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Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis

Journal of Clinical and Translational Hepatology 2022年第1期10卷 80-89页

作者： Li Han Maolong Wang yuling yang Hanlin Xu Lili Wei Xia Huang Department of Nursing Affiliated Hospital of Qingdao UniversityQingdaoShandongChina Department of Thoracic Surgery The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina Department of Infectious diseases The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina

Background and Aims:The prognosis of hepatocellular carcinoma(HCC)is extremely poor;therefore,there is an urgent need for novel prognostic molecular biomarkers of HCC.The current investigation utilized circular(circ)RNA-associated competing endogenous(ce)RNAs analysis in order to identify significant prognostic biomarkers of HCC.Methods:CircRNAs and mRNAs that were differentially expressed between normal and HCC tissues were identi-fied.Their respective functions were predicted with Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analyses.A nomogram was used for model verification.Results:A ceRNA network composed of differentially expressed circRNAs and mRNAs was con-structed.Significant hub nodes in the ceRNA network were hsa_circ_0004662,hsa_circ_0005735,hsa_circ_0006990,hsa_circ_0018403 and hsa_circ_0100609.By using this in-formation,a prognostic risk assessment tool was developed based on the expressions of seven genes(PLOD2,TARS,RNF19B,CCT2,RAN,C5orf30 and MCM10).Furthermore,multivariate Cox regression analysis revealed risk and T-stage parameters as independent prognostic factors.The nomograms that were constructed from risk and T-stage groups were used to further assess the prediction of HCC patient survival rates.The nomogram,which consisted of risk and T-stage scores assessment models,was found to be an independent factor for predicting prognosis of HCC.Conclusions:Five circRNAs,including hsa_circ_0004662,hsa_circ_0005735,hsa_circ_0006990,hsa_circ_0018403 and hsa_circ_0100609,that may play key roles in the pro-gression of HCC were identified.Seven gene signatures were identified,which were associated with the aforemen-tioned circRNAs,including PLOD2,TARS,RNF19B,CCT2,RAN,C5orf30 and MCM10,all of which were significant genes involved in the pathophysiology of HCC.These genes may be used as a prognosticating tool in HCC patients.

关键词： Hepatocellular carcinoma CircRNA Signature Prognosis CeRNA

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Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center

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Frontiers of Medicine 2022年第5期16卷 760-765页

作者： yuling yang Xinnan Xu Ming Liu Yanfeng Zhao Yongmei Yu Xiaogang Liu Chang Chen Gening Jiang Wenxin He Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai 200092China Department of Cardiothoracic Surgery Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhou 363000China

oluntary contribution has become the only source of donor lungs in China since 2015.To elaborate the outcomes of patients awaiting lung transplantation(LTx)after the implementation of donation after brain death,we performed a retrospective study that encompassed 205 patients with end-stage lung disease who registered for LTx at Shanghai Pulmonary Hospital from January 1,2015 to January 1,2021.A total of 180 patients were enrolled in the study.The median waiting time was 1.25 months.Interstitial lung disease(ILD)(103/180,57.2%)and chronic obstructive pulmonary disease(COPD)(56/180,31.1%)were the most common diseases in our study population.The mean pulmonary artery pressure(mPAP)of patients in the died-waiting group was higher than that of the survivors(53.29+21.71 mmHg vs.42.11+18.58 mmHg,P-0.002).The mortality of patients with ILD(34/103,33.00%)was nearly twice that of patients with COPD(10/56,17.86%)while awaiting LTx(P-0.041).In the died-waiting group,patients with ILD had a shorter median waiting time than patients with COPD after being listed(0.865 months vs.4.720 months,P-0.030).ILD as primary disease and mPAP>35 mmHg were two significant independent risk factors for waitlist mortality,with hazard ratios(HR)of 3.483(95%CI 1.311-9.111;P-0.011)and 3.500(95%CI 1.435-8.536;P=0.006).Hence,LTx is more urgently needed in patients with ILD and pulmonary hypertension.

关键词： lung transplantation donation after brain death waitlist

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Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5954-5969页

作者： Daoyuan Xie Yaomei Tian Die Hu Yuanda Wang yuling yang Bailing Zhou Rui Zhang Zhixiang Ren Mohan Liu Jie Xu Chunyan Dong Binyan Zhao Li yang Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China College of Bioengineering Sichuan University of Science&EngineeringZigong 643000China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu 610212China

Despite the remarkable success of immune checkpoint inhibitors(ICIs),primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment(TME).Oncolytic viruses(OVs)can overcome the immunosuppressive TME and promote systemic antitumor immunity in hosts.Engineered OVs armed with ICIs would likely have improved effectiveness as a cancer therapy.According to the diverse immune cell landscapes among different types of tumors,we rationally and precisely generated three recombinant oncolytic adenoviruses(OAds):OAd-SIRPα-Fc,OAd-Siglec10-Fc and OAd-TIGIT-Fc.These viruses were designed to locally deliver SIRPα-Fc,Siglec10-Fc or TIGIT-Fc fusion proteins recognizing CD47,CD24 or CD155,respectively,in the TME to achieve enhanced antitumor effects.Our results suggested that OAd-SIRPα-Fc and OAd-Siglec10-Fc both showed outstanding efficacy in tumor suppression of macrophage-dominated tumors,while OAd-TIGIT-Fc showed the best antitumor immunity in CD8+T-cell-dominated tumors.Importantly,the recombinant OAds activated an inflammatory immune response and generated long-term antitumor memory.In addition,the combination of OAd-Siglec10-Fc with anti-PD-1 significantly enhanced the antitumor effect in a 4T1 tumor model by remodeling the TME.In summary,rationally designed OAds expressing ICIs tailored to the immune cell landscape in the TME can precisely achieve tumor-specific immunotherapy of cancer.

关键词： immunity expressing landscape

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融媒词典《JUZI汉语》的研发理念与实现路径

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语言战略研究 2024年第3期9卷 61-72页

作者：杨玉玲北京语言大学教师教育学院/国际中文教育研究院北京100083

信息生产和传播方式正在发生着融媒转型,外向型汉语词典要实现跨越式发展、走出国门,必须迎接转型挑战,抓住融媒化机遇。《JUZI汉语》是外向型融媒词典在实践层面的落地尝试,从理念到实现,体现为4个维度的“融”:(1)内容的“融”,即多... 详细信息

信息生产和传播方式正在发生着融媒转型,外向型汉语词典要实现跨越式发展、走出国门,必须迎接转型挑战,抓住融媒化机遇。《JUZI汉语》是外向型融媒词典在实践层面的落地尝试,从理念到实现,体现为4个维度的“融”:(1)内容的“融”,即多模态化、融通化、集成化;(2)生产过程的“融”,即编写编辑同步化、用户参与全程化、信息数据化和标注量子化、进展阶段化;(3)使用过程的“融”,即检索智能化和应用个性化;(4)服务的“融”,即服务社区化。《JUZI汉语》的实践所反映出的融媒词典涉及领域之广、环节之众、问题之多、难度之大,都是传统辞书所未曾遇到的。要使其健康发展,尚需科学建构汉语融媒辞书的评价体系,尽快创建完善并推广应用融媒体共享平台,积极探索融媒辞书的宣传传播方式和运营盈利模式。

关键词：融媒词典 JUZI汉语多模态用户中心词典服务社区

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Scalability and efficiency challenges for the exascale supercomputing system:practice of a parallel supporting environment on the Sunway exascale prototype system

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Frontiers of Information Technology & Electronic Engineering 2023年第1期24卷 41-58页

作者： Xiaobin HE Xin CHEN Heng GUO Xin LIU Dexun CHEN yuling yang Jie GAO Yunlong FENG Longde CHEN Xiaona DIAO Zuoning CHEN National Research Center of Parallel Computer Engineering and Technology Beijing 100190China

With the continuous improvement of supercomputer performance and the integration of artificial intelligence with traditional scientific computing,the scale of applications is gradually increasing,from millions to tens of millions of computing cores,which raises great challenges to achieve high scalability and efficiency of parallel applications on super-large-scale systems.Taking the Sunway exascale prototype system as an example,in this paper we first analyze the challenges of high scalability and high efficiency for parallel applications in the exascale era.To overcome these challenges,the optimization technologies used in the parallel supporting environment software on the Sunway exascale prototype system are highlighted,including the parallel operating system,input/output(I/O)optimization technology,ultra-large-scale parallel debugging technology,10-million-core parallel algorithm,and mixed-precision method.Parallel operating systems and I/O optimization technology mainly support largescale system scaling,while the ultra-large-scale parallel debugging technology,10-million-core parallel algorithm,and mixed-precision method mainly enhance the efficiency of large-scale applications.Finally,the contributions to various applications running on the Sunway exascale prototype system are introduced,verifying the effectiveness of the parallel supporting environment design.

关键词： Parallel computing Sunway Ultra-large-scale Supercomputer

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马克思生产力思想的逻辑进程及现实启示

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北京理工大学学报（社会科学版） 2024年第1期26卷 1-11页

作者：王欢杨渝玲苏州大学马克思主义学院江苏苏州215123

马克思对生产力的认识经历了感性具体、具体到抽象、抽象到具体的逻辑进程。在早期著作中,马克思基于人本主义框架审视资产阶级发展生产力的手段及其对工人的剥削,在感性具体的材料中总结出生产力的多种形式及基本属性。从《关于费尔巴... 详细信息

马克思对生产力的认识经历了感性具体、具体到抽象、抽象到具体的逻辑进程。在早期著作中,马克思基于人本主义框架审视资产阶级发展生产力的手段及其对工人的剥削,在感性具体的材料中总结出生产力的多种形式及基本属性。从《关于费尔巴哈的提纲》到《哲学的贫困》阶段,马克思在物质活动中认识到人的主体性及建构性,确认评判社会制度的标准以及历史发展的动力,从社会生产的具体形式中抽象出生产力的本质规定及其发展规律。在《资本论》及其手稿中,马克思通过对劳动、机器、资本的详细解析,揭示了生产力的劳动主体属性、物化对象化表现及其被占有的发生机制,在思维具体层面综合分析生产力的多重本质及其内在关联。马克思生产力思想对当代中国激发劳动者创造力、改造劳动方式、优化经济制度具有重要的指导价值。

关键词：感性具体思维抽象思维具体生产力生产关系唯物史观

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Synthesis and Antioxidant Activity of(E)ω-Formylcamphene-Based Thiazole Hydrazone Derivatives

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Journal of Renewable Materials 2023年第1期11卷 379-391页

作者： Jiayu Chang Qingying Ding Chong Zhong Yao Long Zhuanquan Xiao Hai Luo yuling yang Zongde Wang Shengliang Liao Jinzhu Chen Shangxing Chen Ji Zhang College of Forestry Jiangxi Agricultural UniversityEast China Woody Fragrance and Flavor Engineering Research Center of National Forestry and Grassland AdministrationCamphor Engineering Research Center of NFGANanchang330045China College of Science Jiangxi Agricultural UniversityNanchang330045China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang330027China

(E)ω-formylcamphene was synthesized fromα-pinene,the main component of turpentine,and then reacted with thiosemicarbazide to obtain(E)ω-formylcamphene thiosemicarbazide 3,which was reacted with 14α-bromoace-tophenone compounds to obtain 14(E)ω-formylcamphene thiazole hydrazone compounds 5a–5n;the yields were all above 80%.The structures of the target compounds were characterized by IR,^(1)H-NMR,^(13)C-NMR,and HR-MS analyses.Then,500,250,125,62.5,and 31.25 mg/L drug solutions were prepared.Free radical scavenging experi-ments of 1,1-diphenyl-2-picrylhydrazyl(DPPH)and 2,2-bis(3-ethyl-benzothiazole-6-sulfonic acid)diammonium salt(ABTS)were carried out with Trolox and L-ascorbic acid as the control samples.The scavenging rates of 14 compounds for DPPH and ABTS free radicals were obtained;the IC_(50) values of scavenging free radicals were fitted using SPSS software.The results show that 14(E)ω-formylcamphene-based thiazole hydrazone compounds exhibited good scavenging effects on the two free radicals,especially when the concentration of the drug solution was 125 and 62.5 mg/L;most compounds exceeded the scavenging efficiency of Trolox and L-ascorbic acid.

关键词： (E)ω-formylcamphene thiosemicarbazone thiazohydrazone structural analysis antioxidant activity

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Transposon-based screen identifies a XRE family regulator crucial for candicidin biosynthesis in Streptomyces albus J1074

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Science China(Life Sciences) 2020年第9期63卷 1421-1424页

作者： Jun Tian Leixin Ye yuling yang Yalin Zhang Changhua Hu Guojian Liao Institute of Modern Biopharmaceuticals College of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China

Dear Editor,Polyene macrolides are a group of natural products with potent antifungal activity (Caffrey et al., 2016). Candicidin/FR-008, a potent broad-spectrum anti-fungal agent, is produced by several Streptomycetes, including Streptomycetes sp. strain FR-008 (Chen et al., 2003), S. griseus 3570(Campelo and Gil, 2002) and S. albus J1074 (Olano et al.,2014). Due to its medical importance, considerable effort has been applied to elucidate its biosynthetic pathway and identify key regulatory genes (Chen et al., 2003;Zhang et al.,2015).

关键词： agent cidin identif

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基于内容分析法的在线英语学习词典用户评价模型构建

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外国语文 2024年第1期40卷 156-167页

作者：陈贤德杨玉玲北京语言大学教师教育学院北京100083

词典评价研究对词典编纂具有重要意义,但以往研究鲜少从用户视角来建立词典评价模型。以App Store上用户对五部在线英语学习词典的评价为样本,运用ROST Content Mining 6软件从在线词典用户积极评价与消极评价文本中提炼高频词并进行社... 详细信息

词典评价研究对词典编纂具有重要意义,但以往研究鲜少从用户视角来建立词典评价模型。以App Store上用户对五部在线英语学习词典的评价为样本,运用ROST Content Mining 6软件从在线词典用户积极评价与消极评价文本中提炼高频词并进行社会语义网络分析,挖掘出用户的潜在需求和使用偏好。结合高频词表和社会语义网络图选取100个有效分析单元,对分析单元进行编码并进行分类检验后,初步建立起用户评价模型。结合词典用户需求研究,完善评价模型。最后,以有道为调查对象,将模型运用于评价实践中。验证结果显示,模型具有较好的信效度。

关键词：内容分析法在线英语学习词典使用偏好用户评价:评价模型

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基于相似性原则的橡胶颗粒-砂混合物热导率理论模型

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岩土工程学报 2024年第2期46卷 436-444页

作者：张涛杨玉玲张家铭周逸文刘松玉南京工业大学交通运输工程学院江苏南京210009 中国地质大学(武汉)工程学院湖北武汉430074 东南大学岩土工程研究所江苏南京210096

为准确定量评价人工隔热材料橡胶颗粒-砂混合物的导热性能,突破现有经验关系模型适用性较差的局限性,以Wiener土体热导率模型为框架,基于相似性原则,通过对混合物中各介质的导热性能进行分析,建立用于计算混合物热导率的理论模型,分析... 详细信息

为准确定量评价人工隔热材料橡胶颗粒-砂混合物的导热性能,突破现有经验关系模型适用性较差的局限性,以Wiener土体热导率模型为框架,基于相似性原则,通过对混合物中各介质的导热性能进行分析,建立用于计算混合物热导率的理论模型,分析模型中计算参数的意义和确定方法,根据文献报道热导率测试数据,对比验证模型的有效性,并探讨模型进一步完善和拓展的研究方向。研究结果表明:橡胶颗粒和孔隙液的导热能力相似,可将两者归属为相似类传热介质应用于Wiener串、并联模型中;模型综合考虑了橡胶掺量、粒径比、饱和度和孔隙率等对橡胶颗粒-砂混合物结构和导热性能的影响,准确描述了混合物热导率和橡胶掺量、粒径比的相关关系,与实测数据的对比结果显示了较高的精确度。探明复杂应力状态和极端气候条件对刚-柔性颗粒混合物导热性能的作用规律,是进一步完善和拓展本文模型的重要研究内容。

关键词：橡胶颗粒-砂混合物热传导颗粒接触土体结构理论模型

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