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Effects of Perindopril on Left Ventricular Remodeling and Osteopontin Expression in Rats With Myocardial Infarction

South china Journal of cardiology 2007年第3期8卷 159-165页

作者： yuling zhang, shuxian zhou, juan lei, jingmin zhangdepartment of cardiology, the second affiliated hospital, sun yat-sen university, guangzhou 510120, china Department of cardiology The Second Affiliated Hospital Sun Yat-sen University Guangzhou 510120 China

Objectives To observe the effects of perindopril on left ventricular remodeling and myocardial osteopontin expression in rats with myocardial infarction. Methods In this study male adult SD rats were randomly divided into 3 groups: sham-operation group, MI-saline group and MI-perindopril group. Left anterior descending artery was ligated to generate myocardial infarction. Perindopril (2 mg/kg body weight/day) was administered from the next day of MI. Four weeks later, left ventricular diameter (LVEDD and LVESD) and left ventricular ejection fraction was estimated with echocardiography, LVSP, LVEDP and±dp/dtmax was detected with hemodynamic measurement, cardiomyocyte diameter and interstitial fibrosis infiltration were evaluated with histological methods, and myocardium osteopontin protein expression level was detected with western blot. Results ①Compared with the sham-operation group, all rats with MI developed significant systolic and diastolic dysfunction, as was indicated by decreased LVEF, LVSP and±dp/dtmax, as well as increased LVEDP. ②Rats with MI showed significantly dilated left ventricles and higher ventricular weight / body weight ratio, significantly increased cardiomyocyte diameter and marked interstitial fibrosis in the non-infarction area. ③Perindopril treatment partly prevented cardiac dysfunction and left ventricular remodeling as indicated by the parameters mentioned above. ④No osteopontin protein was detected in myocardium of sham-operation rats. In rats with MI, high level osteopontin protein expression was significantly inhibited by perindopril treatment. Conclusions In rats with MI, perindopril treatment significantly prevented left ventricular remodeling and myocardium osteopontin protein expression.

关键词： left ventricular remodeling osteopontin expression myocardial infarction rat

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Comparison of the Frequency-dependent Effects of Amiodarone on Ventricular Electrophysiology in Congestive Heart Failure Canine Models and Normal Dogs

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South china Journal of cardiology 2007年第2期8卷 102-106,101页

作者： zhou shuxian zhang yuling lei juan Wu Wei zhang Xuming Division of cardiology Department of Internal Medicine The 2^nd Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510120 China

Objectives To compare the frequency-dependent effects of amiodarone （Ami） on ventricular electrophysiology in fight ventricular rapid pacing-induced congestive heart failure （CHF） canine models. Methods Thirty-two dogs were randomized into four groups： the control group, the Ami group in which the normal dogs were given Ami orally 300 mg a day for 4 -5 weeks, the CHF group induced by right ventricular rapid pacing （240 pulses, min^- 1 for 4 -5 weeks ）, and the group of CHF dogs fed with Ami orally 300 mg a day for 4 - 5 weeks. The techniques of electrical stimulation and monophasic action potential （MAP） recording were used in the electrophysiology studies. Results The effects of Ami on ventricular MAP duration （MAPD90） and effective refractory period （VERP） were not frequency-dependent in CHF dogs. There was also no frequency-dependent effect on the increase in the ratio of VERP to MAPD90 （ VERP/MAPD90 ）. The prolongation of ventricular conduction time was frequencydependent. Conclusions The frequency-dependent effects of Ami on ventricular electrophysiology in CHF dogs were similar to that in normal dogs.

关键词： Amiodarone Congestive heart failure Electrophysiology

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Correlation between Serum Level of Adiponectin and Severity of Coronary Artery Atherosclerosis

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South china Journal of cardiology 2007年第2期8卷 82-86页

作者： lei juan zhou shuxian Xue Shengneng zhang yuling Fang Chang Luo Niansang Department of cardiology Department of Endocrine Medicine The Second Affiliated Hospital of Sun Yat-sen University Guangzhou510120 China

Objectives To investigate the correlation between serum level of adiponectin and severity of coronary artery atherosclerosis. Methods Coronary angiographies were performed and serum levels of adiponectin were measured in 88 patients with suspected coronary heart disease （CHD）. Patients were divided into groups according to the coronary angiographies and Gensini＇s scores of coronary artery atherosclerosis. The serum levels of adiponectin were compared in different groups, and multiple regressions were used to analyze the correlation factors of adiponectin. Results （1）Serum adiponectin concentration in CHD group [ 7. 1 mg/L （2.4 - 21.1 mg/L） ] was decreased as compared with that in control group [ 11.6 mg/L （4.4 - 28.2 mg/L ）, P 〈 0. 01 ] ; （2）The serum levels of adiponectin fell while the Gensini＇ s scores of coronary artery atherosclerosis increased （P 〈 0. 05, P 〈 0. 01 ） ; （3）Serum level of adiponectin was positively correlated with the high-density lipoprotein cholesterol, while negatively correlated with the Gensini＇ s score of coronary artery atherosclerosis and triglyceride （P 〈 0. 01 ）. Conclusions Serum adiponectin concentration was decreased in patients with CHD. Low serum levels of adiponectin reflected the severity of coronary artery atherosclerosis. Adiponectin was a protective factor of cardiovascular system.

关键词： Coronary artery Atherosclerosis Adiponectin Gensini's score

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非糖尿病的冠心病患者尿微量白蛋白与冠脉病变程度的关系

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中国心血管病研究 2007年第9期5卷 644-646页

作者：雷娟周淑娴张玉玲方昶罗年桑中山大学附属第二医院心内科广东省广州市510120

目的探讨非糖尿病的冠心病患者尿微量白蛋白(MAU)与冠脉病变程度的关系。方法对172例可疑冠心病的非糖尿患者进行冠状动脉造影检查并检测其尿白蛋白排泄率(UAER)。根据冠状动脉造影结果将患者分为对照组51例和冠心病组121例。根据病变... 详细信息

目的探讨非糖尿病的冠心病患者尿微量白蛋白(MAU)与冠脉病变程度的关系。方法对172例可疑冠心病的非糖尿患者进行冠状动脉造影检查并检测其尿白蛋白排泄率(UAER)。根据冠状动脉造影结果将患者分为对照组51例和冠心病组121例。根据病变血管的数量分为无血管病变组51例、单支病变组51例、双支病变组32例、三支及以上病变组38例,对比各组间UAER和MAU阳性率之间的差异。结果冠心病组男性患者的比例、UAER、MAU的阳性率、高敏C反应蛋白和纤维蛋白原均高于对照组(P<0.01)。随着冠脉病变数量和程度的增加,UAER(分别为12.9mg/L、34.4mg/L、45.1mg/L和60.7mg/L)和MAU的阳性率(分别为9.8%、41.2%、56.3%和68.4%)均进行性升高(P<0.05,P<0.01)。相关分析显示冠脉病变的Gensini评分与UAER呈正相关(r=0.959,P<0.05)。结论非糖尿病的冠心病患者UAER水平升高,UAER与冠脉病变严重程度呈正相关。

关键词：白蛋白尿冠状动脉疾病

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Blockades of angiotensin and aldosterone reduce osteopontin expression and interstitial fibrosis infiltration in rats with myocardial infarction

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Chinese Medical Journal 2008年第21期121卷 2192-2196页

作者： zhang Yu-ling zhou Shu-xian lei juan YUAN Gui-yi WANG Jing-feng Department of cardiology Second Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China

Background It has been reported that osteopontin has an important role in cardiac fibrosis and remodeling. However, its direct mechanisms remain unclear. The purpose of this study was to investigate the role of angiotensin and aldosterone blockades in cardiac osteopontin expression associated with cardiac remodeling in myocardial infarcted （MI） rats. Methods Fifty SD rats that survived 24 hours after ligating left anterior descending coronary artery were randomly divided into three groups： MI-saline group （n=15, 5 ml/d）, MI-perindopril group （n=18, perindopril 2 mg·kg^-1·d^-1） and MI-spironolacton （n=-17, spironolacton 20 mg·kg^-1·d^-1）. A sham operation group （n=15） was selected as non-infarcted control. At 6 weeks after treatment, hemodynamic pararmeters and left ventricular function were measured with catheterization, interstitial fibrosis infiltration and cardiomyocyte diameters were evaluated histologically. Myocardium osteopontin protein expression level in the non-infarcted myocardium was detected by Western blotting. Results No osteopontin protein was detected in the myocardium of sham-operation rats. High levels of osteopontin protein expression were detected in the MI-saline rats, but the levels were suppressed in the MI-perindopril and MI-spironolacton rats at 6 weeks following MI （P 〈0.01, respectively）. Compared with the sham operation group, all rats in the MI group showed marked interstitial fibrosis infiltration in the non-infarction area, higher ventricular weight/body weight ratio, significantly increased cardiomyocyte diameter （P 〈0.01, respectively）, and developed significant systolic and diastolic dysfunction as indicated by decreased left ventricular systolic pressure （LVSP） and ±dp/dt, as well as increased left ventricular end-diastolic pressure （LVEDP）（P 〈0.01, respectively）. Angiotensin and aldosterone blockades partly prevented cardiac fibrosis and systolic and diastolic dysfunction （P 〈0.01, respectively）. Conclusion Treatment with an

关键词： osteopontin myocardial infarction renin-angiotensin system

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20年間慢性心力衰竭藥物治療的變遷

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镜湖医学 2003年第1期3卷 12-15页

作者：鍾桃娟伍衛劉澤生周淑娴澳門鏡湖醫院内科中國廣州中山大學附属第二醫院心血管内科

目的探討中山大學附屬第二醫院1981、1991、2001年20年間慢性心力衰竭(CHF)住院病例的藥物治療變遷。方法採用回顧性分析方法,按年度進行對比。結果共入選231例CHF住院患者,平均年齡爲(60.0±18.3)歲。20年間CHF平均年齡由47.2歲升至66.... 详细信息

目的探討中山大學附屬第二醫院1981、1991、2001年20年間慢性心力衰竭(CHF)住院病例的藥物治療變遷。方法採用回顧性分析方法,按年度進行對比。結果共入選231例CHF住院患者,平均年齡爲(60.0±18.3)歲。20年間CHF平均年齡由47.2歲升至66.9歲(P<0.0001)。基礎心臟病因構成明顯改變,風心病從1981年的72%降至2001年的16%(P<0.01),冠心病從1981年的16%上升至2001年的47%(P<0.01)。20年來利尿劑、地黃類藥物。利尿劑及地高铀平均日劑磁欄少(P<0.05),低鉀诡及洋地黃中毒的發生逐漸減少(P<0.05)。血管緊張素轉換酶抑制劑和B受體阻滯劑的使用於2001年較以往明顯增多(P<0.0001).結論20年間CHF的基礎心臟病因構成及藥物治療學概念發生了重大變化,將新的治療指南應用於臨床,將進一步改善CHF患者的生活質量和預後。

关键词：心力衰竭慢性回顧性分析藥物治療

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