF-α,and IL-6 in the plasma.Moreover,piglets subjected to LPS challenge and pre-supplemented with BAO exhibited significant improvements in intestinal morphological structure and enhanced integrity,as indicated by restored expression levels of Occludin and Claudin-1 compared to the non-supplemented counterparts.Further analysis revealed that BAO supplementation enhanced the jejunal antioxidative capacity by increasing GSH-Px levels and decreasing MDA levels under the LPS challenge and stimulated the activation of the Nrf2 signaling pathway.Additionally,the reduction of TLR4/NF-κB/MAPK signaling pathways activation and proinflammatory factor were also observed in the jejunal of those piglets fed with BAO.Conclusions In summary,our study demonstrates that

关键词： Anti-stress Benzoic acid Essential oils Intestine LPS Weaned piglets

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of fermented Rosa roxburghii Tratt fruit juice on gut microbiota in a dextran sulfate sodium-induced colitis mouse model

引用

Food Science and Human Wellness 2024年第4期13卷 2234-2243页

作者： Yunyang Zuo Haoxiang Xu Dandan Feng Yuanyuan Shi Jiuchang Li Maoyang wei Ling Wang yulong Zhang Ping Hu School of Liquor and Food Engineering Guizhou UniversityGuiyang 550025China

This study mainly investigated the regulatory effect of Rosa roxburghii Tratt fruit juice fermented by Lacticaseibacillus paracasei SR10-1(LAB-RRTJ)on modulating gut microbiota in dextran sulfate sodium(DSS)-induced ulcerative colitis in mice.Compared to control group,DSS induction decreased body weight of mice,indexes of Shannon,Simpson,Chao1 and Faith_pd,and increased disease activity index(DAI)and levels of interleukin 1β(IL-1β),IL-6,tumor necrosis factorα(TNF-α)and interferon-γ(IFN-γ);And this induction also led to an increase in Proteobacteria,Verrucomicrobia and Actinobacteria at phylum level,harmful bacterial species richness at genus level,and relative richness of S.sciuri,Desulfovibrio C21_c20,R.gnavus and Akkermansia muciniphila at species level,and a decrease in Firmicutes at phylum level and relative richness of B.acidifaciens in mice.LAB-RRTJ increased body weight of mice with DSS induced ulcerative colitis(UC)and indexes of Shannon,Simpson,Chao1 and Faith_pd,reduced DAI and the content of four infl ammatory factors and improved gut microbiota imbalance in DSS induced UC mice.Besides,the number of operational taxonomic units(OTUs)increased,α-diversity andβ-diversity were restored and similar to those in mice in the control group after LAB-RRTJ treatment.Compared with the positive drug treatment group,LAB-RRTJ has a better effect on regulating gut microbiota diversity in colitis mice.Correlation analysis showed that infl ammatory factors were positively correlated with harmful bacteria and negatively correlated with beneficial bacteria which commonly found in some colitis mice.Taken together,our study demonstrated that LAB-RRTJ could alleviate DSS-induced colitis in mice through the modulation of infl ammatory cytokines and gut microbiota composition.

关键词： Rosa roxburghii Tratt Lacticaseibacillus paracasei Ulcerative colitis Fermentation characteristics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Osteoarthritis animal models for biomaterial-assisted osteochondral regeneration

引用

Biomaterials Translational 2022年第4期3卷 264-279页

作者： Yi Wang Yangyang Chen yulong wei Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina.

Clinical therapeutics for the regeneration of osteochondral defects(OCD)in the early stages of osteoarthritis remain an enormous challenge in orthopaedics.For in-depth studies of tissue engineering and regenerative medicine in terms of OCD treatment,the utility of an optimal OCD animal model is crucial for assessing the effects of implanted biomaterials on the repair of damaged osteochondral tissues.Currently,the most frequently used in vivo animal models for OCD regeneration include mice,rats,rabbits,dogs,pigs,goats,sheep,horses and nonhuman primates.However,there is no single“gold standard”animal model to accurately recapitulate human disease in all aspects,thus understanding the benefits and limitations of each animal model is critical for selecting the most suitable one.In this review,we aim to elaborate the complex pathological changes in osteoarthritic joints and to summarise the advantages and limitations of OCD animal models utilised for biomaterial testing along with the methodology of outcome assessment.Furthermore,we review the surgical procedures of OCD creation in different species,and the novel biomaterials that promote OCD regeneration.Above all,it provides a significant reference for selection of an appropriate animal model for use in preclinical in vivo studies of biomaterial-assisted osteochondral regeneration in osteoarthritic joints.

关键词： animal model biomaterial osteochondral defect regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unexpected divergence in magnetoreceptor MagR from robin and pigeon linked to two sequence variations

引用

Zoological Research 2024年第1期45卷 69-78页

作者： Shun Wang Peng Zhang Fan Fei Tianyang Tong Xiujuan Zhou Yajie Zhou Jing Zhang Mengke wei Yanqi Zhang Lei Zhang yulong Huang Lin Zhang Xin Zhang Tiantian Cai Can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Department of Anatomy Anhui Medical UniversityHefeiAnhui 230032China Department of Mechanical and Aerospace Engineering University at BuffaloState University of New YorkBuffaloNY 14260 USA International Magnetobiology Frontier Research Center Science IslandHefeiAnhui 230031China

Birds exhibit extraordinary mobility and remarkable navigational skills,obtaining guidance cues from the Earth’s magnetic field for orientation and long-distance movement.Bird species also show tremendous diversity in navigation strategies,with considerable differences even within the same taxa and among individuals from the same population.The highly conserved iron and iron-sulfur cluster binding magnetoreceptor(MagR)protein is suggested to enable animals,including birds,to detect the geomagnetic field and navigate accordingly.Notably,MagR is also implicated in other functions,such as electron transfer and biogenesis of iron-sulfur clusters,raising the question of whether variability exists in its biochemical and biophysical features among species,particularly birds.In the current study,we conducted a comparative analysis of MagR from two different bird species,including the migratory European robin(Erithacus rubecula)and the homing pigeon(Columba livia).Sequence alignment revealed an extremely high degree of similarity between the MagRs of these species,with only three sequence variations.Nevertheless,two of these variations underpinned significant differences in metal binding capacity,oligomeric state,and magnetic properties.These findings offer compelling evidence for the marked differences in MagR between the two avian species,potentially explaining how a highly conserved protein can mediate such diverse functions.

关键词： Homing and migration Animal navigation Magnetoreceptor(MagR) Diverse navigation pattern Conserved protein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

案例研究方法在院校研究中的应用特征及规范

引用

高教发展与评估 2024年第1期40卷 36-46,I0004页

作者：马玉龙魏署光华中科技大学教育科学研究院湖北武汉430074 石河子大学医学院新疆石河子832000

以中国院校研究案例辑及四大核心期刊上的案例研究论文为研究对象,从案例研究的特征及规范性两个维度构建分析框架,评估案例研究方法的应用现状,结果发现:案例研究方法的应用,体现了院校研究自我研究和管理研究的基本特征,案例研究主题... 详细信息

以中国院校研究案例辑及四大核心期刊上的案例研究论文为研究对象,从案例研究的特征及规范性两个维度构建分析框架,评估案例研究方法的应用现状,结果发现:案例研究方法的应用,体现了院校研究自我研究和管理研究的基本特征,案例研究主题分布不均匀、整体规范性不足,当前案例研究的规模与质量尚不足以形成系统的研究专题及院校研究理论。院校研究主体价值取向的二元矛盾、案例研究方法的复杂性以及院校研究共同体内部缺乏案例研究的统一标准及系统规划,是问题产生的主要原因。

关键词：院校研究教育研究方法案例研究高校决策

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

油橄榄果渣的营养与功能特性及其在畜禽生产中的应用研究进展

引用

动物营养学报 2024年第1期36卷 1-11页

作者：韦良开张安宁李瑞印遇龙湖南农业大学动物科学技术学院湖南畜禽安全生产协同创新中心长沙410128 中国科学院亚热带农业生态研究所中国科学院亚热带农业生态过程重点实验室畜禽养殖污染控制与资源化技术国家工程实验室动物营养生理与代谢过程湖南省重点实验室长沙410125 南宁大北农饲料科技有限责任公司南宁530105 甘肃新牧原丹谷生态农业发展集团股份有限公司陇南746000

油橄榄果渣是油橄榄榨油后的主要副产物,其粗脂肪、粗蛋白质、可溶性纤维、矿物质等营养成分含量丰富,且富含植物多酚、黄酮、环烯醚、甾醇等多种天然活性成分,有降血脂、抗氧化、抗菌、抗炎症等功效。油橄榄果渣作为畜禽饲料原料,不仅... 详细信息

油橄榄果渣是油橄榄榨油后的主要副产物,其粗脂肪、粗蛋白质、可溶性纤维、矿物质等营养成分含量丰富,且富含植物多酚、黄酮、环烯醚、甾醇等多种天然活性成分,有降血脂、抗氧化、抗菌、抗炎症等功效。油橄榄果渣作为畜禽饲料原料,不仅可以变“废”为宝、降低饲料成本、减少环境污染,还能改善畜禽生长性能、增强机体免疫和抗氧化能力、提高畜禽产品品质。本文概述了油橄榄果渣的营养特点、生物学功能及其在畜禽中的应用现状,旨在为油橄榄果渣作为饲料原料的高效利用提供参考。

关键词：油橄榄果渣营养特性生物学功能畜牧业

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

30%HNO_(3)对2195铝锂合金预腐蚀疲劳特性研究

引用

北京航空航天大学学报 2024年第4期50卷 1129-1137页

作者：刘德俊田干李玉龙张炜张有宏火箭军工程大学导弹工程学院西安710025 中国运载火箭技术研究院北京100076

模拟液体导弹贮箱材料和使用特点,进行2195-T8铝锂合金在30%硝酸溶液中预腐蚀不同时间后的疲劳试验,利用扫描电子显微镜(SEM)、电子背散射衍射仪(EBSD)及透射电子显微镜(TEM)等显微表征方法,研究了预腐蚀对疲劳性能的影响。结果表明:预... 详细信息

模拟液体导弹贮箱材料和使用特点,进行2195-T8铝锂合金在30%硝酸溶液中预腐蚀不同时间后的疲劳试验,利用扫描电子显微镜(SEM)、电子背散射衍射仪(EBSD)及透射电子显微镜(TEM)等显微表征方法,研究了预腐蚀对疲劳性能的影响。结果表明:预腐蚀表面形貌以晶间腐蚀和点蚀为主,在轧制方向上形成条带状腐蚀链,其产生与长条形晶界和金属间粒子连续腐蚀作用相关;经预腐蚀后,铝锂合金试样在210,280,330 MPa中等应力幅下的预腐蚀疲劳寿命较无腐蚀试样有所增加,16 h腐蚀试样寿命提高最为明显,其原因是腐蚀通过将合金表面微裂纹、孔洞等缺陷消除、增加表面粗糙度等方式,降低了应力集中程度,进而延缓了疲劳裂纹萌生。

关键词：铝锂合金推进剂贮箱预腐蚀疲劳特性裂纹萌生

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CO_(2)-多孔材料协同抑制甲烷爆炸特性

引用

高压物理学报 2024年第1期38卷 171-178页

作者：向开军段玉龙何国钦黄维海南拓力特科技有限公司海南海口570100 重庆科技学院安全工程学院重庆401331 油气生产安全与风险控制重庆市重点实验室重庆401331

为探究CO_(2)协同多孔材料对甲烷爆炸特性的影响,自主设计了100 mm×100 mm×1 000 mm爆炸管道并搭建实验平台,研究不同多孔材料孔隙度及CO_(2)喷气压力对甲烷爆炸火焰结构、火焰传播速度和爆炸超压的影响。结果表明:多孔材料对火焰波... 详细信息

为探究CO_(2)协同多孔材料对甲烷爆炸特性的影响,自主设计了100 mm×100 mm×1 000 mm爆炸管道并搭建实验平台,研究不同多孔材料孔隙度及CO_(2)喷气压力对甲烷爆炸火焰结构、火焰传播速度和爆炸超压的影响。结果表明:多孔材料对火焰波有衰减和促进2种效果,当多孔材料孔隙度为10和20 PPI时,未能成功阻爆,而当孔隙度为40 PPI时,阻爆效果明显;CO_(2)喷气压力有一定的阻爆效果,当多孔材料为10和20 PPI时,随着CO_(2)喷气压力的升高,火焰速度峰值逐渐减小,衰减率最大可达13.64%,且爆炸超压峰值也随之下降,其衰减率最大可达52.83%。综合火焰速度和压力变化分析可知,当多孔材料的孔隙度为40 PPI、CO_(2)喷气压力为0.4 MPa时,阻抑爆效果最显著。

关键词： CO_(2) 多孔材料甲烷爆炸协同抑爆孔隙度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

利用独立成分分析法研究新疆地区陆地水储量及其地壳垂向变化

引用

武汉大学学报（信息科学版） 2024年第5期49卷 794-804页

作者：李婉秋郭秋英章传银王伟钟玉龙李伟徐鹏飞山东建筑大学测绘地理信息学院山东济南250101 中国测绘科学研究院北京100830 中国地质大学(武汉)地理与信息工程学院湖北武汉430074 兰州交通大学测绘与地理信息学院甘肃兰州730070 山东理工大学建筑工程与空间信息学院山东淄博255000

中国新疆地区水文气候变化复杂,其水储量变化及其负荷形变特征的精确提取极为重要。采用卫星重力数据GRACE(gravity recovery and climate experiment)反演新疆地区2010—2014年陆地水储量变化,利用独立成分分析法(independent componen... 详细信息

中国新疆地区水文气候变化复杂,其水储量变化及其负荷形变特征的精确提取极为重要。采用卫星重力数据GRACE(gravity recovery and climate experiment)反演新疆地区2010—2014年陆地水储量变化,利用独立成分分析法(independent component analysis,ICA)分解时空模式,提取时空特征信号。在此基础上,反演陆地水负荷迁移引起的地壳垂向变化,引入重力位系数与负荷勒夫数一阶项改正,回加非潮汐大气与海洋信号,结合尺度因子法校正GRACE反演结果,引入全球降水气候计划月降水资料分析形变影响,将其与测区12座连续运行参考站形变位移进行定量比较,重点分析各测站陆地水负荷信号与全球导航卫星系统(global navigation satellite system,GNSS)垂直位移的相关关系。结果表明,经ICA方法分解的新疆地区陆地水储量呈现多时间尺度特征,表现为明显的周年与长期变化;周年信号在西部帕米尔高原附近尤为显著;长期变化以逐年减少为主,在乌鲁木齐西部、天山一带信号较强;总体上,陆地水负荷垂直形变的时间序列波动幅度相对较小,幅值为-1.5~1.5 mm,与WGHM(WaterGAP global hydrology model)模型结果比较一致;形变时序与降水量变化除了存在明显的时间滞后之外,总体趋势相吻合;经非潮汐大气与海洋信号(non-tidal atmospheric and ocean model,GAC)改正后,GRACE结果与GNSS垂直位移的相关程度有所提升,各测站相关系数为0.63~0.91,加权均方根误差达16.18%~58.97%,相位延迟约为0.5~2个月。该研究方法可揭示新疆地区更为精细的水文信号特征,为区域参考框架精确维护提供重要技术支撑。

关键词：独立成分分析法 GRACE 全球导航卫星系统陆地水储量地壳垂向变化

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantitatively Evaluating the Erosion and Preservation of Supergene Oxide Zones:Evidence from the yulong Porphyry Cu Deposit,Eastern Tibetan Plateau

引用

Journal of Earth Science 2024年第1期35卷 280-282页

作者： Xiao-Dong Deng Jian-wei Li State Key Laboratory of Geological Processes and Mineral Resources and School of Earth ResourcesChina University of GeosciencesWuhan 430074China

INTRODUCTION.Weathering and erosion of sulfide ore deposits are important for understanding the post-mineralization processes that have significant effects on the preservation of primary orebodies(Velasco et al.,2013;Braxton et al.,2009;Brimhall et al.,1985).Supergene oxide zones are often developed in sulfide ore deposits,and are mainly composed of iron oxides and hydroxides zones in weathering profile(Andrew,1984;Thornber et al.,1981).

关键词： Eastern Tibetan weathering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：