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Copper-induced liver fibrosis affects the behavior of bone marrow cells in primary culture

Frontiers in Biology 2017年第4期12卷 271-279页

作者： Anatoliy I. Bozhkov Eugeniy G. Ivanov yuliya.a. kuznetsova.svetla.a.l. ohiienko Anastasiya Yu. Bondar 1. Research Institute of Biology of V.N. Karazin Kharkov National University sq. Svobody 4 61022 Kharkov Ukraine

BACKGROUND： The present study investigated the effects （lMCC）, which were administered per os, on the differentiation, of rats in primary culture. of low-molecular-weight components of bovine colostrum growth, and survival of cells obtained from the bone marrow METHODS： Bone marrow cells （BMCs） were obtained from both the rat femurs and were cultured in medium 199 supplemented with antibiotics （8% streptomycin and 8% gentamycin） and 20% inactivated fetal calf serum. In addition, the number of BMCs was counted and their morphotypes were determined. RESUlTS： Animals were treated with copper （Cu） sulfate to induce liver fibrosis. Subsequent treatment with lMCC eliminated growth inhibition and normalized the bodyweight and temperature of animals with Cu-induced liver fibrosis. The number of lymphocytes in the bone marrow of animals with Cu-induced liver fibrosis was significantly higher than that in the bone marrow of control animals. The number ofneutrophils in untreated animals with liver fibrosis and lMCC-treated animals with liver fibrosis was lower than that in control animals. Neutrophils obtained from untreated animals with liver fibrosis and lMCC-treated animals with liver fibrosis underwent two-times faster degradation in vitro than neutrophils obtained from control animals. CONClUSIONS： Our results indicate that lMCC affects the distribution of different morphological types of BMCs but does not prevent their degradation in vitro, which was two-times faster than that of BMCs obtained from control animals.

关键词： bone marrow cells bone marrow colostntm liver fibrosis

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Diclofenac sodium aqueous systems at low concentrations: Interconnection between physicochemical properties and action on hydrobionts

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Journal of Environmental Sciences 2020年第2期32卷 177-186页

作者： Irina S.Ryzhkina yuliya V.Kiseleva lyaisan I.Murtazina Tatyana V.kuznetsova Erik R.Zainulgabidinov Igor V.Knyazev Andrew M.Petrov Sergey E.Kondakov Alexander I.Konovalov Arbuzov Institute of Organic and Physical Chemistry FRC Kazan Scientific CenterRussian Academy of Sciences8 Arbuzov str.Kazan 420088Russia Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences 28 Daurskaya Str.Kazan 420087Russia lomonosov Moscow State University Chemistry Dept.1/3 Lenin HillsMoscow 119899Russia

Diclofenac sodium(DS) is a widely used nonsteroidal anti-inflammatory drug(NSAIDs).NSAIDs are poorly removed during standard wastewater *** consequences of the presence of NSAIDs in rivers and lakes at 10-11–10-8 mol/l are not yet established;therefore, ecotoxicologists have focused their efforts on studying the effect of lowconcentration NSAIDs on fish and hydrobionts, and also on predicting the potential risks to *** provides some information about the bioeffects of some NSAID solutions in low concentrations but there is no physicochemical explanation for these *** the physicochemical patterns of DS solutions in the low range of concentrations and establishing an interconnection between the solutions’ physicochemical properties and bioeffects can provide a conceptually new and important source of information regarding the unknown effects of *** physicochemical properties and action of DS solutions on Ceriodaphnia affinis cladocerans,Paramecium caudatum infusoria, Chlorella vulgaris unicellular green algae, as well as on the growth of the roots of Triticum vulgare wheat seeds, were studied in the calculated concentration range of 1 × 10-3–1 × 10-18 mol/*** relationship between these phenomena was established using the certified procedures for monitoring the toxicity of natural water and *** was shown for the first time that water solutions of DS are dispersed systems in which the dispersed phase undergoes a rearrangement with dilution, accompanied by changes in its size and properties, which affects the nonmonotonic dependences of the system’s physicochemical properties and could cause nonmonotonic changes in action on hydrobionts in the low concentration range.

关键词： Diclofenac sodium low concentration Aqueous solutions Physicochemical properties Hydrobionts Toxicity

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A Three-Dimensional Multi-scale Plasticity Model for Metal-Intermetallic laminate Composites Containing Phases of the l12 Structure

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Acta Metallurgica Sinica(English letters) 2018年第12期31卷 1265-1271页

作者： Yana D.lipatnikova Vladimir A.Starenchenko yuliya V.Solov'eva larisa A.Valuiskaya Tomsk State University of Architecture and Building Solyanaya Sq.2TomskRussia 634003 Siberian State Medical University 2 Moskovsky traktTomskRussia 634055

A three-dimensional plasticity model was developed and applied to metal-intermetallic laminate composites containingphases of the l12 structure. A multi-scale approach that combined the methods of continuum mechanics and dislocationkinetics was used. This model takes account of the different mechanisms of self-locking superdislocations, the dislocationsand the dislocation walls＇ density storage for each type of layer at the micro-scale. At the meso-scale, the solutions to thedislocation kinetics equations, in the form of stress-strain curves, were used to create the properties of a three-dimensionalrepresentative element. The numerical simulation study of the macroscopic deformation was carried out with the finiteelement method using the dynamic model of continuum mechanics, which included the classical conservation laws,constitutive equations and the equation of state. It was shown that the simulation results generated using this model were ingood agreement with the mechanical tests conducted on the single crystals of the l12 structure. The model provides anexcellent description of the high-temperature plastic strain superlocalization effect of single crystal intermetallics of thelI2 structure. This paper describes the numerical results of the study of the tension and compression tests of metal-intermetallic laminate composites containing phases of the l12 structure. The model allows the description of the dis-tribution of the accumulated plastic strain inhomogeneities and is capable of predicting the strengthening properties andplastic behaviour of the metal-intermetallic laminate composites containing phases of the l12 structure.

关键词： Plasticity model Metal-intermetallic laminate composites layered composites l12 structure Tension Compression

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Bone Marrow Cells Obtained from Old Animals Differ from the Young Animals Cells in Their Ability to Divide and in Response to the Presence of liver Fibrosis in Primary Culture

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Advances in Aging Research 2019年第1期8卷 14-27页

作者： S. l. ohiienko A. I. Bozhkov A. Yu. Bondar E. G. Ivanov I. A. Ionov Research Institute of Biology V.N. Karazin Kharkiv National University Kharkov Ukraine G. S. Skovoroda Kharkiv National Pedagogical University Kharkov Ukraine

Dynamics of bone marrow cells number (BMC) in the primary culture isolated from young (3 months) and old (20 months) Wistar rats was investigated. Proliferative activity of BMC of old animals was 2 times higher than that of young animals in the primary culture. Such superiority of the proliferative activity of BMC in the primary culture obtained from old animals is associated with the ability to actively divide lymphocytes and longer “lifespan” of segmented neutrophils obtained from old animals. It should be noted, that the lymphocytes of young animals did not proliferate in the primary culture. The content of intracellular calcium in BMC in the cells of old animals was 3 times higher compared with cells of young animals, which revealed the relationship of intracellular calcium and proliferative activity of BMC. Induction of liver fibrosis led to an increase in the lymphocyte content in young animals by 167%, and in old ones only by 26%, while the lymphocytes of young animals acquired the ability to proliferate in the primary culture. It has been suggested that such differences in the behavior of BMC in primary culture obtained in young and old animals reflect differences in the BMC microenvironment of young and old animals, which leads to changes in the epigenetic-metabolic characteristics of BMC.

关键词： Bone Marrow Aging Proliferation lymphocyte Intracellular Ca2+

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Physiological Response of Halophyte (<i>Suaeda altissima</i>(l.) Pall.) and Glycophyte (<i>Spinacia oleracea</i>l.) to Salinity

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American Journal of Plant Sciences 2013年第2期4卷 427-435页

作者： Nataly R. Meychik yuliya I. Nikolaeva Igor P. Yermakov Plant Physiology Department Faculty of Biology M. V. Lomonosov Mosow State University Moscow Russia Plant Physiology Department Faculty of Biology M. V. Lomonosov Mosow State University Moscow Russia.

We have done a comparative study of ion status, growth and biochemical parameters in shoots and roots of seablite (Suaeda altissima (l.) Pall.) and spinach (Spinacia oleracea l.) grown with different salinity levels in the medium (0.5 - 750 mМ). A distinctive feature of the halophyte was a high Na+ content in tissues at its low concentration in the medium (0.5 mM). In these conditions, Na+ accumulation in seablite roots was four-fold higher than in spinach roots, and Na+ content in seablite leaves was almost 20-fold higher than in spinach. Together with an increase in sodium concentration in the medium, K+ content decreased six-fold in seablite leaves, while in spinach it did not decrease so drastically. We can suppose that in the halophyte, some processes occur only in the presence of sodium, and these functions of sodium cannot be fully fulfilled by potassium. Analysis of protein and total nitrogen content in tissues shows that at high salinity, the ability to synthesize non-protein nitrogen-containing compounds increases in the halophyte and decreases in the glycophyte. Data on proline content dynamics show that its increase in tissues of spinach (salinity levels 150 and 250 mМ) and seablite (salinity levels 0.5 and 750 mМ) is an indicator of plant injury. In seablite and spinach, proline is not a major osmoregulator. Its concentration both in roots and leaves was no more than 2.5 μmol/g fresh weight. The data presented in this work concern the accumulation and distribution of Na+, Cl?, K+ and ions, as well as growth and biochemical parameters. Our data show that the development of adaptation reactions in the whole plants in the conditions of high salinity is determined by morphofunctional systems and their interaction.

关键词： Suaeda altissima (l.) Pall. Spinacia oleracea l. Salinity Ions Praline Nitrogen Protein

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