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GH901合金锻件晶粒级别与均匀性对探伤杂波及底波损失的影响

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模具工业 2024年第1期50卷 55-59页

作者：杨志国蔡培王玉龙邓冠祥王宇锋贵州安大航空锻造有限责任公司贵州安顺561005 空军装备部驻安顺地区军事代表室贵州安顺561008

针对多批次GH901高温合金锻件探伤底波损失与杂波超标不合格的质量问题,开展了多次GH901合金锻造工艺试验,根据锻件不同位置的超声波探伤结果与对应位置晶粒组织进行分析,得出晶粒组织对GH901合金锻件超声波探伤底波损失与杂波的影响。... 详细信息

针对多批次GH901高温合金锻件探伤底波损失与杂波超标不合格的质量问题,开展了多次GH901合金锻造工艺试验,根据锻件不同位置的超声波探伤结果与对应位置晶粒组织进行分析,得出晶粒组织对GH901合金锻件超声波探伤底波损失与杂波的影响。研究结果表明,GH901合金锻件超声波探伤底波损失与晶粒组织的粗细及均匀性存在对应关系,晶粒越细则超声波探伤底波反射回波越高,杂波低;晶粒越粗则超声波探伤底波反射回波越低,杂波高,当合金锻件晶粒达到2级或更粗时,锻件探伤杂波超标;当GH901合金锻件各区域组织差异较大时,锻件探伤底波损失不合格。

关键词：高温合金晶粒组织超声波探伤底波损失探伤杂波

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Ras相关区域家族10蛋白在非小细胞肺癌中的表达及预后价值

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天津医科大学学报 2024年第5期30卷 385-390页

作者：张静怡迟航杨鑫汪玉龙赵伟鹏天津医科大学肿瘤医院国家恶性肿瘤临床医学研究中心天津市恶性肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津300060 天津市中西医结合医院肿瘤内科天津300102 天津市中西医结合医院呼吸内科天津300102

目的:探讨ras-相关结构域家族(ras-association domain family,RASSF)10在非小细胞肺癌中的表达,分析其与非小细胞肺癌临床病理特征和预后的关系。方法:采用qRT-PCR和Western印迹检测RASSF10 mRNA和蛋白的表达;甲基化特异性聚合酶链式反... 详细信息

目的:探讨ras-相关结构域家族(ras-association domain family,RASSF)10在非小细胞肺癌中的表达,分析其与非小细胞肺癌临床病理特征和预后的关系。方法:采用qRT-PCR和Western印迹检测RASSF10 mRNA和蛋白的表达;甲基化特异性聚合酶链式反应(MSP)检测RASSF10启动子甲基化状态,采用免疫组化和酶联免疫吸附测定法(ELISA)检测石蜡组织和血液中RASSF10蛋白表达,Cox回归模型进行生存分析。结果:在非小细胞肺癌细胞株SPCA-1中RASSF10 mRNA及蛋白(z=21.38、33.14,均P<0.05)、在NCI-H157中RASSF10 mRNA及蛋白(z=56.73、56.34,均P<0.05)均低于非肿瘤细胞株。MSP发现RASSF10在SPCA-1和NCI-H157细胞株启动子区甲基化,用5-氮杂-2′-脱氧胞苷处理后,RASSF10在SPCA-1和NCI-H157细胞株中mRNA和蛋白(t=18.14、56.13,均P<0.05)的表达增加。RASSF10启动子甲基化状态与组织中和血清中RASSF10的低表达密切相关(χ^(2)=19.271、4.831,均P<0.05)。预后多因素分析石蜡组织中RASSF10表达(HR=0.508,P<0.05)和N分期(HR=1.839,P<0.001)为非小细胞肺癌患者预后独立因素,RASSF10表达与肿瘤直径(χ^(2)=4.787,P<0.05)、气道内播散(χ^(2)=15.618,P<0.001)和N分期(χ^(2)=11.588,P<0.01)密切相关。结论:RASSF10在非小细胞肺癌中表达降低,与非小细胞肺癌肿瘤进展密切相关,是非小细胞肺癌早期诊断及预后有价值的肿瘤标志物。

关键词：非小细胞肺癌 RASSF10 甲基化预后

Modulating Crystallinity and Miscibility via Side-chain Variation Enable High Performance All-Small-Molecule Organic Solar Cells

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Chinese Journal of Chemistry 2021年第8期39卷 2147-2153页

作者： Yang wang Qunping Fan yulong wang Jin Fang Qi Liu Lei Zhu Jinjing Qiu Xia Guo Feng Liu Wenyan Su Maojie Zhang Laboratory of Advanced Optoelectronic Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China Department of Chemistry City University of Hong KongKowloon 999077Hong KongChina Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Siyuan LaboratoryDepartment of PhysicsJinan UniversityGuangzhouGuangdong 510632China

Side-chain engineering as one of the most important molecular design strategies has been widely used to improve photovoltaic effi-ciency of active layer ***,a series of acceptor-n-donor-n-acceptor typed small molecule(SM)-donors(SL1,SL2,SL3,and SL4),on the basis of high-performance SM-donor BTTzR(SL1)with thiazolo[5,4-d]thiazole as the n-bridging units and 3-butylrho-danine as the terminal electron-withdrawing groups,were designed and synthesized to study the effect of the side-chain substitu-tions of BDT-T on the photovoltaic performanee.

关键词： Organic solar cells Small molecule donor Substituent effects Aggregation Solvent effects

Cooperative Spectrum Sensing Exploiting a Certain Number of CR Users Based on Multi- Antennas in Cognitive Radio Networks

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China Communications 2010年第4期7卷 149-155页

作者： wang Xiaoxiang wang Jing wang yulong MA Bo Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China National key Laboratory of switching and Networking Beijing University of Posts and Telecommunications Beijing 100876 china

In this paper,a cooperative spectrum sensing scheme,which is based on cooperation of a certain number of secondary users and cooperative diversity under multi-antenna scenario,is *** multi-antenna scenario,we set a targeted detection probability and optimize the false alarm probability of the network by choosing a certain number of secondary users with the highest primary user’s signal to noise *** detection performance of the network is also evaluated when all the secondary users are cooperating to illustrate the benefits of the proposed scheme as a *** addition,how to choose the detection threshold of the secondary user is analyzed for the purpose of decreasing the average *** analysis and simulation results show that the optimum false alarm probability can be derived by cooperating a certain number of secondary users rather than all the secondary users and the detection performance of the network can be further improved if secondary users are equipped with multiple ***,a minimum average risk can be obtained by optimizing the detection threshold.

关键词： Cognitive Radio Cooperative Spectrum Sensing Multiple Antennas Detection Threshold.

艾司洛尔围术期应用热点与趋势文献计量学分析

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中国药业 2024年第20期33卷 16-22页

作者：赵俊董丽刘广伟王玉龙刘洪玲青岛大学附属医院山东青岛266003 山东省诸城市人民医院山东潍坊262100 不详

目的探讨艾司洛尔在围术期应用的热点及研究趋势。方法检索Web of Science(WOS)数据库自建库起至2023年5月23日的相关文献,采用Citespace 5.8.R3软件,对涉及的国家/地区发文及合作情况,关键词共现、突现、聚类情况及文献共被引情况进行... 详细信息

目的探讨艾司洛尔在围术期应用的热点及研究趋势。方法检索Web of Science(WOS)数据库自建库起至2023年5月23日的相关文献,采用Citespace 5.8.R3软件,对涉及的国家/地区发文及合作情况,关键词共现、突现、聚类情况及文献共被引情况进行可视化分析。结果共获得有效文献422篇。研究始于1993年,呈波动上升趋势,2013年最多(24篇)。共涉及42个国家/地区,发文量排名前3的为美国(101篇)、日本(55篇)、中国(37篇);美国与其他国家合作最紧密,但多数国家/地区间的合作较少。共198种期刊发表了该领域的文章,Anesthesia and Analgesia(28篇)、Journal of Clinical Anesthesia(17篇)、Canadian Journal of Anesthesia-Journal Canadien D Anesthesie(14篇)是该领域研究发文量较高的3个期刊(期刊引证报告中均位列Q1区)。出现频次较高的关键词有“anes⁃thesia”(89次)、“surgery”(73次)、“remifentanil”(49次)、“propofol”(44次)、“sodium nitroprusside”(31次)、“cardiac surgery”(30次)等;共获得16个突现词,“lidocaine”为2018年至2023年突现度较高(3.67)的关键词;共有19个重要的聚类标签,主要集中于艾司洛尔药理作用及手术、艾司洛尔对比用药、联合使用麻醉剂等方面研究。文献总被引频次7885次,共被引文献的概括性主题包括non-cardiac surgery、eamolot pretreatment等。结论艾司洛尔围术期应用主要集中在心脏手术、心肺旁路手术等,艾司洛尔在非心脏手术中的应用、血流动力学响应、对麻醉药物作用的影响等是目前研究的热点。

关键词：艾司洛尔围术期血流动力学控制性降压文献计量学

Comprehensive Analysis of the Role of Forkhead Box J3(FOXJ3)in Human Cancers

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Wuhan University Journal of Natural Sciences 2024年第1期29卷 74-84页

作者： YANG Yang LI yulong wang Xiaoli School of Public Health Shaanxi University of Chinese MedicineXianyang 712046ShaanxiChina Department of Gastroenterology Shaanxi Provincial People's hospitalXi'an 710068ShaanxiChina Department of Dermatology Affiliated Hospital of Shaanxi University of Chinese MedicineXianyang 712000ShaanxiChina

Forkhead box J3(FOXJ3)is a member of the forkhead box(Fox)***,increasing evidence has revealed the relationship between Fox family members and ***3 is involved in various types of cancer,including lung cancer,tongue squamous carcinoma,and prostate cancer;however,a comprehensive pan-cancer analysis of FOXJ3 remains ***,we explored the function of FOXJ3 across cancers using online websites and databases including TIMER2.0,Sanger Box,UALCAN,GEPIA2.0,c Bio Portal,CancerSEA,STRING,Bio GRID and Metascape to analyze the role of FOXJ3 in *** expression of FOXJ3 was found in various *** genetic alteration percentage in tumors was determined,and elevated FOXJ3 expression was found to be associated with worse overall survival in brain lower grade glioma(LGG),liver hepatocellular carcinoma(LIHC),sarcoma(SARC)and thyroid *** FOXJ3 expression was related to worse prognosis with disease-free survival in adrenocortical carcinoma,LGG and ***3 expression was related to immune infiltration in several *** analysis showed that histone modification,the TGF-βsignaling pathway,and chromatin organization were the top three enriched ontology clusters of the top 100 similar genes of *** pancancer analysis provides comprehensive insights into FOXJ3 from the perspective of bioinformatics in different cancers,where it serves as a potential biomarker for prognosis,especially in LGG and ***3 is also correlated with immune infiltrates in certain human tumors.

关键词： FOXJ3 cancer genetic alteration prognosis

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四川省卫生资源配置及经济发展水平空间分析

中国初级卫生保健 2024年第6期38卷 28-32页

作者：王玉龙鲁旺卓玛刘瑞峰张华敏陈建成都医学院公共卫生学院四川成都610500 四川省卫生健康发展研究中心四川成都610042

目的:分析2016—2021年四川省卫生资源和地区生产总值的空间分布模式及变化特征,为优化卫生资源配置提供参考。方法:运用空间自相关及相对发展率探究四川省卫生资源和地区生产总值的空间分布及发展趋势。结果:四川省卫生资源配置及经济... 详细信息

目的:分析2016—2021年四川省卫生资源和地区生产总值的空间分布模式及变化特征,为优化卫生资源配置提供参考。方法:运用空间自相关及相对发展率探究四川省卫生资源和地区生产总值的空间分布及发展趋势。结果:四川省卫生资源配置及经济发展水平整体呈现东部和西部地区较低、成都市及周边地区水平较高的特点;局部自相关结果显示,2016—2021年,四川省卫生资源及地区生产总值的空间聚集性未得到明显缓解,卫生人力资源的低-低聚集区为四川东北部部分地级市,地区生产总值的低-低聚集区为四川西部的甘孜州;不同时间段卫生资源增长空间格局的变化情况与卫生资源地理空间变化基本不一致。结论:四川省卫生资源空间分布不均衡,四川西部、东北部等部分地级市空间聚集明显,经济水平差异影响卫生资源配置。建议四川省政府部门在提高经济实力的同时加大对卫生领域的投入,根据当地需求加强人才培养和引进,改善人力资源的空间区域分布。

关键词：卫生资源地区生产总值空间配置空间自相关

Impacts of artificial dams on terrestrial water storage changes and the Earth's elastic load response during 1950-2016: A case study of medium and large reservoirs in Chinese mainland

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Geodesy and Geodynamics 2024年第3期15卷 252-263页

作者： Linsong wang Mingtao Zhu yulong Zhong Jianwei Sun Zhenran Peng Hubei Subsurface Multiscale Image Key Laboratory School of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China Three Gorges Research Center for Geo-hazard Ministry of EducationChina University of GeosciencesWuhan 430074China School of Geography and Information Engineering China University of GeosciencesWuhan 430078China

The construction of dams for intercepting and storing water has altered surface water distributions, landsea water exchanges, and the load response of the solid Earth. The lack of accurate estimation of reservoir properties through the land surface and hydrological models can lead to water storage simulation and extraction errors. This impact is particularly evident in many artificial reservoirs in China. The study aims to comprehensively assess the spatiotemporal distribution and trends of water storage in medium and large reservoirs(MLRs) in Chinese mainland during 1950-2016, and to investigate the gravity,displacement, and strain effects induced by the reservoir mass concentration using the load elasticity theory. In addition, the impoundment contributions of MLRs to the relative sea level changes were assessed using a sea-level equation. The results show impoundment increases in the MLRs during1950-2016, particularly in the Yangtze River(Changjiang) and southern basins, causing significant elastic load effects in the surrounding areas of the reservoirs and increasing the relative sea level in China's offshore. However, long-term groundwater estimation trends are overestimated and underestimated in the Yangtze River and southwestern basins, respectively, due to the neglect of the MLRs impacts or the uncertainty of the hydrological model's output(e.g., soil moisture, etc.). The construction of MLRs may reduce the water mass input from land to the ocean, thus slowing global sea level rise. The results of the impact of human activities on the regional water cycle provide important references and data support for improving the integration of hydrological models, evaluating Earth's viscoelastic responses under longterm reservoir storage, enhancing in-situ and satellite geodetic measurements, and identifying the main factors driving sea level changes.

关键词： Man-made dams Terrestrial water storage Elastic load response Sea level changes Chinese mainland

Ag-doped CNT/HAP nanohybrids in a PLLA bone scaffold show significant antibacterial activity

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Bio-Design and Manufacturing 2024年第2期7卷 105-120页

作者： Cijun Shuai Xiaoxin Shi Kai wang yulong Gu Feng Yang Pei Feng State Key Laboratory of Precision Manufacturing for Extreme Service Performance College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China Institute of Additive Manufacturing Jiangxi University of Science and TechnologyNanchang 330013China College of Mechanical Engineering Xinjiang UniversityUrumqi 830017China

Bacterial infection is a major problem following bone implant ***,poly-l-lactic acid/carbon nanotube/hydroxyapatite(PLLA/CNT/HAP)bone scaffolds possess enhanced mechanical properties and show good ***,wesynthesizedsilver(Ag)-dopedCNT/HAP(CNT/Ag-HAP)nanohybrids via the partial replacing of calcium ions(Ca2+)in the HAP lattice with silver ions(Ag+)using an ion doping technique under hydrothermal ***ﬁcally,the doping process was induced using the special lattice structure of HAP and the abundant surface oxygenic functional groups of CNT,and involved the partial replacement of Ca2+in the HAP lattice by doped Ag+as well as the in situ synthesis of Ag-HAP nanoparticles on CNT in a hydrothermal *** result-ing CNT/Ag-HAP nanohybrids were then introduced into a PLLA matrix via laser-based powder bed fusion(PBF-LB)to fabricate PLLA/CNT/Ag-HAP scaffolds that showed sustained antibacterial *** then found that Ag+,which pos-sesses broad-spectrum antibacterial activity,endowed PLLA/CNT/Ag-HAP scaffolds with this activity,with an antibacterial effectiveness of 92.65%.This antibacterial effect is due to the powerful effect of Ag+against bacterial structure and genetic material,as well as the physical destruction of bacterial structures due to the sharp edge structure of *** addition,the scaffold possessed enhanced mechanical properties,showing tensile and compressive strengths of 8.49 MPa and 19.72 MPa,***,the scaffold also exhibited good bioactivity and cytocompatibility,including the ability to form apatite layers and to promote the adhesion and proliferation of human osteoblast-like cells(MG63 cells).

关键词： Ag-doped Carbon nanotube/hydroxyapatite(CNT/HAP) Antibacterial properties Bone scaffold